Christine Tkaczyk

4.7k citations

66 papers · 3.8k indexed · 1 hit paper · h-index 35

Impact in

Immunology and Allergy top 0.5%
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
Immunology top 1%
- Mast cells and histamine
- Immune Cell Function and Interaction

Papers in

Infectious Diseases 35
- Antimicrobial Resistance in Staphylococcus 32
- Clostridium difficile and Clostridium perfringens research 15
Immunology 32
- Mast cells and histamine 23
- Toxin Mechanisms and Immunotoxins 7
- Immune Cell Function and Interaction 6

Co-authors: Alasdair M. Gilfillan Dean D. Metcalfe Bret R. Sellman C. Kendall Stover Michael A. Beaven Salaheddine Mécheri Jamese J. Hilliard Yoshimichi Okayama
Journals: Antimicrobial Agents and Chemotherapy (13 papers)European Journal of Immunology (5 papers)The Journal of Immunology (3 papers)Journal of Biological Chemistry (3 papers)The Journal of Infectious Diseases (3 papers)
Partner nations: United States France Finland

In The Last Decade

Christine Tkaczyk

63 papers receiving 3.7k citations

Hit Papers

align trajectories log scale

Integrated signalling pathways for mast-cell activation 2006 · 772 citations

Peers

Countries citing papers authored by Christine Tkaczyk

Since Specialization

Citations

This map shows the geographic impact of Christine Tkaczyk's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christine Tkaczyk with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christine Tkaczyk more than expected).

