Brian B. Tuch

14.8k citations

36 papers · 6.3k indexed · 5 hit papers · h-index 19

Impact in

Molecular Biology top 1%
- Single-cell and spatial transcriptomics
- Fungal and yeast genetics research
- Gene Regulatory Network Analysis
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
Infectious Diseases top 1%
- Antifungal resistance and susceptibility

Papers in

Cancer Research 6
- Cancer Genomics and Diagnostics 4
Genetics 4
- Chronic Lymphocytic Leukemia Research 3

Co-authors: Alexander D. Johnson Cátálin BárbácioruXiaohui WangM. Azim Surani Kaiqin Lao Asim Siddiqui Fuchou Tang Yangzhou Wang
Journals: Nature (3 papers)Annals of Oncology (3 papers)Science (3 papers)Molecular Cancer Therapeutics (2 papers)Cancer Research (2 papers)
Partner nations: United States France South Korea

In The Last Decade

Brian B. Tuch

36 papers receiving 6.2k citations

Hit Papers

5 papers align trajectories log scale

Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study 2018 · 378 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2018 The Lancet Oncology
2015 Cancer Discovery
2012 Cell
2009 Nature Methods
2009 Science

Peers

Countries citing papers authored by Brian B. Tuch

Since Specialization

Citations

This map shows the geographic impact of Brian B. Tuch's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Brian B. Tuch with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Brian B. Tuch more than expected).

Fields of papers citing papers by Brian B. Tuch

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Brian B. Tuch. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Brian B. Tuch. The network helps show where Brian B. Tuch may publish in the future.

