Cathaline den Besten

1.0k citations

22 papers · 695 indexed · h-index 17

Pharmacology top 5%
- Pharmacogenetics and Drug Metabolism 8
Chemical Health and Safety
Biochemistry top 10%
Health, Toxicology and Mutagenesis top 10%
Molecular Biology
- Advanced biosensing and bioanalysis techniques 3
- DNA and Nucleic Acid Chemistry 3
- Glutathione Transferases and Polymorphisms 2
- RNA Interference and Gene Delivery 2
Oncology
- Drug Transport and Resistance Mechanisms 4
Cancer Research
- Carcinogens and Genotoxicity Assessment 3
Organic Chemistry
- Synthesis and Characterization of Heterocyclic Compounds 2

Co-authors: Peter J. van Bladeren Ivonne M.C.M. Rietjens Greet Vansant Paul Deurenberg JA Weststrate Ben van Ommen Robert P. Hanzlik Rudolf B. Beems
Cited by: Pharmacology Chemical Health and Safety Biochemistry
Journals: Journal of Biological Chemistry (1 paper)American Journal of Clinical Nutrition (1 paper)Biochemical and Biophysical Research Communications (1 paper)
Partner nations: Netherlands United Kingdom United States

In The Last Decade

Cathaline den Besten

21 papers receiving 663 citations

Peers

Countries citing papers authored by Cathaline den Besten

Since Specialization

Citations

This map shows the geographic impact of Cathaline den Besten's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Cathaline den Besten with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Cathaline den Besten more than expected).

Fields of papers citing papers by Cathaline den Besten

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Cathaline den Besten. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Cathaline den Besten. The network helps show where Cathaline den Besten may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Cathaline den Besten, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Cathaline den Besten Line = papers co-authored together Cathaline den Besten links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Outcomes Following Transoral Laser Microsurgery for T1b and T2a Glottic Squamous Cell Carcinoma With and Without Anterior Commissure Involvement: A Retrospective Chart Review Journal of Otolaryngology - Head and Neck Surgery ·Depak Patel,Victoria Taylor,Colin MacKay,Cathaline den Besten,Matthew H. Rigby,Martin Corsten,Timothy S. Brown,Jonathan Trites,S. Mark Taylor	2025	0
2	The Pharmacokinetics of 2′- O -Methyl Phosphorothioate Antisense Oligonucleotides: Experiences from Developing Exon Skipping Therapies for Duchenne Muscular Dystrophy Nucleic Acid Therapeutics ·Sieto Bosgra,Jessica A. Sipkens,S. de Kimpe,Cathaline den Besten,Nicole A. Datson,J. van Deutekom	2019	22
3	QR-421a, an antisense oligonucleotide, for the treatment of retinitis pigmentosa due to USH2A exon 13 mutations Investigative Ophthalmology & Visual Science ·Hester van Diepen,Kalyan Dulla,Hee Lam Chan,Iris A. Schulkens,Wouter Beumer,Lars Vorthoren,Cathaline den Besten,Levi C.M. Buil,Janne J. Turunen,Jiayi Miao,Sanne Broekman,Erik de Vrieze,Margo Dona,Sílvia Albert,Erwin van Wijk,Peter Adamson	2019	8
4	Therapy with 2′-O-Me Phosphorothioate Antisense Oligonucleotides Causes Reversible Proteinuria by Inhibiting Renal Protein Reabsorption Molecular Therapy — Nucleic Acids ·Manoe J. Janssen,Tom T.G. Nieskens,Tessa A. M. Steevels,Pedro Caetano-Pinto,Dirk den Braanker,Melissa Mulder,Yolanda Ponstein,Shaun Jones,Rosalinde Masereeuw,Cathaline den Besten,Martijn J. Wilmer	2019	19
5	Metabolite Profiling of the Antisense Oligonucleotide Eluforsen Using Liquid Chromatography-Mass Spectrometry Molecular Therapy — Nucleic Acids ·Jaeah Kim,Babak Basiri,Cesare Hassan,Carine Punt,Erik van der Hage,Cathaline den Besten,Michael G. Bartlett	2019	41
6	Impurities in Oligonucleotide Drug Substances and Drug Products Nucleic Acid Therapeutics ·Daniel C. Capaldi,Andy Teasdale,Scott P. Henry,Nadim Akhtar,Cathaline den Besten,Samantha Gao-Sheridan,Matthias Kretschmer,Neal Sharpe,B. J. Andrews,Brigitte E. A. Burm,Jeffrey W.-D. Foy	2017	95
7	Species-specific Inflammatory Responses as a Primary Component for the Development of Glomerular Lesions in Mice and Monkeys Following Chronic Administration of a Second-generation Antisense Oligonucleotide Toxicologic Pathology ·Kendall S. Frazier,Cécile Sobry,Victoria Derr,M.J. Adams,Cathaline den Besten,S. de Kimpe,Ian Francis,Tracy L. Gales,Richard Haworth,Shaun R. Maguire,Rosanna C. Mirabile,David W. Mullins,Bernard Palate,Yolanda Ponstein-Simarro Doorten,James E. Ridings,Marshall S. Scicchitano,Jérémy Silvano,Jennie A. Woodfine	2013	43
8	Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors European Journal of Medicinal Chemistry ·Jos H.M. Lange,Jennifer Venhorst,Maria J. P. van Dongen,J. Frankena,Firas Bassissi,Natasja de Bruin,Cathaline den Besten,Stephanie B. A. de Beer,Chris Oostenbrink,Natalia Markova,Chris G. Kruse	2011	21
9	Cytochrome P450-Catalyzed Oxidation of Halobenzene Derivatives Chemical Research in Toxicology ·Ivonne M.C.M. Rietjens,Cathaline den Besten,Robert P. Hanzlik,Peter J. van Bladeren	1997	46
10	Comparative biotransformation of hexachlorobenzene and hexafluorobenzene in relation to the induction of porphyria European Journal of Pharmacology Environmental Toxicology and Pharmacology ·Ivonne M.C.M. Rietjens,Aukje Steensma,Cathaline den Besten,G. van Tintelen,J.W.M. Haas,Ben van Ommen,Peter J. van Bladeren	1995	7
11	Comparison of the urinary metabolite profiles of hexachlorobenzene and pentachlorobenzene in the rat Chemico-Biological Interactions ·Cathaline den Besten,Marjon M.H. Bennik,Marlou van Iersel,Maria A.W. Peters,Cees Teunis,Peter J. van Bladeren	1994	14
12	Biotransfiormation and Toxicity of Halogenated Benzenes Human & Experimental Toxicology ·Cathaline den Besten,Abraham Brouwer,Ivonne M.C.M. Rietjens,Peter J. van Bladeren	1994	21
13	Cytochrome P450-mediated oxidation of pentafluorophenol to tetrafluorobenzoquinone as the primary reaction product Chemical Research in Toxicology ·Cathaline den Besten,Peter J. van Bladeren,Erwin Duizer,Jacques Vervoort,Ivonne M.C.M. Rietjens	1993	36
14	The involvement of primary and secondary metabolism in the covalent binding of 1,2- and 1,4-dichlorobenzenes Chemico-Biological Interactions ·Cathaline den Besten,Marlies Ellenbroek,Marjan A.E. van der Ree,Ivonne M.C.M. Rietjens,Peter J. van Bladeren	1992	28
15	The liver, kidney, and thyroid toxicity of chlorinated benzenes Toxicology and Applied Pharmacology ·Cathaline den Besten,J. Vet,H.T. Besselink,Gert S. Kiel,Birgitte J.M. van Berkel,Rudolf B. Beems,Peter J. van Bladeren	1991	75
16	Metabolic activation of 1,2,4-trichlorobenzene and pentachlorobenzene by rat liver microsomes: A major role for quinone metabolites Toxicology and Applied Pharmacology ·Cathaline den Besten,Marjan C.C. Smink,Erik F. J. de Vries,Peter J. van Bladeren	1991	22
17	Studies on the mechanism of coumarin-induced toxicity in rat hepatocytes Toxicology in Vitro ·Cathaline den Besten,Sally A. Körösi,J.A. Beamand,D. Gareth Walters,Brian G. Lake	1990	17
18	The metabolism of pentachlorobenzene by rat liver microsomes: The nature of the reactive intermediates formed Biochemical and Biophysical Research Communications ·Cathaline den Besten,Melanie Peters,Peter J. van Bladeren	1989	17
19	Glutathione conjugation as a toxication reaction. Socio-Environmental Systems Modeling ·Peter J. van Bladeren,Cathaline den Besten,I.M. Bruggeman,J.J.W.M. Mertens,Ben van Ommen,A. Spenkelink,A.L.M. Rutten,J.H.M. Temmink,R.M.E. Vos	1988	2
20	Body fat distribution and the prognosis for weight reduction: preliminary observations. PubMed ·Greet Vansant,Cathaline den Besten,J. Weststrate,Paul Deurenberg	1988	34

About Cathaline den Besten

Cathaline den Besten is a scholar working on Pharmacology, Transplantation and Pharmaceutical Science, having authored 22 papers that have together received 695 indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (8 papers), Drug Transport and Resistance Mechanisms (4 papers), Carcinogens and Genotoxicity Assessment (3 papers), Advanced biosensing and bioanalysis techniques (3 papers), DNA and Nucleic Acid Chemistry (3 papers), Synthesis and Characterization of Heterocyclic Compounds (2 papers), Glutathione Transferases and Polymorphisms (2 papers) and RNA Interference and Gene Delivery (2 papers). The work is most often cited by research in Pharmacology (114 citations), Chemical Health and Safety (5 citations) and Biochemistry (45 citations). Cathaline den Besten has collaborated with scholars based in Netherlands, United Kingdom and United States. Frequent co-authors include Peter J. van Bladeren, Ivonne M.C.M. Rietjens, Greet Vansant, Paul Deurenberg, JA Weststrate, Ben van Ommen, Robert P. Hanzlik, Rudolf B. Beems, R.M.E. Vos and Franz Müller. Their work appears in journals such as Journal of Biological Chemistry, American Journal of Clinical Nutrition and Biochemical and Biophysical Research Communications.

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