Hartmut Jaeschke

48.6k total citations · 16 hit papers
399 papers, 34.7k citations indexed

About

Hartmut Jaeschke is a scholar working on Pharmacology, Hepatology and Epidemiology. According to data from OpenAlex, Hartmut Jaeschke has authored 399 papers receiving a total of 34.7k indexed citations (citations by other indexed papers that have themselves been cited), including 228 papers in Pharmacology, 185 papers in Hepatology and 119 papers in Epidemiology. Recurrent topics in Hartmut Jaeschke's work include Drug-Induced Hepatotoxicity and Protection (226 papers), Liver Disease and Transplantation (132 papers) and Liver Disease Diagnosis and Treatment (96 papers). Hartmut Jaeschke is often cited by papers focused on Drug-Induced Hepatotoxicity and Protection (226 papers), Liver Disease and Transplantation (132 papers) and Liver Disease Diagnosis and Treatment (96 papers). Hartmut Jaeschke collaborates with scholars based in United States, Germany and Austria. Hartmut Jaeschke's co-authors include Anwar Farhood, Anup Ramachandran, Mitchell R. McGill, Mary Lynn Bajt, John J. Lemasters, Benjamin L. Woolbright, C. David Williams, C. Wayne Smith, Yuchao Xie and Kuo Du and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Journal of Clinical Investigation.

In The Last Decade

Hartmut Jaeschke

395 papers receiving 34.1k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Mechanisms of Hepatotoxicity

2002 1.1k citations Hartmut Jaeschke Toxicological Sciences profile →
Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity

2012 721 citations Hartmut Jaeschke, Mitchell R. McGill et al. profile →
Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning

2003 688 citations Hartmut Jaeschke profile →
Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo

1990 638 citations Hartmut Jaeschke, Anwar Farhood et al. profile →
The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

2012 569 citations Mitchell R. McGill, Steven C. Curry et al. profile →
Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver

1991 562 citations Hartmut Jaeschke, Anwar Farhood profile →
Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis

2013 516 citations Mitchell R. McGill, Hartmut Jaeschke profile →
Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts

2011 478 citations Hartmut Jaeschke profile →
Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential

2016 445 citations Anup Ramachandran, Hartmut Jaeschke et al. profile →
Bile Acids Induce Inflammatory Genes in Hepatocytes

2011 401 citations Hartmut Jaeschke et al. profile →
Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity

2011 372 citations Hartmut Jaeschke, Anup Ramachandran et al. profile →
Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity

2012 339 citations Mitchell R. McGill, Yuchao Xie et al. profile →
Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure

2016 316 citations Benjamin L. Woolbright, Hartmut Jaeschke profile →
Acetaminophen Hepatotoxicity

2019 232 citations Anup Ramachandran, Hartmut Jaeschke profile →
The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress

2020 190 citations Ganesh Raghu, Michael Berk et al. Current Neuropharmacology profile →
Acetaminophen Hepatotoxicity: Paradigm for Understanding Mechanisms of Drug-Induced Liver Injury

2024 90 citations Hartmut Jaeschke, Anup Ramachandran profile →

Peers

Countries citing papers authored by Hartmut Jaeschke

Since Specialization

Citations

This map shows the geographic impact of Hartmut Jaeschke's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hartmut Jaeschke with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hartmut Jaeschke more than expected).

Fields of papers citing papers by Hartmut Jaeschke

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hartmut Jaeschke. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hartmut Jaeschke. The network helps show where Hartmut Jaeschke may publish in the future.

Co-authorship network of co-authors of Hartmut Jaeschke

This figure shows the co-authorship network connecting the top 25 collaborators of Hartmut Jaeschke. A scholar is included among the top collaborators of Hartmut Jaeschke based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hartmut Jaeschke. Hartmut Jaeschke is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Hepatocyte Senescence is Initiated through a Klf6-p21 Mechanism which mediates the Production of Cxcl14, a Novel Prognostic Biomarker of Acute Liver Failure 2023 ·Journal of Pharmacology and Experimental Therapeutics ·David S. Umbaugh, Nga Nguyen, (unknown), (unknown), Bruno Hagenbuch, Anup Ramachandran, Hartmut Jaeschke	2
2	Mitochondria in Acetaminophen-Induced Liver Injury and Recovery: A Concise Review 2023 ·SHILAP Revista de lepidopterología ·Anup Ramachandran, Hartmut Jaeschke	10
3	The chemokine CXCL14 is a novel early prognostic biomarker for poor outcome in acetaminophen-induced acute liver failure 2023 ·Hepatology ·David S. Umbaugh, (unknown), Steven C. Curry, Jody A. Rule, William M. Lee, Anup Ramachandran, Hartmut Jaeschke, (unknown)	9
4	Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways 2022 ·Toxicological Sciences ·(unknown), Stefanie Kennon‐McGill, Stephanie D. Byrum, Samuel G. Mackintosh, Hartmut Jaeschke, (unknown), William M. Lee, Jonathan A. Dranoff, Mitchell R. McGill, (unknown)	21
5	Recovered Hepatocytes Promote Macrophage Apoptosis Through CXCR4 After Acetaminophen-Induced Liver Injury in Mice 2022 ·Toxicological Sciences ·Nga Nguyen, David S. Umbaugh, (unknown), (unknown), (unknown), Anup Ramachandran, Hartmut Jaeschke	8
6	Biomarkers of mitotoxicity after acute liver injury: further insights into the interpretation of glutamate dehydrogenase 2021 ·Journal of Clinical and Translational Research ·Mitchell R. McGill, Hartmut Jaeschke	28
7	The Multifaceted Therapeutic Role of N-Acetylcysteine (NAC) in Disorders Characterized by Oxidative Stress breakdown → 2020 ·Current Neuropharmacology ·Ganesh Raghu, Michael Berk, Peter A. Campochiaro, Hartmut Jaeschke, Giancarlo Marenzi, Luca Richeldi, Fuqiang Wen, Ferdinando Nicoletti, Peter Calverley	190
8	Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms 2020 ·PLoS Computational Biology ·Andrew Smith, Glen E. P. Ropella, Mitchell R. McGill, Preethi Krishnan, (unknown), Ryan Kennedy, Hartmut Jaeschke, C. Anthony Hunt	19
9	Role of extracellular vesicles in release of protein adducts after acetaminophen-induced liver injury in mice and humans 2018 ·Toxicology Letters ·Luqi Duan, Anup Ramachandran, Jephte Y. Akakpo, James L. Weemhoff, Steven C. Curry, Hartmut Jaeschke	26
10	Lack of Direct Cytotoxicity of Extracellular ATP against Hepatocytes: Role in the Mechanism of Acetaminophen Hepatotoxicity 2015 ·Journal of Clinical and Translational Research ·Yuchao Xie, Benjamin L. Woolbright, Milan Kos, Mitchell R. McGill, Kenneth Dorko, Sean Kumer, Timothy M. Schmitt, Hartmut Jaeschke	7
11	Platelet aggregation but not activation and degranulation during the acute post-ischemic reperfusion phase in livers with no underlying disease 2015 ·Journal of Clinical and Translational Research ·Rowan F. van Golen, Katarzyna M. Stevens, Pina Colarusso, Hartmut Jaeschke, Michal Heger	14
12	Circulating microRNA profiles in human patients with acetaminophen hepatotoxicity or ischemic hepatitis 2014 ·Proceedings of the National Academy of Sciences ·Jeanine Ward, Chitra Kanchagar, Isana Veksler‐Lublinsky, Rosalind C. Lee, Mitchell R. McGill, Hartmut Jaeschke, Steven C. Curry, Victor Ambros	143
13	Acetaminophen-induced Liver Injury: from Animal Models to Humans 2014 ·Journal of Clinical and Translational Hepatology ·Hartmut Jaeschke, Yuchao Xie, Mitchell R. McGill	171
14	Apoptosis-Inducing Factor Modulates Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity 2011 ·Toxicological Sciences ·Mary Lynn Bajt, Anup Ramachandran, (unknown), Margitta Lebofsky, Anwar Farhood, John J. Lemasters, Hartmut Jaeschke	89
15	Lysosomal Iron Mobilization and Induction of the Mitochondrial Permeability Transition in Acetaminophen-Induced Toxicity to Mouse Hepatocytes 2010 ·Toxicological Sciences ·Kazuyoshi Kon, Jae‐Sung Kim, Akira Uchiyama, Hartmut Jaeschke, John J. Lemasters	77
16	Reduced oncotic necrosis in Fas receptor-deficient C57BL/6J-lpr mice after bile duct ligation 2004 ·Hepatology ·Jaspreet S. Gujral, Jie Liu, Anwar Farhood, Hartmut Jaeschke	29
17	Reduced oncotic necrosis in fas receptor-deficient C57BL/6J- lpr mice after bile duct ligation 2004 ·Hepatology ·Jaspreet S. Gujral, Jie Liu, Anwar Farhood, Hartmut Jaeschke	92
18	Monoclonal antibody against the CD18 adhesion molecule stimulates glucose uptake by the liver and hepatic nonparenchymal cells 1993 ·Hepatology ·Abraham P. Bautista, Z. Spolarics, Hartmut Jaeschke, Wayne C. Smith, John J. Spitzer	12
19	Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver 1993 ·Hepatology ·Hartmut Jaeschke	16
20	Functional inactivation of neutrophils with a Mac-1 (CD11b/CD18) monoclonal antibody protects against ischemia-reperfusion injury in rat liver 1993 ·Hepatology ·Hartmut Jaeschke, Anwar Farhood, Abraham P. Bautista, Z. Spolarics, John J. Spitzer, Wayne C. Smith	250

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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