Co-authors

The 25 scholars most cited alongside Brian B. Tuch, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Brian B. Tuch Line = papers co-authored together Brian B. Tuch links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Global signal peptide profiling reveals principles of selective Sec61 inhibition Nature Chemical Biology ·Nicole A. Wenzell, Brian B. Tuch, Dustin L. McMinn, Matthew Lyons, Christopher J. Kirk, Jack Taunton	2024	4
2	Zetomipzomib (KZR-616) attenuates lupus in mice via modulation of innate and adaptive immune responses Frontiers in Immunology ·Tony Muchamuel, Rong Fan, Janet L. Anderl, Darrin Bomba, Henry W. B. Johnson, Eric Lowe, Brian B. Tuch, Dustin L. McMinn, Beatriz Millare, Christopher J. Kirk	2023	18
3	Larotrectinib in adult patients with solid tumours: a multi-centre, open-label, phase I dose-escalation study Annals of Oncology ·David S. Hong, Todd M. Bauer, J. Jack Lee, Afshin Dowlati, Marcia S. Brose, Anna F. Farago, Matthew H. Taylor, Alice T. Shaw, Sandra Montez, Funda Meric‐Bernstam, Steven G. Smith, Brian B. Tuch, Kevin Ebata, Scott Cruickshank, M.C. Cox, Howard A. Burris, Robert C. Doebele	2019	114
4	Genetic Modeling and Therapeutic Targeting of ETV6-NTRK3 with Loxo-101in Acute Lymphoblastic Leukemia Blood ·Kathryn G. Roberts, Olga A. Bridges, Laura J. Janke, Kevin Ebata, Brian B. Tuch, Nisha Nanda, Charles G. Mullighan	2016	3
5	An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101 Cancer Discovery ·Robert C. Doebele, Lara E. Davis, Aria Vaishnavi, Anh T. Le, Adriana Estrada‐Bernal, Stephen B. Keysar, Antonio Jimeno, Marileila Varella‐Garcia, Dara L. Aisner, Yali Li, Philip J. Stephens, Deborah Morosini, Brian B. Tuch, Michele Fernandes, Nisha Nanda, Jennifer A. Low Hit paper breakdown →	2015	302
6	Intersecting transcription networks constrain gene regulatory evolution Nature ·Trevor R. Sorrells, Lauren N. Booth, Brian B. Tuch, Alexander D. Johnson	2015	54
7	Nucleosome regulatory dynamics in response to TGF Nucleic Acids Research ·Stefan Enroth, Robin Andersson, Madhusudhan Bysani, Ola Wallerman, Stefan Termén, Brian B. Tuch, Francisco M. De La Vega, Carl‐Henrik Heldin, Aristidis Moustakas, Jan Komorowski, Claes Wadelius	2014	4
8	Extensive DNA-binding specificity divergence of a conserved transcription regulator Proceedings of the National Academy of Sciences ·Christopher R. Baker, Brian B. Tuch, Alexander D. Johnson	2011	66
9	An Iron Homeostasis Regulatory Circuit with Reciprocal Roles in Candida albicans Commensalism and Pathogenesis Cell Host & Microbe ·Changbin Chen, Kalyan Pande, Sarah French, Brian B. Tuch, Suzanne M. Noble	2011	259
10	Deterministic and Stochastic Allele Specific Gene Expression in Single Mouse Blastomeres PLoS ONE ·Fuchou Tang, Cátálin Bárbácioru, Ellen Nordman, Siqin Bao, Caroline Lee, Xiaohui Wang, Brian B. Tuch, Édith Heard, Kaiqin Lao, M. Azim Surani	2011	115
11	Evolution of Yeast Noncoding RNAs Reveals an Alternative Mechanism for Widespread Intron Loss Science ·Quinn M. Mitrovich, Brian B. Tuch, Francisco M. De La Vega, Christine Guthrie, Alexander D. Johnson	2010	35
12	Intercalation of a new tier of transcription regulation into an ancient circuit Nature ·Lauren N. Booth, Brian B. Tuch, Alexander D. Johnson	2010	59
13	The Transcriptomes of Two Heritable Cell Types Illuminate the Circuit Governing Their Differentiation PLoS Genetics ·Brian B. Tuch, Quinn M. Mitrovich, Oliver Homann, Aaron D. Hernday, Cinna K. Monighetti, Francisco M. De La Vega, Alexander D. Johnson	2010	123
14	Global Analysis of Cdk1 Substrate Phosphorylation Sites Provides Insights into Evolution Science ·Liam J. Holt, Brian B. Tuch, Judit Villén, Alexander D. Johnson, Steven P. Gygi, David O. Morgan Hit paper breakdown →	2009	716
15	mRNA-Seq whole-transcriptome analysis of a single cell Nature Methods ·Fuchou Tang, Cátálin Bárbácioru, Yangzhou Wang, Ellen Nordman, Clarence Lee, Nanlan Xu, Xiaohui Wang, John Bodeau, Brian B. Tuch, Asim Siddiqui, Kaiqin Lao, M. Azim Surani Hit paper breakdown →	2009	2536
16	Measuring the prevalence of regional mutation rates: an analysis of silent substitutions in mammals, fungi, and insects BMC Evolutionary Biology ·Aleah K Fox, Brian B. Tuch, Jeffrey H. Chuang	2008	17
17	The Evolution of Combinatorial Gene Regulation in Fungi PLoS Biology ·Brian B. Tuch, David J. Galgoczy, Aaron D. Hernday, Hao Li, Alexander D. Johnson	2008	196
18	Computational and experimental approaches double the number of known introns in the pathogenic yeast Candida albicans Genome Research ·Quinn M. Mitrovich, Brian B. Tuch, Christine Guthrie, Alexander D. Johnson	2007	52
19	Interlocking Transcriptional Feedback Loops Control White-Opaque Switching in Candida albicans PLoS Biology ·Rebecca E. Zordan, Mathew Miller, David J. Galgoczy, Brian B. Tuch, Alexander D. Johnson	2007	234
20	Evolution of alternative transcriptional circuits with identical logic Nature ·Annie E. Tsong, Brian B. Tuch, Hao Li, Alexander D. Johnson	2006	209

About Brian B. Tuch

Brian B. Tuch is a scholar working on Cancer Research, Genetics, Molecular Biology, Pulmonary and Respiratory Medicine and Oncology, having authored 36 papers that have together received 6.3k indexed citations. Recurring topics across this work include Fungal and yeast genetics research (11 papers), Lung Cancer Treatments and Mutations (8 papers), RNA Research and Splicing (5 papers), Cancer Genomics and Diagnostics (4 papers), RNA modifications and cancer (4 papers), Genomics and Chromatin Dynamics (4 papers), Chronic Lymphocytic Leukemia Research (3 papers) and Antifungal resistance and susceptibility (3 papers). The work is most often cited by research in Molecular Biology (4.5k citations), Infectious Diseases (1.1k citations), Cancer Research (873 citations), Biophysics (245 citations) and Aging (63 citations). Brian B. Tuch has collaborated with scholars based in United States, France and South Korea. Frequent co-authors include Alexander D. Johnson, Cátálin Bárbácioru, Xiaohui Wang, M. Azim Surani, Kaiqin Lao, Asim Siddiqui, Fuchou Tang, Yangzhou Wang, John Bodeau and Clarence Lee. Their work appears in journals such as Nature, Annals of Oncology, Science, Molecular Cancer Therapeutics and Cancer Research.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact