Hartmuth C. Kolb

46.7k total citations · 20 hit papers
137 papers, 37.9k citations indexed

About

Hartmuth C. Kolb is a scholar working on Organic Chemistry, Molecular Biology and Radiology, Nuclear Medicine and Imaging. According to data from OpenAlex, Hartmuth C. Kolb has authored 137 papers receiving a total of 37.9k indexed citations (citations by other indexed papers that have themselves been cited), including 48 papers in Organic Chemistry, 45 papers in Molecular Biology and 32 papers in Radiology, Nuclear Medicine and Imaging. Recurrent topics in Hartmuth C. Kolb's work include Alzheimer's disease research and treatments (28 papers), Click Chemistry and Applications (26 papers) and Chemical Synthesis and Analysis (21 papers). Hartmuth C. Kolb is often cited by papers focused on Alzheimer's disease research and treatments (28 papers), Click Chemistry and Applications (26 papers) and Chemical Synthesis and Analysis (21 papers). Hartmuth C. Kolb collaborates with scholars based in United States, Belgium and United Kingdom. Hartmuth C. Kolb's co-authors include K. Barry Sharpless, M. G. Finn, Michael S. VanNieuwenhze, Valery V. Fokin, John Muldoon, Sridhar Narayan, Joseph C. Walsh, Arkadij M. Elizarov, Anna Katrin Szardenings and Fanrong Mu and has published in prestigious journals such as Science, Chemical Reviews and Proceedings of the National Academy of Sciences.

In The Last Decade

Hartmuth C. Kolb

131 papers receiving 37.2k citations

Hit Papers

Click Chemistry: Diverse Chemical Function from a Few Goo... 1992 2026 2003 2014 2001 2001 1994 2003 2001 2.5k 5.0k 7.5k 10.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Click Chemistry: Diverse Chemical Function from a Few Good Reactions
    2001 11.2k citations Hartmuth C. Kolb, K. Barry Sharpless et al. profile →
  2. Click Chemistry: Diverse Chemical Function from a Few Good Reactions
    2001 8.5k citations Hartmuth C. Kolb, K. Barry Sharpless et al. profile →
  3. Catalytic Asymmetric Dihydroxylation
    1994 3.3k citations Hartmuth C. Kolb, K. Barry Sharpless et al. profile →
  4. The growing impact of click chemistry on drug discovery
    2003 2.7k citations Hartmuth C. Kolb, K. Barry Sharpless profile →
  5. Click-Chemie: diverse chemische Funktionalität mit einer Handvoll guter Reaktionen
    2001 1.6k citations Hartmuth C. Kolb, K. Barry Sharpless et al. profile →
  6. “On Water”: Unique Reactivity of Organic Compounds in Aqueous Suspension
    2005 1.5k citations Hartmuth C. Kolb, K. Barry Sharpless et al. profile →
  7. Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808
    2013 531 citations Anna Katrin Szardenings, Joseph C. Walsh et al. Journal of Alzheimer s Disease profile →
  8. Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F-18]-T807
    2013 497 citations Anna Katrin Szardenings, Joseph C. Walsh et al. Journal of Alzheimer s Disease profile →
  9. [18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease
    2013 464 citations Janna Arteaga, Gang Chen et al. Alzheimer s & Dementia profile →
