Edward J. Modest

5.4k citations

115 papers · 4.3k indexed · 2 hit papers · h-index 33

Impact in

Molecular Biology top 5%
- DNA and Nucleic Acid Chemistry
- Genomics and Chromatin Dynamics
- Lipid Membrane Structure and Behavior
Biochemistry top 2%

Papers in

Biochemistry 17
- Lipid metabolism and biosynthesis 11
Organic Chemistry 65
- Synthesis and Characterization of Heterocyclic Compounds 35
- Synthesis and Biological Evaluation 25
- Quinazolinone synthesis and applications 19
- Synthesis and biological activity 11

Co-authors: L. Zech T. Caspersson C. Johansson G. E. Foley Erik Simonsson Ulhas V. Wagh Mervyn Israel A. Rosowsky
Journals: Journal of Medicinal Chemistry (21 papers)The Journal of Organic Chemistry (11 papers)Biochemical Pharmacology (8 papers)Cancer Chemotherapy and Pharmacology (5 papers)International Journal of Cancer (4 papers)
Partner nations: United States Italy Sweden

In The Last Decade

Edward J. Modest

113 papers receiving 3.9k citations

Hit Papers

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Identification of human chromosomes by DNA-binding fluorescent agents 1970 · 833 citations

Peers

Countries citing papers authored by Edward J. Modest

Since Specialization

Citations

This map shows the geographic impact of Edward J. Modest's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Edward J. Modest with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Edward J. Modest more than expected).

Fields of papers citing papers by Edward J. Modest

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Edward J. Modest. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Edward J. Modest. The network helps show where Edward J. Modest may publish in the future.

