Hyam L. Leffert

6.9k total citations · 1 hit paper
97 papers, 5.6k citations indexed

About

Hyam L. Leffert is a scholar working on Molecular Biology, Surgery and Hepatology. According to data from OpenAlex, Hyam L. Leffert has authored 97 papers receiving a total of 5.6k indexed citations (citations by other indexed papers that have themselves been cited), including 43 papers in Molecular Biology, 36 papers in Surgery and 32 papers in Hepatology. Recurrent topics in Hyam L. Leffert's work include Liver physiology and pathology (31 papers), Pancreatic function and diabetes (29 papers) and Ion Transport and Channel Regulation (12 papers). Hyam L. Leffert is often cited by papers focused on Liver physiology and pathology (31 papers), Pancreatic function and diabetes (29 papers) and Ion Transport and Channel Regulation (12 papers). Hyam L. Leffert collaborates with scholars based in United States, Japan and Spain. Hyam L. Leffert's co-authors include Katherine S. Koch, Stewart Sell, Michael Karin, Shin Maeda, Jun‐Li Luo, Hideaki Kamata, Tom Moran, H. Skelly, David A. Brenner and Boanerges Rubalcava and has published in prestigious journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Hyam L. Leffert

97 papers receiving 5.2k citations

Hit Papers

1 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis

2005 948 citations Hyam L. Leffert, Michael Karin et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Hyam L. Leffert United States	37	2.7k	1.6k	1.3k	1.1k	1.0k	97	5.6k
Nancy L. R. Bucher United States	47	4.1k 1.5×	2.4k 1.5×	2.3k 1.7×	846 0.8×	1.8k 1.8×	67	8.2k
Michitaka Ozaki Japan	37	2.0k 0.8×	800 0.5×	882 0.7×	778 0.7×	819 0.8×	133	4.7k
David P. Aden United States	24	2.4k 0.9×	498 0.3×	550 0.4×	727 0.7×	746 0.7×	47	4.8k
Christian Liedtke Germany	40	2.0k 0.8×	1.2k 0.7×	538 0.4×	553 0.5×	1.5k 1.5×	108	4.6k
Frances M. Sladek United States	39	3.4k 1.3×	585 0.4×	1.7k 1.3×	926 0.9×	567 0.6×	68	5.6k
William A. Gaarde United States	30	2.4k 0.9×	743 0.5×	430 0.3×	905 0.8×	812 0.8×	41	4.5k
Maria Luz Martínez‐Chantar Spain	45	3.7k 1.4×	671 0.4×	651 0.5×	614 0.6×	2.1k 2.1×	162	6.5k
Chris J. Weston United Kingdom	31	1.7k 0.6×	982 0.6×	547 0.4×	556 0.5×	1.1k 1.1×	80	4.2k
Melchiorre Cervello Italy	44	3.4k 1.3×	579 0.4×	316 0.2×	1.3k 1.2×	690 0.7×	137	6.0k
Stephen J. Yeaman United Kingdom	49	3.0k 1.1×	1.5k 0.9×	1.3k 0.9×	172 0.2×	1.5k 1.5×	152	7.2k

Countries citing papers authored by Hyam L. Leffert

Since Specialization

Citations

This map shows the geographic impact of Hyam L. Leffert's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hyam L. Leffert with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hyam L. Leffert more than expected).

Fields of papers citing papers by Hyam L. Leffert

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hyam L. Leffert. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hyam L. Leffert. The network helps show where Hyam L. Leffert may publish in the future.

Co-authorship network of co-authors of Hyam L. Leffert

This figure shows the co-authorship network connecting the top 25 collaborators of Hyam L. Leffert. A scholar is included among the top collaborators of Hyam L. Leffert based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hyam L. Leffert. Hyam L. Leffert is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Koch, Katherine S., Tom Moran, W. Thomas Shier, & Hyam L. Leffert. (2018). High-Affinity Low-Capacity and Low-Affinity High-Capacity N-Acetyl-2-Aminofluorene (AAF) Macromolecular Binding Sites Are Revealed During the Growth Cycle of Adult Rat Hepatocytes in Primary Culture. Toxicological Sciences. 163(1). 35–44. 1 indexed citations

Koch, Katherine S., Tom Moran, W. Thomas Shier, & Hyam L. Leffert. (2018). N-Acetyl-2-Aminofluorene (AAF) Processing in Adult Rat Hepatocytes in Primary Culture Occurs by High-Affinity Low-Velocity and Low-Affinity High-Velocity AAF Metabolite-Forming Systems. Toxicological Sciences. 163(1). 26–34. 1 indexed citations

