Longchuan Bai

5.4k citations

68 papers · 3.5k indexed · 1 hit paper · h-index 32

Impact in

Oncology top 2%
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
Hematology top 2%
- Multiple Myeloma Research and Treatments

Papers in

Oncology 31
- Cancer-related Molecular Pathways 11
- Peptidase Inhibition and Analysis 11
Hematology 10
- Multiple Myeloma Research and Treatments 9

Co-authors: Shaomeng Wang Juanita L. Merchant Chao‐Yie Yang Donna McEachern Liu Liu Jeanne A. Stuckey Jennifer L. Meagher Duxin Sun
Journals: Journal of Medicinal Chemistry (21 papers)Cancer Research (6 papers)Journal of Biological Chemistry (4 papers)ACS Medicinal Chemistry Letters (4 papers)Molecular Cancer Therapeutics (2 papers)
Partner nations: United States China Poland

In The Last Decade

Longchuan Bai

66 papers receiving 3.5k citations

Hit Papers

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A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo 2019 · 440 citations

Peers

Countries citing papers authored by Longchuan Bai

Since Specialization

Citations

This map shows the geographic impact of Longchuan Bai's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Longchuan Bai with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Longchuan Bai more than expected).

Fields of papers citing papers by Longchuan Bai

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Longchuan Bai. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Longchuan Bai. The network helps show where Longchuan Bai may publish in the future.

