Hyam L. Leffert

6.9k citations

97 papers · 5.6k indexed · 1 hit paper · h-index 37

Molecular Biology top 2%
Hepatology top 0.5%
Surgery top 2%
Oncology top 2%
Epidemiology top 2%

Co-authors: Katherine S. Koch Stewart Sell Michael Karin Shin Maeda Jun‐Li Luo Hideaki Kamata Tom Moran H. Skelly
Topics: Liver physiology and pathology (31 papers)Pancreatic function and diabetes (29 papers)Ion Transport and Channel Regulation (12 papers)
Cited by: Hepatology Cancer Research Oncology
Journals: Nature Cell Proceedings of the National Academy of Sciences
Partner nations: United States Japan Spain

In The Last Decade

Hyam L. Leffert

97 papers receiving 5.2k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis

2005 948 citations Hyam L. Leffert, Michael Karin et al. profile →

Peers

Countries citing papers authored by Hyam L. Leffert

Since Specialization

Citations

This map shows the geographic impact of Hyam L. Leffert's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hyam L. Leffert with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hyam L. Leffert more than expected).

Fields of papers citing papers by Hyam L. Leffert

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hyam L. Leffert. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hyam L. Leffert. The network helps show where Hyam L. Leffert may publish in the future.

Co-authorship network of co-authors of Hyam L. Leffert

This figure shows the co-authorship network connecting the top 25 collaborators of Hyam L. Leffert. A scholar is included among the top collaborators of Hyam L. Leffert based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hyam L. Leffert. Hyam L. Leffert is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	N-Acetyl-2-Aminofluorene (AAF) Processing in Adult Rat Hepatocytes in Primary Culture Occurs by High-Affinity Low-Velocity and Low-Affinity High-Velocity AAF Metabolite-Forming Systems 2018 ·Toxicological Sciences ·Katherine S. Koch,Tom Moran,W. Thomas Shier,Hyam L. Leffert	1
2	High-Affinity Low-Capacity and Low-Affinity High-Capacity N-Acetyl-2-Aminofluorene (AAF) Macromolecular Binding Sites Are Revealed During the Growth Cycle of Adult Rat Hepatocytes in Primary Culture 2018 ·Toxicological Sciences ·Katherine S. Koch,Tom Moran,W. Thomas Shier,Hyam L. Leffert	1
3	Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation 2010 ·Cancer Cell ·Guobin He,Guann‐Yi Yu,Vladislav Temkin,Hisanobu Ogata,Christian Kuntzen,Toshiharu Sakurai,Wolfgang Sieghart,Markus Peck‐Radosavljevic,Hyam L. Leffert,Michael Karin	359
4	Immune‐privileged embryonic Swiss mouse STO and STO cell‐derived progenitor cells: major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines 2006 ·Immunology ·Katherine S. Koch,(unknown),René Maehr,(unknown),Hidde L. Ploegh,Maurizio Zanetti,Stewart Sell,Hyam L. Leffert	10
5	Giant Hairpins Formed by CUG Repeats in Myotonic Dystrophy Messenger RNAs Might Sterically Block RNA Export Through Nuclear Pores 1998 ·Journal of Theoretical Biology ·Katherine S. Koch,Hyam L. Leffert	19
6	A Simple and Rapid Immunoassay System Using Green Fluorescent Protein Tag 1997 ·Journal of Immunoassay ·Takashi Aoki,(unknown),(unknown),(unknown),Katherine S. Koch,Hyam L. Leffert,Hiroyuki Watabe	10
7	Attenuation of gene expression by a trinucleotide repeat-rich tract from the terminal exon of the rat hepatic polymeric immunoglobulin receptor gene 1997 ·Journal of Molecular Biology ·Takashi Aoki,Katherine S. Koch,Hyam L. Leffert	23
