Standout Papers

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activatin... 2006 2026 2012 2019 3.3k
  1. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α (2006)
    Marie Lagouge, Carmen Argmann et al. Cell
  2. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity (2009)
    Carles Cantó, Zachary Gerhart‐Hines et al. Nature
  3. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation (2006)
    Mitsuhiro Watanabe, Sander M. Houten et al. Nature
  4. Sirtuins as regulators of metabolism and healthspan (2012)
    Riekelt H. Houtkooper, Eija Pirinen et al. Nature Reviews Molecular Cell Biology
  5. TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis (2009)
    Charles Thomas, Antimo Gioiello et al. Cell Metabolism
  6. Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism (1998)
    Bart Staels, Jean Dallongeville et al. Circulation
  7. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity (2004)
    Sung Hee Um, Francesca Frigerio et al. Nature
  8. PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure (2009)
    Carles Cantó, Johan Auwerx Current Opinion in Lipidology
  9. Molecular Basis for Feedback Regulation of Bile Acid Synthesis by Nuclear Receptors (2000)
    Timothy T. Lu, Makoto Makishima et al. Molecular Cell
  10. NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus (2015)
    Carles Cantó, Keir J. Menzies et al. Cell Metabolism
  11. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c (2004)
    Mitsuhiro Watanabe, Sander M. Houten et al. Journal of Clinical Investigation
  12. Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase (2011)
    Jintang Du, Yeyun Zhou et al. Science
  13. Targeting bile-acid signalling for metabolic diseases (2008)
    Charles Thomas, Roberto Pellicciari et al. Nature Reviews Drug Discovery
  14. A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity (1998)
    Samir S. Deeb, Lluís Fajas et al. Nature Genetics
  15. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression (1996)
    Kristina Schoonjans, Bart Staels et al. Journal of Lipid Research
  16. Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans (2011)
    Silvie Timmers, Ellen Konings et al. Cell Metabolism
  17. The Organization, Promoter Analysis, and Expression of the Human PPARγ Gene (1997)
    Lluís Fajas, Didier Auboeuf et al. Journal of Biological Chemistry
  18. PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. (1996)
    Kristina Schoonjans, Julia Peinado‐Onsurbe et al. The EMBO Journal
  19. Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis (2011)
    Pablo J. Fernández-Marcos, Johan Auwerx American Journal of Clinical Nutrition
  20. Transient increase in obese gene expression after food intake or insulin administration (1995)
    Régis Saladin, Piet De Vos et al. Nature
  21. The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity (2012)
    Carles Cantó, Riekelt H. Houtkooper et al. Cell Metabolism
  22. The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling (2013)
    Laurent Mouchiroud, Riekelt H. Houtkooper et al. Cell
  23. The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation (1996)
    Kristina Schoonjans, Bart Staels et al. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism
  24. NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice (2016)
    Hongbo Zhang, Dongryeol Ryu et al. Science
  25. Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β (2012)
    Han Cho, Xuan Zhao et al. Nature
  26. International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors (2006)
    Liliane Michalik, Johan Auwerx et al. Pharmacological Reviews
  27. Mitonuclear protein imbalance as a conserved longevity mechanism (2013)
    Riekelt H. Houtkooper, Laurent Mouchiroud et al. Nature
  28. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents (2016)
    Dongryeol Ryu, Laurent Mouchiroud et al. Nature Medicine
  29. Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle (2010)
    Carles Cantó, Lake Q. Jiang et al. Cell Metabolism
  30. The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways (2010)
    Riekelt H. Houtkooper, Carles Cantó et al. Endocrine Reviews
