Standout Papers

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastas... 2007 2026 2013 2019 4.2k
  1. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis (2010)
    Rajnish A. Gupta, Nilay Shah et al. Nature
  2. Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position (2013)
    Jason D. Buenrostro, Paul G. Giresi et al. Nature Methods
  3. Molecular Mechanisms of Long Noncoding RNAs (2011)
    Ke Wang, Howard Y. Chang Molecular Cell
  4. Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs (2007)
    John L. Rinn, Michael A. Kertesz et al. Cell
  5. Genome Regulation by Long Noncoding RNAs (2012)
    John L. Rinn, Howard Y. Chang Annual Review of Biochemistry
  6. Unique features of long non-coding RNA biogenesis and function (2015)
    Jeffrey J. Quinn, Howard Y. Chang Nature Reviews Genetics
  7. Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes (2010)
    Miao-Chih Tsai, Ohad Manor et al. Science
  8. Long Noncoding RNAs in Cancer Pathways (2016)
    Adam M. Schmitt, Howard Y. Chang Cancer Cell
  9. Long Noncoding RNAs: Cellular Address Codes in Development and Disease (2013)
    Pedro J. Batista, Howard Y. Chang Cell
  10. ATAC‐seq: A Method for Assaying Chromatin Accessibility Genome‐Wide (2015)
    Jason D. Buenrostro, Beijing Wu et al. Current Protocols in Molecular Biology
  11. Long noncoding RNAs and human disease (2011)
    Orly L. Wapinski, Howard Y. Chang Trends in Cell Biology
  12. A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression (2011)
    Ke Wang, Yul W. Yang et al. Nature
  13. Single-cell chromatin accessibility reveals principles of regulatory variation (2015)
    Jason D. Buenrostro, Beijing Wu et al. Nature
  14. Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions (2011)
    Ci Chu, Kun Qu et al. Molecular Cell
  15. m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells (2014)
    Pedro J. Batista, Benoit Molinié et al. Cell stem cell
  16. SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span (2009)
    Tiara L.A. Kawahara, Eriko Michishita et al. Cell
  17. Diversity, topographic differentiation, and positional memory in human fibroblasts (2002)
    Howard Y. Chang, Jen‐Tsan Chi et al. Proceedings of the National Academy of Sciences
  18. Clonal replacement of tumor-specific T cells following PD-1 blockade (2019)
    Kathryn E. Yost, Ansuman T. Satpathy et al. Nature Medicine
  19. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin (2008)
    Eriko Michishita, Elisabeth Berber et al. Nature
  20. Systematic Discovery of Xist RNA Binding Proteins (2015)
    Ci Chu, Qiangfeng Cliff Zhang et al. Cell
  21. Control of somatic tissue differentiation by the long non-coding RNA TINCR (2012)
    Markus Kretz, Zurab Siprashvili et al. Nature
  22. Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis (1997)
    Xiaolu Yang, Roya Khosravi‐Far et al. Cell
  23. Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival (2005)
    Howard Y. Chang, Dimitry S.A. Nuyten et al. Proceedings of the National Academy of Sciences
  24. Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds (2004)
    Howard Y. Chang, Julie B. Sneddon et al. PLoS Biology
  25. m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways (2017)
    Huabing Li, Jiyu Tong et al. Nature
  26. HiChIP: efficient and sensitive analysis of protein-directed genome architecture (2016)
    Maxwell R. Mumbach, Adam J. Rubin et al. Nature Methods
  27. Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution (2016)
    M. Ryan Corces, Jason D. Buenrostro et al. Nature Genetics
  28. A histone H3 lysine 27 demethylase regulates animal posterior development (2007)
    Fei Lan, Peter Bayliss et al. Nature
  29. Endothelial cell diversity revealed by global expression profiling (2003)
    Jen‐Tsan Chi, Howard Y. Chang et al. Proceedings of the National Academy of Sciences
  30. Genome-wide measurement of RNA secondary structure in yeast (2010)
    Michael A. Kertesz, Yue Wan et al. Nature
  31. Proteases for Cell Suicide: Functions and Regulation of Caspases (2000)
    Howard Y. Chang, Xiaolu Yang Microbiology and Molecular Biology Reviews
