Eric C. Bigham

733 citations

25 papers · 540 indexed · h-index 15

Impact in

Anesthesiology and Pain Medicine top 10%
- Anesthesia and Sedative Agents
Organic Chemistry top 10%
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Synthesis and Characterization of Heterocyclic Compounds

Papers in ⓘ

Molecular Biology 12
- Receptor Mechanisms and Signaling 6
- Biochemical and Molecular Research 3
Organic Chemistry 11
- Synthesis and Biological Evaluation 2

Co-authors: David S. Duch (5 shared papers)Alexander McKillop (2 shared papers)Michael J. Bishop (9 shared papers)Gail K. Smith (3 shared papers)Andrew J. Peat (3 shared papers)Cecilia S. Koble (2 shared papers)Aaron S. Goetz (3 shared papers)Paul L. Feldman (4 shared papers)
Journals: Journal of Medicinal Chemistry (9 papers)Bioorganic & Medicinal Chemistry Letters (7 papers)Journal of the American Chemical Society (1 paper)Organic Letters (1 paper)Journal of Biological Chemistry (1 paper)
Partner nations: United States United Kingdom

In The Last Decade

Eric C. Bigham

25 papers receiving 520 citations

Peers

Countries citing papers authored by Eric C. Bigham

Since Specialization

Citations

This map shows the geographic impact of Eric C. Bigham's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Eric C. Bigham with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Eric C. Bigham more than expected).

Fields of papers citing papers by Eric C. Bigham

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Eric C. Bigham. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Eric C. Bigham. The network helps show where Eric C. Bigham may publish in the future.

