Janice L. Hyatt

1.8k citations

27 papers · 1.5k indexed · h-index 23

Molecular Biology
Pharmacology top 1%
Computational Theory and Mathematics top 1%
Organic Chemistry top 5%
Oncology

Co-authors: Philip M. Potter Carol C. Edwards Lyudmila Tsurkan Mary K. Danks Christopher L. Morton M. Jason Hatfield Randy M. Wadkins Monika Wierdl
Topics: Cholinesterase and Neurodegenerative Diseases (23 papers)Computational Drug Discovery Methods (15 papers)Cancer therapeutics and mechanisms (9 papers)
Cited by: Pharmacology Computational Theory and Mathematics
Journals: Journal of Molecular Biology Cancer Research Journal of Medicinal Chemistry
Partner nations: United States Israel

In The Last Decade

Janice L. Hyatt

26 papers receiving 1.5k citations

Peers

Countries citing papers authored by Janice L. Hyatt

Since Specialization

Citations

This map shows the geographic impact of Janice L. Hyatt's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Janice L. Hyatt with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Janice L. Hyatt more than expected).

Fields of papers citing papers by Janice L. Hyatt

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Janice L. Hyatt. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Janice L. Hyatt. The network helps show where Janice L. Hyatt may publish in the future.

Co-authorship network of co-authors of Janice L. Hyatt

This figure shows the co-authorship network connecting the top 25 collaborators of Janice L. Hyatt. A scholar is included among the top collaborators of Janice L. Hyatt based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Janice L. Hyatt. Janice L. Hyatt is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Selective Inhibitors of Human Liver Carboxylesterase Based on a β-Lapachone Scaffold: Novel Reagents for Reaction Profiling 2017 ·Journal of Medicinal Chemistry ·M. Jason Hatfield,Jingwen Chen,(unknown),Liying Chi,John C. Bollinger,(unknown),John J. Bowling,Janice L. Hyatt,(unknown),Cynthia Jeffries,Philip M. Potter	33
2	Carboxylesterases: General detoxifying enzymes 2016 ·Chemico-Biological Interactions ·M. Jason Hatfield,Robyn A. Umans,Janice L. Hyatt,Carol C. Edwards,Monika Wierdl,Lyudmila Tsurkan,Michael R. Taylor,Philip M. Potter	129
3	Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors 2012 ·Chemico-Biological Interactions ·Lyudmila Tsurkan,M. Jason Hatfield,Carol C. Edwards,Janice L. Hyatt,Philip M. Potter	48
4	Requirements for mammalian carboxylesterase inhibition by substituted ethane-1,2-diones 2011 ·Bioorganic & Medicinal Chemistry ·Elizabeth I. Parkinson,M. Jason Hatfield,Lyudmila Tsurkan,Janice L. Hyatt,Carol C. Edwards,(unknown),Bing Yan,Philip M. Potter	20
5	Organ-specific carboxylesterase profiling identifies the small intestine and kidney as major contributors of activation of the anticancer prodrug CPT-11 2010 ·Biochemical Pharmacology ·M. Jason Hatfield,Lyudmila Tsurkan,Michael R. Garrett,Timothy M. Shaver,Janice L. Hyatt,Carol C. Edwards,(unknown),Philip M. Potter	75
6	An improved human carboxylesterase for enzyme/prodrug therapy with CPT-11 2008 ·Cancer Gene Therapy ·Monika Wierdl,Lyudmila Tsurkan,Janice L. Hyatt,(unknown),M. Jason Hatfield,Christopher L. Morton,Peter J. Houghton,Mary K. Danks,Matthew R. Redinbo,Philip M. Potter	43
7	Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils 2007 ·Bioorganic & Medicinal Chemistry ·(unknown),Janice L. Hyatt,(unknown),Carol C. Edwards,Lyudmila Tsurkan,Monika Wierdl,Antonio M. Ferreira,Randy M. Wadkins,Philip M. Potter	37
8	Planarity and Constraint of the Carbonyl Groups in 1,2-Diones Are Determinants for Selective Inhibition of Human Carboxylesterase 1 2007 ·Journal of Medicinal Chemistry ·Janice L. Hyatt,Randy M. Wadkins,Lyudmila Tsurkan,(unknown),M. Jason Hatfield,Carol C. Edwards,Charles R. Ross,(unknown),Guy Crundwell,Mary K. Danks,R. Kiplin Guy,Philip M. Potter	34
9	Selective Inhibition of Carboxylesterases by Isatins, Indole-2,3-diones 2007 ·Journal of Medicinal Chemistry ·Janice L. Hyatt,(unknown),M. Jason Hatfield,Lyudmila Tsurkan,Carol C. Edwards,Monika Wierdl,Mary K. Danks,Randy M. Wadkins,Philip M. Potter	60
10	Analysis of Mammalian Carboxylesterase Inhibition by Trifluoromethylketone-Containing Compounds 2006 ·Molecular Pharmacology ·Randy M. Wadkins,Janice L. Hyatt,Carol C. Edwards,Lyudmila Tsurkan,Matthew R. Redinbo,Craig E. Wheelock,Paul D. Jones,Bruce D. Hammock,Philip M. Potter	34