He, Guobin, Guann‐Yi Yu, Vladislav Temkin, et al.. (2010). Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation. Cancer Cell. 17(3). 286–297. 359 indexed citations

Koch, Katherine S., René Maehr, Hidde L. Ploegh, et al.. (2006). Immune‐privileged embryonic Swiss mouse STO and STO cell‐derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines. Immunology. 119(1). 98–115. 10 indexed citations

Aoki, Takashi, Katherine S. Koch, & Hyam L. Leffert. (1997). Attenuation of gene expression by a trinucleotide repeat-rich tract from the terminal exon of the rat hepatic polymeric immunoglobulin receptor gene. Journal of Molecular Biology. 267(2). 229–236. 23 indexed citations

Westwick, John, et al.. (1995). Activation of Jun kinase is an early event in hepatic regeneration.. Journal of Clinical Investigation. 95(2). 803–810. 129 indexed citations

Koch, Katherine S., et al.. (1994). Primary Rat Hepatocytes Express Cyclin D1 Messenger RNA During Their Growth Cycle and During Mitogenic Transitions Induced by Transforming Growth Factor-α. Biochemical and Biophysical Research Communications. 204(1). 91–97. 8 indexed citations

Hattori, Masahira, Antonio Tugores, John Westwick, et al.. (1993). Activation of activating protein 1 during hepatic acute phase response. American Journal of Physiology-Gastrointestinal and Liver Physiology. 264(1). G95–G103. 43 indexed citations

Koch, Katherine S., et al.. (1990). Mitogens and hepatocyte growth control in vivo and in vitro. In Vitro Cellular & Developmental Biology - Plant. 26(11). 1011–1023. 28 indexed citations

10.

Brenner, David A., Katherine S. Koch, & Hyam L. Leffert. (1989). Transforming Growth Factor-α Stimulates Proto-Oncogene c- jun Expression and a Mitogenic Program in Primary Cultures of Adult Rat Hepatocytes. DNA. 8(4). 279–285. 55 indexed citations

11.

Koch, Katherine S. & Hyam L. Leffert. (1989). Do transplanted human livers regenerate?. Hepatology. 9(5). 789–790. 7 indexed citations

12.

Wolff, Jon A., et al.. (1987). Adult mammalian hepatocyte as target cell for retroviral gene transfer: A model for gene therapy. Somatic Cell and Molecular Genetics. 13(4). 423–428. 6 indexed citations

13.

Brown, John W., et al.. (1984). Expression of differentiated function by hepatocytes in primary culture: Variable effects of glucagon and insulin on gluconeogenesis during cell growth. Differentiation. 25(1-3). 176–184. 11 indexed citations

14.

Lad, Pushkaraj J., W. Thomas Shier, H. Skelly, Bernard de Hemptinne, & Hyam L. Leffert. (1982). Adult Rat Hepatocytes in Primary Culture. VI. Developmental Changes in Alcohol Dehydrogenase Activity and Ethanol Conversion during the Growth Cycle. Alcoholism Clinical and Experimental Research. 6(1). 64–71. 19 indexed citations

15.

Sell, Stewart & Hyam L. Leffert. (1982). An Evaluation of Cellular Lineages in the Pathogenesis of Experimental Hepatocellular Carcinoma. Hepatology. 2(1). 77S–86S. 135 indexed citations

16.

Leffert, Hyam L., Pushkaraj J. Lad, & W. Thomas Shier. (1980). Effects of ethanol on cultured rat hepatocytes. Alcoholism Clinical and Experimental Research. 4(2). 2 indexed citations

17.

Leffert, Hyam L., Katherine S. Koch, Tom Moran, & Margaret Williams. (1979). [47] Liver cells. Methods in enzymology on CD-ROM/Methods in enzymology. 58. 536–544. 107 indexed citations

18.

Leffert, Hyam L., Katherine S. Koch, & Boanerges Rubalcava. (1976). Present paradoxes in the environmental control of hepatic proliferation.. Munich Personal RePEc Archive (Ludwig Maximilian University of Munich). 36(11 Pt. 2). 4250–5. 30 indexed citations

19.

Leffert, Hyam L. & Natalie Alexander. (1976). Thyroid Hormone Metabolism During Liver Regeneration in Rats. Endocrinology. 98(5). 1241–1247. 32 indexed citations

20.

Koch, Katherine S. & Hyam L. Leffert. (1976). Control of hepatic proliferation: A working hypothesis involving hormones, lipoproteins, and novel nucleotides. Metabolism. 25(11). 1419–1422. 6 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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