Bruce D. Roth

3.2k citations

61 papers · 2.6k indexed · h-index 30

Impact in

Organic Chemistry top 1%
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Catalytic C–H Functionalization Methods
- Synthesis and biological activity
Biotechnology top 2%

Papers in

Toxicology 4
Pharmacology 7
- Pharmacogenetics and Drug Metabolism 6

Co-authors: George A. Kraus Drago R. Sliskovic Roger S. Newton Brian R. Krause W. Howard Roark Pauline J. Sanfilippo Andrew S. Kende Erika Ferguson
Journals: Journal of Medicinal Chemistry (18 papers)Bioorganic & Medicinal Chemistry Letters (7 papers)Tetrahedron Letters (6 papers)Bioorganic & Medicinal Chemistry (4 papers)The Journal of Organic Chemistry (4 papers)
Partner nations: United States United Kingdom Russia

In The Last Decade

Bruce D. Roth

61 papers receiving 2.4k citations

Peers

Countries citing papers authored by Bruce D. Roth

Since Specialization

Citations

This map shows the geographic impact of Bruce D. Roth's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Bruce D. Roth with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Bruce D. Roth more than expected).

Fields of papers citing papers by Bruce D. Roth

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bruce D. Roth. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bruce D. Roth. The network helps show where Bruce D. Roth may publish in the future.

Co-authors

The 25 scholars most cited alongside Bruce D. Roth, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Bruce D. Roth Line = papers co-authored together Bruce D. Roth links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Hepatoselectivity of statins: Design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors Bioorganic & Medicinal Chemistry Letters ·William K.C. Park, Robert M. Kennedy, Scott D. Larsen, Steve Miller, Bruce D. Roth, Yuntao Song, Bruce A. Steinbaugh, Pasiskevicius, Bradley D. Tait, Mark C. Kowala, Bharat K. Trivedi, Bruce J. Auerbach, FU Yao-yao, Birte Wiebusch, Jeffrey C. Hanselman, Zhiwu Lin, Gina H. Lu, Andrew Robertson, Catherine Sekerke	2007	45
2	Inhibitors of lipoprotein(a) assembly Bioorganic & Medicinal Chemistry ·Karen E. Sexton, Helen T. Lee, Mark A. Massa, Janak Padia, William C. Patt, E. Kahveci, Jason K. Pontrello, Bruce D. Roth, Mark A. Spahr, Marit Løset Eriksen	2003	6
3	1 The Discovery and Development of Atorvastatin, A Potent Novel Hypolipidemic Agent Progress in medicinal chemistry ·Bruce D. Roth	2002	171
4	Metabolism and Excretion of Atorvastatin in Rats And Dogs Drug Metabolism and Disposition ·Ann E. Black, Roger N. Hayes, Bruce D. Roth, Peter W. K. Woo, Thomas F. Woolf	1999	71
5	Inhibitors of Acyl-CoA:Cholesterol O-acyltransferase (ACAT) as hypocholesterolemic agents: Synthesis and structure-activity relationships of novel series of sulfonamides, acylphosphonamides and acylphosphoramidates Bioorganic & Medicinal Chemistry Letters ·Jagirdar Agathya, W. Howard Roark, Daniel Covatariu, Drago R. Sliskovic, Bruce D. Roth, Richard L. Stanfield, Louis M. Johnson, Richard F. Bousley, Brian R. Krause	1998	18
6	Cholecystokinin B antagonists. Synthesis and quantitative structure-activity relationships of a series of C-terminal analogues of CI-988 Bioorganic & Medicinal Chemistry ·Corinne E. Augelli‐Szafran, Amparo Colina Cantillo, Clare O. Kneen, Daniel F. Ortwine, Martyn C. Pritchard, S M Indhudara, Bruce D. Roth, Bharat K. Trivedi, David R. Hill, Nirmala Suman‐Chauhan, Louise Webdale	1996	12
7	Bioisosterism in drug design: Identification of and structure-activity relationships in a series of glycine anilide ACAT inhibitors Bioorganic & Medicinal Chemistry ·W. Howard Roark, Janak Padia, Gary L. Bolton, C. John Blankley, Arnold D. Essenburg, Richard L. Stanfield, Richard F. Bousley, E Zs, Bruce D. Roth	1995	3
8	Inhibitors of acyl-coa:cholesterol acyltransferase (ACAT). 15. sulfonylurea inhibitors with excellent hypocholesterolemic activity in vivo. Bioorganic & Medicinal Chemistry Letters ·Bruce D. Roth, W. Howard Roark, Joseph A. Picard, Richard L. Stanfield, Richard F. Bousley, Maureen Anderson, Katherine L. Hamelehle, Reynold Homan, Brian R. Krause	1995	7
9	Antiatherosclerotic activity of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase in cholesterol-fed rabbits: a biochemical and morphological evaluation Atherosclerosis ·Thomas Bocan, 基一波多野, Sandra Bak Mueller, Jean-Grégory Cormier, Drago R. Sliskovic, Patrick O’Brien, Óscar Valdemoros, Helen Lee, Paul D. Uhlendorf, Bruce D. Roth, Roger S. Newton	1994	70
10	Inhibitors of Acyl-CoA:Cholesterol O-Acyl Transferase (ACAT) as Hypocholesterolemic Agents. 8. Incorporation of Amide or Amine Functionalities into a Series of Disubstituted Ureas and Carbamates. Effects on ACAT Inhibition in vitro and Efficacy in vivo Journal of Medicinal Chemistry ·Philip O’Brien, Drago R. Sliskovic, C. John Blankley, Bruce D. Roth, D. P. Bow, Louis M. Johnson, Brian R. Krause, Richard L. Stanfield	1994	45
11	Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 2. Modification of fatty acid anilide ACAT inhibitors: bioisosteric replacement of the amide bond Journal of Medicinal Chemistry ·W. Howard Roark, Bruce D. Roth, Ann Holmes, Bharat K. Trivedi, Karen A. Kieft, Arnold D. Essenburg, Brian R. Krause, Richard L. Stanfield	1993	25
12	Inhibitors of acyl-CoA:cholesterol acyltransferase. 1. Identification and structure-activity relationships of a novel series of fatty acid anilide hypocholesterolemic agents Journal of Medicinal Chemistry ·Bruce D. Roth, C. John Blankley, M. L. HOEFLE, Ann Holmes, W. Howard Roark, Bharat K. Trivedi, Arnold D. Essenburg, Karen A. Kieft, Brian R. Krause, Richard L. Stanfield	1992	57
13	Inhibitors of cholesterol biosynthesis. 6. trans-6-[2-(2-N-heteroaryl-3,5-disubstituted-pyrazol-4-yl)ethyl/ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-ones Journal of Medicinal Chemistry ·Drago R. Sliskovic, C. John Blankley, Brian R. Krause, Roger S. Newton, Daniel Covatariu, W. Howard Roark, Bruce D. Roth, Catherine Sekerke, Maxwell K. Shaw, Richard L. Stanfield	1992	16
14	Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981: Comparison with selected HMG-CoA reductase inhibitors Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism ·Thomas Bocan, Erika Ferguson, W. McNally, Paul D. Uhlendorf, Sandra Bak Mueller, Peter D. DeHart, Drago R. Sliskovic, Bruce D. Roth, Brian R. Krause, Roger S. Newton	1992	74
15	Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran 2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus Journal of Medicinal Chemistry ·Bruce D. Roth, C. John Blankley, Alexander Chucholowski, Erika Ferguson, M. L. HOEFLE, Daniel F. Ortwine, Roger S. Newton, Catherine Sekerke, Drago R. Sliskovic, Michael Wilson	1991	151
16	Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase Journal of Medicinal Chemistry ·Bruce D. Roth, Thomas Bocan, C. John Blankley, Alexander Chucholowski, Paul L. Creger, Óscar Valdemoros, Erika Ferguson, Roger S. Newton, Patrick O’Brien	1991	46
17	Inhibitors of cholesterol biosynthesis. 4. trans-6-[2-(Substituted-quinolinyl)ethenyl/ethyl]tetrahydro-4-hydroxy-2H-pyran-2-ones, a novel series of HMG-CoA reductase inhibitors Journal of Medicinal Chemistry ·Drago R. Sliskovic, Daniel Covatariu, W. Howard Roark, Bruce D. Roth, Erika Ferguson, Brian R. Krause, Roger S. Newton, Catherine Sekerke, Maxwell K. Shaw	1991	44
18	Inhibitors of cholesterol biosynthesis. 2. 1,3,5-Trisubstituted [2-(tetrahydro-4-hydroxy-2-oxopyran-6-yl)ethyl]pyrazoles Journal of Medicinal Chemistry ·Drago R. Sliskovic, Bruce D. Roth, D. P. Bow, M. L. HOEFLE, Roger S. Newton	1990	48
19	Hep-G2 cells and primary rat hepatocytes differ in their response to inhibitors of HMG-CoA reductase Biochemical and Biophysical Research Communications ·A. S. Jaffe, Roger S. Newton, Drago R. Sliskovic, Bruce D. Roth, Erika Ferguson, Brian R. Krause	1990	46
20	Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-Pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus Journal of Medicinal Chemistry ·Bruce D. Roth, Daniel F. Ortwine, M. L. HOEFLE, 義六藤井, Drago R. Sliskovic, D. P. Bow, Roger S. Newton	1990	51

About Bruce D. Roth

Bruce D. Roth is a scholar working on Toxicology, Pharmacology, Cancer Research, Pharmacology and Surgery, having authored 61 papers that have together received 2.6k indexed citations. Recurring topics across this work include Lipoproteins and Cardiovascular Health (19 papers), Cholesterol and Lipid Metabolism (16 papers), Plant biochemistry and biosynthesis (8 papers), Steroid Chemistry and Biochemistry (7 papers), Pharmacogenetics and Drug Metabolism (6 papers), Computational Drug Discovery Methods (6 papers), Microbial Metabolism and Applications (5 papers) and Cancer, Lipids, and Metabolism (5 papers). The work is most often cited by research in Organic Chemistry (1.4k citations), Biotechnology (230 citations), Pharmacology (325 citations), Computational Theory and Mathematics (261 citations) and Cancer Research (237 citations). Bruce D. Roth has collaborated with scholars based in United States, United Kingdom and Russia. Frequent co-authors include George A. Kraus, Drago R. Sliskovic, Roger S. Newton, Brian R. Krause, W. Howard Roark, Pauline J. Sanfilippo, Andrew S. Kende, Erika Ferguson, M. L. HOEFLE and Daniel F. Ortwine. Their work appears in journals such as Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Tetrahedron Letters, Bioorganic & Medicinal Chemistry and The Journal of Organic Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact