Gary D. Lopaschuk

42.5k total citations · 11 hit papers
378 papers, 33.0k citations indexed

About

Gary D. Lopaschuk is a scholar working on Cardiology and Cardiovascular Medicine, Molecular Biology and Physiology. According to data from OpenAlex, Gary D. Lopaschuk has authored 378 papers receiving a total of 33.0k indexed citations (citations by other indexed papers that have themselves been cited), including 203 papers in Cardiology and Cardiovascular Medicine, 161 papers in Molecular Biology and 126 papers in Physiology. Recurrent topics in Gary D. Lopaschuk's work include Cardiovascular Function and Risk Factors (168 papers), Adipose Tissue and Metabolism (96 papers) and Mitochondrial Function and Pathology (89 papers). Gary D. Lopaschuk is often cited by papers focused on Cardiovascular Function and Risk Factors (168 papers), Adipose Tissue and Metabolism (96 papers) and Mitochondrial Function and Pathology (89 papers). Gary D. Lopaschuk collaborates with scholars based in Canada, United States and Iraq. Gary D. Lopaschuk's co-authors include William C. Stanley, John R. Ussher, Jagdip S. Jaswal, Jason R.B. Dyck, Fabio A. Recchia, Clifford D.L. Folmes, Rick L. Barr, Cory S. Wagg, Maruf Saddik and Subodh Verma and has published in prestigious journals such as Proceedings of the National Academy of Sciences, The Lancet and Journal of Biological Chemistry.

In The Last Decade

Gary D. Lopaschuk

372 papers receiving 32.5k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Myocardial Fatty Acid Metabolism in Health and Disease

2010 1.6k citations Gary D. Lopaschuk, John R. Ussher et al. profile →
Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

2008 1.6k citations John R. Ussher, Jason R.B. Dyck et al. profile →
Myocardial Substrate Metabolism in the Normal and Failing Heart

2005 1.6k citations Gary D. Lopaschuk et al. profile →
A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth

2007 1.2k citations Gary D. Lopaschuk et al. profile →
The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus

2002 749 citations Brian N. Finck, John J. Lehman et al. Journal of Clinical Investigation profile →
The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus

2002 663 citations Brian N. Finck, John J. Lehman et al. Journal of Clinical Investigation profile →
The Antianginal Drug Trimetazidine Shifts Cardiac Energy Metabolism From Fatty Acid Oxidation to Glucose Oxidation by Inhibiting Mitochondrial Long-Chain 3-Ketoacyl Coenzyme A Thiolase

2000 625 citations Paul F. Kantor, Gary D. Lopaschuk et al. Circulation Research profile →
Cardiovascular remodelling in coronary artery disease and heart failure

2014 571 citations Gary D. Lopaschuk et al. profile →
Mechanisms of Cardiovascular Benefits of Sodium Glucose Co-Transporter 2 (SGLT2) Inhibitors

2020 566 citations Gary D. Lopaschuk et al. profile →
Empagliflozin Increases Cardiac Energy Production in Diabetes

2018 293 citations Kim L. Ho, Cory S. Wagg et al. profile →
Mitochondrial fatty acid oxidation is the major source of cardiac adenosine triphosphate production in heart failure with preserved ejection fraction

2024 48 citations Cory S. Wagg, Liyan Zhang et al. Cardiovascular Research profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Gary D. Lopaschuk Canada	93	16.4k	14.1k	10.3k	4.0k	3.7k	378	33.0k
Kathy K. Griendling United States	95	17.0k 1.0×	12.9k 0.9×	17.1k 1.7×	4.1k 1.0×	5.8k 1.6×	231	46.1k
E. Dale Abel United States	90	13.9k 0.8×	9.5k 0.7×	7.9k 0.8×	3.6k 0.9×	3.5k 1.0×	278	28.7k
Rudi Busse Germany	101	10.3k 0.6×	9.8k 0.7×	18.2k 1.8×	3.9k 1.0×	4.7k 1.3×	316	35.8k
George L. King United States	90	12.6k 0.8×	4.9k 0.3×	6.3k 0.6×	4.0k 1.0×	7.3k 2.0×	276	32.5k
Ulrich Förstermann Germany	87	8.8k 0.5×	7.1k 0.5×	16.4k 1.6×	2.9k 0.7×	2.4k 0.7×	263	32.4k
Jason R.B. Dyck Canada	81	10.4k 0.6×	5.9k 0.4×	6.3k 0.6×	3.2k 0.8×	2.5k 0.7×	298	21.3k
Junichi Sadoshima United States	101	20.9k 1.3×	11.2k 0.8×	5.8k 0.6×	2.7k 0.7×	1.7k 0.5×	372	36.7k
Wilson S. Colucci United States	97	9.5k 0.6×	21.7k 1.5×	4.5k 0.4×	4.3k 1.1×	1.9k 0.5×	319	32.8k
Heinrich Taegtmeyer United States	68	7.5k 0.5×	7.6k 0.5×	4.6k 0.4×	2.4k 0.6×	1.7k 0.5×	251	16.7k
Bradford C. Berk United States	100	16.6k 1.0×	7.2k 0.5×	5.9k 0.6×	3.6k 0.9×	2.0k 0.6×	318	29.8k

Countries citing papers authored by Gary D. Lopaschuk

Since Specialization

Citations

This map shows the geographic impact of Gary D. Lopaschuk's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Gary D. Lopaschuk with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Gary D. Lopaschuk more than expected).

Fields of papers citing papers by Gary D. Lopaschuk

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Gary D. Lopaschuk. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Gary D. Lopaschuk. The network helps show where Gary D. Lopaschuk may publish in the future.

Co-authorship network of co-authors of Gary D. Lopaschuk

This figure shows the co-authorship network connecting the top 25 collaborators of Gary D. Lopaschuk. A scholar is included among the top collaborators of Gary D. Lopaschuk based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Gary D. Lopaschuk. Gary D. Lopaschuk is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Greenwell, Amanda A., Cory S. Wagg, Farah Eaton, et al.. (2024). Pharmacological Inhibition of Succinyl Coenzyme A:3‐Ketoacid Coenzyme A Transferase Alleviates the Progression of Diabetic Cardiomyopathy. Journal of the American Heart Association. 13(7). e032697–e032697. 5 indexed citations

Abdualkader, Abdualrahman Mohammed, Qutuba G. Karwi, Gary D. Lopaschuk, & Rami Al Batran. (2024). The role of branched-chain amino acids and their downstream metabolites in mediating insulin resistance. Journal of Pharmacy & Pharmaceutical Sciences. 27. 13040–13040. 13 indexed citations

Lopaschuk, Gary D. & Jason R.B. Dyck. (2023). Ketones and the cardiovascular system. Nature Cardiovascular Research. 2(5). 425–437. 45 indexed citations

Greenwell, Amanda A., Kim L. Ho, Keshav Gopal, et al.. (2022). An isoproteic cocoa butter-based ketogenic diet fails to improve glucose homeostasis and promote weight loss in obese mice. American Journal of Physiology-Endocrinology and Metabolism. 323(1). E8–E20. 8 indexed citations

Greenwell, Amanda A., Keshav Gopal, Tariq Altamimi, et al.. (2021). Barth syndrome-related cardiomyopathy is associated with a reduction in myocardial glucose oxidation. American Journal of Physiology-Heart and Circulatory Physiology. 320(6). H2255–H2269. 10 indexed citations

Gao, Su, S. P. Ghoshal, Liyan Zhang, et al.. (2019). The peptide hormone adropin regulates signal transduction pathways controlling hepatic glucose metabolism in a mouse model of diet-induced obesity. Journal of Biological Chemistry. 294(36). 13366–13377. 58 indexed citations

Marzilli, Mario, Dragoş Vinereanu, Gary D. Lopaschuk, et al.. (2019). Trimetazidine in cardiovascular medicine. International Journal of Cardiology. 293. 39–44. 59 indexed citations

Patel, Vaibhav B., Jun Mori, Brent A. McLean, et al.. (2016). ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity. PMC. 3 indexed citations

Zhang, Liyan, Alda Huqi, Arata Fukushima, et al.. (2015). Activating PPARα Prevents Post–Ischemic Contractile Dysfunction in Hypertrophied Neonatal Hearts. Circulation Research. 117(1). 41–51. 31 indexed citations

10.

Lucchinetti, Eliana, Lianguo Wang, Kerry W.S. Ko, et al.. (2011). Enhanced glucose uptake via GLUT4 fuels recovery from calcium overload after ischaemia–reperfusion injury in sevoflurane- but not propofol-treated hearts. British Journal of Anaesthesia. 106(6). 792–800. 16 indexed citations

11.

Wang, Lianguo, Kerry W.S. Ko, Eliana Lucchinetti, et al.. (2010). Metabolic Profiling of Hearts Exposed to Sevoflurane and Propofol Reveals Distinct Regulation of Fatty Acid and Glucose Oxidation. Anesthesiology. 113(3). 541–551. 25 indexed citations

12.

Kandalam, Vijay, Ratnadeep Basu, Thomas Abraham, et al.. (2010). Early activation of matrix metalloproteinases underlies the exacerbated systolic and diastolic dysfunction in mice lacking TIMP3 following myocardial infarction. American Journal of Physiology-Heart and Circulatory Physiology. 299(4). H1012–H1023. 67 indexed citations

13.

Zhang, Liyan, John R. Ussher, Tatsujiro Oka, et al.. (2010). Cardiac diacylglycerol accumulation in high fat-fed mice is associated with impaired insulin-stimulated glucose oxidation. Cardiovascular Research. 89(1). 148–156. 103 indexed citations

14.

Yan, Jie, Martin E. Young, Lei Cui, et al.. (2009). Increased Glucose Uptake and Oxidation in Mouse Hearts Prevent High Fatty Acid Oxidation but Cause Cardiac Dysfunction in Diet-Induced Obesity. Circulation. 119(21). 2818–2828. 170 indexed citations

15.

Jaswal, Jagdip S., Virgilio J. J. Cadete, & Gary D. Lopaschuk. (2008). Optimizing cardiac energy substrate metabolism: a novel therapeutic intervention for ischemic heart disease. 5–14. 4 indexed citations

16.

Yan, Jie, Martin E. Young, Gary D. Lopaschuk, Ronglih Liao, & Rong Tian. (2006). Abstract 775: Substrate Availability Regulates Energy Metabolism via Transcriptional Mechanisms. Circulation. 114. 1 indexed citations

17.

Finck, Brian N., John J. Lehman, Teresa C. Leone, et al.. (2002). The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus. Journal of Clinical Investigation. 109(1). 121–130. 45 indexed citations

18.

19.

Sidossis, Labros S., Charles Stuart, Gerald I. Shulman, Gary D. Lopaschuk, & Robert R. Wolfe. (1996). Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria.. Journal of Clinical Investigation. 98(10). 2244–2250. 191 indexed citations

20.

Lopaschuk, Gary D., Jonathan R.T. Lakey, Rick L. Barr, et al.. (1993). Islet transplantation improves glucose oxidation and mechanical function in diabetic rat hearts. Canadian Journal of Physiology and Pharmacology. 71(12). 896–903. 8 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact