Haruo Takaku

1.1k citations

32 papers · 948 indexed · h-index 18

Co-authors: Hideya Hayashi S. Misawa Kaoru Miyazaki Yoshiaki Isobe Ayumu Kurimoto Masanori Tobe Shinichiro Abe K. Miyazaki
Topics: Immune Response and Inflammation (10 papers)Immune Cell Function and Interaction (7 papers)Cancer Research and Treatments (5 papers)
Cited by: Biotechnology Microbiology Virology
Journals: The Journal of Immunology Journal of Medicinal Chemistry International Journal of Cancer
Partner nations: Japan United Kingdom United States

In The Last Decade

Haruo Takaku

32 papers receiving 920 citations

Peers

Countries citing papers authored by Haruo Takaku

Since Specialization

Citations

This map shows the geographic impact of Haruo Takaku's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Haruo Takaku with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Haruo Takaku more than expected).

Fields of papers citing papers by Haruo Takaku

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Haruo Takaku. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Haruo Takaku. The network helps show where Haruo Takaku may publish in the future.

Co-authorship network of co-authors of Haruo Takaku

This figure shows the co-authorship network connecting the top 25 collaborators of Haruo Takaku. A scholar is included among the top collaborators of Haruo Takaku based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Haruo Takaku. Haruo Takaku is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Biological characterization of a novel class of toll‐like receptor 7 agonists designed to have reduced systemic activity 2011 ·British Journal of Pharmacology ·Mark Biffen,Hiroyuki Matsui,(unknown),Andrew J. Leishman,(unknown),(unknown),(unknown),Ian Doyle,Hiroki Wada,(unknown),(unknown),Mikio Aoki,Hideyuki Tomizawa,(unknown),Haruo Takaku,Tom McInally,Clare Murray	30
2	Biological Activity Of Novel TLR7 Ante-drug Agonists For The Treatment Of Allergic Diseases 2010 ·Mark Biffen,Hiroyuki Matsui,(unknown),(unknown),Ian Doyle,(unknown),Andrew J. Leishman,(unknown),(unknown),Hideyuki Tomizawa,Haruo Takaku,Clare Murray	2
3	Synthesis and Biological Evaluation of 8-Oxoadenine Derivatives as Toll-like Receptor 7 Agonists Introducing the Antedrug Concept 2010 ·Journal of Medicinal Chemistry ·Ayumu Kurimoto,Kazuki Hashimoto,Tomoaki Nakamura,(unknown),(unknown),Haruo Takaku,Roger V. Bonnert,Tom McInally,Hiroki Wada,Yoshiaki Isobe	45
4	Synthesis and Biological Evaluation of Novel 9-Substituted-8-Hydroxyadenine Derivatives as Potent Interferon Inducers 2006 ·Journal of Medicinal Chemistry ·Yoshiaki Isobe,Ayumu Kurimoto,Masanori Tobe,Kazuki Hashimoto,Tomoaki Nakamura,(unknown),(unknown),Haruo Takaku	33
5	Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities 2004 ·Bioorganic & Medicinal Chemistry ·Ayumu Kurimoto,(unknown),Shinji Ichii,Yoshiaki Isobe,Masanori Tobe,(unknown),Haruo Takaku,Hironao Sajiki,Kosaku Hirota,(unknown)	68
6	Synthesis and structure–activity relationships of 2-substituted-8-hydroxyadenine derivatives as orally available interferon inducers without emetic side effects 2003 ·Bioorganic & Medicinal Chemistry ·Yoshiaki Isobe,Masanori Tobe,(unknown),Ayumu Kurimoto,(unknown),(unknown),Haruo Takaku,Hironao Sajiki,Kosaku Hirota,Hideya Hayashi	25
7	Structure–activity and structure–metabolism relationships of HIV protease inhibitors containing the 3-hydroxy-2-methylbenzoyl-allophenylnorstatine structure 2003 ·Bioorganic & Medicinal Chemistry ·Tsutomu Mimoto,(unknown),Satoshi Nojima,Haruo Takaku,(unknown),Makoto Shintani,Takashi Yamaoka,Hideya Hayashi	23
8	Synthesis and structure–Activity relationships of 2-Amino-8-hydroxyadenines as orally active interferon inducing agents 2003 ·Bioorganic & Medicinal Chemistry ·Ayumu Kurimoto,(unknown),Shinji Ichii,Yoshiaki Isobe,Masanori Tobe,(unknown),Haruo Takaku,Hironao Sajiki,Kosaku Hirota,(unknown)	33
