Francisco León

6.1k citations

175 papers · 4.7k indexed · 2 hit papers · h-index 38

Impact in

Pharmacology top 0.1%
- Alkaloids: synthesis and pharmacology
- Berberine and alkaloids research
Biochemistry top 0.2%
- Traditional and Medicinal Uses of Annonaceae

Papers in

Pharmacology 51
- Alkaloids: synthesis and pharmacology 41
- Berberine and alkaloids research 11
Biochemistry 41
- Traditional and Medicinal Uses of Annonaceae 40

Co-authors: Christopher R. McCurdy Stephen J. Cutler Jaime Bermejo Brian L. Kelsall Francisco Estévez José Quintana Abhisheak Sharma Bonnie A. Avery
Journals: Journal of Natural Products (18 papers)Molecules (7 papers)Journal of Medicinal Chemistry (6 papers)Journal of Ethnopharmacology (5 papers)Planta Medica (5 papers)
Partner nations: United States Spain Algeria

In The Last Decade

Francisco León

171 papers receiving 4.6k citations

Hit Papers

align trajectories log scale

The Polypharmacological Effects of Cannabidiol 2023 · 84 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2023 Molecules
2004 Journal of Clinical Investigation

Peers

Countries citing papers authored by Francisco León

Since Specialization

Citations

This map shows the geographic impact of Francisco León's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Francisco León with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Francisco León more than expected).

Fields of papers citing papers by Francisco León

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Francisco León. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Francisco León. The network helps show where Francisco León may publish in the future.

