John Parrington

8.6k total citations · 2 hit papers
123 papers, 7.0k citations indexed

About

John Parrington is a scholar working on Physiology, Public Health, Environmental and Occupational Health and Molecular Biology. According to data from OpenAlex, John Parrington has authored 123 papers receiving a total of 7.0k indexed citations (citations by other indexed papers that have themselves been cited), including 61 papers in Physiology, 40 papers in Public Health, Environmental and Occupational Health and 36 papers in Molecular Biology. Recurrent topics in John Parrington's work include Calcium signaling and nucleotide metabolism (56 papers), Reproductive Biology and Fertility (39 papers) and Sperm and Testicular Function (30 papers). John Parrington is often cited by papers focused on Calcium signaling and nucleotide metabolism (56 papers), Reproductive Biology and Fertility (39 papers) and Sperm and Testicular Function (30 papers). John Parrington collaborates with scholars based in United Kingdom, United States and Belgium. John Parrington's co-authors include Karl Swann, Kevin Coward, F. Anthony Lai, Margarida Ruas, Michael X. Zhu, Lianne C. Davis, Mark G. Larman, Lynda Blayney, Christopher M. Saunders and Jianjie Ma and has published in prestigious journals such as Nature, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

John Parrington

122 papers receiving 6.9k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

PLCζ: a sperm-specific trigger of Ca2+ oscillations in eggs and embryo development

2002 804 citations John Parrington, Karl Swann et al. Development profile →
NAADP mobilizes calcium from acidic organelles through two-pore channels

2009 621 citations Margarida Ruas, Abdelilah Arredouani et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
John Parrington United Kingdom	46	3.0k	2.7k	2.6k	2.0k	1.3k	123	7.0k
Harvey M. Florman United States	32	2.9k 1.0×	495 0.2×	3.3k 1.2×	1.6k 0.8×	231 0.2×	46	4.6k
Rafael A. Fissore United States	45	4.5k 1.5×	251 0.1×	3.5k 1.3×	2.1k 1.0×	193 0.1×	116	6.0k
Keith T. Jones United Kingdom	46	3.7k 1.2×	197 0.1×	2.1k 0.8×	2.7k 1.3×	79 0.1×	105	5.7k
R. M. Moor United Kingdom	59	6.3k 2.1×	199 0.1×	3.5k 1.3×	3.4k 1.7×	146 0.1×	188	10.0k
Douglas Kline United States	27	1.8k 0.6×	204 0.1×	1.3k 0.5×	1.2k 0.6×	80 0.1×	57	2.9k
A. L. Johnson United States	41	2.0k 0.7×	236 0.1×	1.6k 0.6×	1.9k 0.9×	60 0.0×	128	5.9k
John J. Peluso United States	45	1.8k 0.6×	132 0.0×	1.6k 0.6×	1.8k 0.9×	85 0.1×	159	5.4k
Deborah A. O’Brien United States	36	1.8k 0.6×	221 0.1×	2.5k 1.0×	2.7k 1.3×	31 0.0×	75	5.4k
Mariano G. Buffone Argentina	35	1.8k 0.6×	282 0.1×	2.2k 0.8×	738 0.4×	19 0.0×	95	3.0k
Trish Berger United States	33	1.5k 0.5×	311 0.1×	1.9k 0.7×	589 0.3×	11 0.0×	115	3.3k

Countries citing papers authored by John Parrington

Since Specialization

Citations

This map shows the geographic impact of John Parrington's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Parrington with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Parrington more than expected).

Fields of papers citing papers by John Parrington

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Parrington. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Parrington. The network helps show where John Parrington may publish in the future.

Co-authorship network of co-authors of John Parrington

This figure shows the co-authorship network connecting the top 25 collaborators of John Parrington. A scholar is included among the top collaborators of John Parrington based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John Parrington. John Parrington is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

D’Amore, Antonella, Ali Hanbashi, Fioretta Palombi, et al.. (2024). Endolysosomal two‐pore channel 2 plays opposing roles in primary and metastatic malignant melanoma cells. Cell Biology International. 48(4). 521–540. 2 indexed citations

Boel, Annekatrien, Andreï Rybouchkin, Susana M. Chuva de Sousa Lopes, et al.. (2024). Various repair events following CRISPR/Cas9-based mutational correction of an infertility-related mutation in mouse embryos. Journal of Assisted Reproduction and Genetics. 41(6). 1605–1617. 2 indexed citations

Parrington, John, et al.. (2022). Effect of Aphidicolin, a Reversible Inhibitor of Eukaryotic Nuclear DNA Replication, on the Production of Genetically Modified Porcine Embryos by CRISPR/Cas9. International Journal of Molecular Sciences. 23(4). 2135–2135. 8 indexed citations

Hanbashi, Ali, César Flores‐Flores, Andrew Bassett, et al.. (2021). Generation of Nonmosaic, Two-Pore Channel 2 Biallelic Knockout Pigs in One Generation by CRISPR-Cas9 Microinjection Before Oocyte Insemination. The CRISPR Journal. 4(1). 132–146. 18 indexed citations

D’Amore, Antonella, Ali Hanbashi, Silvia Di Agostino, et al.. (2020). Loss of Two-Pore Channel 2 (TPC2) Expression Increases the Metastatic Traits of Melanoma Cells by a Mechanism Involving the Hippo Signalling Pathway and Store-Operated Calcium Entry. Cancers. 12(9). 2391–2391. 24 indexed citations

Gadea, J., Francisco Alberto García‐Vázquez, Andrew Bassett, et al.. (2018). Generation of TPC2 knock out pig embryos by CRISPR-Cas technology. Reproduction in Domestic Animals. 53. 87–88. 1 indexed citations

Godwin, Jonathan, Margarida Ruas, Goli Ardestani, et al.. (2018). PLC zeta is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence. Genetics Research. 100. 3 indexed citations

Godwin, Jonathan, Margarida Ruas, Hoi Chang Lee, et al.. (2017). PLCζ is the physiological trigger of the Ca2+ oscillations that induce embryogenesis in mammals but conception can occur in its absence. Development. 144(16). 2914–2924. 122 indexed citations

Cane, Matthew C., et al.. (2015). The two pore channel TPC2 is dispensable in pancreatic β-cells for normal Ca2+ dynamics and insulin secretion. Cell Calcium. 59(1). 32–40. 26 indexed citations

10.

Davis, Lianne C., et al.. (2014). Measurement of Luminal pH of Acidic Stores as a Readout for NAADP Action. Cold Spring Harbor Protocols. 2014(10). pdb.prot076935–pdb.prot076935. 1 indexed citations

11.

Kalungia, Aubrey Chichonyi, Duncan Bloor-Young, Margarida Ruas, et al.. (2013). The Involvement of NAADP and Two-Pore Ca2+ Channels in the Cardiac Beta-Adrenergic Response. Biophysical Journal. 104(2). 614a–614a. 1 indexed citations

12.

Davis, Lianne C., Anthony J. Morgan, Duncan Bloor-Young, et al.. (2012). NAADP Activates Two-Pore Channels on T Cell Cytolytic Granules to Stimulate Exocytosis and Killing. Current Biology. 22(24). 2331–2337. 111 indexed citations

13.

Parrington, John, et al.. (2011). Nicotinic acid adenine dinucleotide phosphate evokes global calcium signals in mouse pulmonary arterial smooth muscle cells by activating Two Pore Segment Channel 2. Proceedings of The Physiological Society. 1 indexed citations

14.

Pitt, Samantha J., et al.. (2010). Luminal Ca2+ is a Major Sensitiser of Two-Pore Channels to NAADP. Biophysical Journal. 98(3). 682a–683a. 4 indexed citations

15.

Arredouani, Abdelilah, et al.. (2010). An emerging role for NAADP-mediated Ca²⁺signaling in the pancreatic β-cell. Islets. 2(5). 323–330. 23 indexed citations

16.

Heytens, Elke, Jan Gerris, Marc Dhont, et al.. (2008). First evidence of disturbed expression of the oocyte-activating factor PLCzeta in globozoospermic men. Ghent University Academic Bibliography (Ghent University). 5 indexed citations

17.

Yoon, Sook‐Young, Teru Jellerette, Ana M. Salicioni, et al.. (2008). Human sperm devoid of PLC, zeta 1 fail to induce Ca2+ release and are unable to initiate the first step of embryo development. Journal of Clinical Investigation. 118(11). 3671–3681. 253 indexed citations

18.

Parrington, John. (2004). Kiss of life. 1(2). 38–40. 34 indexed citations

19.

Berridge, G., et al.. (2002). Solubilization of Receptors for the Novel Ca2+-mobilizing Messenger, Nicotinic Acid Adenine Dinucleotide Phosphate. Journal of Biological Chemistry. 277(46). 43717–43723. 49 indexed citations

20.

Parrington, John, et al.. (2001). Mammalian sperm contain a Ca2+-sensitive phospholipase C activity that can generate InsP(3) from PIP2 associated with intracellular organelles (vol 228, pg 125, 2000). Developmental Biology. 239. 388–388. 3 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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