Standout Papers

Gene set enrichment analysis: A knowledge-based ap... 1987 2026 2000 2013 32.9k
  1. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles (2005)
    Aravind Subramanian, Pablo Tamayo et al. Proceedings of the National Academy of Sciences
  2. Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring (1999)
    Todd R. Golub, Donna K. Slonim et al. Science
  3. MAPMAKER: An interactive computer package for constructing primary genetic linkage maps of experimental and natural populations (1987)
    Eric S. Lander, Philip Green et al. Genomics
  4. Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome (2009)
    Erez Lieberman-Aiden, Nynke L. van Berkum et al. Science
  5. The Structure of Haplotype Blocks in the Human Genome (2002)
    Stacey Gabriel, S. F. Schaffner et al. Science
  6. A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping (2014)
    Suhas S.P. Rao, Miriam Huntley et al. Cell
  7. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results (1995)
    Eric S. Lander, Leonid Kruglyak Nature Genetics
  8. Development and Applications of CRISPR-Cas9 for Genome Engineering (2014)
    Patrick D. Hsu, Eric S. Lander et al. Cell
  9. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. (1989)
    Eric S. Lander, David Botstein Genetics
  10. A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells (2006)
    B Bernstein, Tarjei S. Mikkelsen et al. Cell
  11. The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease (2006)
    Justin Lamb, Emily Crawford et al. Science
  12. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals (2009)
    Mitchell Guttman, Ido Amit et al. Nature
  13. Genetic Dissection of Complex Traits (1994)
    Eric S. Lander, Nicholas J. Schork Science
  14. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression (2009)
    Ahmad M. Khalil, Mitchell Guttman et al. Proceedings of the National Academy of Sciences
  15. Parametric and nonparametric linkage analysis: a unified multipoint approach. (1996)
    Leonid Kruglyak, Mark J. Daly et al. PubMed
  16. Detecting Novel Associations in Large Data Sets (2011)
    David N. Reshef, Yakir Reshef et al. Science
  17. Discovery and saturation analysis of cancer genes across 21 tumour types (2014)
    Michael S. Lawrence, Petar Stojanov et al. Nature
  18. Reactive oxygen species have a causal role in multiple forms of insulin resistance (2006)
    Nicholas Houstis, Evan D. Rosen et al. Nature
  19. Interpreting patterns of gene expression with self-organizing maps: Methods and application to hematopoietic differentiation (1999)
    Pablo Tamayo, Donna K. Slonim et al. Proceedings of the National Academy of Sciences
  20. Juicer Provides a One-Click System for Analyzing Loop-Resolution Hi-C Experiments (2016)
    Neva C. Durand, Muhammad S. Shamim et al. Cell Systems
  21. Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening (2009)
    Piyush B. Gupta, Tamer T. Önder et al. Cell
  22. Genome-scale DNA methylation maps of pluripotent and differentiated cells (2008)
    Alexander Meissner, Tarjei S. Mikkelsen et al. Nature
  23. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses (2001)
    Arindam Bhattacharjee, William G. Richards et al. Proceedings of the National Academy of Sciences
  24. Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning (2002)
    Margaret A. Shipp, Ken N. Ross et al. Nature Medicine
  25. A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response (2010)
    Maite Huarte, Mitchell Guttman et al. Cell
  26. Gene expression correlates of clinical prostate cancer behavior (2002)
    Dinesh Singh, Phillip G. Febbo et al. Cancer Cell
  27. Transcriptional regulatory code of a eukaryotic genome (2004)
    Christopher Harbison, Tong Ihn Lee et al. Nature
  28. C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector (2016)
    Omar O. Abudayyeh, Jonathan S. Gootenberg et al. Science
  29. Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations (2018)
    Amit V. Khera, Mark Chaffin et al. Nature Genetics
  30. lincRNAs act in the circuitry controlling pluripotency and differentiation (2011)
    Mitchell Guttman, Julie Donaghey et al. Nature
  31. De novo assembly of the Aedes aegypti genome using Hi-C yields chromosome-length scaffolds (2017)
    Olga Dudchenko, Sanjit Singh Batra et al. Science
  32. The Mammalian Epigenome (2007)
    B Bernstein, Alexander Meissner et al. Cell
  33. Dissecting the Regulatory Circuitry of a Eukaryotic Genome (1998)