Co-authors

The 25 scholars most cited alongside Eric C. Bigham, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Eric C. Bigham Line = papers co-authored together Eric C. Bigham links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 25 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	2-Acetylpyridine thiocarbonohydrazones. Potent inactivators of herpes simplex virus ribonucleotide reductase Journal of Medicinal Chemistry ·Todd A. Blumenkopf, Joan A. Harrington, Cecilia S. Koble, Donald Bankston, Robert W. Morrison, Eric C. Bigham, Virgil L. Styles, Thomas Spector	1992	59
2	Solid phase synthesis and SAR of small molecule agonists for the GPR40 receptor Bioorganic & Medicinal Chemistry Letters ·Stephen C. McKeown, David F. Corbett, Aaron S. Goetz, Thomas R. Littleton, Eric C. Bigham, Celia P. Briscoe, Andrew J. Peat, Steve P. Watson, Deirdre M. B. Hickey	2007	56
3	Thallium in organic synthesis. XXXII. Oxidative rearrangement of olefins using thallium(III) nitrate (TTN) Journal of the American Chemical Society ·Alexander McKillop, John D. Hunt, Frank Kienzle, Eric C. Bigham, Edward C. Taylor	1973	45
4	The discovery and optimization of pyrimidinone-containing MCH R1 antagonists Bioorganic & Medicinal Chemistry Letters ·Donald L. Hertzog, Kamal Albarazanji, Eric C. Bigham, Michael J. Bishop, Christy S. Britt, David L. Carlton, Joel P. Cooper, Alex J. Daniels, Dulce Garrido, Aaron S. Goetz, Mary K. Grizzle, Yu Guo, Anthony L. Handlon, Diane M. Ignar, Ronda O. Morgan, Andrew J. Peat, Francis X. Tavares, Huiqiang Zhou	2006	39
5	New inhibitors of sepiapterin reductase. Lack of an effect of intracellular tetrahydrobiopterin depletion upon in vitro proliferation of two human cell lines. Journal of Biological Chemistry ·Gail K. Smith, David S. Duch, Mark Edelstein, Eric C. Bigham	1992	33
6	Bis- and Mixed-Tetrahydroisoquinolinium Chlorofumarates: New Ultra-Short-Acting Nondepolarizing Neuromuscular Blockers Journal of Medicinal Chemistry ·Eric E. Boros, Eric C. Bigham, G. Evan Boswell, Robert A. Mook, Sanjay S. Patel, John J. Savarese, John A. Ray, James B. Thompson, Mir A. Hashim, James C. Wisowaty, Paul L. Feldman, Vicente Sámano	1999	30
7	Synthesis of Ultra-Short-Acting Neuromuscular Blocker GW 0430: A Remarkably Stereo- and Regioselective Synthesis of Mixed Tetrahydroisoquinolinium Chlorofumarates Organic Letters ·Vicente Sámano, John A. Ray, James B. Thompson, Robert A. Mook, David Jung, Cecilia S. Koble, Michael T. Martin, Eric C. Bigham, Craig S. Regitz, Paul L. Feldman, Eric E. Boros	1999	30
8	Inhibition of arabinose 5-phosphate isomerase. An approach to the inhibition of bacterial lipopolysaccharide biosynthesis Journal of Medicinal Chemistry ·Eric C. Bigham, Charles E. Gragg, William R. Hall, John E. Kelsey, W. Revill Mallory, D.C. Richardson, Charles D. Benedict, Paul H. Ray	1984	30
9	Potent, Selective, and Orally Efficacious Antagonists of Melanin-Concentrating Hormone Receptor 1 Journal of Medicinal Chemistry ·Francis X. Tavares, Kamal Albarazanji, Eric C. Bigham, Michael J. Bishop, Christy S. Britt, David L. Carlton, Paul L. Feldman, Aaron S. Goetz, Mary K. Grizzle, Yu Guo, Anthony L. Handlon, Donald L. Hertzog, Diane M. Ignar, Daniel G. Lang, Ronda J. Ott, Andrew J. Peat, Huiqiang Zhou	2006	28
10	Synthesis and biological activity of open-chain analogs of 5,6,7,8-tetrahydrofolic acid-potential antitumor agents Journal of Medicinal Chemistry ·Eric C. Bigham, Stephen J. Hodson, W. Revill Mallory, David J. Wilson, David S. Duch, Gary K. Smith, Robert Ferone	1992	26
11	2-(Anilinomethyl)imidazolines as α₁ Adrenergic Receptor Agonists: the Discovery of α₁_a Subtype Selective 2‘-Alkylsulfonyl-Substituted Analogues Journal of Medicinal Chemistry ·Stephen J. Hodson, Michael J. Bishop, Jason D. Speake, Frank Navas, Deanna T. Garrison, Eric C. Bigham, David L. Saussy, James A. Liacos, Paul E Irving, Michael J Gobel, Bryan W. Sherman	2002	24
12	Thallium in organic synthesis. 45. Synthesis of aromatic fluorides The Journal of Organic Chemistry ·Edward C. Taylor, Eric C. Bigham, David K. Johnson, Alexander McKillop	1977	21
13	Bis- and Mixed-Tetrahydroisoquinolinium Chlorofumarates: New Ultra-Short-Acting Nondepolarizing Neuromuscular Blockers Journal of Medicinal Chemistry ·Eric E. Boros, Eric C. Bigham, G. Evan Boswell, Robert A. Mook, Sanjay S. Patel, John J. Savarese, John A. Ray, James B. Thompson, Mir A. Hashim, James C. Wisowaty, Paul L. Feldman, Vicente Sámano	1999	21
14	α1-Adrenoceptor Agonists: The Identification of Novel α1A Subtype Selective 2′-Heteroaryl-2-(phenoxymethyl)imidazolines Bioorganic & Medicinal Chemistry Letters ·Michael J. Bishop, Kevin A Barvian, Judd Berman, Eric C. Bigham, Deanna T. Garrison, Michael J Gobel, Stephen J. Hodson, Paul E Irving, James A. Liacos, Frank Navas, David L. Saussy, Jason D. Speake	2002	17
15	2-(Anilinomethyl)imidazolines as α1 adrenergic receptor agonists: α1a subtype selective 2′-heteroaryl compounds Bioorganic & Medicinal Chemistry Letters ·Jason D. Speake, Frank Navas, Michael J. Bishop, Deanna T. Garrison, Eric C. Bigham, Stephen J. Hodson, David L. Saussy, Jim Liacos, Paul E Irving, Bryan W. Sherman	2003	15
16	Synthetic analogs of tetrahydrobiopterin with cofactor activity for aromatic amino acid hydroxylases Journal of Medicinal Chemistry ·Eric C. Bigham, Gail K. Smith, John F. Reinhard, W. Revill Mallory, Charles A. Nichol, R.W. Morrison	1987	12
17	In vivo antitumor activity and metabolism of a series of 5-deazaacyclotetrahydrofolate (5-DACTHF) analogues Biochemical Pharmacology ·Robert J. Mullin, Barry R. Keith, Eric C. Bigham, David S. Duch, Robert Ferone, Louise S. Heath, Sara C. Singer, Kathleen A. Waters, H.Robert Wilson	1992	11
18	2-(Anilinomethyl)imidazolines as α1A Adrenergic Receptor Agonists: 2′-Heteroaryl and 2′-Oxime Ether Series Bioorganic & Medicinal Chemistry Letters ·Frank Navas, Michael J. Bishop, Deanna T. Garrison, Stephen J. Hodson, Jason D. Speake, Eric C. Bigham, David H. Drewry, David L. Saussy, James H. Liacos, Paul E Irving, Michael J Gobel	2002	9
19	Multisubstrate Analogue Inhibitors of Glycinamide Ribonucleotide Transformylase Based on 5-Deazaacyclo Tetrahudrofolate (5-DACTHF) Heterocycles ·Eric C. Bigham, W. Revill Mallory, Steven J. Hodson, David S. Duch, Robert Ferone, Gary K. Smith	1993	7
20	On the substrate specificity of bovine liver dihydrofolate reductase: New unconjugated dihydropterin substrates Archives of Biochemistry and Biophysics ·Gary K. Smith, Sheila D. Banks, Eric C. Bigham, Charles A. Nichol	1987	6

About Eric C. Bigham

Eric C. Bigham is a scholar working on Molecular Biology, Organic Chemistry, Cellular and Molecular Neuroscience, Pollution and Endocrine and Autonomic Systems, having authored 25 papers that have together received 540 indexed citations. Recurring topics across this work include Receptor Mechanisms and Signaling (6 papers), Biochemical and Molecular Research (3 papers), Neuroscience and Neuropharmacology Research (3 papers), Metabolism and Genetic Disorders (2 papers), Biochemical Analysis and Sensing Techniques (2 papers), Chemical Reactions and Isotopes (2 papers), Synthesis and Biological Evaluation (2 papers) and Neuropeptides and Animal Physiology (2 papers). The work is most often cited by research in Anesthesiology and Pain Medicine (47 citations), Organic Chemistry (222 citations), Endocrine and Autonomic Systems (35 citations), Molecular Biology (275 citations) and Developmental Neuroscience (16 citations). Eric C. Bigham has collaborated with scholars based in United States and United Kingdom. Frequent co-authors include David S. Duch, Alexander McKillop, Michael J. Bishop, Gail K. Smith, Andrew J. Peat, Cecilia S. Koble, Aaron S. Goetz, Paul L. Feldman, Frank Kienzle and John D. Hunt. Their work appears in journals such as Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Journal of the American Chemical Society, Organic Letters and Journal of Biological Chemistry.

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