Standout Papers

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling 2007 2026 2013 2019 2.1k
  1. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling (2007)
    Luke O'neill, Andrew Bowie Nature reviews. Immunology
  2. A guide to immunometabolism for immunologists (2016)
    Luke O'neill, Rigel J. Kishton et al. Nature reviews. Immunology
  3. Trained immunity: A program of innate immune memory in health and disease (2016)
    Mihai G. Netea, Leo A. B. Joosten et al. Science
  4. Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages (2016)
    Evanna L. Mills, Beth Kelly et al. Cell
  5. Metabolic reprogramming in macrophages and dendritic cells in innate immunity (2015)
    Beth Kelly, Luke O'neill Cell Research
  6. The history of Toll-like receptors — redefining innate immunity (2013)
    Luke O'neill, Douglas T. Golenbock et al. Nature reviews. Immunology
  7. Negative regulation of Toll-like receptor-mediated immune responses (2005)
    Foo Y. Liew, Damo Xu et al. Nature reviews. Immunology
  8. Immunometabolism governs dendritic cell and macrophage function (2015)
    Luke O'neill, Edward J. Pearce The Journal of Experimental Medicine
  9. Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4 (2004)
    Eva M. Pålsson‐McDermott, Luke O'neill Immunology
  10. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction (2001)
    Katherine A. Fitzgerald, Eva M. Pålsson‐McDermott et al. Nature
  11. Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages (2015)
    Eva M. Pålsson‐McDermott, Annie M. Curtis et al. Cell Metabolism
  12. Metabolism of inflammation limited by AMPK and pseudo-starvation (2013)
    Luke O'neill, D. Grahame Hardie Nature
  13. NF-kB: a crucial transcription factor for glial and neuronal cell function (1997)
    Luke O'neill, Christian Kaltschmidt Trends in Neurosciences
  14. Resolution of in flammation: state of the art, definitions and terms (2007)
    Charles N. Serhan, Susan D. Brain et al. The FASEB Journal
  15. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21 (2009)
    Frederick J. Sheedy, Eva M. Pålsson‐McDermott et al. Nature Immunology
  16. Macrophage Immunometabolism: Where Are We (Going)? (2017)
    Jan Van den Bossche, Luke O'neill et al. Trends in Immunology
  17. A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes (2013)
    Susan Carpenter, Maninjay Atianand et al. Science
  18. Oxidative stress and nuclear factor-κB activation (2000)
    Andrew Bowie, Luke O'neill Biochemical Pharmacology
  19. Mitochondria are the powerhouses of immunity (2017)
    Evanna L. Mills, Beth Kelly et al. Nature Immunology
  20. MicroRNAs: the fine-tuners of Toll-like receptor signalling (2011)
    Luke O'neill, Frederick J. Sheedy et al. Nature reviews. Immunology
  21. Targeting Toll-like receptors: emerging therapeutics? (2010)
    Elizabeth J. Hennessy, Andrew E. Parker et al. Nature Reviews Drug Discovery
  22. Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice (2018)
    Richard D. Gordon, Eduardo A. Albornoz et al. Science Translational Medicine
  23. TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity (2006)
    Emma M. Creagh, Luke O'neill Trends in Immunology
  24. The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense (2003)
    Aisling Dunne, Luke O'neill Science s STKE
  25. Succinate: a metabolic signal in inflammation (2013)
    Evanna L. Mills, Luke O'neill Trends in Cell Biology
  26. How Toll-like receptors signal: what we know and what we don’t know (2005)
    Luke O'neill Current Opinion in Immunology
  27. Toll-like receptors: From the discovery of NFκB to new insights into transcriptional regulations in innate immunity (2006)
    Sarah Doyle, Luke O'neill Biochemical Pharmacology
  28. HIF1α and metabolic reprogramming in inflammation (2016)
    Sarah E. Corcoran, Luke O'neill Journal of Clinical Investigation
  29. Circadian Clock Proteins and Immunity (2014)
    Annie M. Curtis, Marina Maria Bellet et al. Immunity
  30. The Role of HIF in Immunity and Inflammation (2020)
    Anne F. McGettrick, Luke O'neill Cell Metabolism
  31. Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice (2016)
    Ana Rubio‐Araiz, Karen Bryson et al. Brain Behavior and Immunity
  32. A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation (2018)
    Niamh C. Williams, Luke O'neill Frontiers in Immunology
  33. Itaconate: the poster child of metabolic reprogramming in macrophage function (2019)
    Luke O'neill, Maxim N. Artyomov Nature reviews. Immunology
  34. The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation (2020)
    Alexander Hooftman, Stefano Angiari et al. Cell Metabolism
  35. Targeting immunometabolism as an anti-inflammatory strategy (2020)
    Eva M. Pålsson‐McDermott, Luke O'neill Cell Research
  36. BCG-induced trained immunity: can it offer protection against COVID-19? (2020)
    Luke O'neill, Mihai G. Netea Nature reviews. Immunology
  37. Role for NLRP3 Inflammasome–mediated, IL-1β–Dependent Responses in Severe, Steroid-Resistant Asthma (2017)
    Richard Kim, James Pinkerton et al. American Journal of Respiratory and Critical Care Medicine
  38. Krebs Cycle Reborn in Macrophage Immunometabolism (2020)
    Dylan G. Ryan, Luke O'neill Annual Review of Immunology
  39. A break in mitochondrial endosymbiosis as a basis for inflammatory diseases (2024)
    Michael P. Murphy, Luke O'neill Nature
  40. From periphery to center stage: 50 years of advancements in innate immunity (2024)
    Susan Carpenter, Luke O'neill Cell

Immediate Impact

36 by Nobel laureates 80 from Science/Nature 235 standout
Sub-graph 1 of 17

Citing Papers

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Works of Luke O'neill being referenced

Macrophage Immunometabolism: Where Are We (Going)?
2017 Standout
A guide to immunometabolism for immunologists
2016 Standout
and 2 more

Author Peers

Author Last Decade Papers Cites
Luke O'neill 31895 23194 11016 380 59.7k
Bruce Beutler 37780 17041 5969 401 63.8k
Katherine A. Fitzgerald 39041 37056 6753 331 67.9k
Douglas T. Golenbock 30420 14972 4463 287 50.3k
Eicke Latz 31007 31605 3603 278 59.6k
Ruslan Medzhitov 60569 27356 8820 221 95.1k
Jürg Tschopp 42911 51322 7960 282 86.1k
Taro Kawai 46136 19829 8641 175 65.8k
Kiyoshi Takeda 56555 27378 10436 454 91.3k
Peter Vandenabeele 20547 36202 8299 449 60.6k
Sankar Ghosh 26826 25455 22557 193 57.8k

All Works

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2026