Carson C. Thoreen

16.9k citations

36 papers · 12.7k indexed · 9 hit papers · h-index 25

Aging top 0.5%
Molecular Biology top 0.2%
- PI3K/AKT/mTOR signaling in cancer 24
- RNA and protein synthesis mechanisms 11
- RNA Research and Splicing 7
- Protein Kinase Regulation and GTPase Signaling 6
- Polyamine Metabolism and Applications 6
- CRISPR and Genetic Engineering 4
- Metabolism, Diabetes, and Cancer 4
Cell Biology top 0.5%
Physiology top 0.5%
Spectroscopy top 0.5%
Immunology
- Mast cells and histamine 3

Co-authors: David M. Sabatini Yasemin Sancak Timothy R. Peterson Nathanael S. Gray Junmin Peng Steven P. Gygi Seong A. Kang Robert A. Lindquist
Cited by: Aging Molecular Biology Cell Biology
Journals: Journal of Medicinal Chemistry (2 papers)Proceedings of the National Academy of Sciences (2 papers)Biochemical Society Transactions (2 papers)
Partner nations: United States Australia Malaysia

In The Last Decade

Carson C. Thoreen

36 papers receiving 12.6k citations

Hit Papers

9 papers align trajectories log scale

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

2012 Nature
2009 Cell
2009 Journal of Biological Chemistry
2008 Science
2007 Molecular Cell
2006 Current Biology
2006 Developmental Cell
2003 Nature Biotechnology
2002 Journal of Proteome Research

Peers

Countries citing papers authored by Carson C. Thoreen

Since Specialization

Citations

This map shows the geographic impact of Carson C. Thoreen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Carson C. Thoreen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Carson C. Thoreen more than expected).

Fields of papers citing papers by Carson C. Thoreen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Carson C. Thoreen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Carson C. Thoreen. The network helps show where Carson C. Thoreen may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Carson C. Thoreen, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Carson C. Thoreen Line = papers co-authored together Carson C. Thoreen links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	mRNA 5′ terminal sequences drive 200-fold differences in expression through effects on synthesis, translation and decay PLoS Genetics ·W. N. Zhang,Vitória Dekkers Carneiro,Carson C. Thoreen	2022	8
2	Global analysis of LARP1 translation targets reveals tunable and dynamic features of 5′ TOP motifs Proceedings of the National Academy of Sciences ·Lucas Philippe,Antonia van den Elzen,Vitória Dekkers Carneiro,Carson C. Thoreen	2020	99
3	Roadblock-qPCR: a simple and inexpensive strategy for targeted measurements of mRNA stability RNA ·Vitória Dekkers Carneiro,Yeonwoo Park,Carson C. Thoreen	2020	7
4	Archaeal Ribosomal Proteins Possess Nuclear Localization Signal-Type Motifs: Implications for the Origin of the Cell Nucleus Molecular Biology and Evolution ·Sergey Melnikov,Amir Havili,Kasidet Manakongtreecheep,Antonia van den Elzen,Carson C. Thoreen,Dieter Söll	2019	12
5	mTORC1 Balances Cellular Amino Acid Supply with Demand for Protein Synthesis through Post-transcriptional Control of ATF4 Cell Reports ·Yeonwoo Park,Andrea Reyna‐Neyra,Lucas Philippe,Carson C. Thoreen	2017	173
6	La-related protein 1 (LARP1) repression of TOP mRNA translation is mediated through its cap-binding domain and controlled by an adjacent regulatory region Nucleic Acids Research ·Lucas Philippe,Jean‐Jacques Vasseur,Françoise Debart,Carson C. Thoreen	2017	94
7	ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP Cancer Research ·Taru Muranen,Laura M. Selfors,Julie Hwang,Lisa L. Gallegos,Jonathan L. Coloff,Carson C. Thoreen,Seong A. Kang,David M. Sabatini,Gordon B. Mills,Joan S. Brugge	2016	53
8	A unifying model for mTORC1-mediated regulation of mRNA translationbreakdown → Nature ·Carson C. Thoreen,Lynne Chantranupong,Heather R. Keys,Timothy C. Wang,Nathanael S. Gray,David M. Sabatini	2012	1100
9	Genome-scale RNAi on living-cell microarrays identifies novel regulators ofDrosophila melanogasterTORC1–S6K pathway signaling Genome Research ·Robert A. Lindquist,Kathleen Ottina,Douglas B. Wheeler,Peggy P. Hsu,Carson C. Thoreen,David A. Guertin,Siraj M. Ali,Shomit Sengupta,Yoav D. Shaul,Michael R. Lamprecht,Mervin Singham,Rutz H-G,Thouis R. Jones,David M. Sabatini,Anne E. Carpenter	2011	26
10	Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability Bioorganic & Medicinal Chemistry Letters ·Qingsong Liu,Jinhua Wang,Seong A. Kang,Carson C. Thoreen,Wooyoung Hur,Hwan Geun Choi,David Waller,Taebo Sim,David M. Sabatini,Nathanael S. Gray	2011	10
11	Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer DSpace@MIT (Massachusetts Institute of Technology) ·Qingsong Liu,Jae Won Chang,Jinhua Wang,Seong A. Kang,Carson C. Thoreen,Andrew L. Markhard,Wooyoung Hur,Jianming Zhang,Taebo Sim,David M. Sabatini,Nathanael S. Gray	2010	11
12	mTOR mediated anti-cancer drug discovery Drug Discovery Today Therapeutic Strategies ·Qingsong Liu,Carson C. Thoreen,Jinhua Wang,David M. Sabatini,Nathanael S. Gray	2009	148
13	Rapamycin inhibits mTORC1, but not completely Autophagy ·Carson C. Thoreen,David M. Sabatini	2009	222
14	DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survivalbreakdown → Cell ·Timothy R. Peterson,Mathieu Laplante,Carson C. Thoreen,Yasemin Sancak,Seong A. Kang,W. Michael Kuehl,Nathanael S. Gray,David M. Sabatini	2009	950
15	The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1breakdown → Science ·Yasemin Sancak,Timothy R. Peterson,Yoav D. Shaul,Robert A. Lindquist,Carson C. Thoreen,Liron Bar‐Peled,David M. Sabatini	2008	2092
16	mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2sbreakdown → Current Biology ·María A. Frías,Carson C. Thoreen,Jacob D. Jaffe,Wayne A. Schroder,Tom Sculley,Steven A. Carr,David M. Sabatini	2006	540
17	Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1breakdown → Developmental Cell ·David A. Guertin,Deanna M. Stevens,Carson C. Thoreen,Aurora A. Burds,Nada Y. Kalaany,Jason Moffat,Michael Brown,Kevin Fitzgerald,David M. Sabatini	2006	1158
18	Functional Genomics Identifies TOR-Regulated Genes that Control Growth and Division Current Biology ·David A. Guertin,Kalyani Guntur,George W. Bell,Carson C. Thoreen,David M. Sabatini	2006	128
19	AMPK and p53 help cells through lean times Cell Metabolism ·Carson C. Thoreen,David M. Sabatini	2005	32
20	A proteomics approach to understanding protein ubiquitinationbreakdown → Nature Biotechnology ·Junmin Peng,Daniel Schwartz,Joshua E. Elias,Carson C. Thoreen,Dongmei Cheng,Gerald Marsischky,Jeroen Roelofs,Daniel Finley,Steven P. Gygi	2003	1302

About Carson C. Thoreen

Carson C. Thoreen is a scholar working on Molecular Biology, Cell Biology and Toxicology, having authored 36 papers that have together received 12.7k indexed citations. Recurring topics across this work include PI3K/AKT/mTOR signaling in cancer (24 papers), RNA and protein synthesis mechanisms (11 papers), RNA Research and Splicing (7 papers), Protein Kinase Regulation and GTPase Signaling (6 papers), Polyamine Metabolism and Applications (6 papers), CRISPR and Genetic Engineering (4 papers), Metabolism, Diabetes, and Cancer (4 papers) and Mast cells and histamine (3 papers). The work is most often cited by research in Aging (330 citations), Molecular Biology (10.3k citations) and Cell Biology (1.9k citations). Carson C. Thoreen has collaborated with scholars based in United States, Australia and Malaysia. Frequent co-authors include David M. Sabatini, Yasemin Sancak, Timothy R. Peterson, Nathanael S. Gray, Junmin Peng, Steven P. Gygi, Seong A. Kang, Robert A. Lindquist, Joshua E. Elias and Yoav D. Shaul. Their work appears in journals such as Journal of Medicinal Chemistry, Proceedings of the National Academy of Sciences, Biochemical Society Transactions, Current Biology and Molecular Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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