11	Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity 2006 ·Molecular Cancer Therapeutics ·Janice L. Hyatt,Lyudmila Tsurkan,Monika Wierdl,Carol C. Edwards,Mary K. Danks,Philip M. Potter	41
12	Structural Insights into Drug Processing by Human Carboxylesterase 1: Tamoxifen, Mevastatin, and Inhibition by Benzil 2005 ·Journal of Molecular Biology ·Christopher D. Fleming,Sompop Bencharit,Carol C. Edwards,Janice L. Hyatt,Lyudmila Tsurkan,Feng Bai,Charles H. Fraga,Christopher L. Morton,Escher L. Howard-Williams,Philip M. Potter,Matthew R. Redinbo	122
13	The Crystal Structure of the Complex of the Anticancer Prodrug 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica Acetylcholinesterase Provides a Molecular Explanation for Its Cholinergic Action 2005 ·Molecular Pharmacology ·Michal Harel,Janice L. Hyatt,Boris Brumshtein,Christopher L. Morton,Kyoung Jin P. Yoon,Randy M. Wadkins,Israel Silman,Joel L. Sussman,Philip M. Potter	34
14	Activation and antitumor activity of CPT-11 in plasma esterase-deficient mice 2005 ·Cancer Chemotherapy and Pharmacology ·Christopher L. Morton,Lisa Iacono,Janice L. Hyatt,(unknown),Pamela J. Cheshire,Peter J. Houghton,Mary K. Danks,Clinton F. Stewart,Philip M. Potter	57
15	Inhibition of acetylcholinesterase by the anticancer prodrug CPT-11 2005 ·Chemico-Biological Interactions ·Janice L. Hyatt,Lyudmila Tsurkan,Christopher L. Morton,Kyoung Jin P. Yoon,Michal Harel,Boris Brumshtein,Israel Silman,Joel L. Sussman,Randy M. Wadkins,Philip M. Potter	34
16	The 3D structure of the anticancer prodrug CPT-11 with Torpedo californica acetylcholinesterase rationalizes its inhibitory action on AChE and its hydrolysis by butyrylcholinesterase and carboxylesterase 2005 ·Chemico-Biological Interactions ·Michal Harel,Janice L. Hyatt,Boris Brumshtein,Christopher L. Morton,Randy M. Wadkins,Israel Silman,Joel L. Sussman,Philip M. Potter	13
17	Inhibition of Carboxylesterases by Benzil (Diphenylethane-1,2-dione) and Heterocyclic Analogues Is Dependent upon the Aromaticity of the Ring and the Flexibility of the Dione Moiety 2005 ·Journal of Medicinal Chemistry ·Janice L. Hyatt,(unknown),Randy M. Wadkins,Kyoung Jin P. Yoon,Monika Wierdl,Carol C. Edwards,Matthias Zeller,A.D. Hunter,Mary K. Danks,Guy Crundwell,Philip M. Potter	61
18	Discovery of Novel Selective Inhibitors of Human Intestinal Carboxylesterase for the Amelioration of Irinotecan-Induced Diarrhea: Synthesis, Quantitative Structure-Activity Relationship Analysis, and Biological Activity 2004 ·Molecular Pharmacology ·Randy M. Wadkins,Janice L. Hyatt,Kyoung Jin P. Yoon,Christopher L. Morton,Richard Lee,Komath Damodaran,Paul Beroza,Mary K. Danks,Philip M. Potter	81
19	Characterization of inhibitors of specific carboxylesterases: Development of carboxylesterase inhibitors for translational application 2004 ·Molecular Cancer Therapeutics ·Kyoung Jin P. Yoon,Janice L. Hyatt,Christopher L. Morton,Richard Lee,Philip M. Potter,Mary K. Danks	25
20	Crystal Structure of Human Carboxylesterase 1 Complexed with the Alzheimer's Drug Tacrine 2003 ·Chemistry & Biology ·Sompop Bencharit,Christopher L. Morton,Janice L. Hyatt,Peter Kühn,Mary K. Danks,Philip M. Potter,Matthew R. Redinbo	144

About Janice L. Hyatt

Janice L. Hyatt is a scholar working on Pharmacology, Computational Theory and Mathematics and Organic Chemistry, having authored 27 papers that have together received 1.5k indexed citations. Recurring topics across this work include Cholinesterase and Neurodegenerative Diseases (23 papers), Computational Drug Discovery Methods (15 papers) and Cancer therapeutics and mechanisms (9 papers). The work is most often cited by research in Pharmacology (628 citations), Computational Theory and Mathematics (423 citations) and Pharmacology (192 citations). Janice L. Hyatt has collaborated with scholars based in United States and Israel. Frequent co-authors include Philip M. Potter, Carol C. Edwards, Lyudmila Tsurkan, Mary K. Danks, Christopher L. Morton, M. Jason Hatfield, Randy M. Wadkins, Monika Wierdl, Kyoung Jin P. Yoon and Matthew R. Redinbo. Their work appears in journals such as Journal of Molecular Biology, Cancer Research and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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