Brian O’Rourke

28.5k citations

281 papers · 21.3k indexed · 4 hit papers · h-index 80

Impact in

Developmental Neuroscience top 0.2%
- Anesthesia and Neurotoxicity Research
Cardiology and Cardiovascular Medicine top 0.1%
- Cardiac electrophysiology and arrhythmias

Papers in ⓘ

Cardiology and Cardiovascular Medicine 118
- Cardiac electrophysiology and arrhythmias 83
Biophysics 23
- Electron Spin Resonance Studies 19

Co-authors: Eduardo Marbán (50 shared papers)Miguel A. Aon (59 shared papers)Sonia Cortassa (46 shared papers)Ting Liu (39 shared papers)Raimond L. Winslow (23 shared papers)Toshiaki Sato (5 shared papers)Yongge Liu (10 shared papers)Christoph Maack (10 shared papers)
Journals: Circulation Research (37 papers)Biophysical Journal (30 papers)Journal of Molecular and Cellular Cardiology (16 papers)Journal of Biological Chemistry (13 papers)American Journal of Physiology-Heart and Circulatory Physiology (12 papers)
Partner nations: United States United Kingdom Germany

In The Last Decade

Brian O’Rourke

274 papers receiving 21.0k citations

Hit Papers

align trajectories log scale

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK 2019 · 302 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2019 Cell Reports
2002 Nature
1999 Circulation Research
1998 Circulation

Peers

Replace Elizabeth Murphy with:

Elizabeth Murphy United States

Masatsugu Hori Japan

Rainer Schulz Germany

Eduardo Marbán United States

Masafumi Kitakaze Japan

Daria Mochly‐Rosen United States

Paul T. Schumacker United States

Colin G. Nichols United States

Frances M. Ashcroft United Kingdom

Stephen F. Vatner United States

Brian O’Rourke relative to Elizabeth Murphy United States Elizabeth Murphy's profile →

Citations per field

00.5×1.6×

Elizabeth Murphy · 1×

×1.4 1k/1k

DN

×1.6 8k/5k

CCM

×1.0 6k/6k

PFM

×1.2 13k/11k

MB

×1.0 2k/2k

EM

Citations per year

2016

2017

2018

2019

2020

2021

2022

2023

2024

2025

2026

Countries citing papers authored by Brian O’Rourke

Since Specialization

Citations

This map shows the geographic impact of Brian O’Rourke's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Brian O’Rourke with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Brian O’Rourke more than expected).

Fields of papers citing papers by Brian O’Rourke

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Brian O’Rourke. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Brian O’Rourke. The network helps show where Brian O’Rourke may publish in the future.