  10. Inhibitors of HIV‐1 Protease by Using In Situ Click Chemistry
    2006 462 citations Hartmuth C. Kolb, K. Barry Sharpless et al. profile →
  11. In Situ Click Chemistry:  Enzyme Inhibitors Made to Their Own Specifications
    2004 346 citations Zoran Radić, K. Barry Sharpless et al. profile →
  12. “On Water”: Unique Reactivity of Organic Compounds in Aqueous Suspension
    2005 294 citations Hartmuth C. Kolb, K. Barry Sharpless et al. profile →
  13. In Situ Selection of Lead Compounds by Click Chemistry:  Target-Guided Optimization of Acetylcholinesterase Inhibitors
    2005 294 citations Zoran Radić, K. Barry Sharpless et al. profile →
  14. Cerebrospinal fluid p-tau217 performs better than p-tau181 as a biomarker of Alzheimer’s disease
    2020 292 citations Shorena Janelidze, Gallen Triana‐Baltzer et al. profile →
  15. Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation
    2004 288 citations Yves Bourne, Hartmuth C. Kolb et al. Proceedings of the National Academy of Sciences profile →
  16. A simplified procedure for the stereospecific transformation of 1,2-diols into epoxides
    1992 252 citations Hartmuth C. Kolb, K. Barry Sharpless profile →
  17. Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer’s disease
    2022 242 citations Gallen Triana‐Baltzer, Henrik Zetterberg et al. profile →
  18. Improved enantioselectivity in asymmetric dihydroxylations of terminal olefins using pyrimidine ligands
    1993 197 citations Hartmuth C. Kolb, K. Barry Sharpless et al. profile →
  19. Toward an Understanding of the High Enantioselectivity in the Osmium-Catalyzed Asymmetric Dihydroxylation (AD). 1. Kinetics
    1994 179 citations Hartmuth C. Kolb, K. Barry Sharpless et al. profile →
  20. A two-step workflow based on plasma p-tau217 to screen for amyloid β positivity with further confirmatory testing only in uncertain cases
    2023 101 citations Joseph Therriault, Andréa Lessa Benedet et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Hartmuth C. Kolb United States 48 24.5k 15.4k 4.4k 3.9k 3.9k 137 37.9k
Valery V. Fokin United States 76 33.3k 1.4× 18.5k 1.2× 3.4k 0.8× 3.7k 0.9× 2.1k 0.5× 185 40.7k
Zijian Guo China 81 6.9k 0.3× 8.3k 0.5× 9.1k 2.1× 1.2k 0.3× 5.5k 1.4× 510 27.8k
Fernando Alberício Spain 85 14.9k 0.6× 20.0k 1.3× 1.7k 0.4× 1.9k 0.5× 2.1k 0.5× 935 30.7k
Tony D. James United Kingdom 88 6.9k 0.3× 10.2k 0.7× 15.6k 3.5× 705 0.2× 7.0k 1.8× 584 34.7k
K. Barry Sharpless United States 121 71.6k 2.9× 37.3k 2.4× 10.1k 2.3× 6.2k 1.6× 5.5k 1.4× 451 91.8k
Nicholas J. Turro United States 97 20.7k 0.8× 10.3k 0.7× 14.1k 3.2× 597 0.2× 4.0k 1.0× 825 45.4k
Tetsuo Nagano Japan 95 4.7k 0.2× 10.5k 0.7× 13.9k 3.1× 788 0.2× 6.3k 1.6× 378 34.6k
Thomas P. Davis Australia 107 25.0k 1.0× 6.4k 0.4× 10.3k 2.3× 683 0.2× 8.0k 2.1× 612 40.6k
Binghe Wang United States 75 4.5k 0.2× 11.4k 0.7× 2.7k 0.6× 1.3k 0.3× 2.1k 0.5× 499 22.7k
Yasuteru Urano Japan 86 3.8k 0.2× 9.4k 0.6× 12.5k 2.8× 963 0.2× 7.5k 1.9× 356 29.8k