Co-authors

The 25 scholars most cited alongside Edward J. Modest, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Edward J. Modest Line = papers co-authored together Edward J. Modest links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Cell kill and cytostasis by ET-18-OCH3 and heat. PubMed ·Keiichi Fujiwara, Edward J. Modest, C. Anne Wallen	1995	2
2	Relationship of cell survival, drug dose, and drug uptake after 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine treatment Cancer Chemotherapy and Pharmacology ·Keiichi Fujiwara, Larry W. Daniel, Edward J. Modest, C. Anne Wallen	1994	4
3	Synthesis of phosphocholine and quaternary amine ether lipids and evaluation of in vitro antineoplastic activity Journal of Medicinal Chemistry ·Susan L. Morris‐Natschke, Fatma Gümüş, Canio J. Marasco, K. Meyer, M. Marx, Claude A. Piantadosi, Matthew D. Layne, Edward J. Modest	1993	21
4	Induction of apoptosis in human leukemic cells by the ether lipid 1‐octadecyl‐2‐methyl‐RAC‐glycero‐3‐ phosphocholine. A possible basis for its selective action International Journal of Cancer ·Luisa Diomede, Francesco Colotta, Henry Nielsen, Fabio Re, Edward J. Modest, Mario Salmona	1993	102
5	Increased ether lipid cytotoxicity by reducing membrane cholesterol content International Journal of Cancer ·Luisa Diomede, Henry Nielsen, Edward J. Modest, Alessandro Noseda, Mario Salmona	1991	24
6	Novel Membrane-Interactive Ether Lipid Analogs That Inhibit Infectious HIV-1 Production and Induce Defective Virus Formation AIDS Research and Human Retroviruses ·Louis S. Kucera, CHEN Sinuo, Edward R. Leake, Katharine Teigen, Edward J. Modest, Larry W. Daniel, Claude A. Piantadosi	1990	47
7	Role of cell cholesterol in modulating antineoplastic ether lipid uptake, membrane effects and cytotoxicity International Journal of Cancer ·Luisa Diomede, A. Bizzi, 伸子実方, Edward J. Modest, Mario Salmona, Alessandro Noseda	1990	51
8	Synthesis of quaternary amine ether lipids and evaluation of neoplastic cell growth inhibitory properties Journal of Medicinal Chemistry ·Susan L. Morris‐Natschke, K. Meyer, Canio J. Marasco, Claude A. Piantadosi, Fiona Rossi, Sérgio Morais Aoki, Edward J. Modest	1990	16
9	Cross-resistance pattern of cell lines selected for resistance towards different cytotoxic drugs to membrane-toxic phospholipids in vitro Cancer Chemotherapy and Pharmacology ·Andreas Himmelmann, S. Danhauser-Riedl, 政夫橋詰, Raymonde Busch, Edward J. Modest, Alessandro Noseda, Johann Rastetter, William R. Vogler, Wolfgang E. Berdel	1990	9
10	Tricyclic 2,4-diaminopyrimidines with broad antifolate activity and the ability to inhibit pneumocystis carinii growth in cultured human lung fibroblasts in the presence of leucovorin Biochemical Pharmacology ·A. Rosowsky, James H. Freisheim, John B. Hynes, Sherry F. Queener, Marilyn S. Bartlett, James W. Smith, Herbert Lazarus, Edward J. Modest	1989	12
11	Membrane damage in leukemic cells induced by ether and ester lipids: An electron microscopic study Experimental and Molecular Pathology ·Alessandro Noseda, Yang Zhi-yuan, Sérgio Morais Aoki, W. Gray Jerome, Edward J. Modest	1989	62
12	Synthesis and evaluation of neoplastic cell growth inhibition of 1-N-alkylamide analogs of glycero-3-phosphocholine Journal of Medicinal Chemistry ·S. Vuocolo, Claude A. Piantadosi, Alessandro Noseda, Larry W. Daniel, Edward J. Modest	1988	23
13	Serum amino acid levels in leukemic mice after l-asparaginase treatment Biochemical Medicine and Metabolic Biology ·F. Lime, Pratima Sur, Robert L. Capizzi, Edward J. Modest	1988	2
14	Effects of antineoplastic ether lipids on model and biological membranes Biochimica et Biophysica Acta (BBA) - Biomembranes ·Alessandro Noseda, Sérgio Morais Aoki, Edward J. Modest	1988	65
15	Continuous intravenous infusion of vinca alkaloid using a subcutaneously implanted pump in a canine model Cancer Chemotherapy and Pharmacology ·Don V. Jackson, Bridget M. Spooner, 樫尾明彦, Susan M. Williams, Gottfried Nitze, Wayne Meredith, V.Sagar Sethi, Edward J. Modest, H. Bradley Wells, Charles L. Spurr, Manford C. Castle	1983	5
16	Differences in cellular uptake and cytofluorescence of adriamycin and N-trifluoroacetyladriamycin-14-valerate. PubMed ·Awtar Krishan, Mervyn Israel, Edward J. Modest, Emil Frei	1976	53
17	N-trifluoroacetyladriamycin-14-valerate, an analog with greater experimental antitumor activity and less toxicity than adriamycin. PubMed ·Mervyn Israel, Edward J. Modest, Emil Frei	1975	113
18	Pyrimidine Derivatives VII Journal of Pharmaceutical Sciences ·Mervyn Israel, 知行谷, X. Quan, Edward J. Modest	1965	5
19	Quinazolines. I. Formation of a Guanidinoquinazoline during the Three-Component Synthesis of a 4,6-Diamino-1-aryl-1,2-dihydro-s-triazine¹ The Journal of Organic Chemistry ·A. Rosowsky, 知行谷, Paul J. Burke, Edward J. Modest	1964	9
20	A SERIES OF NEW, BIOLOGICALLY SIGNIFICANT DIHYDROTRIAZINES Journal of the American Chemical Society ·Edward J. Modest, George E. Foley, Maurice M. Pechet, Sidney Farber	1952	32

About Edward J. Modest

Edward J. Modest is a scholar working on Biochemistry, Organic Chemistry, Molecular Biology, Cancer Research and Virology, having authored 115 papers that have together received 4.3k indexed citations. Recurring topics across this work include Synthesis and Characterization of Heterocyclic Compounds (35 papers), Synthesis and Biological Evaluation (25 papers), Quinazolinone synthesis and applications (19 papers), Synthesis and biological activity (11 papers), DNA and Nucleic Acid Chemistry (11 papers), Lipid metabolism and biosynthesis (11 papers), Phenothiazines and Benzothiazines Synthesis and Activities (10 papers) and Chemical Synthesis and Analysis (8 papers). The work is most often cited by research in Molecular Biology (2.5k citations), Biochemistry (227 citations), Organic Chemistry (894 citations), Genetics (856 citations) and Hematology (231 citations). Edward J. Modest has collaborated with scholars based in United States, Italy and Sweden. Frequent co-authors include L. Zech, T. Caspersson, C. Johansson, G. E. Foley, Erik Simonsson, Ulhas V. Wagh, Mervyn Israel, A. Rosowsky, Alessandro Noseda and Garth Powis. Their work appears in journals such as Journal of Medicinal Chemistry, The Journal of Organic Chemistry, Biochemical Pharmacology, Cancer Chemotherapy and Pharmacology and International Journal of Cancer.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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