Fields of papers citing papers by Christine Tkaczyk

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christine Tkaczyk. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christine Tkaczyk. The network helps show where Christine Tkaczyk may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Christine Tkaczyk, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Christine Tkaczyk Line = papers co-authored together Christine Tkaczyk links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Epitope Conservation of AZD5148, a Broadly Neutralizing Anti-Toxin B Monoclonal Antibody, Among Diverse and Global Contemporary Clostridioides difficile Isolates The Journal of Infectious Diseases ·Binggeli, Anmo Zhou, Victoria Godfrey, Pere Ayling, Tyler Brady, Xiao R. Chen, Hamad Alkhenaini, Justin Green, Ondřej Podlaha, Bret R. Sellman, Christine Tkaczyk, Vancheswaran Gopalakrishnan	2025	0
2	The monoclonal antibody AZD5148 confers broad protection against TcdB-diverse Clostridioides difficile strains in mice PLoS Pathogens ·ジェイスティフラー, Heather K. Kroh, John A. Shupe, Kelly C. Thompson, 热甫开提, Shannon L. Kordus, M. Kay Washington, Reece J. Knippel, Pere Ayling, Xiao R. Chen, Christine Tkaczyk, D. Borden Lacy	2025	0
3	Alanine Scanning Mutagenesis of the MEDI4893 (Suvratoxumab) Epitope Reduces Alpha Toxin Lytic Activity In Vitro and Staphylococcus aureus Fitness in Infection Models Antimicrobial Agents and Chemotherapy ·Christine Tkaczyk, Е. А. Семенова, Yuru Shi, Hamad Alkhenaini, Vaheh Oganesyan, Paul Warrener, Hyang‐Hee Um, Bret R. Sellman	2018	17
4	Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone Bone Research ·Julie E. Pickett, John M. Thompson, Agnieszka Sadowska, Christine Tkaczyk, Bret R. Sellman, Andrea Minola, Davide Corti, Antonio Lanzavecchia, Lloyd Miller, Daniel L.J. Thorek	2018	29
5	α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis Cell Host & Microbe ·Bas G. J. Surewaard, Ajitha Thanabalasuriar, Zhutian Zeng, Christine Tkaczyk, Taylor S. Cohen, Bart W. Bardoel, Selina K. Jorch, Carsten Deppermann, Juliane Bubeck Wardenburg, Rachelle P. Davis, Craig N. Jenne, Erkan Uysal, Bret R. Sellman, Paul Kubes	2018	114
6	Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets JCI Insight ·John M. Thompson, Robert J. Miller, Alyssa G. Ashbaugh, Carly Dillen, Julie E. Pickett, Jessica Cruz Whitley, Roger V. Ortines, Robert S. Sterling, Kevin P. Francis, Nicholas M. Bernthal, Taylor S. Cohen, Christine Tkaczyk, Li Yu, C. Kendall Stover, Antonio DiGiandomenico, Bret R. Sellman, Daniel L.J. Thorek, Lloyd Miller	2018	27
7	Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections Science Translational Medicine ·Taylor S. Cohen, Jamese J. Hilliard, Omari Jones-Nelson, Ashley Keller, Terrence O’Day, Christine Tkaczyk, Antonio DiGiandomenico, Melissa Hamilton, Mark Pelletier, Qun Wang, Binh An Diep, Vien T. M. Le, Lily Cheng, JoAnn Suzich, C. Kendall Stover, Bret R. Sellman	2016	93
8	A Novel Dual Expression Platform for High Throughput Functional Screening of Phage Libraries in Product like Format PLoS ONE ·Xiaodong Xiao, Yan Chen, Sara M Tony, Changshou Gao, Christine Tkaczyk, Yariv Mazor, Peter Pavlik, Herren Wu, William F. Dall’Acqua, Partha S. Chowdhury	2015	11
9	Mechanisms of Neutralization of a Human Anti-α-toxin Antibody Journal of Biological Chemistry ·Vaheh Oganesyan, Li Peng, Melissa Damschroder, Cheng Li, Agnieszka Sadowska, Christine Tkaczyk, Bret R. Sellman, Herren Wu, William F. Dall’Acqua	2014	66
10	Staphylococcus aureus Alpha Toxin Suppresses Effective Innate and Adaptive Immune Responses in a Murine Dermonecrosis Model PLoS ONE ·Christine Tkaczyk, Melissa Hamilton, Vivekananda Datta, Robert Anthony Lucas, Jamese J. Hilliard, Geoffrey L. Stephens, Agnieszka Sadowska, Lei Hua, Terrence O’Day, JoAnn Suzich, C. Kendall Stover, Bret R. Sellman	2013	69
11	Identification of Anti-Alpha Toxin Monoclonal Antibodies That Reduce the Severity of Staphylococcus aureus Dermonecrosis and Exhibit a Correlation between Affinity and Potency Clinical and Vaccine Immunology ·Christine Tkaczyk, Hua Long, Ni Putu Wulan Pratami Dewi, Yuru Shi, Pedro José Fernández‐Esparcia, Robert M. Woods, Arnita Barnes, Randall S. MacGill, Susan Wilson, Partha S. Chowdhury, C. Kendall Stover, Bret R. Sellman	2012	105
12	Kit- and FcɛRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells Cellular Signalling ·Shoko Iwaki, Jiřı́ Špička, Christine Tkaczyk, Bettina M. Jensen, Yasuko Furumoto, Nicolas Charles, Martina Kovářová, Juan Rivera, Václav Hořejšı́, Dean D. Metcalfe, Alasdair M. Gilfillan	2007	52
13	Btk Plays a Crucial Role in the Amplification of FcϵRI-mediated Mast Cell Activation by Kit Journal of Biological Chemistry ·Shoko Iwaki, Christine Tkaczyk, Anne B. Satterthwaite, Keri Stophel, Michael A. Beaven, Dean D. Metcalfe, Alasdair M. Gilfillan	2005	89
14	Fcγ Receptors on Mast Cells: Activatory and Inhibitory Regulation of Mediator Release International Archives of Allergy and Immunology ·Christine Tkaczyk, Yoshimichi Okayama, Dean D. Metcalfe, Alasdair M. Gilfillan	2004	65
15	Essential role for the p110δ phosphoinositide 3-kinase in the allergic response Nature ·Khaled Ali, Antonio Bilancio, Matthew J. Thomas, Wayne Pearce, Alasdair M. Gilfillan, Christine Tkaczyk, Russell Kirk, Alexander Gray, June Giddings, Emma Peskett, Roy Fox, Ian Bruce, Christoph Walker, P. Pénzes, Klaus Okkenhaug, Peter M. Finan, Bart Vanhaesebroeck	2004	332
16	Comparison of FcϵRI‐ and FcγRI‐mediated degranulation and TNF‐α synthesis in human mast cells: selective utilization of phosphatidylinositol‐3‐kinase for FcγRI‐induced degranulation European Journal of Immunology ·Yoshimichi Okayama, Christine Tkaczyk, Dean D. Metcalfe, Alasdair M. Gilfillan	2003	51
17	Activation of human mast cells through the high affinity IgG receptor Molecular Immunology ·Christine Tkaczyk, Yoshimichi Okayama, Michael R. Woolhiser, David Hagaman, Alasdair M. Gilfillan, Dean D. Metcalfe	2002	56
18	FcεRI-Dependent Signaling Pathways in Human Mast Cells Clinical Immunology ·Christine Tkaczyk, Alasdair M. Gilfillan	2001	43
19	IL-4 mRNA transcription is induced in mouse bone marrow-derived mast cells through an MHC class II-dependent signaling pathway European Journal of Immunology ·NORIO INO, Walid Mourad, Christine Tkaczyk, Monique Singer, Bernard David, Jean‐Hervé Colle, Salaheddine Mécheri	1998	2
20	Exogenous and endogenous antigens are differentially presented by mast cells to CD4⁺ T lymphocytes European Journal of Immunology ·NORIO INO, Christine Tkaczyk, Carole A. Oskeritzian, Bernard David, Catherine Desaymard, Salaheddine Mécheri	1996	87

About Christine Tkaczyk

Christine Tkaczyk is a scholar working on Infectious Diseases, Immunology, Immunology and Allergy, Genetics and Rehabilitation, having authored 66 papers that have together received 3.8k indexed citations. Recurring topics across this work include Antimicrobial Resistance in Staphylococcus (32 papers), Mast cells and histamine (23 papers), Clostridium difficile and Clostridium perfringens research (15 papers), Bacterial biofilms and quorum sensing (15 papers), Monoclonal and Polyclonal Antibodies Research (10 papers), Toxin Mechanisms and Immunotoxins (7 papers), Immune Cell Function and Interaction (6 papers) and Orthopedic Infections and Treatments (6 papers). The work is most often cited by research in Immunology and Allergy (697 citations), Immunology (2.2k citations), Infectious Diseases (860 citations), Microbiology (215 citations) and Physiology (771 citations). Christine Tkaczyk has collaborated with scholars based in United States, France and Finland. Frequent co-authors include Alasdair M. Gilfillan, Dean D. Metcalfe, Bret R. Sellman, Bret R. Sellman, C. Kendall Stover, Michael A. Beaven, Salaheddine Mécheri, Jamese J. Hilliard, Yoshimichi Okayama and Taylor S. Cohen. Their work appears in journals such as Antimicrobial Agents and Chemotherapy, European Journal of Immunology, The Journal of Immunology, Journal of Biological Chemistry and The Journal of Infectious Diseases.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact