Standout Papers

Sphingosine-1-phosphate: an enigmatic signalling lipid 2003 2026 2010 2018 1.7k
  1. Sphingosine-1-phosphate: an enigmatic signalling lipid (2003)
    Sarah Spiegel, Sheldon Milstien Nature Reviews Molecular Cell Biology
  2. Sphingosine-1-phosphate signaling and its role in disease (2011)
    Michael Maceyka, Kuzhuvelil B. Harikumar et al. Trends in Cell Biology
  3. Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate (2009)
    Nitai C. Hait, Jeremy C. Allegood et al. Science
  4. The outs and the ins of sphingosine-1-phosphate in immunity (2011)
    Sarah Spiegel, Sheldon Milstien Nature reviews. Immunology
  5. Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2 (2010)
    Sergio E. Alvarez, Kuzhuvelil B. Harikumar et al. Nature
  6. “Inside-Out” Signaling of Sphingosine-1-Phosphate: Therapeutic Targets (2008)
    Kazuaki Takabe, Steven W. Paugh et al. Pharmacological Reviews
  7. Molecular Cloning and Functional Characterization of a Novel Mammalian Sphingosine Kinase Type 2 Isoform (2000)
    Hong Liu, Masako Sugiura et al. Journal of Biological Chemistry
  8. SphK1 and SphK2, Sphingosine Kinase Isoenzymes with Opposing Functions in Sphingolipid Metabolism (2005)
    Michael Maceyka, Heidi Sankala et al. Journal of Biological Chemistry

Immediate Impact

12 by Nobel laureates 36 from Science/Nature 118 standout
Sub-graph 1 of 19

Citing Papers

De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
IL-10 constrains sphingolipid metabolism to limit inflammation
2024 StandoutNature
124 intermediate papers

Works of Sheldon Milstien being referenced

Aberrant ORM (yeast)–like protein isoform 3 (ORMDL3) expression dysregulates ceramide homeostasis in cells and ceramide exacerbates allergic asthma in mice
2015
Generation and metabolism of bioactive sphingosine‐1‐phosphate
2004
and 76 more

Author Peers

Author Last Decade Papers Cites
Sheldon Milstien 20247 7285 4795 236 26.2k
John H. Exton 17990 5686 5753 274 27.0k
Daria Mochly‐Rosen 17008 2703 3857 318 25.6k
Jerold Chun 23705 6655 4109 330 31.2k
Junken Aoki 15743 4600 3037 392 21.0k
Lina M. Obeid 26024 7323 5249 289 30.0k
Robin F. Irvine 21171 7525 3701 223 30.8k
Luca Scorrano 24703 4109 4818 182 30.9k
Peter J. Parker 25180 7559 3000 401 33.5k
Dale E. Bredesen 16439 4157 5096 230 28.4k
Jean‐Claude Martinou 21766 2273 2129 192 27.5k

All Works

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2026