Ernest L. Mehler

5.3k citations

75 papers · 4.0k indexed · 1 hit paper · h-index 29

Molecular Biology top 2%
Atomic and Molecular Physics, and Optics top 5%
Immunology top 5%
Materials Chemistry top 10%
Oncology top 10%

Co-authors: Harel Weinstein Sergio A. Hassan Frank Guarnieri Bruce D. Gelb Hannie Kremer Raju Kucherlapati Marco Tartaglia Kamini Kalidas
Topics: Protein Structure and Dynamics (27 papers)Spectroscopy and Quantum Chemical Studies (19 papers)Advanced Chemical Physics Studies (14 papers)
Cited by: Molecular Biology Immunology Physical and Theoretical Chemistry
Journals: Journal of the American Chemical Society Journal of Clinical Investigation The Journal of Chemical Physics
Partner nations: United States Switzerland Netherlands

In The Last Decade

Ernest L. Mehler

74 papers receiving 4.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome

2001 1.2k citations Marco Tartaglia, Ernest L. Mehler et al. Nature Genetics profile →

Peers

Countries citing papers authored by Ernest L. Mehler

Since Specialization

Citations

This map shows the geographic impact of Ernest L. Mehler's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ernest L. Mehler with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ernest L. Mehler more than expected).

Fields of papers citing papers by Ernest L. Mehler

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ernest L. Mehler. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ernest L. Mehler. The network helps show where Ernest L. Mehler may publish in the future.

