Standout Papers

The Hallmarks of Aging 1993 2026 2004 2015 10.0k
  1. The Hallmarks of Aging (2013)
    Carlos López-Otı́n, Marı́a A. Blasco et al. Cell
  2. Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a (1997)
    Manuel Serrano, Athena W. Lin et al. Cell
  3. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 (1993)
    Manuel Serrano, Gregory J. Hannon et al. Nature
  4. Hallmarks of aging: An expanding universe (2023)
    Carlos López-Otı́n, Marı́a A. Blasco et al. Cell
  5. Cellular senescence: from physiology to pathology (2014)
    Daniel Muñoz‐Espín, Manuel Serrano Nature Reviews Molecular Cell Biology
  6. Role of the INK4a Locus in Tumor Suppression and Cell Mortality (1996)
    Manuel Serrano, Han‐Woong Lee et al. Cell
  7. Cellular Senescence in Cancer and Aging (2007)
    Manuel Collado, Marı́a A. Blasco et al. Cell
  8. Senescence in premalignant tumours (2005)
    Manuel Collado, Jesús Gil et al. Nature
  9. Programmed Cell Senescence during Mammalian Embryonic Development (2013)
    Daniel Muñoz‐Espín, Marta Cañamero et al. Cell
  10. A p16 INK4a -Insensitive CDK4 Mutant Targeted by Cytolytic T Lymphocytes in a Human Melanoma (1995)
    Thomas Wölfel, Jörg Schneider et al. Science
  11. Senescence in tumours: evidence from mice and humans (2009)
    Manuel Collado, Manuel Serrano Nature reviews. Cancer
  12. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity (2009)
    Rosa M. Marión, Katerina Strati et al. Nature
  13. The common biology of cancer and ageing (2007)
    Toren Finkel, Manuel Serrano et al. Nature
  14. Sirt1 protects against high-fat diet-induced metabolic damage (2008)
    Paul T. Pfluger, Daniel Herranz et al. Proceedings of the National Academy of Sciences
  15. The Ink4/Arf locus is a barrier for iPS cell reprogramming (2009)
    Han Li, Manuel Collado et al. Nature
  16. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling (1998)
    Athena W. Lin, Marta Barradas et al. Genes & Development
  17. GLP-1 Agonism Stimulates Brown Adipose Tissue Thermogenesis and Browning Through Hypothalamic AMPK (2014)
    Daniel Beiroa, Mónica Imbernón et al. Diabetes
  18. Tissue damage and senescence provide critical signals for cellular reprogramming in vivo (2016)
    Lluc Mosteiro, Cristina Pantoja et al. Science

Immediate Impact

29 by Nobel laureates 132 from Science/Nature 398 standout
Sub-graph 1 of 12

Citing Papers

Autophagy maintains stemness by preventing senescence
2016 StandoutNature
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 StandoutNature
227 intermediate papers

Works of Manuel Serrano being referenced

Programmed Cell Senescence during Mammalian Embryonic Development
2013 Standout
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
1997 Standout
and 47 more

Author Peers

Author Last Decade Papers Cites
Manuel Serrano 30375 15694 12523 268 50.9k
Judith Campisi 32391 27471 8647 320 63.9k
Toren Finkel 29908 11262 4859 211 54.3k
Carlos López-Otı́n 24442 7675 9580 407 49.4k
Ronald A. DePinho 55409 16273 22760 416 84.9k
Marı́a A. Blasco 28481 23970 4327 286 47.8k
Anne Brunet 26195 5837 4025 143 37.9k
Jerry W. Shay 34712 31580 8781 512 56.7k
Eric Verdin 24476 10713 4982 275 46.5k
Frederick W. Alt 41129 7807 12296 482 72.9k
Vilhelm A. Bohr 29665 7819 5177 536 40.8k

All Works

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2026