Carl W. Sigel

2.2k total citations · 1 hit paper
51 papers, 1.7k citations indexed

About

Carl W. Sigel is a scholar working on Molecular Biology, Organic Chemistry and Pharmacology. According to data from OpenAlex, Carl W. Sigel has authored 51 papers receiving a total of 1.7k indexed citations (citations by other indexed papers that have themselves been cited), including 20 papers in Molecular Biology, 17 papers in Organic Chemistry and 10 papers in Pharmacology. Recurrent topics in Carl W. Sigel's work include Antibiotics Pharmacokinetics and Efficacy (9 papers), Synthesis and Characterization of Heterocyclic Compounds (5 papers) and Pneumocystis jirovecii pneumonia detection and treatment (5 papers). Carl W. Sigel is often cited by papers focused on Antibiotics Pharmacokinetics and Efficacy (9 papers), Synthesis and Characterization of Heterocyclic Compounds (5 papers) and Pneumocystis jirovecii pneumonia detection and treatment (5 papers). Carl W. Sigel collaborates with scholars based in United States, Norway and United Kingdom. Carl W. Sigel's co-authors include S. Morris Kupchan, Charles A. Nichol, Myra F. Ziegler, Ronald W. Britton, E. M. GRIVSKY, David S. Duch, Shuliang Lee, R. F. Bryan, M Matz and Joseph L. Woolley and has published in prestigious journals such as Journal of the American Chemical Society, Biochemistry and Journal of Medicinal Chemistry.

In The Last Decade

Carl W. Sigel

51 papers receiving 1.6k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Synthesis and antitumor activity of 2,4-diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine

1980 327 citations Carl W. Sigel, Charles A. Nichol et al. Journal of Medicinal Chemistry profile →

Peers

Carl W. Sigel

PHARM

BIOTE

Urs Séquin Switzerland

Eduardo G. Gros Argentina

Shigenobu Okuda Japan

Takashi Tatsuno Japan

John L. Occolowitz United States

Juichi Awaya Japan

Christiane Poupat France

Mitsuo Hayashi Japan

H.‐W. Fehlhaber Germany

Urs Séquin Switzerland

Carl W. Sigel

669 ×1.0

509 ×0.8

280 ×1.0

PHARM

214 ×1.0

131 ×0.9

BIOTE

Citations per year, relative to Carl W. Sigel Carl W. Sigel (= 1×) peers Urs Séquin

Countries citing papers authored by Carl W. Sigel

Since Specialization

Citations

This map shows the geographic impact of Carl W. Sigel's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Carl W. Sigel with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Carl W. Sigel more than expected).

Fields of papers citing papers by Carl W. Sigel

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Carl W. Sigel. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Carl W. Sigel. The network helps show where Carl W. Sigel may publish in the future.

Co-authorship network of co-authors of Carl W. Sigel

This figure shows the co-authorship network connecting the top 25 collaborators of Carl W. Sigel. A scholar is included among the top collaborators of Carl W. Sigel based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Carl W. Sigel. Carl W. Sigel is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Daluge, Susan M., et al.. (1993). Baquiloprim, a new antifolate antibacterial: in vitro activity and pharmacokinetic properties in cattle. Research in Veterinary Science. 54(3). 372–378. 14 indexed citations

Woolley, Joseph L., et al.. (1991). The disposition and metabolism of [14C]piritrexim in rats after intravenous and oral administration.. Drug Metabolism and Disposition. 19(3). 600–608. 1 indexed citations

Patel, Darshana, et al.. (1991). Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat.. Drug Metabolism and Disposition. 19(2). 491–497. 7 indexed citations

Woolley, Joseph L., et al.. (1991). The disposition and metabolism of [14C]piritrexim in dogs after intravenous and oral administration.. Drug Metabolism and Disposition. 19(6). 1139–1146. 2 indexed citations

Patel, Dipak, John P. Shockcor, Sai Y. Chang, Carl W. Sigel, & Brian E. Huber. (1991). Metabolism of a novel antitumor agent, crisnatol, by a human hepatoma cell line, Hep G2, and hepatic microsomes. Biochemical Pharmacology. 42(2). 337–346. 9 indexed citations

Woolley, Joseph L., et al.. (1990). High-Performance Liquid Chromatographic Assay for the Simultaneous Measurement of Trimethoprim and Sulfamethoxazole in Plasma or Urine. Therapeutic Drug Monitoring. 12(4). 382–392. 24 indexed citations

Woolley, Joseph L., et al.. (1989). Competitive Protein Binding Assay for Piritrexim. Journal of Pharmaceutical Sciences. 78(9). 749–752. 3 indexed citations

Roth, Barbara, et al.. (1989). 2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 13. Some alkenyl derivatives with high in vitro activity against anaerobic organisms. Journal of Medicinal Chemistry. 32(8). 1949–1958. 9 indexed citations

Woolley, Joseph L. & Carl W. Sigel. (1982). Development of pharmacokinetic models for sulfonamides in food animals: Metabolic depletion profile of sulfadiazine in the calf. American Journal of Veterinary Research. 43(5). 768–774. 2 indexed citations

10.

Sigel, Carl W., et al.. (1981). Pharmacokinetics of Trimethoprim and Sulfadiazine in the Dog: Urine Concentrations After Oral Administration. American Journal of Veterinary Research. 42(6). 996–1001. 18 indexed citations

11.

Divers, Thomas J., T. D. Byars, Oliver Murch, & Carl W. Sigel. (1981). Experimental Induction of Proteus mirabilis Cystitis in the Pony and Evaluation of Therapy with Trimethoprim-Sulfadiazine. American Journal of Veterinary Research. 42(7). 1203–1205. 3 indexed citations

12.

Nichol, Charles A., et al.. (1978). Lipid-soluble inhibitors of dihydrofolate reductase. I. Kinetics, tissue distribution, and extent of metabolism of pyrimethamine, metoprine, and etoprine in the rat, dog, and man.. Drug Metabolism and Disposition. 6(3). 329–337. 63 indexed citations

13.

Meyer, Walter L., et al.. (1977). Diterpenoid total synthesis, an A .fwdarw. B .fwdarw. C approach. 12. Aromatic C rings without alkyl substituents. Model systems for podocarpic acid and diterpenoid alkaloids. The Journal of Organic Chemistry. 42(25). 4131–4136. 4 indexed citations

14.

Meyer, Walter L., et al.. (1977). Diterpenoid total synthesis, an A .fwdarw. B .fwdarw. C approach. 10. Bicyclic intermediates for resin acids and alkaloids. The Journal of Organic Chemistry. 42(16). 2761–2769. 10 indexed citations

15.

Kupchan, S. Morris, Ronald W. Britton, John A. Lacadie, Myra F. Ziegler, & Carl W. Sigel. (1975). Tumor inhibitors. 100. Isolation and structural elucidation of bruceantin and bruceantinol, new potent antileukemic quassinoids from Brucea antidysenterica. The Journal of Organic Chemistry. 40(5). 648–654. 131 indexed citations

16.

Sigel, Carl W., Joseph L. Woolley, & Charles A. Nichol. (1975). Specific TLC Tissue Residue Determination of Sulfadiazine following Fluorescamine Derivatization. Journal of Pharmaceutical Sciences. 64(6). 973–976. 28 indexed citations

17.

Meyer, Walter L., et al.. (1975). Use of proton nuclear magnetic resonance spectroscopy for sequence configuration analysis of cyclic tetrapeptides. Structure of tentoxin. Journal of the American Chemical Society. 97(13). 3802–3809. 38 indexed citations

18.

Kupchan, S. Morris, Ronald W. Britton, Myra F. Ziegler, & Carl W. Sigel. (1973). Bruceantin, a new potent antileukemic simaroubolide from Brucea antidysenterica. The Journal of Organic Chemistry. 38(1). 178–179. 227 indexed citations

19.

Lillehaug, Johan R., Kjell Kleppe, Carl W. Sigel, & S. Morris Kupchan. (1973). Reaction of biological thiols with the tumor inhibitor of jatrophone Inhibition of RNA polymerase. Biochimica et Biophysica Acta (BBA) - Enzymology. 327(1). 92–100. 14 indexed citations

20.

Kupchan, S. Morris, et al.. (1972). Tumor inhibitors. LXXII. Datiscoside, a novel antileukemic cucurbitacin glycoside from Datisca glomerata. Journal of the American Chemical Society. 94(4). 1353–1354. 30 indexed citations

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