James C. Powers

12.7k citations

197 papers · 10.8k indexed · 2 hit papers · h-index 54

Cancer Research top 0.5%
- Protease and Inhibitor Mechanisms 45
Immunology and Allergy top 0.5%
Oncology top 1%
- Peptidase Inhibition and Analysis 65
Biotechnology top 0.5%
- Enzyme Production and Characterization 11
Molecular Biology top 1%
- Chemical Synthesis and Analysis 32
- Protein Hydrolysis and Bioactive Peptides 13
- Biochemical and Molecular Research 11
Hematology
- Blood Coagulation and Thrombosis Mechanisms 13
Immunology
- Mast cells and histamine 11

Co-authors: Karen E. James Chih-Min Kam Juliana L. Asgian Özlem Doǧan Ekici Kiichiro Nakajima Norikazu Nishino Józef Oleksyszyn J. Wade Harper
Cited by: Cancer Research Immunology and Allergy Oncology
Journals: Biochemistry (34 papers)Journal of Medicinal Chemistry (15 papers)Journal of Biological Chemistry (14 papers)
Partner nations: United States Canada Germany

In The Last Decade

James C. Powers

196 papers receiving 10.0k citations

Hit Papers

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Peers

Countries citing papers authored by James C. Powers

Since Specialization

Citations

This map shows the geographic impact of James C. Powers's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James C. Powers with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James C. Powers more than expected).

Fields of papers citing papers by James C. Powers

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James C. Powers. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James C. Powers. The network helps show where James C. Powers may publish in the future.

