Bronwyn G. Siim

1.7k total citations · 1 hit paper
23 papers, 1.4k citations indexed

About

Bronwyn G. Siim is a scholar working on Cancer Research, Molecular Biology and Organic Chemistry. According to data from OpenAlex, Bronwyn G. Siim has authored 23 papers receiving a total of 1.4k indexed citations (citations by other indexed papers that have themselves been cited), including 16 papers in Cancer Research, 15 papers in Molecular Biology and 6 papers in Organic Chemistry. Recurrent topics in Bronwyn G. Siim's work include Cancer, Hypoxia, and Metabolism (14 papers), Glioma Diagnosis and Treatment (5 papers) and Cancer therapeutics and mechanisms (4 papers). Bronwyn G. Siim is often cited by papers focused on Cancer, Hypoxia, and Metabolism (14 papers), Glioma Diagnosis and Treatment (5 papers) and Cancer therapeutics and mechanisms (4 papers). Bronwyn G. Siim collaborates with scholars based in New Zealand, United States and United Kingdom. Bronwyn G. Siim's co-authors include Amato J. Giaccia, Randall S. Johnson, William R. Wilson, Frederik B. Pruijn, Kevin O. Hicks, J. Martin Brown, William A. Denny, Michael P. Hay, Alison Hogg and Cameron J. Koch and has published in prestigious journals such as Nature Reviews Drug Discovery, Cancer Research and Clinical Cancer Research.

In The Last Decade

Bronwyn G. Siim

23 papers receiving 1.4k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

HIF-1 as a target for drug development

2003 518 citations Amato J. Giaccia, Bronwyn G. Siim et al. Nature Reviews Drug Discovery profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Bronwyn G. Siim New Zealand	17	766	738	276	245	183	23	1.4k
Frederik B. Pruijn New Zealand	25	729 1.0×	791 1.1×	297 1.1×	364 1.5×	347 1.9×	57	1.7k
Vivien E. Prise United Kingdom	17	576 0.8×	1.1k 1.4×	401 1.5×	313 1.3×	252 1.4×	34	1.9k
Kevin O. Hicks New Zealand	25	879 1.1×	718 1.0×	321 1.2×	167 0.7×	429 2.3×	56	1.7k
G. M. Tozer United Kingdom	11	353 0.5×	647 0.9×	264 1.0×	226 0.9×	153 0.8×	14	1.3k
D. Lynn Kirkpatrick United States	18	436 0.6×	1.4k 1.8×	282 1.0×	224 0.9×	108 0.6×	34	1.8k
M.R.L. Stratford United Kingdom	20	565 0.7×	765 1.0×	318 1.2×	273 1.1×	269 1.5×	57	1.7k
J A Double United Kingdom	15	374 0.5×	821 1.1×	523 1.9×	191 0.8×	165 0.9×	29	1.7k
Susan M. Pullen New Zealand	19	346 0.5×	528 0.7×	190 0.7×	248 1.0×	118 0.6×	25	953
Karine Ilc France	12	720 0.9×	1.1k 1.5×	239 0.9×	164 0.7×	74 0.4×	14	1.6k
Silvia Peppicelli Italy	26	638 0.8×	1.0k 1.4×	430 1.6×	217 0.9×	169 0.9×	56	1.7k

Countries citing papers authored by Bronwyn G. Siim

Since Specialization

Citations

This map shows the geographic impact of Bronwyn G. Siim's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Bronwyn G. Siim with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Bronwyn G. Siim more than expected).

Fields of papers citing papers by Bronwyn G. Siim

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bronwyn G. Siim. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bronwyn G. Siim. The network helps show where Bronwyn G. Siim may publish in the future.

Co-authorship network of co-authors of Bronwyn G. Siim

This figure shows the co-authorship network connecting the top 25 collaborators of Bronwyn G. Siim. A scholar is included among the top collaborators of Bronwyn G. Siim based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Bronwyn G. Siim. Bronwyn G. Siim is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Hicks, Kevin O., Bronwyn G. Siim, Jagdish K. Jaiswal, et al.. (2010). Pharmacokinetic/Pharmacodynamic Modeling Identifies SN30000 and SN29751 as Tirapazamine Analogues with Improved Tissue Penetration and Hypoxic Cell Killing in Tumors. Clinical Cancer Research. 16(20). 4946–4957. 103 indexed citations

Kumar, G.D. Kishore, Tracy E. Strecker, Bronwyn G. Siim, et al.. (2010). Functionalized benzophenone, thiophene, pyridine, and fluorene thiosemicarbazone derivatives as inhibitors of cathepsin L. Bioorganic & Medicinal Chemistry Letters. 20(22). 6610–6615. 34 indexed citations

Kumar, G.D. Kishore, Tracy E. Strecker, Shen-En Chen, et al.. (2010). Design, synthesis, and biological evaluation of potent thiosemicarbazone based cathepsin L inhibitors. Bioorganic & Medicinal Chemistry Letters. 20(4). 1415–1419. 37 indexed citations