Co-authors

The 25 scholars most cited alongside Brian O’Rourke, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Brian O’Rourke Line = papers co-authored together Brian O’Rourke links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Showing the 20 most-cited of 281 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Mitochondrial ATP-Dependent Potassium Channels Circulation ·Yongge Liu, Toshiaki Sato, Brian O’Rourke, Eduardo Marbán Hit paper breakdown →	1998	708
2	Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms Nature ·Lili A. Barouch, Robert W. Harrison, Michel Skaf, Gisele O. Rosas, Thomas P. Cappola, Z. Kobeissi, Ion A. Hobai, Christopher A. Lemmon, Arthur L. Burnett, Brian O’Rourke, E. René Rodríguez, Paul L. Huang, João A.C. Lima, Dan E. Berkowitz, Joshua M. Hare Hit paper breakdown →	2002	633
3	Mechanisms of Altered Excitation-Contraction Coupling in Canine Tachycardia-Induced Heart Failure, II Circulation Research ·Raimond L. Winslow, John Jeremy Rice, Saleet Jafri, Eduardo Marbán, Brian O’Rourke Hit paper breakdown →	1999	627
4	Ionic Mechanism of Action Potential Prolongation in Ventricular Myocytes From Dogs With Pacing-Induced Heart Failure Circulation Research ·Stefan Kääb, Hanne Nuss, Nipavan Chiamvimonvat, Brian O’Rourke, Peter H. Pak, David A. Kass, Eduardo Marbán, Gordon F. Tomaselli	1996	447
5	Synchronized Whole Cell Oscillations in Mitochondrial Metabolism Triggered by a Local Release of Reactive Oxygen Species in Cardiac Myocytes Journal of Biological Chemistry ·Miguel A. Aon, Sonia Cortassa, Eduardo Marbán, Brian O’Rourke	2003	436
6	Cytoprotective Role of Ca ²⁺ - Activated K ⁺ Channels in the Cardiac Inner Mitochondrial Membrane Science ·Wenhong Xu, Yongge Liu, Sheng Wang, Todd McDonald, Jennifer E. Van Eyk, Agnieszka Sidor, Brian O’Rourke	2002	399
7	Nitric Oxide Regulates Exocytosis by S-Nitrosylation of N-ethylmaleimide-Sensitive Factor Cell ·Kenji Matsushita, Craig N. Morrell, Béatrice Cambien, Shui-xiang Yang, Munekazu Yamakuchi, Clare Bao, Makoto R. Hara, Richard A. Quick, Wangsen Cao, Brian O’Rourke, John M. Lowenstein, Jonathan Pevsner, Denisa D. Wagner, Charles J. Lowenstein	2003	361
8	Evidence for Mitochondrial K ⁺ Channels and Their Role in Cardioprotection Circulation Research ·Brian O’Rourke	2004	353
9	Modulation of Mitochondrial ATP-Dependent K⁺Channels by Protein Kinase C Circulation Research ·Toshiaki Sato, Brian O’Rourke, Eduardo Marbán	1998	316
10	Smoke-free Legislation and Hospitalizations for Acute Coronary Syndrome New England Journal of Medicine ·Jill P. Pell, Sally Haw, Stuart M. Cobbe, David E. Newby, A C H Pell, Colin Fischbacher, Alex McConnachie, Stuart D. Pringle, David Murdoch, F G Dunn, Keith G. Oldroyd, Paul MacIntyre, Brian O’Rourke, W Borland	2008	314
11	Elevated Cytosolic Na ⁺ Decreases Mitochondrial Ca ²⁺ Uptake During Excitation-Contraction Coupling and Impairs Energetic Adaptation in Cardiac Myocytes Circulation Research ·Christoph Maack, Sonia Cortassa, Miguel A. Aon, Anand N. Ganesan, Ting Liu, Brian O’Rourke	2006	313
12	Redox-optimized ROS balance: A unifying hypothesis Biochimica et Biophysica Acta (BBA) - Bioenergetics ·Miguel A. Aon, Sonia Cortassa, Brian O’Rourke	2010	310
13	Mitochondrial ATP-Sensitive Potassium Channels Attenuate Matrix Ca ²⁺ Overload During Simulated Ischemia and Reperfusion Circulation Research ·Mitsushige Murata, Masaharu Akao, Brian O’Rourke, Eduardo Marbán	2001	309
14	Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK Cell Reports ·Yu Wang, Hongying An, Ting Liu, Caolitao Qin, Hiromi Sesaki, Shaodong Guo, Sally Radovick, Mehboob A. Hussain, Akhil Maheshwari, Fredric E. Wondisford, Brian O’Rourke, Ling He Hit paper breakdown →	2019	302
15	Activation of Mitochondrial ATP-Dependent Potassium Channels by Nitric Oxide Circulation ·Norihito Sasaki, Toshiaki Sato, Andreas Ohler, Brian O’Rourke, Eduardo Marbán	2000	296
16	An Integrated Model of Cardiac Mitochondrial Energy Metabolism and Calcium Dynamics Biophysical Journal ·Sonia Cortassa, Miguel A. Aon, Eduardo Marbán, Raimond L. Winslow, Brian O’Rourke	2003	291
17	Mechanisms of Altered Excitation-Contraction Coupling in Canine Tachycardia-Induced Heart Failure, I Circulation Research ·Brian O’Rourke, David A. Kass, Gordon F. Tomaselli, Stefan Kääb, Richard S. Tunin, Eduardo Marbán	1999	282
18	Endocardial Cells Form the Coronary Arteries by Angiogenesis through Myocardial-Endocardial VEGF Signaling Cell ·Bingruo Wu, Zheng Zhang, Wendy Lui, Xiangjian Chen, Yidong Wang, Alyssa A. Chamberlain, Ricardo A. Moreno‐Rodriguez, Roger R. Markwald, Brian O’Rourke, David Sharp, Deyou Zheng, Jack Lenz, H. Scott Baldwin, Ching-Pin Chang, Bin Zhou	2012	277
19	Myocardial K_ATPChannels in Preconditioning Circulation Research ·Brian O’Rourke	2000	277
20	Elevated Cytosolic Na ⁺ Increases Mitochondrial Formation of Reactive Oxygen Species in Failing Cardiac Myocytes Circulation ·Michael Kohlhaas, Ting Liu, Andreas Knopp, Tanja Zeller, Mei Fang Ong, Michael Böhm, Brian O’Rourke, Christoph Maack	2010	259

About Brian O’Rourke

Brian O’Rourke is a scholar working on Cardiology and Cardiovascular Medicine, Biophysics, Pathology and Forensic Medicine, Developmental Neuroscience and Molecular Biology, having authored 281 papers that have together received 21.3k indexed citations. Recurring topics across this work include Mitochondrial Function and Pathology (104 papers), Cardiac electrophysiology and arrhythmias (83 papers), Cardiac Ischemia and Reperfusion (70 papers), Ion channel regulation and function (52 papers), ATP Synthase and ATPases Research (33 papers), Adipose Tissue and Metabolism (20 papers), Electron Spin Resonance Studies (19 papers) and Fuel Cells and Related Materials (19 papers). The work is most often cited by research in Developmental Neuroscience (1.4k citations), Cardiology and Cardiovascular Medicine (7.6k citations), Pathology and Forensic Medicine (5.6k citations), Molecular Biology (13.2k citations) and Emergency Medicine (1.8k citations). Brian O’Rourke has collaborated with scholars based in United States, United Kingdom and Germany. Frequent co-authors include Eduardo Marbán, Miguel A. Aon, Sonia Cortassa, Ting Liu, Raimond L. Winslow, Toshiaki Sato, Yongge Liu, Christoph Maack, Ion A. Hobai and Gordon F. Tomaselli. Their work appears in journals such as Circulation Research, Biophysical Journal, Journal of Molecular and Cellular Cardiology, Journal of Biological Chemistry and American Journal of Physiology-Heart and Circulatory Physiology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact