Donna McEachern

7.5k total citations · 1 hit paper
72 papers, 4.1k citations indexed

About

Donna McEachern is a scholar working on Molecular Biology, Oncology and Hematology. According to data from OpenAlex, Donna McEachern has authored 72 papers receiving a total of 4.1k indexed citations (citations by other indexed papers that have themselves been cited), including 59 papers in Molecular Biology, 37 papers in Oncology and 12 papers in Hematology. Recurrent topics in Donna McEachern's work include Protein Degradation and Inhibitors (31 papers), Ubiquitin and proteasome pathways (30 papers) and Peptidase Inhibition and Analysis (14 papers). Donna McEachern is often cited by papers focused on Protein Degradation and Inhibitors (31 papers), Ubiquitin and proteasome pathways (30 papers) and Peptidase Inhibition and Analysis (14 papers). Donna McEachern collaborates with scholars based in United States, China and Poland. Donna McEachern's co-authors include Shaomeng Wang, Liu Liu, Duxin Sun, Chao‐Yie Yang, Longchuan Bai, Jianfeng Lü, Bo Wen, Yujun Zhao, Jeanne A. Stuckey and Angelo Aguilar and has published in prestigious journals such as Journal of the American Chemical Society, Angewandte Chemie International Edition and Nature Communications.

In The Last Decade

Donna McEachern

71 papers receiving 4.0k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

2019 440 citations Longchuan Bai, Haibin Zhou et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Donna McEachern United States	33	2.9k	1.5k	850	557	265	72	4.1k
László Őrfi Hungary	31	1.6k 0.6×	1.0k 0.7×	539 0.6×	385 0.7×	335 1.3×	113	3.3k
Uwe Rix United States	38	2.6k 0.9×	1.0k 0.7×	841 1.0×	901 1.6×	476 1.8×	89	4.9k
Longchuan Bai United States	32	2.7k 0.9×	1.2k 0.8×	363 0.4×	469 0.8×	421 1.6×	68	3.5k
Erkan Baloglu United States	30	1.9k 0.7×	1.2k 0.8×	319 0.4×	346 0.6×	298 1.1×	85	3.0k
Steven W. Elmore United States	24	3.2k 1.1×	1.2k 0.8×	716 0.8×	510 0.9×	623 2.4×	37	4.8k
Sylvie M. Guichard United Kingdom	33	2.3k 0.8×	1.6k 1.0×	555 0.7×	202 0.4×	235 0.9×	96	4.0k
Peter Charlton United Kingdom	34	2.7k 0.9×	2.1k 1.4×	602 0.7×	277 0.5×	126 0.5×	74	4.5k
Michel Vidal France	31	1.6k 0.5×	897 0.6×	571 0.7×	207 0.4×	239 0.9×	182	3.3k
Kathryn Packman United States	28	2.6k 0.9×	2.2k 1.5×	343 0.4×	302 0.5×	286 1.1×	65	3.9k
Sally Przybranowski United States	16	1.8k 0.6×	757 0.5×	316 0.4×	267 0.5×	278 1.0×	24	2.5k

Countries citing papers authored by Donna McEachern

Since Specialization

Citations

This map shows the geographic impact of Donna McEachern's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Donna McEachern with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Donna McEachern more than expected).

Fields of papers citing papers by Donna McEachern

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Donna McEachern. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Donna McEachern. The network helps show where Donna McEachern may publish in the future.

Co-authorship network of co-authors of Donna McEachern

This figure shows the co-authorship network connecting the top 25 collaborators of Donna McEachern. A scholar is included among the top collaborators of Donna McEachern based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Donna McEachern. Donna McEachern is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Dhruv, Harshil, Qiaolin Deng, Matthew Tudor, et al.. (2025). Discovery of a Novel Series of iso-Indolinone-Based Glutarimides as Highly Efficacious and Selective IKZF2 Molecular Glue Degraders. Journal of Medicinal Chemistry. 68(17). 18230–18257.

Chen, Zhixiang, Harshil Dhruv, Xuqing Zhang, et al.. (2025). Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy. Nature Communications. 16(1). 4095–4095. 6 indexed citations

Zhou, Haibin, Longchuan Bai, Hoda Metwally, et al.. (2024). Abstract 3881: Discovery of highly potent, selective and efficacious STAT3 PROTAC degraders capable of achieving long-lasting tumor regression. Cancer Research. 84(6_Supplement). 3881–3881. 1 indexed citations

Bai, Longchuan, Mi Wang, Donna McEachern, et al.. (2023). A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo. Nature Chemical Biology. 19(6). 703–711. 40 indexed citations

Zhou, Haibin, Jianfeng Lü, Krishnapriya Chinnaswamy, et al.. (2021). Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity. Nature Communications. 12(1). 2621–2621. 34 indexed citations

Han, Xin, Lijie Zhao, Weiguo Xiang, et al.. (2021). Strategies toward Discovery of Potent and Orally Bioavailable Proteolysis Targeting Chimera Degraders of Androgen Receptor for the Treatment of Prostate Cancer. Journal of Medicinal Chemistry. 64(17). 12831–12854. 104 indexed citations

Xiang, Weiguo, Lijie Zhao, Xin Han, et al.. (2021). Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer. Journal of Medicinal Chemistry. 64(18). 13487–13509. 110 indexed citations

Xu, Shilin, Angelo Aguilar, Tianfeng Xu, et al.. (2017). Design of the First‐in‐Class, Highly Potent Irreversible Inhibitor Targeting the Menin‐MLL Protein–Protein Interaction. Angewandte Chemie International Edition. 57(6). 1601–1605. 51 indexed citations

Lü, Jianfeng, Donna McEachern, Shunqiang Li, Matthew J. Ellis, & Shaomeng Wang. (2016). Reactivation of p53 by MDM2 Inhibitor MI-77301 for the Treatment of Endocrine-Resistant Breast Cancer. Molecular Cancer Therapeutics. 15(12). 2887–2893. 30 indexed citations

10.

Hoffman-Luca, C. Gianna, Donna McEachern, Yujun Zhao, et al.. (2015). Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo. Clinical Cancer Research. 21(11). 2558–2568. 44 indexed citations

11.

Hoffman-Luca, C. Gianna, et al.. (2015). Significant Differences in the Development of Acquired Resistance to the MDM2 Inhibitor SAR405838 between In Vitro and In Vivo Drug Treatment. PLoS ONE. 10(6). e0128807–e0128807. 22 indexed citations

12.

Bai, Longchuan, Jianfang Chen, Donna McEachern, et al.. (2014). BM-1197: A Novel and Specific Bcl-2/Bcl-xL Inhibitor Inducing Complete and Long-Lasting Tumor Regression In Vivo. PLoS ONE. 9(6). e99404–e99404. 70 indexed citations

13.

Bai, Longchuan, Donna McEachern, Chao‐Yie Yang, et al.. (2012). LRIG1 Modulates Cancer Cell Sensitivity to Smac Mimetics by Regulating TNFα Expression and Receptor Tyrosine Kinase Signaling. Cancer Research. 72(5). 1229–1238. 28 indexed citations

14.

Yang, Jie, Donna McEachern, Wenyan Li, et al.. (2011). Radiosensitization of Head and Neck Squamous Cell Carcinoma by a SMAC-Mimetic Compound, SM-164, Requires Activation of Caspases. Molecular Cancer Therapeutics. 10(4). 658–669. 43 indexed citations

15.

Lü, Jianfeng, Donna McEachern, Haiying Sun, et al.. (2011). Therapeutic Potential and Molecular Mechanism of a Novel, Potent, Nonpeptide, Smac Mimetic SM-164 in Combination with TRAIL for Cancer Treatment. Molecular Cancer Therapeutics. 10(5). 902–914. 51 indexed citations

16.

Shangary, Sanjeev, Ke Ding, Su Qiu, et al.. (2008). Reactivation of p53 by a specific MDM2 antagonist (MI-43) leads to p21-mediated cell cycle arrest and selective cell death in colon cancer. Molecular Cancer Therapeutics. 7(6). 1533–1542. 75 indexed citations

17.

Lü, Jianfeng, Longchuan Bai, Haiying Sun, et al.. (2008). SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP. Cancer Research. 68(22). 9384–9393. 174 indexed citations

18.

McEachern, Donna, et al.. (1992). Sequential alteration of peanut agglutinin binding-glycoprotein expression during progression of murine mammary neoplasia. British Journal of Cancer. 65(5). 641–648. 53 indexed citations

19.

Aslakson, Cheryl J., Donna McEachern, Dale H. Conaway, & Fred R. Miller. (1991). Inhibition of lung colonization at two different steps in the metastatic sequence. Clinical & Experimental Metastasis. 9(2). 139–150. 13 indexed citations

20.

McEachern, Donna, et al.. (1990). Efficiency of communication between tumour cells in collagen gel cultures. British Journal of Cancer. 62(3). 360–363. 7 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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