  31. The human leukemia cell line, THP-1: A multifacetted model for the study of monocyte-macrophage differentiation (1991)
    Johan Auwerx Cellular and Molecular Life Sciences
  32. PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation (2011)
    Péter Bai, Carles Cantó et al. Cell Metabolism
  33. Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein (1998)
    Mercedes Ricote, Lluís Fajas et al. Proceedings of the National Academy of Sciences
  34. Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation (2008)
    Jérôme N. Feige, Marie Lagouge et al. Cell Metabolism
  35. Tissue Distribution and Quantification of the Expression of mRNAs of Peroxisome Proliferator–Activated Receptors and Liver X Receptor-α in Humans: No Alteration in Adipose Tissue of Obese and NIDDM Patients (1997)
    Didier Auboeuf, Jennifer Rieusset et al. Diabetes
  36. Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals (2017)
    Pedro M. Quirós, Miguel A. Prado et al. The Journal of Cell Biology
  37. Mitonuclear communication in homeostasis and stress (2016)
    Pedro M. Quirós, Adrienne Mottis et al. Nature Reviews Molecular Cell Biology
  38. Activation of the peroxisome proliferator-activated receptor γ promotes the development of colon tumors in C57BL/6J-APCMin/+ mice (1998)
    Anne‐Marie Lefebvre, Pierre Desreumaux et al. Nature Medicine
  39. Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity (2017)
    Vincenzo Sorrentino, Mario Romani et al. Nature
  40. TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading (2011)
    Thijs W.H. Pols, Mitsunori Nomura et al. Cell Metabolism
  41. Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism (2009)
    Mary‐Elizabeth Patti, Sander M. Houten et al. Obesity
  42. NAD+ homeostasis in health and disease (2020)
    Elena Katsyuba, Mario Romani et al. Nature Metabolism
  43. The gut microbiota influences skeletal muscle mass and function in mice (2019)
    Shawon Lahiri, Hyejin Kim et al. Science Translational Medicine
  44. The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans (2019)
    Pénélope A. Andreux, William Blanco-Bose et al. Nature Metabolism
  45. De novo NAD+ synthesis enhances mitochondrial function and improves health (2018)
    Elena Katsyuba, Adrienne Mottis et al. Nature
  46. Impact of the Natural Compound Urolithin A on Health, Disease, and Aging (2021)
    Davide D’Amico, Pénélope A. Andreux et al. Trends in Molecular Medicine
  47. Mitochondrial Deacetylase Sirt3 Reduces Vascular Dysfunction and Hypertension While Sirt3 Depletion in Essential Hypertension Is Linked to Vascular Inflammation and Oxidative Stress (2019)
    Anna Dikalova, Arvind K. Pandey et al. Circulation Research
  48. Mitophagy in human health, ageing and disease (2023)
    Anna Picca, Julie Faitg et al. Nature Metabolism
  49. Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults (2022)
    Anurag Singh, Davide D’Amico et al. Cell Reports Medicine
  50. Pleiotropic effects of mitochondria in aging (2022)
    Tanes Lima, Terytty Yang Li et al. Nature Aging

Immediate Impact

3 by Nobel laureates 56 from Science/Nature 248 standout
Sub-graph 1 of 15

Citing Papers

De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Bile acid metabolites control TH17 and Treg cell differentiation
2019 StandoutNature
32 intermediate papers

Works of Johan Auwerx being referenced

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading
2011 Standout
Targeting bile-acid signalling for metabolic diseases
2008 Standout
and 49 more

Author Peers

Author Last Decade Papers Cites
Johan Auwerx 50378 29334 19326 632 94.3k
Bruce M. Spiegelman 72203 70072 38538 344 135.0k
C. Ronald Kahn 36433 26211 13383 511 73.3k
Steven P. Gygi 87120 15287 14303 689 119.3k
D. Grahame Hardie 49963 15640 10068 444 69.7k
Mark P. Mattson 50681 51943 7304 948 125.5k
Gerald I. Shulman 48857 44043 28433 614 104.2k
Jerrold M. Olefsky 34169 24518 18710 588 70.4k
Benoı̂t Viollet 26757 9410 10690 340 41.4k
Toren Finkel 29908 11262 7650 211 54.3k
Masayuki Yamamoto 84605 10188 9104 1.3k 117.7k

All Works

Loading papers...

Rankless by CCL
2026