    Frank C. P. Holstege, Ezra G. Jennings et al. Cell
  34. Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals (2005)
    Xiaohui Xie, Jun Lü et al. Nature
  35. RNA targeting with CRISPR–Cas13 (2017)
    Omar O. Abudayyeh, Jonathan S. Gootenberg et al. Nature
  36. Detecting recent positive selection in the human genome from haplotype structure (2002)
    Pardis C. Sabeti, David Reich et al. Nature
  37. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease (2003)
    Kirk E. Lohmueller, Celeste Leigh Pearce et al. Nature Genetics
  38. A Lentiviral RNAi Library for Human and Mouse Genes Applied to an Arrayed Viral High-Content Screen (2006)
    Jason Moffat, Dorre A. Grueneberg et al. Cell
  39. Sequencing and comparison of yeast species to identify genes and regulatory elements (2003)
    Manolis Kellis, Nick Patterson et al. Nature
  40. Multiclass cancer diagnosis using tumor gene expression signatures (2001)
    Sridhar Ramaswamy, Pablo Tamayo et al. Proceedings of the National Academy of Sciences
  41. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes (2000)
    David Altshuler, Joel N. Hirschhorn et al. Nature Genetics
  42. Characterization of single-nucleotide polymorphisms in coding regions of human genes (1999)
    Michele Cargill, David Altshuler et al. Nature Genetics
  43. Linkage disequilibrium in the human genome (2001)
    David Reich, Michele Cargill et al. Nature
  44. Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways (2008)
    Tamer T. Önder, Piyush B. Gupta et al. Cancer Research
  45. The NIH Roadmap Epigenomics Mapping Consortium (2010)
    B Bernstein, J Stamatoyannopoulos et al. Nature Biotechnology
  46. Genomic analysis of metastasis reveals an essential role for RhoC (2000)
    Edwin Clark, Todd R. Golub et al. Nature
  47. High-resolution haplotype structure in the human genome (2001)
    Mark J. Daly, John D. Rioux et al. Nature Genetics
  48. Juicebox Provides a Visualization System for Hi-C Contact Maps with Unlimited Zoom (2016)
    Neva C. Durand, James Robinson et al. Cell Systems
  49. Genomic Maps and Comparative Analysis of Histone Modifications in Human and Mouse (2005)
    B Bernstein, Michael Kamal et al. Cell
  50. Absolute quantification of somatic DNA alterations in human cancer (2012)
    Scott L. Carter, Kristian Cibulskis et al. Nature Biotechnology
  51. Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes (2015)
    Adrian L. Sanborn, Suhas S.P. Rao et al. Proceedings of the National Academy of Sciences
  52. Dissecting direct reprogramming through integrative genomic analysis (2008)
    Tarjei S. Mikkelsen, Jacob H. Hanna et al. Nature
  53. Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells (2011)
    Piyush B. Gupta, Christine M. Fillmore et al. Cell
  54. The Human Cell Atlas (2017)
    Aviv Regev, Sarah A. Teichmann et al. Zurich Open Repository and Archive (University of Zurich)
  55. Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae (2004)
    Manolis Kellis, Bruce W. Birren et al. Nature
  56. Remodeling of Yeast Genome Expression in Response to Environmental Changes (2001)
    Helen C. Causton, Bing Ren et al. Molecular Biology of the Cell
  57. Identification and characterization of essential genes in the human genome (2015)
    Timothy C. Wang, Kıvanç Birsoy et al. Science
  58. High-quality draft assemblies of mammalian genomes from massively parallel sequence data (2010)
    Sante Gnerre, Iain MacCallum et al. Proceedings of the National Academy of Sciences
  59. The mystery of missing heritability: Genetic interactions create phantom heritability (2012)
    Or Zuk, Eliana Hechter et al. Proceedings of the National Academy of Sciences
  60. A genetic map of the mouse suitable for typing intraspecific crosses. (1992)
    William F. Dietrich, H Katz et al. Genetics
  61. Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing (2009)
    Andreas Gnirke, Alexandre Melnikov et al. Nature Biotechnology
  62. Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites (2014)
    Schraga Schwartz, Maxwell R. Mumbach et al. Cell Reports
  63. Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens (2016)
    Atray Dixit, Oren Parnas et al. Cell
  64. Ab initio reconstruction of cell type–specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs (2010)
    Mitchell Guttman, Manuel Garber et al. Nature Biotechnology
  65. Local regulation of gene expression by lncRNA promoters, transcription and splicing (2016)
    J Engreitz, Jenna E. Haines et al. Nature
  66. Genetic Mapping in Human Disease (2008)
    David Altshuler, Mark J. Daly et al. Science
  67. Lessons from the Cancer Genome (2013)
    Levi A. Garraway, Eric S. Lander Cell
  68. Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia (2002)
    Adolfo A. Ferrando, Donna Neuberg et al. Cancer Cell
  69. The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3 (2015)
    Colleen A. McHugh, Chun‐Kan Chen et al. Nature
  70. Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes (2010)
    Joseph H. Taube, Jason I. Herschkowitz et al. Proceedings of the National Academy of Sciences
  71. Positive Natural Selection in the Human Lineage (2006)
    Pardis C. Sabeti, S. F. Schaffner et al. Science
  72. The New Genomics: Global Views of Biology (1996)
    Eric S. Lander Science
  73. Genomewide Analysis of PRC1 and PRC2 Occupancy Identifies Two Classes of Bivalent Domains (2008)
    Manching Ku, Richard P. Koche et al. PLoS Genetics
  74. Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA (2014)
    Schraga Schwartz, Douglas A. Bernstein et al. Cell
  75. Complete multipoint sib-pair analysis of qualitative and quantitative traits. (1995)
    Leonid Kruglyak, Eric S. Lander PubMed
  76. Integrated Analysis of Protein Composition, Tissue Diversity, and Gene Regulation in Mouse Mitochondria (2003)
    Vamsi K. Mootha, Jakob Bunkenborg et al. Cell
  77. Mendelian factors underlying quantitative traits in tomato: comparison across species, generations, and environments. (1991)
    Andrew H. Paterson, John D. Hewitt et al. Genetics
  78. Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability (2016)
    Moran Yassour, Tommi Vatanen et al. Science Translational Medicine
  79. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion (2000)
    Hilary A. Coller, Carla Grandori et al. Proceedings of the National Academy of Sciences
  80. Identification of genetic factors contributing to heterosis in a hybrid from two elite maize inbred lines using molecular markers. (1992)
    C. W. Stuber, Stephen E. Lincoln et al. Genetics
  81. Homozygosity Mapping: A Way to Map Human Recessive Traits with the DNA of Inbred Children (1987)
    Eric S. Lander, David Botstein Science
  82. Initial impact of the sequencing of the human genome (2011)
    Eric S. Lander Nature
  83. Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat (1991)
    Howard J. Jacob, Klaus Lindpaintner et al. Cell
  84. Errα and Gabpa/b specify PGC-1α-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle (2004)
    Vamsi K. Mootha, Christoph Handschin et al. Proceedings of the National Academy of Sciences
  85. Assessing the impact of population stratification on genetic association studies (2004)
    Matthew L. Freedman, David Reich et al. Nature Genetics
  86. An SNP map of the human genome generated by reduced representation shotgun sequencing (2000)
    David Altshuler, Jennifer Baldwin et al. Nature
  87. ALLPATHS: De novo assembly of whole-genome shotgun microreads (2008)
    Jonathan A. Butler, Iain MacCallum et al. Genome Research
  88. Ploidy Regulation of Gene Expression (1999)
    Timothy Galitski, Alok J. Saldanha et al. Science
  89. Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre (2014)
    Ezgi Hacisuleyman, Loyal A. Goff et al. Nature Structural & Molecular Biology
  90. A Composite of Multiple Signals Distinguishes Causal Variants in Regions of Positive Selection (2010)
    Sharon R. Grossman, Elinor K. Karlsson et al. Science

Immediate Impact

66 by Nobel laureates 93 from Science/Nature 221 standout
Sub-graph 1 of 17

Citing Papers

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
65 intermediate papers

Works of Eric S. Lander being referenced

RNA targeting with CRISPR–Cas13
2017 StandoutNature
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
2016 StandoutScience
and 22 more

Author Peers

Author Last Decade Papers Cites
Eric S. Lander 140597 51048 34056 394 214.1k
David Botstein 106977 27481 22439 413 156.4k
Gordon K. Smyth 68030 12841 20147 333 118.5k
Bert Vogelstein 133033 28497 56218 546 226.9k
Steven L. Salzberg 106489 24093 18460 233 174.6k
Matthias Mann 148683 11805 14084 837 211.4k
Peer Bork 93864 14899 9279 510 140.1k
Wolfgang Huber 64845 12160 14172 228 105.3k
Patrick O. Brown 82551 14464 24176 266 117.1k
Douglas Hanahan 78402 13213 35907 224 134.4k
David Baltimore 75494 18597 32214 701 140.0k

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