Tanpure, Rajendra P., Tracy E. Strecker, David J. Chaplin, et al.. (2010). Regio- and Stereospecific Synthesis of Mono-β-d-Glucuronic Acid Derivatives of Combretastatin A-1. Journal of Natural Products. 73(6). 1093–1101. 8 indexed citations

Hicks, Kevin O., Adam V. Patterson, Frederik B. Pruijn, et al.. (2007). Oxygen Dependence and Extravascular Transport of Hypoxia-Activated Prodrugs: Comparison of the Dinitrobenzamide Mustard PR-104A and Tirapazamine. International Journal of Radiation Oncology*Biology*Physics. 69(2). 560–571. 55 indexed citations

Hay, Michael P., Frederik B. Pruijn, Kevin O. Hicks, et al.. (2007). Hypoxia-Selective 3-Alkyl 1,2,4-Benzotriazine 1,4-Dioxides: The Influence of Hydrogen Bond Donors on Extravascular Transport and Antitumor Activity. Journal of Medicinal Chemistry. 50(26). 6654–6664. 36 indexed citations

Hicks, Kevin O., Bronwyn G. Siim, Frederik B. Pruijn, & William R. Wilson. (2004). Oxygen Dependence of the Metabolic Activation and Cytotoxicity of Tirapazamine: Implications for Extravascular Transport andActivity in Tumors. Radiation Research. 161(6). 656–666. 38 indexed citations

Siim, Bronwyn G., Frederik B. Pruijn, Alison Hogg, et al.. (2004). Selective Potentiation of the Hypoxic Cytotoxicity of Tirapazamine by Its 1- N -Oxide Metabolite SR 4317. Cancer Research. 64(2). 736–742. 43 indexed citations

Giaccia, Amato J., Bronwyn G. Siim, & Randall S. Johnson. (2003). HIF-1 as a target for drug development. Nature Reviews Drug Discovery. 2(10). 803–811. 518 indexed citations breakdown →

10.

Tercel, Moana, Stephen M. Stribbling, Hilary M. Sheppard, et al.. (2003). Unsymmetrical DNA Cross-Linking Agents: Combination of the CBI and PBD Pharmacophores. Journal of Medicinal Chemistry. 46(11). 2132–2151. 54 indexed citations

11.

Siim, Bronwyn G., et al.. (2003). Marked potentiation of the antitumour activity of chemotherapeutic drugs by the antivascular agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA). Cancer Chemotherapy and Pharmacology. 51(1). 43–52. 83 indexed citations

12.

Tercel, Moana, Alison Hogg, Robert F. Anderson, et al.. (2001). Hypoxia-Selective Antitumor Agents. 16. Nitroarylmethyl Quaternary Salts as Bioreductive Prodrugs of the Alkylating Agent Mechlorethamine. Journal of Medicinal Chemistry. 44(21). 3511–3522. 49 indexed citations

13.

Siim, Bronwyn G., et al.. (2000). Comparison of aromatic and tertiary amine N-oxides of acridine DNA intercalators as bioreductive drugs. Biochemical Pharmacology. 60(7). 969–978. 26 indexed citations

14.

Kestell, Philip, Frederik B. Pruijn, Bronwyn G. Siim, Brian D. Palmer, & William R. Wilson. (2000). Pharmacokinetics and metabolism of the nitrogen mustard bioreductive drug 5-[ N , N -bis(2-chloroethyl)amino]-2,4-dinitrobenzamide (SN 23862) and the corresponding aziridine (CB 1954) in KHT tumour-bearing mice. Cancer Chemotherapy and Pharmacology. 46(5). 365–374. 14 indexed citations

15.

Hicks, Kevin O., et al.. (1998). Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model. International Journal of Radiation Oncology*Biology*Physics. 42(3). 641–649. 77 indexed citations

16.

Elwell, James H., Bronwyn G. Siim, James Evans, & Jeffrey M. Brown. (1997). Adaptation of human tumor cells to tirapazamine under aerobic conditions. Biochemical Pharmacology. 54(2). 249–257. 54 indexed citations

17.

Siim, Bronwyn G., Graham J. Atwell, Robert F. Anderson, et al.. (1997). Hypoxia-Selective Antitumor Agents. 15. Modification of Rate of Nitroreduction and Extent of Lysosomal Uptake by Polysubstitution of 4-(Alkylamino)-5-nitroquinoline Bioreductive Drugs. Journal of Medicinal Chemistry. 40(9). 1381–1390. 15 indexed citations

18.

Brown, J. Martin & Bronwyn G. Siim. (1996). Hypoxia-specific cytotoxins in cancer therapy. Seminars in Radiation Oncology. 6(1). 22–36. 77 indexed citations

19.

Siim, Bronwyn G., et al.. (1995). Efficient redox cycling of nitroquinoline bioreductive drugs due to aerobic nitroreduction in Chinese hamster cells. Biochemical Pharmacology. 50(1). 75–82. 5 indexed citations

20.

Siim, Bronwyn G., Graham J. Atwell, & William R. Wilson. (1994). Metabolic and radiolytic reduction of 4-alkylamino-5-nitroquinoline bioreductive drugs. Biochemical Pharmacology. 48(8). 1593–1604. 7 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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