Co-authorship network

The 25 scholars most cited alongside James C. Powers, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with James C. Powers Line = papers co-authored together James C. Powers links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum Nature Chemical Biology ·Shirin Arastu‐Kapur,Elizabeth L. Ponder,Urša Pečar Fonović,Sharon Yeoh,Fang Yuan,Marko Fonovič,Munira Grainger,Suyog Wagh,James C. Powers,Matthew Bogyo	2008	201
2	Crystal Structures Reveal an Induced-fit Binding of a Substrate-like Aza-peptide Epoxide to SARS Coronavirus Main Peptidase Journal of Molecular Biology ·Ahmed H.A. Hafez,M.M. Cherney,Jie Liu,Karen E. James,James C. Powers,Lindsay D. Eltis,Michael N.G. James	2006	43
3	Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases Bioorganic & Medicinal Chemistry ·Marion G. Götz,Conor R. Caffrey,Elizabeth Hansell,James H. McKerrow,James C. Powers	2004	37
4	Fluorescently labeled inhibitors detect localized serine protease activities in Drosophila melanogaster pole cells, embryos, and ovarian egg chambers Histochemistry and Cell Biology ·Ryusuke Hikawa,Shin Ono,James C. Powers,Robert DeLotto	2004	10
5	Efficacy of Novel Calpain Inhibitors in Preventing Renal Cell Death Journal of Pharmacology and Experimental Therapeutics ·H. Treutler,Carolina Minari Ittavo,Erika Lorena Plazas Barbosa,James C. Powers,Rick G. Schnellmann	2000	15
6	Synthesis and kinetic studies of an amidine-containing phosphonofluoridate: a novel potent inhibitor of trypsin-like enzymes Bioorganic & Medicinal Chemistry ·Liming Ni,James C. Powers	1998	10
7	Synthesis and Kinetic Studies of Diphenyl 1-(N-Peptidylamino)alkanephosphonate Esters and Their Biotinylated Derivatives as Inhibitors of Serine Proteases and Probes for Lymphocyte Granzymes Archives of Biochemistry and Biophysics ·Tawfeeq Alghazali, M. Vasuki, Mbonigaba Celestin, A. Dinesh Kumar,Belisa Bordin de Sales,Dorothy Hudig,Susan L. Woodard,James C. Powers	1997	26
8	Characterization, application and potential uses of biotin-tagged inhibitors for lymphocyte serine proteases (granzymes) Molecular Immunology ·Ulrike Winkler,Nigel Allison,Susan L. Woodard,I.R. Povorotnya,M. Wiedemann,Chih-Min Kam,Tawfeeq Alghazali, M. Vasuki, Mbonigaba Celestin, A. Dinesh Kumar,James C. Powers,Dorothy Hudig	1996	13
9	Inhibition of Thrombin by Arginine-Containing Peptide Chloromethyl Ketones and Bis Chloromethyl Ketone-Albumin Conjugates Journal of enzyme inhibition ·Shinjiro Odake,Chih-Min Kam,James C. Powers	1995	4
10	Chymase-directed serine protease inhibitor that reacts with a single 30-kDa granzyme and blocks NK-mediated cytotoxicity. The Journal of Immunology ·Susan L. Woodard,Belisa Bordin de Sales,Tawfeeq Alghazali, M. Vasuki, Mbonigaba Celestin, A. Dinesh Kumar,James C. Powers,Ulf Winkler,Dorothy Hudig	1994	28
11	Mechanism-Based Isocoumarin Inhibitors for Blood Coagulation Serine Proteases. Effect of the 7-Substituent in 7-Amino-4-chloro-3-(isothioureidoalkoxy)isocoumarins on Inhibitory and Anticoagulant Potency Journal of Medicinal Chemistry ·Chih-Min Kam,John E. Kerrigan,R. Richard Plaskon,Zhuo Liu,Pete Lollar,F. L. Suddath,James C. Powers	1994	48
12	Met-ase: cloning and distinct chromosomal location of a serine protease preferentially expressed in human natural killer cells. The Journal of Immunology ·Mark J. Smyth,Thomas J. Sayers,T A Wiltrout,James C. Powers,Joseph A. Trapani	1993	52
13	Further Evidence for the Importance of Free Carboxylate in Epoxysuccinate Inhibitors of Thiol Proteases Journal of enzyme inhibition ·Ron Bihovsky,James C. Powers,Chih-Min Kam,Андрій Ігорович Палюх,Lois Margaret Cook	1993	11
14	Inhibition of Porcine Pancreatic Elastase by 7-Substituted 4-Chloro-3-Ethoxyisocoumarins: Structural Characteristics of Modeled Noncovalent Complexes Relate to the Measured Inhibition Kinetics Archives of Biochemistry and Biophysics ·R. Richard Plaskon,Chih Min Kam,John E. Kerrigan,Edward M. Burgess,James C. Powers,F. L. Suddath	1993	3
15	Sulfonyl fluoride serine protease inhibitors inactivate RNK-16 lymphocyte granule proteases and reduce lysis by granule extracts and perforin Molecular Immunology ·M. Wiedemann,Ulf Winkler,James C. Powers,Dorothy Hudig	1992	21
16	Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. The Journal of Experimental Medicine ·L Shi,Chih Min Kam,James C. Powers,Ruedi Aebersold,Harry B. Greenberg	1992	392
17	Substrate and inhibitor studies on proteinase 3 FEBS Letters ·Chih-Min Kam,John E. Kerrigan,Koert M. Dolman,Roel Goldschmeding,A. E. G. Kr. von dem Borne,James C. Powers	1992	51
18	Michaelis complexes of porcine pancreatic elastase with 7‐[(alkylcarbamoyl)amino]‐4‐chloro‐3‐ethoxyisocoumarins: Translational sampling of inhibitor position and kinetic measurements Proteins Structure Function and Bioinformatics ·R. Richard Plaskon,R.H.T.M. Filho,Edward M. Burgess,James C. Powers,F. L. Suddath	1992	2
19	Elastase Inhibitors for Treatment of Emphysema American Review of Respiratory Disease ·James C. Powers,小野清	1986	37
20	Inhibition of human leukocyte elastase by peptide chloromethyl ketones FEBS Letters ·Peter M. Tuhy,James C. Powers	1975	41

About James C. Powers

James C. Powers is a scholar working on Cancer Research, Oncology and Molecular Biology, having authored 197 papers that have together received 10.8k indexed citations. Recurring topics across this work include Peptidase Inhibition and Analysis (65 papers), Protease and Inhibitor Mechanisms (45 papers), Chemical Synthesis and Analysis (32 papers), Blood Coagulation and Thrombosis Mechanisms (13 papers), Protein Hydrolysis and Bioactive Peptides (13 papers), Biochemical and Molecular Research (11 papers), Mast cells and histamine (11 papers) and Enzyme Production and Characterization (11 papers). The work is most often cited by research in Cancer Research (2.2k citations), Immunology and Allergy (622 citations) and Oncology (2.6k citations). James C. Powers has collaborated with scholars based in United States, Canada and Germany. Frequent co-authors include Karen E. James, Chih-Min Kam, Juliana L. Asgian, Özlem Doǧan Ekici, Kiichiro Nakajima, Norikazu Nishino, Józef Oleksyszyn, J. Wade Harper, Chih Min Kam and Wolfram Bode. Their work appears in journals such as Biochemistry, Journal of Medicinal Chemistry, Journal of Biological Chemistry, Archives of Biochemistry and Biophysics and Journal of the American Chemical Society.

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