Standout Papers

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase 1999 2026 2008 2017 2.6k
  1. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase (1999)
    Heather P. Harding, Yuhong Zhang et al. Nature
  2. An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress (2003)
    Heather P. Harding, Yuhong Zhang et al. Molecular Cell
  3. Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells (2000)
    Heather P. Harding, Isabel Novoa et al. Molecular Cell
  4. Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1 (2000)
    Fumihiko Urano, Xiao-Zhong Wang et al. Science
  5. IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA (2002)
    Marcella A. Calfon, Huiqing Zeng et al. Nature
  6. Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response (2000)
    Anne Bertolotti, Yuhong Zhang et al. Nature Cell Biology
  7. Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response (2000)
    Heather P. Harding, Yuhong Zhang et al. Molecular Cell
  8. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum (2004)
    Stefan J. Marciniak, Chi Young Yun et al. Genes & Development
  9. A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress (2005)
    Michael Boyce, Kevin F. Bryant et al. Science
  10. Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α (2001)
    Isabel Novoa, Huiqing Zeng et al. The Journal of Cell Biology
  11. Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival (2001)
    Heather P. Harding, Huiqing Zeng et al. Molecular Cell
  12. GCN2 Kinase in T Cells Mediates Proliferative Arrest and Anergy Induction in Response to Indoleamine 2,3-Dioxygenase (2005)
    David H. Munn, Madhav Sharma et al. Immunity
  13. Transcriptional and Translational Control in the Mammalian Unfolded Protein Response (2002)
    Heather P. Harding, Marcella A. Calfon et al. Annual Review of Cell and Developmental Biology
  14. Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response (2004)
    Phoebe D. Lu, Heather P. Harding et al. The Journal of Cell Biology
  15. The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages (2003)
    Bo Feng, Pin Mei Yao et al. Nature Cell Biology
  16. Targeting the unfolded protein response in disease (2013)
    Claudio Hetz, Éric Chevet et al. Nature Reviews Drug Discovery
  17. Differential Activation of Peroxisome Proliferator-activated Receptors by Eicosanoids (1995)
    Ker Yu, William Bayona et al. Journal of Biological Chemistry
  18. ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth (2005)
    Meixia Bi, Christine Naczki et al. The EMBO Journal
  19. Translational Repression Mediates Activation of Nuclear Factor Kappa B by Phosphorylated Translation Initiation Factor 2 (2004)
    Jing Deng, Phoebe D. Lu et al. Molecular and Cellular Biology
  20. Role of ERO1-α–mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress–induced apoptosis (2009)
    Gang Li, Marco Mongillo et al. The Journal of Cell Biology
  21. The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule (2012)
    Benedict C. S. Cross, Peter J. Bond et al. Proceedings of the National Academy of Sciences

Immediate Impact

8 by Nobel laureates 70 from Science/Nature 173 standout
Sub-graph 1 of 15

Citing Papers

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173 intermediate papers

Works of Heather P. Harding being referenced

A Selective Inhibitor of eIF2α Dephosphorylation Protects Cells from ER Stress
2005 StandoutScience
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
2004 Standout
and 68 more

Author Peers

Author Last Decade Papers Cites
Heather P. Harding 25369 22068 12490 122 40.3k
David Ron 44731 39939 22019 264 73.4k
Kazutoshi Mori 17468 12161 8331 151 23.0k
Keiji Tanaka 11397 37364 19640 427 54.1k
Ana María Cuervo 13815 20769 29935 251 51.4k
Claudio Hetz 12115 11514 7666 197 23.1k
Michael N. Hall 6600 33837 4838 241 44.2k
Dario R. Alessi 10045 50134 5007 308 64.7k
Yoshinori Ohsumi 17959 28185 40623 259 55.8k
Junying Yuan 8020 35952 10840 251 51.9k
Akitsugu Yamamoto 7838 13986 15129 210 29.1k

All Works

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