Countries citing papers authored by Hartmuth C. Kolb

Since Specialization
Citations

This map shows the geographic impact of Hartmuth C. Kolb's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hartmuth C. Kolb with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hartmuth C. Kolb more than expected).

Fields of papers citing papers by Hartmuth C. Kolb

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hartmuth C. Kolb. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hartmuth C. Kolb. The network helps show where Hartmuth C. Kolb may publish in the future.

Co-authorship network of co-authors of Hartmuth C. Kolb

This figure shows the co-authorship network connecting the top 25 collaborators of Hartmuth C. Kolb. A scholar is included among the top collaborators of Hartmuth C. Kolb based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hartmuth C. Kolb. Hartmuth C. Kolb is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Feizpour, Azadeh, Vincent Doré, Natasha Krishnadas, et al.. (2025). Alzheimer’s disease biological PET staging using plasma p217+tau. Communications Medicine. 5(1). 53–53.
2.
Teunissen, Charlotte E., Rachel Kolster, Gallen Triana‐Baltzer, et al.. (2024). Plasma p‐tau immunoassays in clinical research for Alzheimer's disease. Alzheimer s & Dementia. 21(1). e14397–e14397. 24 indexed citations
3.
Benedet, Andréa Lessa, Gallen Triana‐Baltzer, Guglielmo Di Molfetta, et al.. (2023). Plasma pTau217: single vs multiple phospho‐site assays.. Alzheimer s & Dementia. 19(S24). 2 indexed citations
4.
Feizpour, Azadeh, Vincent Doré, James D. Doecke, et al.. (2023). Prognostic utility of plasma p217+tau vs amyloid and tau PET in the Alzheimer’s continuum. Alzheimer s & Dementia. 19(S14). 1 indexed citations
5.
Simoes, Sabrina, Jessica Neufeld, Gallen Triana‐Baltzer, et al.. (2020). Tau and other proteins found in Alzheimer’s disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans. Science Translational Medicine. 12(571). 30 indexed citations
6.
Kolb, Hartmuth C., Olivier Barret, Anindya Bhattacharya, et al.. (2019). Preclinical Evaluation and Nonhuman Primate Receptor Occupancy Study of18F-JNJ-64413739, a PET Radioligand for P2X7 Receptors. Journal of Nuclear Medicine. 60(8). 1154–1159. 36 indexed citations
7.
Berdyyeva, Tamara, Chunfang Xia, Natalie Taylor, et al.. (2019). PET Imaging of the P2X7 Ion Channel with a Novel Tracer [18F]JNJ-64413739 in a Rat Model of Neuroinflammation. Molecular Imaging and Biology. 21(5). 871–878. 44 indexed citations
8.
Rombouts, Frederik, Lieven Declercq, José-Ignacio Andrés, et al.. (2019). Discovery of N-(4-[18F]Fluoro-5-methylpyridin-2-yl)isoquinolin-6-amine (JNJ-64326067), a New Promising Tau Positron Emission Tomography Imaging Tracer. Journal of Medicinal Chemistry. 62(6). 2974–2987. 27 indexed citations
9.
Koole, Michel, Mark E. Schmidt, Paulien Ravenstijn, et al.. (2018). 18F-JNJ-64413739, a Novel PET Ligand for the P2X7 Ion Channel: Radiation Dosimetry, Kinetic Modeling, Test-Retest Variability, and Occupancy of the P2X7 Antagonist JNJ-54175446. Journal of Nuclear Medicine. 60(5). 683–690. 64 indexed citations
10.
Wagner, Stefan, Sven Hermann, Michael Schäfers, et al.. (2018). Synthesis, radiosynthesis, in vitro and first in vivo evaluation of a new matrix metalloproteinase inhibitor based on γ-fluorinated α-sulfonylaminohydroxamic acid. EJNMMI Radiopharmacy and Chemistry. 3(1). 10–10. 9 indexed citations
11.
Richards, Erica M., Paolo Zanotti‐Fregonara, Masahiro Fujita, et al.. (2018). PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects. EJNMMI Research. 8(1). 57–57. 118 indexed citations
12.
Walsh, Joseph C., et al.. (2014). The Clinical Importance of Assessing Tumor Hypoxia: Relationship of Tumor Hypoxia to Prognosis and Therapeutic Opportunities. Antioxidants and Redox Signaling. 21(10). 1516–1554. 302 indexed citations
13.
Zhang, Wei, Janna Arteaga, Daniel K. Cashion, et al.. (2012). A Highly Selective and Specific PET Tracer for Imaging of Tau Pathologies. Journal of Alzheimer s Disease. 31(3). 601–612. 158 indexed citations
14.
Yokell, Daniel, Artem Y. Lebedev, Reza Miraghaie, et al.. (2012). Microfluidic single vessel production of hypoxia tracer 1H-1-(3-[18F]-fluoro-2-hydroxy-propyl)-2-nitro-imidazole ([18F]-FMISO). Applied Radiation and Isotopes. 70(10). 2313–2316. 18 indexed citations
15.
Tamarappoo, Balaji, Helen C. Su, Janna Arteaga, et al.. (2012). Abstract 18681: Molecular Imaging of Angiogenesis in Atherosclerosis Using a Caspase 3 Targeted PET Tracer 18 F-CP18. Circulation. 126(suppl_21).
16.
Elizarov, Arkadij M., Carl Meinhart, Reza Miraghaie, et al.. (2010). Flow optimization study of a batch microfluidics PET tracer synthesizing device. Biomedical Microdevices. 13(1). 231–242. 11 indexed citations
17.
Sánchez-Alavez, Manuel, Iustin V. Tabarean, Olivia Osborn, et al.. (2009). Insulin Causes Hyperthermia by Direct Inhibition of Warm-Sensitive Neurons. Diabetes. 59(1). 43–50. 78 indexed citations
18.
Elizarov, Arkadij M., et al.. (2007). Automated Microfluidic Chip and System for the Synthesis of Radiopharmaceuticals on Human-Dose Scales. TechConnect Briefs. 3(2007). 300–303. 1 indexed citations
19.
Bourne, Yves, Hartmuth C. Kolb, Zoran Radić, et al.. (2004). Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation. Proceedings of the National Academy of Sciences. 101(6). 1449–1454. 288 indexed citations breakdown →
20.
Katritzky, Alan R., Suoming Zhang, Mingyi Wang, Hartmuth C. Kolb, & Peter J. Steel. (2002). Novel syntheses of polysubstituted pyrroles and oxazoles by 1,3‐dipolar cycloaddition reactions of benzotriazole‐stabilized nitrile ylides. Journal of Heterocyclic Chemistry. 39(4). 759–765. 20 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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