Standout Papers

JAKS AND STATS: Biological Implications 1998 2026 2007 2016 1.5k
  1. JAKS AND STATS: Biological Implications (1998)
    Warren J. Leonard, John J. O’Shea Annual Review of Immunology
  2. Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation (2007)
    Arian Laurence, Cristina M. Tato et al. Immunity
  3. The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention (2015)
    John J. O’Shea, Daniella M. Schwartz et al. Annual Review of Medicine
  4. Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4 + T Cells (2010)
    John J. O’Shea, William E. Paul Science
  5. Cytokine Signaling in 2002 (2002)
    John J. O’Shea, Massimo Gadina et al. Cell
  6. Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells (2009)
    Gang Wei, Lai Wei et al. Immunity
  7. JAK inhibition as a therapeutic strategy for immune and inflammatory diseases (2017)
    Daniella M. Schwartz, Yuka Kanno et al. Nature Reviews Drug Discovery
  8. JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease (2012)
    John J. O’Shea, Robert Plenge Immunity
  9. Mechanisms and consequences of Jak–STAT signaling in the immune system (2017)
    Alejandro V. Villarino, Yuka Kanno et al. Nature Immunology
  10. Janus kinases in immune cell signaling (2009)
    Kamran Ghoreschi, Arian Laurence et al. Immunological Reviews
  11. Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome (2008)
    Joshua D. Milner, Jason M. Brenchley et al. Nature
  12. The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17–producing effector T helper cells in vivo (2009)
    Mandy J. McGeachy, Yi Chen et al. Nature Immunology
  13. Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system (2006)
    Jason S. Stumhofer, Arian Laurence et al. Nature Immunology
  14. Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10 (2007)
    Jason S. Stumhofer, Jonathan S. Silver et al. Nature Immunology
  15. JAKs and STATs in Immunity, Immunodeficiency, and Cancer (2013)
    John J. O’Shea, Steven M. Holland et al. New England Journal of Medicine
  16. Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development (1995)
    Sarah M. Russell, Nahid Tayebi et al. Science
  17. T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells (2001)
    David M. Frucht, Dragana Janković et al. Proceedings of the National Academy of Sciences
  18. Cytokine Signaling Modules in Inflammatory Responses (2008)
    John J. O’Shea, Peter J. Murray Immunity
  19. Lymphoid tissue inducer–like cells are an innate source of IL-17 and IL-22 (2008)
    Hiroaki Takatori, Yuka Kanno et al. The Journal of Experimental Medicine
  20. Interaction of IL-2Rβ and γ c Chains with Jak1 and Jak3: Implications for XSCID and XCID (1994)
    Sarah M. Russell, James A. Johnston et al. Science
  21. Diverse Targets of the Transcription Factor STAT3 Contribute to T Cell Pathogenicity and Homeostasis (2010)
    Lydia Durant, Wendy T. Watford et al. Immunity
  22. Alterations in Signal Transduction Molecules in T Lymphocytes from Tumor-Bearing Mice (1992)
    Hiromoto Mizoguchi, John J. O’Shea et al. Science
  23. Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells (2006)
    Zhi Chen, Arian Laurence et al. Proceedings of the National Academy of Sciences
  24. Cytokines and autoimmunity (2002)
    John J. O’Shea, Averil Ma et al. Nature reviews. Immunology
  25. IL-21 Is Produced by Th17 Cells and Drives IL-17 Production in a STAT3-dependent Manner (2007)
    Lai Wei, Arian Laurence et al. Journal of Biological Chemistry
  26. Modulation of Innate and Adaptive Immune Responses by Tofacitinib (CP-690,550) (2011)
    Kamran Ghoreschi, Michael I. Jesson et al. The Journal of Immunology
  27. Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5 (2011)
    Xiang‐Ping Yang, Kamran Ghoreschi et al. Nature Immunology
  28. Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases (2015)
    Daniella M. Schwartz, Michael Bonelli et al. Nature Reviews Rheumatology
  29. Mechanisms of Jak/STAT Signaling in Immunity and Disease (2014)
    Alejandro V. Villarino, Yuka Kanno et al. The Journal of Immunology
  30. Janus kinase inhibitors in autoimmune diseases (2013)
    John J. O’Shea, Apostolos Kontzias et al. Annals of the Rheumatic Diseases
  31. The JAK-STAT pathway at 30: Much learned, much more to do (2022)
    Rachael L. Philips, Yuxin Wang et al. Cell
  32. Janus kinase-targeting therapies in rheumatology: a mechanisms-based approach (2022)
    Yoshiya Tanaka, Yiming Luo et al. Nature Reviews Rheumatology

Immediate Impact

8 by Nobel laureates 60 from Science/Nature 157 standout
Sub-graph 1 of 18

Citing Papers

Fibrosis: from mechanisms to medicines
2020 StandoutNature
PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
2018 StandoutNature
3 intermediate papers

Works of John J. O’Shea being referenced

Gata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis
2019
Inflammasome-Mediated Disease Animal Models Reveal Roles for Innate but Not Adaptive Immunity
2009
and 2 more

Author Peers

Author Last Decade Papers Cites
John J. O’Shea 30779 14988 10988 321 48.8k
Robert M. Strieter 23746 16972 12590 505 56.2k
Shimon Sakaguchi 53058 15276 8763 303 66.9k
Kouji Matsushima 25342 12827 11715 556 48.5k
Vijay K. Kuchroo 58286 20240 12985 424 77.7k
Thomas F. Tedder 26748 6924 7885 342 40.7k
Joost J. Oppenheim 28632 11389 15004 448 53.5k
Stefan Rose‐John 18253 17357 13501 563 47.2k
Marc Feldmann 23651 7826 11157 554 52.9k
Eugene C. Butcher 31675 10154 12306 336 52.9k
Steven L. Kunkel 21415 9731 9559 524 47.5k

All Works

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2026