David S. Duch

3.0k total citations · 2 hit papers
62 papers, 2.6k citations indexed

About

David S. Duch is a scholar working on Molecular Biology, Organic Chemistry and Clinical Biochemistry. According to data from OpenAlex, David S. Duch has authored 62 papers receiving a total of 2.6k indexed citations (citations by other indexed papers that have themselves been cited), including 32 papers in Molecular Biology, 14 papers in Organic Chemistry and 14 papers in Clinical Biochemistry. Recurrent topics in David S. Duch's work include Biochemical and Molecular Research (17 papers), Metabolism and Genetic Disorders (14 papers) and Amino Acid Enzymes and Metabolism (11 papers). David S. Duch is often cited by papers focused on Biochemical and Molecular Research (17 papers), Metabolism and Genetic Disorders (14 papers) and Amino Acid Enzymes and Metabolism (11 papers). David S. Duch collaborates with scholars based in United States, United Kingdom and Chile. David S. Duch's co-authors include Charles A. Nichol, Mark Edelstein, Gary K. Smith, Yoshisuke Ozaki, E. M. GRIVSKY, Carl W. Sigel, Shuliang Lee, Gail K. Smith, Robert Ferone and Norman Kirshner and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Annual Review of Biochemistry.

In The Last Decade

David S. Duch

62 papers receiving 2.5k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

BIOSYNTHESIS AND METABOLISM OF TETRAHYDROBIOPTERIN AND MOLYBDOPTERIN

1985 489 citations Charles A. Nichol, Gary K. Smith et al. profile →
Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine

1980 327 citations David S. Duch, Charles A. Nichol et al. Journal of Medicinal Chemistry profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
David S. Duch United States	25	1.2k	548	461	342	311	62	2.6k
Camilo Rojas United States	37	1.9k 1.6×	267 0.5×	144 0.3×	623 1.8×	180 0.6×	108	4.6k
Johan Palmfeldt Denmark	32	1.5k 1.3×	137 0.3×	304 0.7×	267 0.8×	111 0.4×	110	2.5k
Joseph B. Monahan United States	36	1.7k 1.4×	317 0.6×	38 0.1×	461 1.3×	105 0.3×	76	3.4k
Ramesh Kekuda United States	28	1.7k 1.5×	133 0.2×	566 1.2×	272 0.8×	71 0.2×	56	3.6k
Federico Da Settimo Italy	42	2.4k 2.0×	1.9k 3.5×	95 0.2×	366 1.1×	111 0.4×	210	5.3k
T. Phillip Waalkes United States	31	1.9k 1.6×	127 0.2×	183 0.4×	462 1.4×	39 0.1×	69	3.6k
Robert Silber United States	29	2.2k 1.9×	184 0.3×	96 0.2×	392 1.1×	29 0.1×	87	4.5k
You-Jun Fei United States	21	1.4k 1.2×	163 0.3×	259 0.6×	192 0.6×	71 0.2×	22	2.8k
June R. Aprille United States	28	2.5k 2.1×	161 0.3×	1.1k 2.5×	471 1.4×	78 0.3×	76	3.6k
Sabrina Taliani Italy	36	1.8k 1.5×	1.2k 2.2×	66 0.1×	286 0.8×	104 0.3×	145	3.6k

Countries citing papers authored by David S. Duch

Since Specialization

Citations

This map shows the geographic impact of David S. Duch's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David S. Duch with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David S. Duch more than expected).

Fields of papers citing papers by David S. Duch

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David S. Duch. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David S. Duch. The network helps show where David S. Duch may publish in the future.

Co-authorship network of co-authors of David S. Duch

This figure shows the co-authorship network connecting the top 25 collaborators of David S. Duch. A scholar is included among the top collaborators of David S. Duch based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David S. Duch. David S. Duch is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Chandrasekaran, B., Timothy E. Kute, & David S. Duch. (1995). Synchronization of cells in the S phase of the cell cycle by 3?-azido-3?-deoxythymidine: implications for cell cytotoxicity. Cancer Chemotherapy and Pharmacology. 35(6). 489–495. 20 indexed citations

Bigham, Eric C., et al.. (1994). Thienyl and Thiazolyl Acyclic Analogs of 5-Deazatetrahydrofolic Acid. Journal of Medicinal Chemistry. 37(13). 2112–2115. 5 indexed citations

Jansen, Marilyn, Michael Dykstra, Jeremy N. Stables, et al.. (1994). Effect of purine synthesis inhibition on WiDr spheroids in vitro or on WiDr or colon 38 tumors in vivo. Biochemical Pharmacology. 47(6). 1067–1078. 7 indexed citations

Pendergast, William, Scott H. Dickerson, I K Dev, et al.. (1993). Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some 3-amino- and 3-methylbenzo[f]quinazolin-1(2H)-ones. Journal of Medicinal Chemistry. 36(16). 2279–2291. 45 indexed citations

Bigham, Eric C., et al.. (1992). Synthesis and biological activity of open-chain analogs of 5,6,7,8-tetrahydrofolic acid-potential antitumor agents. Journal of Medicinal Chemistry. 35(8). 1399–1410. 26 indexed citations

Priest, David G., Marlene A. Bunni, Robert J. Mullin, et al.. (1992). A Comparison of Hplc and Ternary Complex-Based Assays of Tissue Reduced Folates. Analytical Letters. 25(2). 219–230. 5 indexed citations

Duch, David S., et al.. (1991). Studies on the mechanism of antitumor action of 2-desamino-2-methyl-5,8-dideazaisofolic acid. Biochemical Pharmacology. 41(5). 781–787. 13 indexed citations

Mullin, Robert J. & David S. Duch. (1991). Preparation of a chiral matrix. Journal of Chromatography A. 555(1-2). 254–259. 3 indexed citations

Knowles, Richard G., et al.. (1991). The Role of Tryptophan and Kynurenine Transport in the Catabolism of Tryptophan Through Indoleamine 2,3-Dioxygenase. Advances in experimental medicine and biology. 294. 161–166. 6 indexed citations

10.

Nair, Muraleedharan G., Roy L. Kisliuk, Y. Gaumont, et al.. (1991). Folate analogs. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogs of N10-propargyl-5,8-dideazafolic acid. Journal of Medicinal Chemistry. 34(9). 2746–2754. 59 indexed citations

11.

Kelley, James L., Ed W. McLean, Mark Edelstein, et al.. (1990). Synthesis and biological activity of an acyclic analog of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]benzoyl]-L-glutamic acid. Journal of Medicinal Chemistry. 33(2). 561–567. 24 indexed citations

12.

Smith, Gary K., Thomas J. Monaco, R. Rigual, et al.. (1990). Activity of an NAD-dependent 5,10-methylenetetrahydrofolate dehydrogenase in normal tissue, neoplastic cells, and oncogene-transformed cells. Archives of Biochemistry and Biophysics. 283(2). 367–371. 23 indexed citations

13.

Johnson, Dana L., Robert J. Mullin, David S. Duch, & Stephen J. Benkovic. (1990). Direct demonstration of the active salvage of preformed purines by murine tumors. Biochemical and Biophysical Research Communications. 170(3). 1164–1169. 1 indexed citations

14.

Laufman, Leslie R., Wayne D. Brenckman, Mary Collier, et al.. (1989). Clinical experience with leucovorin and 5-fluorouracil. Cancer. 63(S6). 1031–1035. 23 indexed citations

15.

Nair, Muraleedharan G., John Galivan, Frank Maley, et al.. (1989). Folate analogs. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds. Journal of Medicinal Chemistry. 32(6). 1284–1289. 22 indexed citations

16.

Nair, Muraleedharan G., Roy L. Kisliuk, Y. Gaumont, et al.. (1989). Folate analogs. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase. Journal of Medicinal Chemistry. 32(6). 1277–1283. 11 indexed citations

17.

Duch, David S., et al.. (1988). In vivo measurement of dihydrofolate reductase and its inhibition by antifolates. Analytical Biochemistry. 172(1). 169–175. 2 indexed citations

18.

Duch, David S., et al.. (1983). Biosynthesis of tetrahydrobiopterin in the presence of dihydrofolate reductase inhibitors.. Molecular Pharmacology. 24(1). 103–108. 23 indexed citations

19.

Duch, David S., Mark Edelstein, & Charles A. Nichol. (1980). Inhibition of Histamine-Metabolizing Enzymes and Elevation of Histamine Levels in Tissues by Lipid-Soluble Anticancer Folate Antagonists. Molecular Pharmacology. 18(1). 100–104. 39 indexed citations

20.

Duch, David S., et al.. (1979). Dihydrofolate reductase in primary brain tumors, cell cultures of central nervous system origin, and normal brain during fetal and neonatal growth.. Munich Personal RePEc Archive (Ludwig Maximilian University of Munich). 39(2 Pt 1). 487–91. 13 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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