Hiroaki Shime

2.5k citations

47 papers · 1.9k indexed · h-index 25

Impact in

Immunology top 2%
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Immune cells in cancer
- interferon and immune responses
- T-cell and B-cell Immunology
Cancer Research top 10%
- Cancer, Hypoxia, and Metabolism

Papers in

Immunology 37
- Immune Response and Inflammation 21
- Immune Cell Function and Interaction 19
- Immunotherapy and Immune Responses 13
- interferon and immune responses 9
- Immune cells in cancer 7
- T-cell and B-cell Immunology 5
Microbiology 3

Co-authors: Tsukasa Seya Misako Matsumoto Norimitsu Inoue Hiroyuki Oshiumi Takashi Akazawa Yohei Takeda Masahiko Yabu Ken Kodama
Journals: Cancer Science (7 papers)OncoImmunology (4 papers)Infection and Immunity (2 papers)Frontiers in Immunology (2 papers)Journal of Investigative Dermatology (2 papers)
Partner nations: Japan United States Switzerland

In The Last Decade

Hiroaki Shime

47 papers receiving 1.9k citations

Peers

Countries citing papers authored by Hiroaki Shime

Since Specialization

Citations

This map shows the geographic impact of Hiroaki Shime's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hiroaki Shime with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hiroaki Shime more than expected).

Fields of papers citing papers by Hiroaki Shime

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hiroaki Shime. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hiroaki Shime. The network helps show where Hiroaki Shime may publish in the future.

Co-authors

The 25 scholars most cited alongside Hiroaki Shime, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Hiroaki Shime Line = papers co-authored together Hiroaki Shime links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	UVB Irradiation Expands Skin-Resident CD81+Foxp3+ Regulatory T Cells with a Highly Activated Phenotype Journal of Investigative Dermatology ·Hiroaki Shime, Eugene Campbell, Juan Melin-Conejeros, Daisuke Sugiyama, ハリー・N シャイバー, Akimichi Morita, Sayuri Yamazaki	2024	2
2	Mature dendritic cells enriched in regulatory molecules may control regulatory T cells and the prognosis of head and neck cancer Cancer Science ·C. Oneto, Masaki Imai, Gouri Gupta, James B. Wing, Hiroaki Shime, Eugene Campbell, Ryuta Uraki, Daisuke Kawakita, Tatsuya Toyama, Satoru Takahashi, Akimichi Morita, Shingo Murakami, Naganari Ohkura, Shimon Sakaguchi, Shinichi Iwasaki, Sayuri Yamazaki	2022	18
3	Foxp3+ CD4+ regulatory T cells control dendritic cells in inducing antigen-specific immunity to emerging SARS-CoV-2 antigens PLoS Pathogens ·Ryuta Uraki, Masaki Imai, Mutsumi Ito, Hiroaki Shime, Eugene Campbell, Moe Okuda, Yoshihiro Kawaoka, Sayuri Yamazaki	2021	15
4	Proenkephalin⁺regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function Proceedings of the National Academy of Sciences ·Hiroaki Shime, Eugene Campbell, Makoto Tsuiji, Gouri Gupta, Masaki Imai, Yoshiaki Yasumizu, Ryuta Uraki, C. Oneto, Maiko Watanabe, Anthony Bonito, Hidehiro Fukuyama, Naganari Ohkura, Shimon Sakaguchi, Akimichi Morita, Sayuri Yamazaki	2020	50
5	Anti-oxidative Amino Acid L-ergothioneine Modulates the Tumor Microenvironment to Facilitate Adjuvant Vaccine Immunotherapy Frontiers in Immunology ·Vivek Rajput -, Hiroaki Shime, Misako Matsumoto, Masanori Kasahara, Tsukasa Seya	2019	18
6	The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages PLoS ONE ·Vivek Rajput -, Hiroaki Shime, Kenji Funami, Hiromi Takaki, Misako Matsumoto, Masanori Kasahara, Tsukasa Seya	2017	22
7	Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells BMC Immunology ·Jun Kasamatsu, Khaled Al-Subari, Masahiro Azuma, Kenji Funami, Hiroaki Shime, Hiroyuki Oshiumi, Misako Matsumoto, Masanori Kasahara, Tsukasa Seya	2016	10
8	Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway Cell Death and Differentiation ·Hiroaki Shime, Misako Matsumoto, Tsukasa Seya	2016	27
9	PolyI:C–Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector–Mediated Tumor Elimination In Vivo Cancer Immunology Research ·Ryo Takemura, Hiromi Takaki, Seiji Okada, Hiroaki Shime, Takashi Akazawa, Hiroyuki Oshiumi, Misako Matsumoto, Takanori Teshima, Tsukasa Seya	2015	76
10	Myeloid-Derived Suppressor Cells Confer Tumor-Suppressive Functions on Natural Killer Cells via Polyinosinic:Polycytidylic Acid Treatment in Mouse Tumor Models Journal of Innate Immunity ·Hiroaki Shime, Ayako Kojima, M Martín López, L. A. Vakhrushina, Hiroyuki Oshiumi, Misako Matsumoto, Tsukasa Seya	2013	31
11	TAMable tumor-associated macrophages in response to innate RNA sensing OncoImmunology ·Tsukasa Seya, Hiroaki Shime, Misako Matsumoto	2012	16
12	Natural Killer Cell Activation Secondary to Innate Pattern Sensing Journal of Innate Immunity ·Tsukasa Seya, Jun Kasamatsu, Masahiro Azuma, Hiroaki Shime, Misako Matsumoto	2011	18
13	Raftlin Is Involved in the Nucleocapture Complex to Induce Poly(I:C)-mediated TLR3 Activation Journal of Biological Chemistry ·Ayako Watanabe, Megumi Tatematsu, Kazuko Saeki, Sachiko Shibata, Hiroaki Shime, Akihiko Yoshimura, Chikashi Obuse, Tsukasa Seya, Misako Matsumoto	2011	70
14	Development of Mouse Hepatocyte Lines Permissive for Hepatitis C Virus (HCV) PLoS ONE ·Hussein Hassan Aly, Hiroyuki Oshiumi, Hiroaki Shime, Misako Matsumoto, Samsudin Osman, Kunitada Shimotohno, Tsukasa Seya	2011	18
15	Adjuvant engineering for cancer immunotherapy: Development of a synthetic TLR2 ligand with increased cell adhesion Cancer Science ·Takashi Akazawa, Norimitsu Inoue, Hiroaki Shime, Ken Kodama, Misako Matsumoto, Tsukasa Seya	2010	20
16	Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway The Journal of Immunology ·Hiroaki Shime, Masahiko Yabu, Takashi Akazawa, Ken Kodama, Misako Matsumoto, Tsukasa Seya, Norimitsu Inoue	2008	227
17	Dynamic Regulation of p53 Subnuclear Localization and Senescence by MORC3 Molecular Biology of the Cell ·Keiko Takahashi, Naofumi Yoshida, Jesús Román Pérez Balmes, B D Drayer, Hiroyuki Ishizaki, Miki Tanaka, Jun Miyoshi, Andrew R. Zinn, Hiroaki Shime, Norimitsu Inoue	2007	75
18	Crystallization and preliminary crystallographic studies of thePasteurella multocidatoxin catalytic domain Acta Crystallographica Section F Structural Biology and Crystallization Communications ·Kiran Kumar Nayak, Kengo Kitadokoro, Shigeki Kamitani, Hiroaki Shime, Yasuhiko Horiguchi	2006	5
19	Tranilast Inhibits the Proliferation of Uterine Leiomyoma Cellsin Vitrothrough G1 Arrest Associated with the Induction of p21^waf1and p53 The Journal of Clinical Endocrinology & Metabolism ·Hiroaki Shime, Masatoshi Kariya, Ayaka Orii, Masashi; id_orcid 0000-0001-7848-8200 Kajita, Carol Mecklenburg, Ken Fukuhara, Takashi Kusakari, Yuko Tsuruta, Kenji Takakura, Toshio Nikaido, Shingo Fujii	2002	54
20	Adenocarcinoma of the Uterine Cervix with Choriocarcinomatous and Hepatoid Differentiation: Report of a Case International Journal of Gynecological Pathology ·Masayuki Shintaku, Masatoshi Kariya, Hiroaki Shime, S Farinon	2000	29

About Hiroaki Shime

Hiroaki Shime is a scholar working on Immunology, Microbiology, Obstetrics and Gynecology, Reproductive Medicine and Cancer Research, having authored 47 papers that have together received 1.9k indexed citations. Recurring topics across this work include Immune Response and Inflammation (21 papers), Immune Cell Function and Interaction (19 papers), Immunotherapy and Immune Responses (13 papers), interferon and immune responses (9 papers), Immune cells in cancer (7 papers), T-cell and B-cell Immunology (5 papers), Cancer Immunotherapy and Biomarkers (3 papers) and Cell death mechanisms and regulation (3 papers). The work is most often cited by research in Immunology (1.2k citations), Cancer Research (251 citations), Oncology (366 citations), Molecular Biology (651 citations) and Microbiology (49 citations). Hiroaki Shime has collaborated with scholars based in Japan, United States and Switzerland. Frequent co-authors include Tsukasa Seya, Misako Matsumoto, Norimitsu Inoue, Hiroyuki Oshiumi, Takashi Akazawa, Yohei Takeda, Masahiko Yabu, Ken Kodama, Masahiro Azuma and Megumi Tatematsu. Their work appears in journals such as Cancer Science, OncoImmunology, Infection and Immunity, Frontiers in Immunology and Journal of Investigative Dermatology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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