Co-authorship network of co-authors of Ernest L. Mehler

This figure shows the co-authorship network connecting the top 25 collaborators of Ernest L. Mehler. A scholar is included among the top collaborators of Ernest L. Mehler based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ernest L. Mehler. Ernest L. Mehler is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Calculation of pK_a in proteins with the microenvironment modulated‐screened coulomb potential 2011 ·Proteins Structure Function and Bioinformatics ·Jufang Shan,Ernest L. Mehler	12
2	Progress in the prediction of pK_avalues in proteins 2011 ·Proteins Structure Function and Bioinformatics ·Emil Alexov,Ernest L. Mehler,Nathan Baker,António M. Baptista,Yong Huang,Francesca Milletti,Jens Erik Nielsen,Damien Farrell,Tommy Carstensen,Mats H. M. Olsson,Jana K. Shen,Jim Warwicker,Sarah Williams,J. Michael Word	221
3	Probing the Dynamic Structure and Function of Intracellular Loop 2 in Structurally Cognate GPCRs 2009 ·Biophysical Journal ·Jufang Shan,Ernest L. Mehler,Harel Weinstein	1
4	Quantitative expression of protein heterogeneity: Response of amino acid side chains to their local environment 2008 ·Proteins Structure Function and Bioinformatics ·(unknown),Ernest L. Mehler	10
5	Ab initio computational modeling of loops in G‐protein‐coupled receptors: Lessons from the crystal structure of rhodopsin 2006 ·Proteins Structure Function and Bioinformatics ·Ernest L. Mehler,Sergio A. Hassan,Sandhya Kortagere,Harel Weinstein	30
6	Ab initio computational modeling of long loops in G-protein coupled receptors 2006 ·Journal of Computer-Aided Molecular Design ·Sandhya Kortagere,Amitava Roy,Ernest L. Mehler	11
7	Long dynamics simulations of proteins using atomistic force fields and a continuum representation of solvent effects: Calculation of structural and dynamic properties 2005 ·Proteins Structure Function and Bioinformatics ·Xianfeng Li,Sergio A. Hassan,Ernest L. Mehler	46
8	Molecular dynamics simulations of peptides and proteins with a continuum electrostatic model based on screened Coulomb potentials 2003 ·Proteins Structure Function and Bioinformatics ·Sergio A. Hassan,Ernest L. Mehler,(unknown),Harel Weinstein	56
9	The role of hydrophobic microenvironments in modulating pK_a shifts in proteins 2002 ·Proteins Structure Function and Bioinformatics ·Ernest L. Mehler,Mónika Fuxreiter,István Simon,(unknown)	118
10	A critical analysis of continuum electrostatics: The screened Coulomb potential–implicit solvent model and the study of the alanine dipeptide and discrimination of misfolded structures of proteins 2002 ·Proteins Structure Function and Bioinformatics ·Sergio A. Hassan,Ernest L. Mehler	51
11	Key issues in the computational simulation of GPCR function: representation of loop domains 2002 ·Journal of Computer-Aided Molecular Design ·Ernest L. Mehler,(unknown),(unknown),(unknown)	45
12	Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndromebreakdown → 2001 ·Nature Genetics ·Marco Tartaglia,Ernest L. Mehler,Rosalie Goldberg,Giuseppe Zampino,Han G. Brunner,Hannie Kremer,(unknown),Andrew H. Crosby,(unknown),Steve Jeffery,Kamini Kalidas,Michael A. Patton,Raju Kucherlapati,Bruce D. Gelb	1195
13	A Self-Consistent, Microenvironment Modulated Screened Coulomb Potential Approximation to Calculate pH-Dependent Electrostatic Effects in Proteins 1999 ·Biophysical Journal ·Ernest L. Mehler,Frank Guarnieri	141
14	Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis 1999 ·Journal of Clinical Investigation ·Wu-Shiun Hou,Dieter Brömme,Yingming Zhao,Ernest L. Mehler,(unknown),Harel Weinstein,Clara Sá-Miranda,(unknown),Fenella Greig,John C. Carey,D L Rimoin,Robert J. Desnick,Bruce D. Gelb	125
15	Structure and Dynamics of Calmodulin in Solution 1998 ·Biophysical Journal ·Willy Wriggers,Ernest L. Mehler,(unknown),Harel Weinstein,Klaus Schulten	137
16	Functional Role of Arginine-11 in the N-Terminal Helix of Skeletal Troponin C: Combined Mutagenesis and Molecular Dynamics Investigation 1995 ·Biochemistry ·Jagdish Gulati,(unknown),(unknown),Ernest L. Mehler,Harel Weinstein	4
17	Ca²⁺-Binding and Structural Dynamics in the Functions of Calmodulin 1994 ·Annual Review of Physiology ·Harel Weinstein,Ernest L. Mehler	98
18	Electrostatic screening in molecular dynamics simulations 1991 ·Protein Engineering Design and Selection ·(unknown),Ernest L. Mehler	40
19	Structural dynamics of calmodulin and troponin C 1991 ·Protein Engineering Design and Selection ·Ernest L. Mehler,Juan-Luis Pascual-Ahuir,Harel Weinstein	36
20	Comparison of dielectric response models for simulating electrostatic effects in proteins 1990 ·Protein Engineering Design and Selection ·Ernest L. Mehler	19

About Ernest L. Mehler

Ernest L. Mehler is a scholar working on Physical and Theoretical Chemistry, Atomic and Molecular Physics, and Optics and Spectroscopy, having authored 75 papers that have together received 4.0k indexed citations. Recurring topics across this work include Protein Structure and Dynamics (27 papers), Spectroscopy and Quantum Chemical Studies (19 papers) and Advanced Chemical Physics Studies (14 papers). The work is most often cited by research in Molecular Biology (3.0k citations), Immunology (667 citations) and Physical and Theoretical Chemistry (246 citations). Ernest L. Mehler has collaborated with scholars based in United States, Switzerland and Netherlands. Frequent co-authors include Harel Weinstein, Sergio A. Hassan, Frank Guarnieri, Bruce D. Gelb, Hannie Kremer, Raju Kucherlapati, Marco Tartaglia, Kamini Kalidas, Andrew H. Crosby and Steve Jeffery. Their work appears in journals such as Journal of the American Chemical Society, Journal of Clinical Investigation and The Journal of Chemical Physics.

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