9	Evaluating the immune responses stimulated by CpG oligodeoxynucleotides 2003 ·Nucleic Acids Symposium Series ·(unknown),Michio Kuwahara,(unknown),(unknown),Takayuki Abe,(unknown),(unknown),Masayuki Fujii,(unknown),Haruo Takaku	5
10	Synthesis and Structure–Activity Relationship of Diarylamide Derivatives as Selective Inhibitors of the Proliferation of Human Endothelial Cells 2002 ·Bioorganic & Medicinal Chemistry ·(unknown),Yoshiaki Isobe,Haruo Takaku,(unknown),(unknown),S. Misawa,Hideya Hayashi	21
11	Synthesis and structure–activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells 2001 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),Yoshiaki Isobe,Haruo Takaku,(unknown),(unknown),S. Misawa,Hideya Hayashi	10
12	Structure-Activity Relationship of Orally Potent Tripeptide-Based HIV Protease Inhibitors Containing Hydroxymethylcarbonyl Isostere. 2000 ·Chemical and Pharmaceutical Bulletin ·Tsutomu Mimoto,Naoko Hattori,Haruo Takaku,(unknown),Tominaga Fukazawa,(unknown),Ryohei Kato,Satoshi Nojima,S. Misawa,Takamasa Ueno,Junya Imai,Hiroshi Enomoto,(unknown),(unknown),Makoto Shintani,Hideya Hayashi,Yoshiaki Kiso	37
13	CX‐397: A Novel Antithrombotic Recombinant Hirudin Analog 2000 ·Cardiovascular Drug Reviews ·Yasuhiko Komatsu,Yoshifumi Inoue,(unknown),S. Misawa,Haruo Takaku,Hideya Hayashi	4
14	KNI-577, a Potent Small-Sized HIV Protease Inhibitor Based on the Dipeptide Containing the Hydroxymethylcarbonyl Isostere as an Ideal Transition-State Mimic 1998 ·Archiv der Pharmazie ·Yoshiaki Kiso,Satoshi Yamaguchi,Hikaru Matsumoto,Tsutomu Mimoto,Ryohei Kato,Satoshi Nojima,Haruo Takaku,Tominaga Fukazawa,Tooru Kimura,Kenichi Akaji	24
15	Anti‐tumor Activity of Arginine Deiminase from Mycoplasma arginini and Its Growth‐inhibitory Mechanism 1995 ·Japanese Journal of Cancer Research ·Haruo Takaku,(unknown),S. Misawa,K. Miyazaki	80
16	High-level expression of Mycoplasma arginine deiminase in Escherichia coli and its efficient renaturation as an anti-tumor enzyme 1994 ·Journal of Biotechnology ·S. Misawa,Miho Aoshima,Haruo Takaku,Mitsuhiro Matsumoto,Hideya Hayashi	59
17	Chemical Modification by Polyethylene Glycol of the Anti‐tumor Enzyme Arginine Deiminase from Mycoplasma arginini 1993 ·Japanese Journal of Cancer Research ·Haruo Takaku,S. Misawa,Hideya Hayashi,Kaoru Miyazaki	34
18	In vivo anti‐tumor activity of arginine deiminase purified from Mycoplasma arginini 1992 ·International Journal of Cancer ·Haruo Takaku,(unknown),Shinichiro Abe,Hideya Hayashi,Kaoru Miyazaki	107
19	Potent growth inhibition of human tumor cells in culture by arginine deiminase purified from a culture medium of a Mycoplasma-infected cell line. 1990 ·PubMed ·Kaoru Miyazaki,Haruo Takaku,Masaaki Umeda,Takuya Fujita,(unknown),Toshikiro Kimura,Jun K. Yamashita,Takekazu Horio	102
20	[Treatment of multiple myeloma with LAK cells plus interleukin 2 or interleukin 2 alone]. 1989 ·PubMed ·(unknown),(unknown),(unknown),Kazuo Oshimi,Hiroaki Satoh,Haruo Takaku	1

About Haruo Takaku

Haruo Takaku is a scholar working on Virology, Immunology and Biotechnology, having authored 32 papers that have together received 948 indexed citations. Recurring topics across this work include Immune Response and Inflammation (10 papers), Immune Cell Function and Interaction (7 papers) and Cancer Research and Treatments (5 papers). The work is most often cited by research in Biotechnology (280 citations), Microbiology (101 citations) and Virology (70 citations). Haruo Takaku has collaborated with scholars based in Japan, United Kingdom and United States. Frequent co-authors include Hideya Hayashi, S. Misawa, Kaoru Miyazaki, Yoshiaki Isobe, Ayumu Kurimoto, Masanori Tobe, Shinichiro Abe, K. Miyazaki, Kosaku Hirota and Hironao Sajiki. Their work appears in journals such as The Journal of Immunology, Journal of Medicinal Chemistry and International Journal of Cancer.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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