Co-authors

The 25 scholars most cited alongside Longchuan Bai, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Longchuan Bai Line = papers co-authored together Longchuan Bai links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Discovery of a Novel Series of iso-Indolinone-Based Glutarimides as Highly Efficacious and Selective IKZF2 Molecular Glue Degraders Journal of Medicinal Chemistry ·Xuqing Zhang, Harshil Dhruv, Qiaolin Deng, Matthew Tudor, Nelisa Bechtel, Rakesh Nagilla, Larry J. Jolivette, Cory Rice, Peter P. Orth, Elham Behshad, Corey Strickland, Helai P. Mohammad, Longchuan Bai, Donna McEachern, Shaomeng Wang, Zhihua Sui, E. Scott Priestley	2025	0
2	Integrated Oxygen Consumption Rate, Energy Metabolism, and Transcriptome Analysis Reveal the Heat Sensitivity of Wild Amur Grayling (Thymallus grubii) Under Acute Warming Biology ·Cunhua Zhai, Ziyang Wang, Longchuan Bai, Bo Ma	2025	0
3	Development of PVTX-405 as a potent and highly selective molecular glue degrader of IKZF2 for cancer immunotherapy Nature Communications ·Zhixiang Chen, Harshil Dhruv, Xuqing Zhang, Rohan Kalyan Rej, Longchuan Bai, Donna McEachern, Paul D. Kirchhoff, Rakesh Nagilla, Larry J. Jolivette, Cory Rice, Peter Orth, Corey O. Strickland, E. Scott Priestley, Helai P. Mohammad, Meilin Wang, Bo Wen, Duxin Sun, Zhihua Sui, Shaomeng Wang	2025	6
4	IL-4–STAT6 axis amplifies histamine-induced vascular endothelial dysfunction and hypovolemic shock Journal of Allergy and Clinical Immunology ·James Krempski, Amnah Yamani, Lakshmi Narasimha Thota, Sahiti Marella, Varsha Ganesan, Ankit Sharma, Atsunori Kaneshige, Longchuan Bai, Haibin Zhou, Paul S. Foster, Shaomeng Wang, T. Andrea, Simon P. Hogan	2024	3
5	Abstract 3881: Discovery of highly potent, selective and efficacious STAT3 PROTAC degraders capable of achieving long-lasting tumor regression Cancer Research ·Haibin Zhou, Dimin Wu, Longchuan Bai, Ranjan Kumar Acharyya, Hoda Metwally, Donna McEachern, Bo Wen, Duxin Sun, Shaomeng Wang	2024	1
6	A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo Nature Chemical Biology ·Atsunori Kaneshige, Longchuan Bai, Mi Wang, Donna McEachern, Jennifer L. Meagher, Renqi Xu, Yu Wang, Wei Jiang, Hoda Metwally, Paul D. Kirchhoff, Lijie Zhao, Hui Jiang, Meilin Wang, Bo Wen, Duxin Sun, Jeanne A. Stuckey, Shaomeng Wang	2023	40
7	Mcl-1 levels critically impact the sensitivities of human colorectal cancer cells to APG-1252-M1, a novel Bcl-2/Bcl-XL dual inhibitor that induces Bax-dependent apoptosis Neoplasia ·Weilong Yao, Longchuan Bai, Shaomeng Wang, Yifan Zhai, Shi‐Yong Sun	2022	11
8	Small-molecule PROTAC degraders of the Bromodomain and Extra Terminal (BET) proteins — A review Drug Discovery Today Technologies ·Chao‐Yie Yang, Chong Qin, Longchuan Bai, Shaomeng Wang	2019	89
9	MCL-1 inhibition in cancer treatment OncoTargets and Therapy ·Weiguo Xiang, Chao‐Yie Yang, Longchuan Bai	2018	109
10	Small-molecule SMAC mimetics as new cancer therapeutics Pharmacology & Therapeutics ·Longchuan Bai, David C. Smith, Shaomeng Wang	2014	160
11	LRIG1 Modulates Cancer Cell Sensitivity to Smac Mimetics by Regulating TNFα Expression and Receptor Tyrosine Kinase Signaling Cancer Research ·Longchuan Bai, Donna McEachern, Chao‐Yie Yang, Jianfeng Lü, Haiying Sun, Shaomeng Wang	2012	28
12	Targeting Inhibitors of Apoptosis Proteins (IAPs) For New Breast Cancer Therapeutics Journal of Mammary Gland Biology and Neoplasia ·Shaomeng Wang, Longchuan Bai, Jianfeng Lü, Liu Liu, Chao‐Yie Yang, Haiying Sun	2012	33
13	Radiosensitization of Head and Neck Squamous Cell Carcinoma by a SMAC-Mimetic Compound, SM-164, Requires Activation of Caspases Molecular Cancer Therapeutics ·Jie Yang, Donna McEachern, Wenyan Li, Mary A. Davis, Hua Li, Meredith A. Morgan, Longchuan Bai, Jonathan T. Sebolt, Haiying Sun, Theodore S. Lawrence, Shaomeng Wang, Yi Sun	2011	43
14	Therapeutic Potential and Molecular Mechanism of a Novel, Potent, Nonpeptide, Smac Mimetic SM-164 in Combination with TRAIL for Cancer Treatment Molecular Cancer Therapeutics ·Jianfeng Lü, Donna McEachern, Haiying Sun, Longchuan Bai, Yuefeng Peng, Su Qiu, Rebecca S. Miller, Jinhui Liao, Yi Han, Meilan Liu, Anita C. Bellail, Chunhai Hao, Shi-Yong Sun, Adrian T. Ting, Shaomeng Wang	2011	51
15	SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP Cancer Research ·Jianfeng Lü, Longchuan Bai, Haiying Sun, Zaneta Nikolovska‐Coleska, Donna McEachern, Su Qiu, Rebecca S. Miller, Yi Han, Sanjeev Shangary, Yi Sun, Jennifer L. Meagher, Jeanne A. Stuckey, Shaomeng Wang	2008	174
16	Advance in the research of phospholipase B and the its action on Candida albicans Zhongguo redai yixue ·Longchuan Bai	2008	1
17	Sumoylation-dependent Control of Homotypic and Heterotypic Synergy by the Krüppel-type Zinc Finger Protein ZBP-89 Journal of Biological Chemistry ·Sergey Chupreta, Holly Brevig, Longchuan Bai, Juanita L. Merchant, Jorge A. Iñiguez‐Lluhí	2007	23
18	A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion FEBS Letters ·Longchuan Bai, Juanita L. Merchant	2007	48
19	Hypoxic repression of STAT1 and its downstream genes by a pVHL/HIF-1 target DEC1/STRA13 Oncogene ·Sergey V. Ivanov, Konstantin Salnikow, A. V. Ivanova, Longchuan Bai, Michael I. Lerman	2006	65
20	ZBP-89-induced apoptosis is p53-independent and requires JNK Cell Death and Differentiation ·Longchuan Bai, Sung Ok Yoon, Philip D. King, Juanita L. Merchant	2004	44

About Longchuan Bai

Longchuan Bai is a scholar working on Oncology, Hematology, Molecular Biology, Toxicology and Immunology, having authored 68 papers that have together received 3.5k indexed citations. Recurring topics across this work include Protein Degradation and Inhibitors (22 papers), Ubiquitin and proteasome pathways (22 papers), Cell death mechanisms and regulation (18 papers), Cancer-related Molecular Pathways (11 papers), Peptidase Inhibition and Analysis (11 papers), Multiple Myeloma Research and Treatments (9 papers), Epigenetics and DNA Methylation (8 papers) and RNA Interference and Gene Delivery (7 papers). The work is most often cited by research in Oncology (1.2k citations), Hematology (469 citations), Molecular Biology (2.7k citations), Toxicology (88 citations) and Cancer Research (310 citations). Longchuan Bai has collaborated with scholars based in United States, China and Poland. Frequent co-authors include Shaomeng Wang, Juanita L. Merchant, Chao‐Yie Yang, Donna McEachern, Liu Liu, Jeanne A. Stuckey, Jennifer L. Meagher, Duxin Sun, Bo Wen and Yujun Zhao. Their work appears in journals such as Journal of Medicinal Chemistry, Cancer Research, Journal of Biological Chemistry, ACS Medicinal Chemistry Letters and Molecular Cancer Therapeutics.

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