Standout Papers

The Amyloid Hypothesis of Alzheimer's Disease: Progress and Prob... 1991 2026 2002 2014 10.8k
  1. The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics (2002)
    John Hardy, Dennis J. Selkoe Science
  2. Alzheimer's Disease: The Amyloid Cascade Hypothesis (1992)
    John Hardy, Gerald A. Higgins Science
  3. The amyloid hypothesis of Alzheimer's disease at 25 years (2016)
    Dennis J. Selkoe, John Hardy EMBO Molecular Medicine
  4. Amyloid deposition as the central event in the aetiology of Alzheimer's disease (1991)
    John Hardy, David Allsop Trends in Pharmacological Sciences
  5. Alzheimer's disease (2017)
    Chris Lane, John Hardy et al. European Journal of Neurology
  6. Parkinson's disease (2009)
    Andrew J. Lees, John Hardy et al. The Lancet
  7. Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease (2000)
    Dave Morgan, David M. Diamond et al. Nature
  8. Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP (2001)
    Jada Lewis, Dennis W. Dickson et al. Science
  9. Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1 (1996)
    Karen Duff, Chris Eckman et al. Nature
  10. Amyloid, the presenilins and Alzheimer's disease (1997)
    John Hardy Trends in Neurosciences
  11. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes (1998)
    Leigh A. Holcomb, Marcia N. Gordon et al. Nature Medicine
  12. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein (2000)
    Jada Lewis, Eileen McGowan et al. Nature Genetics
  13. The Amyloid-β Pathway in Alzheimer’s Disease (2021)
    Harald Hampel, John Hardy et al. Molecular Psychiatry
  14. Toxic Proteins in Neurodegenerative Disease (2002)
    J. Paul Taylor, John Hardy et al. Science
  15. Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene (1991)
    Marie‐Christine Chartier‐Harlin, Fiona Crawford et al. Nature
  16. Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo (1996)
    Gopal Thinakaran, David Borchelt et al. Neuron
  17. Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia (2003)
    Eric M. Reiman, Kewei Chen et al. Proceedings of the National Academy of Sciences
  18. Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria (2009)
    Dennis W. Dickson, Heiko Braak et al. The Lancet Neurology
  19. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies (2011)
    Michael A. Nalls, Vincent Plagnol et al. The Lancet
  20. The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal (2009)
    John Hardy Journal of Neurochemistry
  21. Association of an Extended Haplotype in the Tau Gene with Progressive Supranuclear Palsy (1999)
    Mary V. Baker, Irene Litvan et al. Human Molecular Genetics
  22. Green Tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice (2005)
    Kavon Rezai‐Zadeh, Doug Shytle et al. Journal of Neuroscience
  23. Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease (2009)
    José Brás, Emma Deas et al. Brain
  24. The Neuropathology and Neurobiology of Traumatic Brain Injury (2012)
    Kaj Blennow, John Hardy et al. Neuron
  25. APP mouse models for Alzheimer's disease preclinical studies (2017)
    Hiroki Sasaguri, Per Nilsson et al. The EMBO Journal
  26. Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences (2016)
    Claudia Manzoni, Demis A. Kia et al. Briefings in Bioinformatics
  27. Genomewide Association Studies and Human Disease (2009)
    John Hardy, Andrew Singleton New England Journal of Medicine
  28. Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives (2010)
    Harald Hampel, Richard Frank et al. Nature Reviews Drug Discovery
  29. Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains (2012)
    Matthew E. Gegg, Derek Burke et al. Annals of Neurology
  30. Genetic variability in the regulation of gene expression in ten regions of the human brain (2014)
    Adaikalavan Ramasamy, Daniah Trabzuni et al. Nature Neuroscience
  31. A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome (2015)
    Frances K. Wiseman, Tamara Al‐Janabi et al. Nature reviews. Neuroscience
  32. Selective vulnerability in neurodegenerative diseases (2018)
    Hongjun Fu, John Hardy et al. Nature Neuroscience

Immediate Impact

31 by Nobel laureates 94 from Science/Nature 226 standout
Sub-graph 1 of 13

Citing Papers

Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
How neuroinflammation contributes to neurodegeneration
2016 StandoutScience
26 intermediate papers

Works of John Hardy being referenced

The amyloid hypothesis of Alzheimer's disease at 25 years
2016 Standout
Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease
2015
and 38 more

Author Peers

Author Last Decade Papers Cites
John Hardy 34144 48936 21879 871 90.9k
Eliezer Masliah 33703 46485 33392 841 103.4k
Bradley T. Hyman 31994 59624 14577 723 111.3k
Virginia M.‐Y. Lee 33759 47594 43152 666 96.0k
Dennis J. Selkoe 48869 83348 10112 475 113.9k
Mark P. Mattson 50681 51943 9237 948 125.5k
David M. Holtzman 26534 52505 8304 574 96.4k
Dennis W. Dickson 24716 47638 39226 1.2k 100.8k
Colin L. Masters 30676 51387 7477 1.1k 81.0k
Kaj Blennow 32614 64391 23752 2.0k 118.7k
John Q. Trojanowski 45584 68747 58998 1.1k 148.3k

All Works

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