James C. Powers

12.7k total citations · 2 hit papers
197 papers, 10.8k citations indexed

About

James C. Powers is a scholar working on Molecular Biology, Oncology and Cancer Research. According to data from OpenAlex, James C. Powers has authored 197 papers receiving a total of 10.8k indexed citations (citations by other indexed papers that have themselves been cited), including 108 papers in Molecular Biology, 68 papers in Oncology and 56 papers in Cancer Research. Recurrent topics in James C. Powers's work include Peptidase Inhibition and Analysis (65 papers), Protease and Inhibitor Mechanisms (45 papers) and Chemical Synthesis and Analysis (32 papers). James C. Powers is often cited by papers focused on Peptidase Inhibition and Analysis (65 papers), Protease and Inhibitor Mechanisms (45 papers) and Chemical Synthesis and Analysis (32 papers). James C. Powers collaborates with scholars based in United States, Canada and Germany. James C. Powers's co-authors include Karen E. James, Chih-Min Kam, Juliana L. Asgian, Özlem Doǧan Ekici, Kiichiro Nakajima, Norikazu Nishino, Józef Oleksyszyn, J. Wade Harper, Chih Min Kam and Wolfram Bode and has published in prestigious journals such as Chemical Reviews, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

James C. Powers

196 papers receiving 10.0k citations

Hit Papers

Irreversible Inhibitors of Serine, Cysteine... 1979 2026 1994 2010 2002 1979 250 500 750
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Irreversible Inhibitors of Serine, Cysteine, and Threonine Proteases
    2002 896 citations James C. Powers, Karen E. James et al. profile →
  2. Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site.
    1979 556 citations James C. Powers et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
James C. Powers United States 54 5.7k 2.6k 2.2k 2.2k 1.5k 197 10.8k
William G. Bornmann United States 66 7.7k 1.3× 3.6k 1.4× 1.5k 0.7× 2.9k 1.3× 1.2k 0.8× 167 14.7k
Luiz Juliano Brazil 53 5.3k 0.9× 1.9k 0.7× 1.4k 0.6× 848 0.4× 1.1k 0.7× 389 11.2k
Janko Kos Slovenia 57 4.3k 0.8× 2.1k 0.8× 3.6k 1.6× 796 0.4× 1.3k 0.9× 314 10.9k
Tatsuro Irimura Japan 58 7.0k 1.2× 1.9k 0.7× 871 0.4× 1.4k 0.6× 4.0k 2.6× 286 11.7k
Harald Tschesche Germany 50 3.7k 0.6× 2.4k 0.9× 3.5k 1.5× 376 0.2× 674 0.4× 251 9.3k
Faustino Mollinedo Spain 55 5.8k 1.0× 1.1k 0.4× 1.1k 0.5× 979 0.5× 1.6k 1.1× 207 9.6k
Benjamin Bonavida United States 70 7.4k 1.3× 4.5k 1.7× 2.5k 1.1× 555 0.3× 5.7k 3.7× 467 16.4k
James W. Dennis Canada 63 10.8k 1.9× 2.0k 0.8× 1.1k 0.5× 2.7k 1.2× 5.5k 3.6× 206 15.8k
Werner Reutter Germany 54 7.1k 1.2× 2.1k 0.8× 578 0.3× 2.3k 1.1× 1.7k 1.1× 384 11.6k
Elliott Shaw United States 39 3.8k 0.7× 1.3k 0.5× 1.2k 0.5× 725 0.3× 394 0.3× 97 6.8k

Countries citing papers authored by James C. Powers

Since Specialization
Citations

This map shows the geographic impact of James C. Powers's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James C. Powers with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James C. Powers more than expected).

Fields of papers citing papers by James C. Powers

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James C. Powers. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James C. Powers. The network helps show where James C. Powers may publish in the future.

