Standout Papers

Therapeutic potential of resveratrol: the in vivo evidence 2003 2026 2010 2018 3.1k
  1. Therapeutic potential of resveratrol: the in vivo evidence (2006)
    Joseph A. Baur, David Sinclair Nature Reviews Drug Discovery
  2. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan (2003)
    Konrad T. Howitz, Kevin J. Bitterman et al. Nature
  3. Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase (2004)
    Anne Brunet, Lora B. Sweeney et al. Science
  4. Mammalian Sirtuins: Biological Insights and Disease Relevance (2010)
    Marcia C. Haigis, David Sinclair Annual Review of Pathology Mechanisms of Disease
  5. Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase (2004)
    Haim Cohen, Christine Miller et al. Science
  6. Sirtuin activators mimic caloric restriction and delay ageing in metazoans (2004)
    Jason G. Wood, Blanka Rogina et al. Nature
  7. Sirtuins in mammals: insights into their biological function (2007)
    Shaday Michán, David Sinclair Biochemical Journal
  8. Extrachromosomal rDNA Circles— A Cause of Aging in Yeast (1997)
    David Sinclair, Leonard Guarente Cell
  9. Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging (2013)
    Ana P. Gomes, Nathan L. Price et al. Cell
  10. The Intersection Between Aging and Cardiovascular Disease (2012)
    Brian J. North, David Sinclair Circulation Research
  11. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis (2007)
    Do‐Hoon Kim, Minh Dang Nguyen et al. The EMBO Journal
  12. Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1 (2002)
    Kevin J. Bitterman, Rozalyn M. Anderson et al. Journal of Biological Chemistry
  13. Nutrient-Sensitive Mitochondrial NAD+ Levels Dictate Cell Survival (2007)
    Hongying Yang, Tianle Yang et al. Cell
  14. Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice (2010)
    Richard A. Miller, Randy Strong et al. The Journals of Gerontology Series A
  15. The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice (2014)
    Samantha M. Solon‐Biet, Aisling C. McMahon et al. Cell Metabolism
  16. Molecular Biology of Aging (1999)
    F. Brad Johnson, David Sinclair et al. Cell
  17. Why does COVID-19 disproportionately affect older people? (2020)
    Amber L. Mueller, Maeve S. McNamara et al. Aging
  18. SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging (2008)
    Philipp Oberdoerffer, Shaday Michán et al. Cell
  19. Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds (2016)
    Michael S. Bonkowski, David Sinclair Nature Reviews Molecular Cell Biology
  20. Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence (2018)
    Luis A. Rajman, Karolina Chwalek et al. Cell Metabolism
  21. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae (2003)
    Rozalyn M. Anderson, Kevin J. Bitterman et al. Nature
  22. Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism (2012)
    Rubén Nogueiras, Kirk M. Habegger et al. Physiological Reviews
  23. Mitochondrial and metabolic dysfunction in ageing and age-related diseases (2022)
    João A. Amorim, Giuseppe Coppotelli et al. Nature Reviews Endocrinology
  24. NAD+ in Brain Aging and Neurodegenerative Disorders (2019)
    Sofie Lautrup, David Sinclair et al. Cell Metabolism
  25. Small molecule SIRT1 activators for the treatment of aging and age-related diseases (2014)
    Basil P. Hubbard, David Sinclair Trends in Pharmacological Sciences
  26. Sirtuin activators and inhibitors: Promises, achievements, and challenges (2018)
    Han Dai, David Sinclair et al. Pharmacology & Therapeutics
  27. Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases (2018)
    Alice E. Kane, David Sinclair Circulation Research
  28. Human trials exploring anti-aging medicines (2024)
    Leonard Guarente, David Sinclair et al. Cell Metabolism

Immediate Impact

13 by Nobel laureates 100 from Science/Nature 292 standout
Sub-graph 1 of 9

Citing Papers

The central role of DNA damage in the ageing process
2021 StandoutNature
From discoveries in ageing research to therapeutics for healthy ageing
2019 StandoutNature
307 intermediate papers

Works of David Sinclair being referenced

Sirtuins and NAD + in the Development and Treatment of Metabolic and Cardiovascular Diseases
2018 Standout
Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase
2004 StandoutScience
and 63 more

Author Peers

Author Last Decade Papers Cites
David Sinclair 19099 17569 13207 356 45.6k
Eric Verdin 24476 10594 10713 275 46.5k
Claudio Franceschi 23205 2752 15796 802 60.2k
Vilhelm A. Bohr 29665 2739 7819 536 40.8k
Manuel Serrano 30375 2841 15694 268 50.9k
Judith Campisi 32391 1846 27471 320 63.9k
Ronald A. DePinho 55409 1819 16273 416 84.9k
Kenneth Walsh 27962 1123 12861 456 53.0k
Clary B. Clish 22738 1329 8367 372 38.7k
Joshua D. Rabinowitz 30191 1117 4770 322 47.5k
Steve Horvath 42656 831 7250 437 67.8k

All Works

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2026