8	Construction of a fusion protein between protein A and green fluorescent protein and its application to Western blotting 1996 ·FEBS Letters ·Takashi Aoki,(unknown),Katherine S. Koch,Hyam L. Leffert,Hiroyuki Watabe	64
9	Activation of Jun kinase is an early event in hepatic regeneration. 1995 ·Journal of Clinical Investigation ·John Westwick,(unknown),Hyam L. Leffert,David A. Brenner	129
10	Discordant expression and variable numbers of neighboring GGA- and GAA-rich triplet repeats in the 3' untranslated regions of two groups of messenger RNAs encoded by the rat polymeric immunoglobulin receptor gene 1995 ·Nucleic Acids Research ·Katherine S. Koch,Anatoli S. Gleiberman,Takashi Aoki,Hyam L. Leffert,Anna Feren,Albert L. Jones,Eric Fodor	25
11	Primary Rat Hepatocytes Express Cyclin D1 Messenger RNA During Their Growth Cycle and During Mitogenic Transitions Induced by Transforming Growth Factor-α 1994 ·Biochemical and Biophysical Research Communications ·Katherine S. Koch,(unknown),Hyam L. Leffert	8
12	Differential expression of the transfected liver-specific α1-inhibitor III gene in normal hepatocytes and hepatoma cells in culture 1992 ·Biochemical and Biophysical Research Communications ·Katherine S. Koch,(unknown),David A. Brenner,Hyam L. Leffert	3
13	Mitogens and hepatocyte growth control in vivo and in vitro 1990 ·In Vitro Cellular & Developmental Biology - Plant ·Katherine S. Koch,(unknown),David A. Brenner,G H Fey,(unknown),Hyam L. Leffert	28
14	Transforming Growth Factor-α Stimulates Proto-Oncogene c- jun Expression and a Mitogenic Program in Primary Cultures of Adult Rat Hepatocytes 1989 ·DNA ·David A. Brenner,Katherine S. Koch,Hyam L. Leffert	55
15	Do transplanted human livers regenerate? 1989 ·Hepatology ·Katherine S. Koch,Hyam L. Leffert	7
16	Adult mammalian hepatocyte as target cell for retroviral gene transfer: A model for gene therapy 1987 ·Somatic Cell and Molecular Genetics ·Jon A. Wolff,(unknown),(unknown),Jane C. Moores,James Respess,(unknown),Hyam L. Leffert	6
17	An Evaluation of Cellular Lineages in the Pathogenesis of Experimental Hepatocellular Carcinoma 1982 ·Hepatology ·Stewart Sell,Hyam L. Leffert	135
18	Effects of ethanol on cultured rat hepatocytes 1980 ·Alcoholism Clinical and Experimental Research ·Hyam L. Leffert,Pushkaraj J. Lad,W. Thomas Shier	2
19	[47] Liver cells 1979 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Hyam L. Leffert,Katherine S. Koch,Tom Moran,Margaret Williams	107
20	Present paradoxes in the environmental control of hepatic proliferation. 1976 ·Munich Personal RePEc Archive (Ludwig Maximilian University of Munich) ·Hyam L. Leffert,Katherine S. Koch,Boanerges Rubalcava	30

About Hyam L. Leffert

Hyam L. Leffert is a scholar working on Hepatology, Clinical Biochemistry and Biochemistry, having authored 97 papers that have together received 5.6k indexed citations. Recurring topics across this work include Liver physiology and pathology (31 papers), Pancreatic function and diabetes (29 papers) and Ion Transport and Channel Regulation (12 papers). The work is most often cited by research in Hepatology (1.6k citations), Cancer Research (973 citations) and Oncology (1.1k citations). Hyam L. Leffert has collaborated with scholars based in United States, Japan and Spain. Frequent co-authors include Katherine S. Koch, Stewart Sell, Michael Karin, Shin Maeda, Jun‐Li Luo, Hideaki Kamata, Tom Moran, H. Skelly, David A. Brenner and Boanerges Rubalcava. Their work appears in journals such as Nature, Cell and Proceedings of the National Academy of Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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