Co-authorship network of co-authors of James C. Powers

This figure shows the co-authorship network connecting the top 25 collaborators of James C. Powers. A scholar is included among the top collaborators of James C. Powers based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with James C. Powers. James C. Powers is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Buccafusco, Jerry J., et al.. (2007). MHP-133, a Drug with Multiple CNS Targets: Potential for Neuroprotection and Enhanced Cognition. Neurochemical Research. 32(7). 1224–1237. 7 indexed citations
2.
Cherney, M.M., Jie Liu, Karen E. James, et al.. (2006). Crystal Structures Reveal an Induced-fit Binding of a Substrate-like Aza-peptide Epoxide to SARS Coronavirus Main Peptidase. Journal of Molecular Biology. 366(3). 916–932. 43 indexed citations
3.
Cherney, M.M., Carly Huitema, Jie Liu, et al.. (2005). Crystal Structures of the Main Peptidase from the SARS Coronavirus Inhibited by a Substrate-like Aza-peptide Epoxide. Journal of Molecular Biology. 353(5). 1137–1151. 139 indexed citations
4.
Götz, Marion G., Conor R. Caffrey, Elizabeth Hansell, James H. McKerrow, & James C. Powers. (2004). Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases. Bioorganic & Medicinal Chemistry. 12(19). 5203–5211. 37 indexed citations
5.
James, Karen E., Marion G. Götz, Conor R. Caffrey, et al.. (2003). Aza-Peptide Epoxides: Potent and Selective Inhibitors of Schistosoma mansoni and Pig Kidney Legumains (Asparaginyl Endopeptidases). Biological Chemistry. 384(12). 1613–1618. 27 indexed citations
6.
7.
Woodard, Susan L., Stephanie A. Fraser, Ulrike Winkler, et al.. (1998). Purification and Characterization of Lymphocyte Chymase I, a Granzyme Implicated in Perforin-Mediated Lysis. The Journal of Immunology. 160(10). 4988–4993. 19 indexed citations
8.
Ni, Liming & James C. Powers. (1998). Synthesis and kinetic studies of an amidine-containing phosphonofluoridate: a novel potent inhibitor of trypsin-like enzymes. Bioorganic & Medicinal Chemistry. 6(10). 1767–1773. 10 indexed citations
9.
Kerrigan, John E., James C. Powers, & Don VanDerveer. (1996). 4-Chloro-7-(iodoacetyl)amino-3-methoxyisocoumarin. Acta Crystallographica Section C Crystal Structure Communications. 52(2). 451–453. 3 indexed citations
10.
Grams, Frank, Peter Reinemer, James C. Powers, et al.. (1995). X-ray Structures of Human Neutrophil Collagenase Complexed with Peptide Hydroxamate and Peptide Thiol Inhibitors. Implications for Substrate Binding and Rational Drug Design. European Journal of Biochemistry. 228(3). 830–841. 155 indexed citations
11.
Woodard, Susan L., et al.. (1994). Chymase-directed serine protease inhibitor that reacts with a single 30-kDa granzyme and blocks NK-mediated cytotoxicity.. The Journal of Immunology. 153(11). 5016–5025. 28 indexed citations
12.
13.
Caputo, Antonio, Michael N.G. James, James C. Powers, Dorothy Hudig, & R. Chris Bleackley. (1994). Conversion of the substrate specificity of mouse proteinase granzyme B. Nature Structural & Molecular Biology. 1(6). 364–367. 60 indexed citations
14.
Smyth, Mark J., Thomas J. Sayers, T A Wiltrout, James C. Powers, & Joseph A. Trapani. (1993). Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells.. The Journal of Immunology. 151(11). 6195–6205. 52 indexed citations
15.
Bihovsky, Ron, et al.. (1993). Further Evidence for the Importance of Free Carboxylate in Epoxysuccinate Inhibitors of Thiol Proteases. Journal of enzyme inhibition. 7(1). 15–25. 11 indexed citations
16.
17.
Shi, L, Chih Min Kam, James C. Powers, Ruedi Aebersold, & Harry B. Greenberg. (1992). Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions.. The Journal of Experimental Medicine. 176(6). 1521–1529. 392 indexed citations
18.
Zunino, Susan J., Nigel Allison, Chih-Min Kam, James C. Powers, & Dorothy Hudig. (1988). Localization, implications for function, and gene expression of chymotrypsin-like proteinases of cytotoxic RNK-16 lymphocytes. Biochimica et Biophysica Acta (BBA) - General Subjects. 967(3). 331–340. 10 indexed citations
19.
Rasnick, David, et al.. (1985). Clostridium histolyticum collagenase: development of new thio ester, fluorogenic, and depsipeptide substrates and new inhibitors. Biochemistry. 24(13). 3149–3157. 35 indexed citations
20.
Tuhy, Peter M. & James C. Powers. (1975). Inhibition of human leukocyte elastase by peptide chloromethyl ketones. FEBS Letters. 50(3). 359–361. 41 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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