Alexander J. Groffen

2.2k citations

45 papers · 1.5k indexed · h-index 23

Cell Biology top 2%
- Cellular transport and secretion 24
- Proteoglycans and glycosaminoglycans research 6
Nephrology top 5%
Cellular and Molecular Neuroscience top 5%
- Neuroscience and Neuropharmacology Research 7
Physiology top 5%
Immunology and Allergy top 5%
Molecular Biology
- Lipid Membrane Structure and Behavior 12
- Ion channel regulation and function 5
- Glycosylation and Glycoproteins Research 4
- Ubiquitin and proteasome pathways 3
Surgery
- Pancreatic function and diabetes 6

Co-authors: Matthijs Verhage L.A.H. Monnens Jacques H. Veerkamp Lambert P.W.J. van den Heuvel Carin A. F. Buskens Roberta Mancini Uri Ashery Jakob B. Sørensen
Cited by: Cell Biology Nephrology Cellular and Molecular Neuroscience
Journals: Science (1 paper)Journal of Biological Chemistry (2 papers)Nature Communications (2 papers)
Partner nations: Netherlands United States United Kingdom

In The Last Decade

Alexander J. Groffen

44 papers receiving 1.5k citations

Peers

Countries citing papers authored by Alexander J. Groffen

Since Specialization

Citations

This map shows the geographic impact of Alexander J. Groffen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alexander J. Groffen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alexander J. Groffen more than expected).

Fields of papers citing papers by Alexander J. Groffen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alexander J. Groffen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alexander J. Groffen. The network helps show where Alexander J. Groffen may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Alexander J. Groffen, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Alexander J. Groffen Line = papers co-authored together Alexander J. Groffen links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes Nature Communications ·Marieke Meijer,Miriam Öttl,Jie Yang,Aygul Subkhangulova,Avinash Kumar,Zicheng Feng,Torben W. van Voorst,Alexander J. Groffen,Jan R.T. van Weering,Yongli Zhang,Matthijs Verhage	2024	0
2	Long-term prognosis of patients with an SCN5A loss-of-function variant and progressive cardiac conduction disorder or Brugada syndrome Heart Rhythm ·Fenna Tuijnenburg,Virginnio Proost,Aurélie Thollet,Julien Barc,Alexander J. Groffen,Christiaan C. Veerman,Saskia N. van der Crabben,Vincent R. van der Pas,Florence Kyndt,Sean J. Jurgens,Michael W.T. Tanck,Pieter G. Postema,J. Peter van Tintelen,Connie R. Bezzina,Vincent Probst,Arthur A.M. Wilde,Jean‐Baptiste Gourraud,Ahmad S. Amin	2024	2
3	Tomosyn affects dense core vesicle composition but not exocytosis in mammalian neurons eLife ·Aygul Subkhangulova,Miguel A. Gonzalez‐Lozano,Alexander J. Groffen,Jan R.T. van Weering,August B. Smit,Ruud F. Toonen,Matthijs Verhage	2023	3
4	Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs eLife ·Sébastien Houy,Alexander J. Groffen,Iwona Ziomkiewicz,Matthijs Verhage,Paulo S. Pinheiro,Jakob B. Sørensen	2017	27
5	Direct Quantitative Detection of Doc2b-Induced Hemifusion in Optically Trapped Membranes Biophysical Journal ·Ineke Brouwer,Asiya Giniatullina,Niels Laurens,Jan R.T. van Weering,Dirk Bald,Alexander J. Groffen,Gijs J. L. Wuite	2016	1
6	Tomosyn Interacts with the SUMO E3 Ligase PIASγ PLoS ONE ·Cornelia J. Geerts,Linda Jacobsen,Rhea van de Bospoort,Matthijs Verhage,Alexander J. Groffen	2014	7
7	DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake Diabetologia ·Jialin Li,James Cantley,James G. Burchfield,Christopher C. Meoli,Jacqueline Stöckli,P. Tess Whitworth,H. C. Pant,К. Ray Chaudhuri,Alexander J. Groffen,Matthijs Verhage,David E. James	2014	29
8	Doc2b Synchronizes Secretion from Chromaffin Cells by Stimulating Fast and Inhibiting Sustained Release Journal of Neuroscience ·Paulo S. Pinheiro,Heidi de Wit,Alexander M. Walter,Alexander J. Groffen,Matthijs Verhage,Jakob B. Sørensen	2013	15
9	TRIM3 Regulates the Motility of the Kinesin Motor Protein KIF21B PLoS ONE ·Dorthe Labonté,Edda Thies,Yvonne Pechmann,Alexander J. Groffen,Matthijs Verhage,August B. Smit,Ronald E. van Kesteren,Matthias Kneussel	2013	30
10	Doc2b Is a Key Effector of Insulin Secretion and Skeletal Muscle Insulin Sensitivity Diabetes ·Latha Ramalingam,Eunjin Oh,Stephanie M. Yoder,Joseph T. Brozinick,Michael A. Kalwat,Alexander J. Groffen,Matthijs Verhage,Debbie C. Thurmond	2012	41
11	Paroxysmal kinesigenic dyskinesia: Cortical or non-cortical origin Parkinsonism & Related Disorders ·Teun W. van Strien,Anne‐Fleur van Rootselaar,Anthony A. J. Hilgevoord,Wim H.J.P. Linssen,Alexander J. Groffen,Marina A.J. Tijssen	2012	20
12	Genetic and phenotypic heterogeneity in sporadic and familial forms of paroxysmal dyskinesia Journal of Neurology ·Alexander J. Groffen,Thom Klapwijk,Anne‐Fleur van Rootselaar,J Groen,Marina A.J. Tijssen	2012	40
13	Doc2b Is a High-Affinity Ca ²⁺ Sensor for Spontaneous Neurotransmitter Release Science ·Alexander J. Groffen,Sascha Martens,Rocío Díez Arazola,L. Niels Cornelisse,Natalia Lozovaya,Arthur P.H. de Jong,Natalia A. Goriounova,Ron L. P. Habets,Yoshimi Takai,J. Gerard G. Borst,Nils Brose,Harvey T. McMahon,Matthijs Verhage	2010	253
14	DOC2A and DOC2B are sensors for neuronal activity with unique calcium‐dependent and kinetic properties Journal of Neurochemistry ·Alexander J. Groffen,Reut Friedrich,Elisabeth C. Brian,Uri Ashery,Matthijs Verhage	2006	83
15	Decreased Glomerular Expression of Agrin in Diabetic Nephropathy and Podocytes, Cultured in High Glucose Medium Nephron Experimental Nephrology ·Benito Yard,Stefan Kahlert,R. Engelleiter,S. Resch,R. Waldherr,Alexander J. Groffen,Lambert P.W.J. van den Heuvel,Jan Van Der Watt Born,Jo H. M. Berden,Stephan Kröger,M. Häfner,Fokko J. van der Woude	2001	34
16	Recent insights into the structure and functions of heparan sulfate proteoglycans in the human glomerular basement membrane Nephrology Dialysis Transplantation ·Alexander J. Groffen,Jacques H. Veerkamp,L.A.H. Monnens,Lambert P.W.J. van den Heuvel	1999	67
17	Agrin Is a Major Heparan Sulfate Proteoglycan in the Human Glomerular Basement Membrane Journal of Histochemistry & Cytochemistry ·Alexander J. Groffen,Markus A. Rüegg,Henri B.P.M. Dijkman,Thea J. van de Velden,Carin A. F. Buskens,Jacob van den Born,Karel J.M. Assmann,L.A.H. Monnens,Jacques H. Veerkamp,Lambert P. van den Heuvel	1998	141
18	Primary structure and high expression of human agrin in basement membranes of adult lung and kidney European Journal of Biochemistry ·Alexander J. Groffen,Carin A. F. Buskens,Toin H. Van Kuppevelt,Jacques H. Veerkamp,L.A.H. Monnens,Lambert P.W.J. van den Heuvel	1998	63
19	Evidence for the Existence of Multiple Heparan Sulfate Proteoglycans in the Human Glomerular Basement Membrane and Mesangial Matrix European Journal of Biochemistry ·Alexander J. Groffen,Frank W. H. Hop,Karl Trygovason,Henri B.P.M. Dijkman,Karel J.M. Assmann,Jacques H. Veerkamp,L.A.H. Monnens,Lambert P.W.J. van den Heuvel	1997	27
20	Expression and Characterization of Human Perlecan Domains I and II Synthesized by Baculovirus‐Infected Insect Cells European Journal of Biochemistry ·Alexander J. Groffen,Carin A. F. Buskens,Karl Tryggvason,Jacques H. Veerkamp,L.A.H. Monnens,Lambert P.W.J. van den Heuvel	1996	27

About Alexander J. Groffen

Alexander J. Groffen is a scholar working on Cell Biology, Physiology and Immunology and Allergy, having authored 45 papers that have together received 1.5k indexed citations. Recurring topics across this work include Cellular transport and secretion (24 papers), Lipid Membrane Structure and Behavior (12 papers), Neuroscience and Neuropharmacology Research (7 papers), Proteoglycans and glycosaminoglycans research (6 papers), Pancreatic function and diabetes (6 papers), Ion channel regulation and function (5 papers), Glycosylation and Glycoproteins Research (4 papers) and Ubiquitin and proteasome pathways (3 papers). The work is most often cited by research in Cell Biology (684 citations), Nephrology (139 citations) and Cellular and Molecular Neuroscience (350 citations). Alexander J. Groffen has collaborated with scholars based in Netherlands, United States and United Kingdom. Frequent co-authors include Matthijs Verhage, L.A.H. Monnens, Jacques H. Veerkamp, Lambert P.W.J. van den Heuvel, Carin A. F. Buskens, Roberta Mancini, Uri Ashery, Jakob B. Sørensen, L. Niels Cornelisse and Nils Brose. Their work appears in journals such as Science, Journal of Biological Chemistry and Nature Communications.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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