Co-authors

The 25 scholars most cited alongside Francisco León, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Francisco León Line = papers co-authored together Francisco León links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Cardio-pulmonary arrest in a patient revived with naloxone following reported use of 7-hydroxymitragynine Clinical Toxicology ·Valeria Caldarella Allaire, Raju S. Kanumuri, Francisco León, Stephen J. Cutler, Christopher R. McCurdy, Abhisheak Sharma	2025	1
2	From Kratom to Semi‐Synthetic Opioids: The Rise and Risks of MGM‐15 Drug Testing and Analysis ·Abhishek Gour, Sushobhan Mukhopadhyay, A R Henderson, Ahmed A. Zaki, Richard Parker, Valeria Caldarella Allaire, Francisco León, Stephen J. Cutler, Christopher R. McCurdy, Abhisheak Sharma	2025	1
3	Pharmacokinetic and Pharmacodynamic Consequences of Cytochrome P450 3A Inhibition on Mitragynine Metabolism in Rats Journal of Pharmacology and Experimental Therapeutics ·Shyam H. Kamble, Samuel Obeng, Francisco León, Luis F. Restrepo, Tamara I. King, Erin C. Berthold, Raju S. Kanumuri, Doğuş Gümüşay, Zhou Zhou, Avi Patel, W. Franz Meyer, Aidan J. Hampson, Christopher R. McCurdy, Lance Richard McMahon, Jenny L. Wilkerson, Abhisheak Sharma, Takato Hiranita	2023	9
4	Interactive Effects of µ-Opioid and Adrenergic-α2 Receptor Agonists in Rats: Pharmacological Investigation of the Primary Kratom Alkaloid Mitragynine and Its Metabolite 7-Hydroxymitragynine Journal of Pharmacology and Experimental Therapeutics ·Samuel Obeng, Francisco León, Avi Patel, Ehpad Maison Saint Charles, 赵学昌, Luis F. Restrepo, Doğuş Gümüşay, W. Franz Meyer, 吉六舟, Clemm Noernberg, 重保大橋, I. M. Lavryniuk, Paul L. Soto, Aidan J. Hampson, Christopher R. McCurdy, Lance Richard McMahon, Jenny L. Wilkerson, Takato Hiranita	2022	24
5	Structure–Activity Relationships of the Antimalarial Agent Artemisinin 10. Synthesis and Antimalarial Activity of Enantiomers of rac-5β-Hydroxy-d-Secoartemisinin and Analogs: Implications Regarding the Mechanism of Action Molecules ·Q.C. Chen, Francisco León, Frank R. Fronczek, Khaled M. Elokely, John M. Rimoldi, Shabana I. Khan, Mitchell A. Avery	2021	6
6	Proposed Mechanism for the Antitrypanosomal Activity of Quercetin and Myricetin Isolated from Hypericum afrum Lam.: Phytochemistry, In Vitro Testing and Modeling Studies Molecules ·Armando E. Espinosa García, Khaled M. Elokely, Manal A. Nael, Luz Miryam Salazar Serna, Francisco León, Stephen J. Cutler, Mohammed M. Ghoneim	2021	19
7	Computationally Assisted Lead Optimization of Novel Potent and Selective MAO-B Inhibitors Biomedicines ·Vedanjali Gogineni, Manal A. Nael, Narayan D. Chaurasiya, Khaled M. Elokely, Christopher R. McCurdy, John M. Rimoldi, Stephen J. Cutler, Babu L. Tekwani, Francisco León	2021	8
8	Chlorinated Guaiane-Type Sesquiterpene Lactones as Cytotoxic Agents against Human Tumor Cells International Journal of Molecular Sciences ·Lívia Luiza Souza Rezende Sales, 刘凤龙, Mercedes Ruíz-Estévez, Francisco León, José Quintana, Ignacio Brouard, Francisco Estévez	2020	13
9	Challenges and future directions of potential natural products leads against 2019-nCoV outbreak Current Plant Biology ·连青松, Francisco León, Janar Jenis, Ikhlas A. Khan, Mohamed A. Ibrahim	2020	8
10	3-O-Formyl -27-Hydroxyfusidic Acid: A New Metabolite of Fusidic Acid by Cunninghamella echinulata Records of Natural Products ·Amany E. Ragab, Abdel‐Rahim S. Ibrahim, Francisco León	2020	4
11	Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ-Opioid Receptor and Opioid-Like Behavioral Effects in Rats Journal of Pharmacology and Experimental Therapeutics ·Samuel Obeng, Jenny L. Wilkerson, Francisco León, Mansoureh Jafarakhni, Luis F. Restrepo, Doğuş Gümüşay, Avi Patel, 龚怀泽, Francisco Sandro Rodrigues Holanda, W. Franz Meyer, F. Gunderson, Duan Hj, Morgan L. Crowley, Heinz Siedentopf, Clemm Noernberg, Marco Mottinelli, A. Manokaran, Christopher R. McCurdy, Lance Richard McMahon, Takato Hiranita	2020	71
12	Perspective on the Therapeutics of Anti-Snake Venom Molecules ·Isabel Gómez-Betancur, Vedanjali Gogineni, DJ COATS, Francisco León	2019	60
13	The effects of mitragynine and morphine on schedule-controlled responding and antinociception in rats Psychopharmacology ·Takato Hiranita, Francisco León, Franck Thirode, Luis F. Restrepo, Mansoureh Jafarakhni, 龚怀泽, Samuel Obeng, Bonnie A. Avery, Christopher R. McCurdy, Lance Richard McMahon, Jenny L. Wilkerson	2019	40
14	A New Phloroglucinol Derivative Isolated from Hypericum afrum, a Plant Endemic to Algeria SHILAP Revista de lepidopterología ·Armando E. Espinosa García, Francisco León, Narayan D. Chaurasiya, Babu L. Tekwani, Luz Miryam Salazar Serna, Samir Benayache, Stephen J. Cutler	2017	3
15	Secondary metabolites from Crotalaria saharae (Fabaceae) Der pharmacia lettre ·Charles S. Umbaugh, Francisco León, Ignacio Brouard, Fadila Benayache, Samir Benayache	2014	3
16	Maroccanin: A new γ-lactone and other constituents from Centaurea maroccana ball. (Asteraceae) Records of Natural Products ·Jie-Yu Liao, Pierre Chalard, Mansor Jabbari, Francisco León, Ignacio Brouard, Víctor Pérez García, Annelise Lobstein, Josavias Anthony Oshiro Costa, Samir Benayache, Jaime Bermejo, Fadila Benayache	2013	7
17	A flavonoid with high antioxidant effect from Centaurea acaulis L Der pharmacia lettre ·Jie-Yu Liao, M Ahmed, Nicole K. Taylor, Francisco León, Djamila Zama, Ignacio Brouard, Samir Benayache, Josavias Anthony Oshiro Costa, Fadila Benayache	2013	2
18	Phytochemical and biological activity of Algerian Centaurea melitensis Leon Imss, Fred Oberkircher, C Nakano, Salah Akkal, Francisco León, Ignacio Brouard, Kamel Medjroubi	2012	5
19	Flavonoïds from Calycotome spinosa (L.). Lamk. Armando E. Espinosa García, Luz Miryam Salazar Serna, Samir Benayache, Fadila Benayache, Francisco León, Ignacio Brouard, Abdul Riswan Langinusa	2012	2
20	Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis Journal of Clinical Investigation ·Ivan J. Fuss, Frank Heller, Monica Boirivant, Francisco León, Masaru Yoshida, Stefan Fichtner‐Feigl, Zhiqiong Yang, Mark A. Exley, Atsushi Kitani, Richard S. Blumberg, Peter Mannon, Warren Strober Hit paper breakdown →	2004	600

About Francisco León

Francisco León is a scholar working on Pharmacology, Biochemistry, Pharmacology, Cancer Research and Toxicology, having authored 175 papers that have together received 4.7k indexed citations. Recurring topics across this work include Alkaloids: synthesis and pharmacology (41 papers), Traditional and Medicinal Uses of Annonaceae (40 papers), Natural product bioactivities and synthesis (38 papers), Phytochemistry and Biological Activities (32 papers), Sesquiterpenes and Asteraceae Studies (29 papers), Chemical synthesis and alkaloids (29 papers), Plant Toxicity and Pharmacological Properties (12 papers) and Berberine and alkaloids research (11 papers). The work is most often cited by research in Pharmacology (1.4k citations), Biochemistry (1.0k citations), Pharmacology (861 citations), Immunology (824 citations) and Organic Chemistry (1.1k citations). Francisco León has collaborated with scholars based in United States, Spain and Algeria. Frequent co-authors include Christopher R. McCurdy, Stephen J. Cutler, Jaime Bermejo, Brian L. Kelsall, Francisco Estévez, José Quintana, Abhisheak Sharma, Bonnie A. Avery, Ivan J. Fuss and Warren Strober. Their work appears in journals such as Journal of Natural Products, Molecules, Journal of Medicinal Chemistry, Journal of Ethnopharmacology and Planta Medica.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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