David Shortle

9.8k total citations · 2 hit papers
90 papers, 8.5k citations indexed

About

David Shortle is a scholar working on Molecular Biology, Materials Chemistry and Genetics. According to data from OpenAlex, David Shortle has authored 90 papers receiving a total of 8.5k indexed citations (citations by other indexed papers that have themselves been cited), including 79 papers in Molecular Biology, 30 papers in Materials Chemistry and 24 papers in Genetics. Recurrent topics in David Shortle's work include RNA and protein synthesis mechanisms (44 papers), Protein Structure and Dynamics (41 papers) and Enzyme Structure and Function (29 papers). David Shortle is often cited by papers focused on RNA and protein synthesis mechanisms (44 papers), Protein Structure and Dynamics (41 papers) and Enzyme Structure and Function (29 papers). David Shortle collaborates with scholars based in United States, Canada and Japan. David Shortle's co-authors include Alan K. Meeker, Ken A. Dill, Daniel Nathans, Michael S. Ackerman, David Botstein, J. R. Gillespie, Wesley E. Stites, Engin H. Serpersu, Albert S. Mildvan and John Sondek and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

In The Last Decade

David Shortle

90 papers receiving 8.1k citations

Hit Papers

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What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

DENATURED STATES OF PROTEINS

1991 778 citations David Shortle et al. profile →
Local mutagenesis: a method for generating viral mutants with base substitutions in preselected regions of the viral genome.

1978 249 citations David Shortle et al. profile →

Peers

Countries citing papers authored by David Shortle

Since Specialization

Citations

This map shows the geographic impact of David Shortle's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David Shortle with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David Shortle more than expected).

Fields of papers citing papers by David Shortle

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David Shortle. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David Shortle. The network helps show where David Shortle may publish in the future.

Co-authorship network of co-authors of David Shortle

This figure shows the co-authorship network connecting the top 25 collaborators of David Shortle. A scholar is included among the top collaborators of David Shortle based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David Shortle. David Shortle is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Characterization of Denatured Proteins Using Residual Dipolar Couplings 2006 ·Humana Press eBooks ·(unknown), David Shortle	3
2	Prediction of protein structure by emphasizing local side-chain/backbone interactions in ensembles of turn fragments 2003 ·Proteins Structure Function and Bioinformatics ·Qiaojun Fang, David Shortle	20
3	The expanded denatured state: An ensemble of conformations trapped in a locally encoded topological space 2002 ·Advances in protein chemistry ·David Shortle	58
4	Structure prediction: The state of the art 1999 ·Current Biology ·David Shortle	10
5	Analysis of long‐range interactions in a model denatured state of staphylococcal nuclease based on correlated changes in backbone dynamics 1999 ·Protein Science ·James F. Sinclair, David Shortle	25
6	Characterization of long-range structure in the denatured state of staphylococcal nuclease. II. distance restraints from paramagnetic relaxation and calculation of an ensemble of structures 1997 ·Journal of Molecular Biology ·J. R. Gillespie, David Shortle	236
7	Triple-resonance NOESY-based experiments with improved spectral resolution: Applications to structural characterization of unfolded, partially folded and folded proteins 1997 ·Journal of Biomolecular NMR ·Ouwen Zhang, Julie D. Forman‐Kay, David Shortle, Lewis E. Kay	71
8	Protein folding for realists: A timeless phenomenon 1996 ·Protein Science ·David Shortle, Yi Wang, J. R. Gillespie, James O. Wrabl	38
9	A dynamic bundle of four adjacent hydrophobic segments in the denatured state of staphylococcal nuclease 1996 ·Protein Science ·Yi Wang, David Shortle	43
10	NMR Structure of a Stable “OB-fold” Sub-domain Isolated from Staphylococcal Nuclease 1995 ·Journal of Molecular Biology ·Andrei T. Alexandrescu, Apostolos G. Gittis, Chitrananda Abeygunawardana, David Shortle	45
11	Equilibrium folding pathway of staphylococcal nuclease: identification of the most stable chain-chain interactions by NMR and CD spectroscopy 1995 ·Biochemistry ·Yi Wang, David Shortle	91
12	Initial studies of the equilibrium folding pathway of staphylococcal nuclease 1995 ·Philosophical Transactions of the Royal Society B Biological Sciences ·Yuchuan Wang, Andrei T. Alexandrescu, David Shortle	16
13	Staphylococcal Nuclease: A Showcase of m-Value Effects 1995 ·Advances in protein chemistry ·David Shortle	128
14	Electrophoretic Characterization of the Denatured States of Staphylococcal Nuclease 1994 ·Journal of Molecular Biology ·Thomas E. Creighton, David Shortle	28
15	NMR analysis of the residual structure in the denatured state of an unusual mutant of staphylococcal nuclease 1993 ·Structure ·David Shortle, Chitrananda Abeygunawardana	67
16	Accommodation of single amino acid insertions by the native state of staphylococcal nuclease 1990 ·Proteins Structure Function and Bioinformatics ·John Sondek, David Shortle	71
17	Diverse interactions between the individual mutations in a double mutant at the active site of staphylococcal nuclease 1990 ·Biochemistry ·David J. Weber, Engin H. Serpersu, David Shortle, Albert S. Mildvan	38
18	Mutant forms of staphylococcal nuclease with altered patterns of guanidine hydrochloride and urea denaturation 1986 ·Proteins Structure Function and Bioinformatics ·David Shortle, Alan K. Meeker	253
19	[31] Directed mutagenesis with sodium bisulfite 1983 ·Methods in enzymology on CD-ROM/Methods in enzymology ·David Shortle, David Botstein	66
20	Trapping of a novel coenzyme a containing intermediate of 3-hydroxy-3-methylglutaryl-CoA synthase 1976 ·Biochemical and Biophysical Research Communications ·Henry M. Miziorko, David Shortle, M. Daniel Lane	10

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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