  32. Long Intergenic Noncoding RNAs: New Links in Cancer Progression (2011)
    Miao-Chih Tsai, Robert C. Spitale et al. Cancer Research
  33. Structural imprints in vivo decode RNA regulatory mechanisms (2015)
    Robert C. Spitale, Ryan A. Flynn et al. Nature
  34. The NeST Long ncRNA Controls Microbial Susceptibility and Epigenetic Activation of the Interferon-γ Locus (2013)
    Orly L. Wapinski, Yul W. Yang et al. Cell
  35. Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx (1998)
    Howard Y. Chang, Hideki Nishitoh et al. Science
  36. Gene regulation in the immune system by long noncoding RNAs (2017)
    Y. Grace Chen, Ansuman T. Satpathy et al. Nature Immunology
  37. ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis (2021)
    Jeffrey M. Granja, M. Ryan Corces et al. Nature Genetics
  38. CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells (2016)
    Siyuan Liu, Max A. Horlbeck et al. Science
  39. Module Map of Stem Cell Genes Guides Creation of Epithelial Cancer Stem Cells (2008)
    David J. Wong, Helen Liu et al. Cell stem cell
  40. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells (2009)
    Keith Syson Chan, Íñigo Espinosa et al. Proceedings of the National Academy of Sciences
  41. c-Jun overexpression in CAR T cells induces exhaustion resistance (2019)
    Rachel C. Lynn, Evan W. Weber et al. Nature
  42. Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons (2013)
    Orly L. Wapinski, Thomas Vierbuchen et al. Cell
  43. RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure (2016)
    Zhipeng Lu, Qiangfeng Cliff Zhang et al. Cell
  44. Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells (2015)
    Edward J. Grow, Ryan A. Flynn et al. Nature
  45. N6-Methyladenosine Modification Controls Circular RNA Immunity (2019)
    Y. Grace Chen, Robert Chen et al. Molecular Cell
  46. Atlas of Subcellular RNA Localization Revealed by APEX-Seq (2019)
    Furqan M. Fazal, Shuo Han et al. Cell
  47. Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing (2021)
    James K. Nuñez, Chen Jin et al. Cell
  48. Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation (2018)
    Jason D. Buenrostro, M. Ryan Corces et al. Cell
  49. Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen (2020)
    Santosha A. Vardhana, Madeline A. Hwee et al. Nature Immunology
  50. Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons (2011)
    Samuele Marro, Zhiping P. Pang et al. Cell stem cell
  51. Engineering circular RNA for enhanced protein production (2022)
    Robert Chen, Sean K. Wang et al. Nature Biotechnology
  52. Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers (2020)
    Hoon Kim, Nam Nguyen et al. Nature Genetics
  53. Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution (2021)
    Alexandro E. Trevino, Fabian Müller et al. Cell
  54. Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions (2021)
    Ryan A. Flynn, Julia A. Belk et al. Cell
  55. Circular RNA vaccine induces potent T cell responses (2023)
    Laura Amaya, Lilit Grigoryan et al. Proceedings of the National Academy of Sciences

Immediate Impact

11 by Nobel laureates 82 from Science/Nature 211 standout
Sub-graph 1 of 15

Citing Papers

Exploring tissue architecture using spatial transcriptomics
2021 StandoutNature
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
34 intermediate papers

Works of Howard Y. Chang being referenced

irCLIP platform for efficient characterization of protein–RNA interactions
2016
Transcriptome-wide interrogation of RNA secondary structure in living cells with icSHAPE
2016
and 24 more

Author Peers

Author Last Decade Papers Cites
Howard Y. Chang 65015 39776 8202 341 81.5k
Aviv Regev 59947 19997 11070 319 77.9k
Thomas Tuschl 60757 34157 7282 219 74.0k
Pier Paolo Pandolfi 61139 22576 10452 449 79.2k
Benjamin L. Ebert 45494 19006 9213 287 71.1k
Randall S. Johnson 22957 19152 11358 351 51.5k
Phillip A. Sharp 75784 18542 8251 428 91.6k
John L. Rinn 51732 35832 4479 143 63.9k
Nahum Sonenberg 75137 12574 8932 664 94.7k
Gregory J. Hannon 83531 34690 6538 320 103.4k
Scott W. Lowe 49438 16688 8330 324 68.3k

All Works

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2026