Standout Papers

Signal transduction by receptors with tyrosine kinase activity 1976 2026 1992 2009 4.7k
  1. Signal transduction by receptors with tyrosine kinase activity (1990)
    Axel Ullrich, Joseph Schlessinger Cell
  2. Cell Signaling by Receptor Tyrosine Kinases (2010)
    Mark A. Lemmon, Joseph Schlessinger Cell
  3. Cell Signaling by Receptor Tyrosine Kinases (2000)
    Joseph Schlessinger Cell
  4. Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells (1984)
    A Ullrich, Lisa M. Coussens et al. Nature
  5. Mobility measurement by analysis of fluorescence photobleaching recovery kinetics (1976)
    Daniel Axelrod, D E Koppel et al. Biophysical Journal
  6. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences (1984)
    Julian Downward, Yosef Yarden et al. Nature
  7. Cellular signaling by fibroblast growth factor receptors (2005)
    Veraragavan P. Eswarakumar, Irit Lax et al. Cytokine & Growth Factor Reviews
  8. Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene (1985)
    Lisa M. Coussens, Teresa L. Yang‐Feng et al. Science
  9. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling (1992)
    Eve J. Lowenstein, Roger J. Daly et al. Cell
  10. Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. (1987)
    Yosef Yarden, Wun-Jing Kuang et al. The EMBO Journal
  11. Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin (1985)
    Towia A. Libermann, Nissim Razon et al. Nature
  12. Growth factor signaling by receptor tyrosine kinases (1992)
    Joseph Schlessinger, A. Ullrich Neuron
  13. Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions (1995)
    Sima Lev, Herman Moreno et al. Nature
  14. Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors (1997)
    Moosa Mohammadi, Gerald McMahon et al. Science
  15. Crystal Structure of a Ternary FGF-FGFR-Heparin Complex Reveals a Dual Role for Heparin in FGFR Binding and Dimerization (2000)
    Joseph Schlessinger, A.N. Plotnikov et al. Molecular Cell
  16. Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases (1992)
    Maria Rozakis-Adcock, Jane McGlade et al. Nature
  17. Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation. (1992)
    Jonathan Backer, Martin G. Myers et al. The EMBO Journal
  18. A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation (1996)
    Ivan Đikić, George Tokiwa et al. Nature
  19. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling (1993)
    Andreas Batzer, Roger J. Daly et al. Nature
  20. Catalytic specificity of protein-tyrosine kinases is critical for selective signalling (1995)
    Zhou Songyang, Kermit L. Carraway et al. Nature
  21. Ligand-Induced, Receptor-Mediated Dimerization and Activation of EGF Receptor (2002)
    Joseph Schlessinger Cell
  22. A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway (1997)
    Haruhiko Kouhara, Yaron R. Hadari et al. Cell
  23. EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling (1989)
    Ben Margolis, Sue Goo Rhee et al. Cell
  24. Human Sos1: a Guanine Nucleotide Exchange Factor for Ras that Binds to GRB2 (1993)
    Pierre Teilhard de Chardin, Jacques Camonis et al. Science
  25. Ganglioside-mediated modulation of cell growth. Specific effects of GM3 on tyrosine phosphorylation of the epidermal growth factor receptor. (1986)
    E. Bremer, Joseph Schlessinger et al. Journal of Biological Chemistry
  26. Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases (1991)
    Edward Y. Skolnik, Ben Margolis et al. Cell
  27. Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells (1987)
    Pier Paolo Di Fiore, Jacalyn H. Pierce et al. Cell
  28. Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. (1990)
    Craig A. Dionne, Gregg Crumley et al. The EMBO Journal
  29. Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation (1994)
    Taly R. Spivak-Kroizman, Mark A. Lemmon et al. Cell
  30. BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein (1993)
    Ann Marie Pendergast, Lawrence A. Quilliam et al. Cell
  31. Fibroblast growth factor receptor tyrosine kinases: molecular analysis and signal transduction (1992)
    Michael Jaye, Joseph Schlessinger et al. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  32. Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells (1978)
    Joseph Schlessinger, Yoram Shechter et al. Proceedings of the National Academy of Sciences
  33. The Function of GRB2 in Linking the Insulin Receptor to Ras Signaling Pathways (1993)
    E. Y. Skolnik, Andreas Batzer et al. Science
  34. Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells. (1987)
    Robert M. Hudziak, Joseph Schlessinger et al. Proceedings of the National Academy of Sciences
  35. Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras (1993)
    Nicholas W. Gale, Susan S. Kaplan et al. Nature
  36. Epidermal growth factor induces rapid, reversible aggregation of the purified epidermal growth factor receptor (1987)
    Yosef Yarden, Joseph Schlessinger Biochemistry
  37. Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer. (1990)
    Soonmyoung Paik, Rachel B. Hazan et al. Journal of Clinical Oncology
  38. Dynamics of fluorescence marker concentration as a probe of mobility (1976)
    D E Koppel, Daniel Axelrod et al. Biophysical Journal
  39. The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases (2014)
    Mark A. Lemmon, Joseph Schlessinger et al. Cold Spring Harbor Perspectives in Biology

Immediate Impact

45 by Nobel laureates 96 from Science/Nature 170 standout
Sub-graph 1 of 16

Citing Papers

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7 intermediate papers

Works of Joseph Schlessinger being referenced

Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Transmembrane Signaling by Receptor Oligomerization
2003
and 12 more

Author Peers

Author Last Decade Papers Cites
Joseph Schlessinger 67577 24781 14006 16283 524 95.5k
Tony Hunter 77156 23136 5073 17369 502 103.0k
Lewis C. Cantley 103801 27070 5960 19466 702 148.2k
Judah Folkman 62209 24238 7818 9974 391 103.7k
Kari Alitalo 56192 44972 3807 8583 713 93.0k
Napoleone Ferrara 60705 20350 9438 5756 257 97.7k
Ira Pastan 45198 29761 11570 7493 1.2k 89.2k
Tony Pawson 49380 10872 4503 13014 446 67.8k
Peter Carmeliet 52350 14817 4026 7612 720 98.1k
Axel Ullrich 31993 22787 11771 4538 256 55.1k
Joan Massagué 94714 46583 3627 12573 356 135.6k

All Works

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