Standout Papers

NLRP3 inflammasomes are required for atherogenesis and activated b... 2003 2026 2010 2018 3.0k
  1. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals (2010)
    Peter Duewell, Hajime Kono et al. Nature
  2. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization (2008)
    Veit Hornung, Franz Bauernfeind et al. Nature Immunology
  3. Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression (2009)
    Franz Bauernfeind, Gábor Horváth et al. The Journal of Immunology
  4. Activation and regulation of the inflammasomes (2013)
    Eicke Latz, Tsan Sam Xiao et al. Nature reviews. Immunology
  5. IKKε and TBK1 are essential components of the IRF3 signaling pathway (2003)
    Katherine A. Fitzgerald, Sarah M. McWhirter et al. Nature Immunology
  6. NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice (2012)
    Michael T. Heneka, Markus P. Kummer et al. Nature
  7. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC (2009)
    Veit Hornung, Andrea Ablasser et al. Nature
  8. The NALP3 inflammasome is involved in the innate immune response to amyloid-β (2008)
    Annett Halle, Veit Hornung et al. Nature Immunology
  9. Trained immunity: A program of innate immune memory in health and disease (2016)
    Mihai G. Netea, Leo A. B. Joosten et al. Science
  10. Defining trained immunity and its role in health and disease (2020)
    Mihai G. Netea, Jorge Domínguez‐Andrés et al. Nature reviews. Immunology
  11. Targeting the NLRP3 inflammasome in inflammatory diseases (2018)
    Matthew Mangan, Edward J. Olhava et al. Nature Reviews Drug Discovery
  12. Necroptosis, pyroptosis and apoptosis: an intricate game of cell death (2021)
    Damien Bertheloot, Eicke Latz et al. Cellular and Molecular Immunology
  13. IFI16 is an innate immune sensor for intracellular DNA (2010)
    Leonie Unterholzner, Sinéad E. Keating et al. Nature Immunology
  14. TLR9 signals after translocating from the ER to CpG DNA in the lysosome (2004)
    Eicke Latz, Alberto Visintin et al. Nature Immunology
  15. Innate immune activation in neurodegenerative disease (2014)
    Michael T. Heneka, Markus P. Kummer et al. Nature reviews. Immunology
  16. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses (2010)
    Vijay Rathinam, Zhaozhao Jiang et al. Nature Immunology
  17. LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF (2003)
    Katherine A. Fitzgerald, Daniel C. Rowe et al. The Journal of Experimental Medicine
  18. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome (2010)
    Christian Bauer, Peter Duewell et al. Gut
  19. CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation (2013)
    Frederick J. Sheedy, Alena Grebe et al. Nature Immunology
  20. Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling (2015)
    Maayan Levy, Christoph A. Thaiss et al. Cell
  21. Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease (2017)
    Carmen Venegas, Sathish Kumar et al. Nature
  22. RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate (2009)
    Andrea Ablasser, Franz Bauernfeind et al. Nature Immunology
  23. HMGB1 SIGNALS THROUGH TOLL-LIKE RECEPTOR (TLR) 4 AND TLR2 (2006)
    Man Yu, Haichao Wang et al. Shock
  24. The Sterile Inflammatory Response (2010)
    Kenneth L. Rock, Eicke Latz et al. Annual Review of Immunology
  25. Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9 (2005)
    Terry K. Means, Eicke Latz et al. Journal of Clinical Investigation
  26. NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis (2018)
    Alena Grebe, Florian Hoß et al. Circulation Research
  27. Innate immunity in Alzheimer's disease (2015)
    Michael T. Heneka, Douglas T. Golenbock et al. Nature Immunology
  28. Inflammasome signalling in brain function and neurodegenerative disease (2018)
    Michael T. Heneka, Róisín M. McManus et al. Nature reviews. Neuroscience
  29. Human Cytomegalovirus Activates Inflammatory Cytokine Responses via CD14 and Toll-Like Receptor 2 (2003)
    Teresa Compton, Evelyn A. Kurt‐Jones et al. Journal of Virology
  30. Western Diet and the Immune System: An Inflammatory Connection (2019)
    Anette Christ, Mario Lauterbach et al. Immunity
  31. Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome (2010)
    Christine A. Juliana, Teresa Fernandes‐Alnemri et al. Journal of Biological Chemistry
  32. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP (2013)
    Andrea Ablasser, Jonathan L. Schmid‐Burgk et al. Nature
  33. The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3 (2017)
    Moritz M. Gaidt, Thomas S. Ebert et al. Cell
  34. HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins (2016)
    Damien Bertheloot, Eicke Latz Cellular and Molecular Immunology
  35. Microglia jointly degrade fibrillar alpha-synuclein cargo by distribution through tunneling nanotubes (2021)
    Hannah Scheiblich, Cira Dansokho et al. Cell
  36. Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3 (2022)
    Inga V. Hochheiser, Michael Pilsl et al. Nature

Immediate Impact

18 by Nobel laureates 147 from Science/Nature 424 standout
Sub-graph 1 of 12

Citing Papers

SARS-CoV-2 is associated with changes in brain structure in UK Biobank
2022 StandoutNature
The changing landscape of atherosclerosis
2021 StandoutNature
14 intermediate papers

Works of Eicke Latz being referenced

Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
2010 StandoutNature
and 9 more

Author Peers

Author Last Decade Papers Cites
Eicke Latz 31007 31605 8780 278 59.6k
Katherine A. Fitzgerald 39041 37056 12136 331 67.9k
Jürg Tschopp 42911 51322 11729 282 86.1k
Luke O'neill 31895 23194 8150 380 59.7k
Anthony Cerami 20595 18668 10646 513 75.8k
Gabriel Núñez 33855 47173 10577 407 83.1k
Siamon Gordon 40753 21755 10477 453 76.9k
Thirumala‐Devi Kanneganti 20907 31105 7220 331 46.2k
Douglas T. Golenbock 30420 14972 10569 287 50.3k
Charles A. Dinarello 46442 36261 15647 864 106.0k
Peter A. Ward 22913 13693 8196 685 52.3k

All Works

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2026