Gene M. Dubowchik

3.9k citations

80 papers · 3.0k indexed · 1 hit paper · h-index 26

Psychiatry and Mental health top 2%
- Migraine and Headache Studies 21
Oncology top 5%
- Peptidase Inhibition and Analysis 10
Radiology, Nuclear Medicine and Imaging top 2%
- Monoclonal and Polyclonal Antibodies Research 6
Organic Chemistry top 5%
Pharmaceutical Science top 5%
Cellular and Molecular Neuroscience
- Neuropeptides and Animal Physiology 12
Pathology and Forensic Medicine
- Trigeminal Neuralgia and Treatments 9
Molecular Biology
- Chemical Synthesis and Analysis 9
Behavioral Neuroscience
- Stress Responses and Cortisol 8
Biological Psychiatry
- Tryptophan and brain disorders 6

Co-authors: Raymond A. Firestone Pamela A. Trail Michael Walker Jay O. Knipe Kathleen Mosure Sandra J. Hofstead Charles M. Conway David Willner
Cited by: Psychiatry and Mental health Oncology Radiology, Nuclear Medicine and Imaging
Journals: New England Journal of Medicine (1 paper)Journal of the American Chemical Society (1 paper)Neurology (5 papers)
Partner nations: United States Germany Belgium

In The Last Decade

Gene M. Dubowchik

79 papers receiving 2.9k citations

Hit Papers

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Peers

Countries citing papers authored by Gene M. Dubowchik

Since Specialization

Citations

This map shows the geographic impact of Gene M. Dubowchik's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gene M. Dubowchik with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gene M. Dubowchik more than expected).

Fields of papers citing papers by Gene M. Dubowchik

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gene M. Dubowchik. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gene M. Dubowchik. The network helps show where Gene M. Dubowchik may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Gene M. Dubowchik, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Gene M. Dubowchik Line = papers co-authored together Gene M. Dubowchik links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Structure–activity relationship (SAR) studies on substituted N-(pyridin-3-yl)-2-amino-isonicotinamides as highly potent and selective glycogen synthase kinase-3 (GSK-3) inhibitors Bioorganic & Medicinal Chemistry Letters ·Guanglin Luo,Ling Chen,Swanee Jacutin-Porte,Ying Han,Catherine R. Burton,Hong Xiao,Carol Krause,Yang Cao,Nengyin Liu,Kevin Kish,H.A. Lewis,John E. Macor,Gene M. Dubowchik	2023	9
2	Cardiovascular Safety of Rimegepant 75 mg in 3 Randomized Clinical Trials and Systematic Evaluations from In Vitro, Ex Vivo, and In Vivo Nonclinical Assays (2141) Neurology ·Charles M. Conway,Robert Croop,Gene M. Dubowchik,Vladimir Coric,Richard B. Lipton	2020	12
3	Antibody drug conjugates for treatment of breast cancer: Novel targets and diverse approaches in ADC design Pharmacology & Therapeutics ·Pamela A. Trail,Gene M. Dubowchik,Timothy B. Lowinger	2017	98
4	Synthesis and SAR of calcitonin gene-related peptide (CGRP) antagonists containing substituted aryl-piperazines and piperidines Bioorganic & Medicinal Chemistry Letters ·Rita L. Civiello,Xiaojun Han,Brett R. Beno,Prasad V. Chaturvedula,John J. Herbst,Cen Xu,Charles M. Conway,John E. Macor,Gene M. Dubowchik	2016	4
5	Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core Bioorganic & Medicinal Chemistry Letters ·Prasanna Sivaprakasam,Xiaojun Han,Rita L. Civiello,Swanee Jacutin-Porte,Kevin Kish,Matt Pokross,H.A. Lewis,Nazia Ahmed,Nicolas Szapiel,John A. Newitt,Eric T. Baldwin,Hong Xiao,Carol Krause,Hyunsoo Park,Michelle Nophsker,Jonathan Lippy,Catherine R. Burton,David R. Langley,John E. Macor,Gene M. Dubowchik	2015	100
6	Design and synthesis of potent antagonists containing rigid spirocyclic privileged structures for the CGRP receptor Bioorganic & Medicinal Chemistry Letters ·Prasad V. Chaturvedula,Sokhom S. Pin,George Tholady,Charlie M. Conway,John E. Macor,Gene M. Dubowchik	2012	8
7	Discovery of BMS-846372, a Potent and Orally Active Human CGRP Receptor Antagonist for the Treatment of Migraine ACS Medicinal Chemistry Letters ·Guanglin Luo,Ling Chen,Charles M. Conway,Rex Denton,Deborah Keavy,Michael Gulianello,Yanling Huang,Walter A. Kostich,Kimberley A. Lentz,Stephen E. Mercer,Richard Schartman,Laura J. Signor,Marc Browning,John E. Macor,Gene M. Dubowchik	2012	32
8	Design, synthesis and evaluation of constrained tetrahydroimidazopyrimidine derivatives as antagonists of corticotropin-releasing factor type 1 receptor (CRF1R) Bioorganic & Medicinal Chemistry Letters ·Vivekananda M. Vrudhula,Bireshwar Dasgupta,Sokhom S. Pin,Kevin D. Burris,Lynn A. Balanda,Lawrence K. Fung,Tracey Fiedler,Kaitlin E. Browman,Matthew T. Taber,Jie Zhang,John E. Macor,Gene M. Dubowchik	2010	4
9	Synthesis and structure–activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists Bioorganic & Medicinal Chemistry Letters ·Xiaojun Han,Sokhom S. Pin,Kevin D. Burris,Lawrence K. Fung,Stella Huang,Matthew T. Taber,Jie Zhang,Gene M. Dubowchik	2005	34
10	An efficient sequence for the preparation of small secondary amine hydrochloride salts for focused library generation without need for distillation or chromatographic purification Bioorganic & Medicinal Chemistry Letters ·Gene M. Dubowchik,Jodi A. Michne,Dmitry Zuev	2004	9
11	Monoclonal antibody mediated intracellular targeting of tallysomycin S10b Bioorganic & Medicinal Chemistry Letters ·Michael Walker,Dalton King,R. A. Dalterio,Pamela A. Trail,Raymond A. Firestone,Gene M. Dubowchik	2004	14
12	Optimization of CRF1R binding affinity of 2-(2,4,6-trichlorophenyl)-4-trifluoromethyl-5-aminomethylthiazoles through rapid and selective parallel synthesis Bioorganic & Medicinal Chemistry Letters ·Dmitry Zuev,Jodi A. Michne,Sokhom S. Pin,Jie Zhang,Matthew T. Taber,Gene M. Dubowchik	2004	3
13	Cephalosporin prodrugs of paclitaxel for immunologically specific activation by L-49-sFv-β-Lactamase fusion protein Bioorganic & Medicinal Chemistry Letters ·Vivekananda M. Vrudhula,David E. Kerr,Nathan O. Siemers,Gene M. Dubowchik,Peter D. Senter	2003	24
14	High-Throughput Fluorescence Polarization Method for Identification of FKBP12 Ligands SLAS DISCOVERY ·Sagarika Bollini,John J. Herbst,G.T. Gaughan,Todd A. Verdoorn,Jonathan L. Ditta,Gene M. Dubowchik,Alexander Vinitsky	2002	45
15	Synthesis of an immunoconjugate of camptothecin Bioorganic & Medicinal Chemistry Letters ·Michael Walker,Gene M. Dubowchik,Sandra J. Hofstead,Pamela A. Trail,Raymond A. Firestone	2002	33
16	Doxorubicin immunoconjugates containing bivalent, lysosomally-Cleavable dipeptide linkages Bioorganic & Medicinal Chemistry Letters ·Gene M. Dubowchik,Shilpa Radia,Harold Mastalerz,Michael Walker,Raymond A. Firestone,Dalton King,Sandra J. Hofstead,David Willner,Shirley J. Lasch,Pamela A. Trail	2002	30
17	Induction of cell death by the lysosomotropic detergent MSDH FEBS Letters ·Wei Li,Xi Yuan,Gunnar Nordgren,Helge Dalen,Gene M. Dubowchik,Raymond A. Firestone,Ulf T. Brunk	2000	209
18	Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin Bioorganic & Medicinal Chemistry Letters ·Gene M. Dubowchik,Raymond A. Firestone	1998	133
19	Improved Cytotoxicity of Antitumor Compounds Deliverable by the LDL Pathway Bioconjugate Chemistry ·Gene M. Dubowchik,Raymond A. Firestone	1995	16
20	Reversal of doxorubicin resistance and catalytic neutralization of lysosomes by a lipophilic imidazole Biochimica et Biophysica Acta (BBA) - Biomembranes ·Gene M. Dubowchik,Linda Padilla,Kurt J. Edinger,Raymond A. Firestone	1994	16

About Gene M. Dubowchik

Gene M. Dubowchik is a scholar working on Biological Psychiatry, Behavioral Neuroscience and Psychiatry and Mental health, having authored 80 papers that have together received 3.0k indexed citations. Recurring topics across this work include Migraine and Headache Studies (21 papers), Neuropeptides and Animal Physiology (12 papers), Peptidase Inhibition and Analysis (10 papers), Trigeminal Neuralgia and Treatments (9 papers), Chemical Synthesis and Analysis (9 papers), Stress Responses and Cortisol (8 papers), Monoclonal and Polyclonal Antibodies Research (6 papers) and Tryptophan and brain disorders (6 papers). The work is most often cited by research in Psychiatry and Mental health (466 citations), Oncology (719 citations) and Radiology, Nuclear Medicine and Imaging (596 citations). Gene M. Dubowchik has collaborated with scholars based in United States, Germany and Belgium. Frequent co-authors include Raymond A. Firestone, Pamela A. Trail, Michael Walker, Jay O. Knipe, Kathleen Mosure, Sandra J. Hofstead, Charles M. Conway, David Willner, Shirley J. Lasch and John E. Macor. Their work appears in journals such as New England Journal of Medicine, Journal of the American Chemical Society and Neurology.

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