Standout Papers

The capsaicin receptor: a heat-activated ion channel in the pain pathway 1997 2026 2006 2016 7.0k
  1. The capsaicin receptor: a heat-activated ion channel in the pain pathway (1997)
    Michael J. Caterina, Mark Schumacher et al. Nature
  2. Cellular and Molecular Mechanisms of Pain (2009)
    Allan I. Basbaum, Diana M. Bautista et al. Cell
  3. Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor (2000)
    Michael J. Caterina, Andreas Leffler et al. Science
  4. The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli (1998)
    Makoto Tominaga, Michael J. Caterina et al. Neuron
  5. Identification of a cold receptor reveals a general role for TRP channels in thermosensation (2002)
    David D. McKemy, Werner Neuhausser et al. Nature
  6. Molecular mechanisms of nociception (2001)
    David Julius, Allan I. Basbaum Nature
  7. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide (1999)
    Peter M. Zygmunt, Jesper Petersson et al. Nature
  8. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1 (2004)
    Sven‐Eric Jordt, Diana M. Bautista et al. Nature
  9. TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents (2006)
    Diana M. Bautista, S.E. Jordt et al. Cell
  10. Structure of the TRPV1 ion channel determined by electron cryo-microscopy (2013)
    Maofu Liao, Erhu Cao et al. Nature
  11. A capsaicin-receptor homologue with a high threshold for noxious heat (1999)
    Michael J. Caterina, Makoto Tominaga et al. Nature
  12. The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway (2001)
    Michael J. Caterina, David Julius Annual Review of Neuroscience
  13. The P2Y12 receptor regulates microglial activation by extracellular nucleotides (2006)
    Gunther Hollopeter, Guang Yang et al. Nature Neuroscience
  14. Identification of the platelet ADP receptor targeted by antithrombotic drugs (2001)
    Gunther Hollopeter, Hans‐Michael Jantzen et al. Nature
  15. TRPA1 mediates formalin-induced pain (2007)
    Diana M. Bautista, Jan Siemens et al. Proceedings of the National Academy of Sciences
  16. The menthol receptor TRPM8 is the principal detector of environmental cold (2007)
    Diana M. Bautista, Jan Siemens et al. Nature
  17. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition (2001)
    Huai-hu Chuang, Haeyoung Kong et al. Nature
  18. Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors (1995)
    Laurence H. Tecott, Susan F. Akana et al. Nature
  19. TRP Channels and Pain (2013)
    David Julius Annual Review of Cell and Developmental Biology
  20. New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor (1994)
    Anthony J. Brake, Michael Wagenbach et al. Nature
  21. TRPV1 structures in distinct conformations reveal activation mechanisms (2013)
    Erhu Cao, Maofu Liao et al. Nature
  22. Primary Structure And Functional Expression of the 5HT 3 Receptor, A Serotonin-gated Ion Channel (1991)
    Andres V. Maricq, Andrew S. Peterson et al. Science
  23. Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers (2002)
    Sven‐Eric Jordt, David Julius Cell
  24. TRP channel activation by reversible covalent modification (2006)
    A. Scott Hinman, Huai-hu Chuang et al. Proceedings of the National Academy of Sciences
  25. Pungent products from garlic activate the sensory ion channel TRPA1 (2005)
    Diana M. Bautista, Pouya Movahed et al. Proceedings of the National Academy of Sciences
  26. TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action (2016)
    Yuan Gao, Erhu Cao et al. Nature
  27. Substitution of three amino acids switches receptor specificity of Gqα to that of Giα (1993)
    Bruce R. Conklin, Zvi Farfel et al. Nature
  28. Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways (2017)
    Nicholas W. Bellono, James R. Bayrer et al. Cell
  29. Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor (1984)
    David Julius, Anthony J. Brake et al. Cell
  30. 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1 (2007)
    Marcello Trevisani, Jan Siemens et al. Proceedings of the National Academy of Sciences
  31. Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor (1988)
    David Julius, Amy B. MacDermott et al. Science
  32. Acid potentiation of the capsaicin receptor determined by a key extracellular site (2000)
    Sven‐Eric Jordt, Makoto Tominaga et al. Proceedings of the National Academy of Sciences
  33. Structure of the TRPA1 ion channel suggests regulatory mechanisms (2015)
    Candice E. Paulsen, Jean‐Paul Armache et al. Nature
  34. Expression cloning of an ATP receptor from mouse neuroblastoma cells. (1993)
    Kevin D. Lustig, Andrew K. Shiau et al. Proceedings of the National Academy of Sciences
  35. A Modular PIP 2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity (2003)
    David Julius et al. Science
  36. Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells (2011)
    Daniel J. Cavanaugh, Alexander T. Chesler et al. Journal of Neuroscience
  37. Glycosylation and processing of prepro-α-factor through the yeast secretory pathway (1984)
    David Julius, Randy Schekman et al. Cell
  38. Yeast α factor is processed from a larger precursor polypeptide: The essential role of a membrane-bound dipeptidyl aminopeptidase (1983)
    David Julius, Lindley C. Blair et al. Cell
  39. Molecular basis of infrared detection by snakes (2010)
    Elena O. Gracheva, Nicholas T. Ingolia et al. Nature
  40. International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels (2005)
    David E. Clapham, David Julius et al. Pharmacological Reviews
  41. Ectopic Expression of the Serotonin 1c Receptor and the Triggering of Malignant Transformation (1989)
    David Julius, Thomas M. Jessell et al. Science
  42. A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain (2011)
    Christopher J. Bohlen, Alexander T. Chesler et al. Nature
  43. TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids (2013)
    Erhu Cao, Julio F. Cordero-Morales et al. Neuron
  44. X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel (2014)
    Isabelle Baconguis, Christopher J. Bohlen et al. Cell
  45. Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain (2016)
    Jeremiah D. Osteen, Volker Herzig et al. Nature
  46. Structure of the human TRPM4 ion channel in a lipid nanodisc (2017)
    Henriette Elisabeth Autzen, Alexander Myasnikov et al. Science
  47. Structural snapshots of TRPV1 reveal mechanism of polymodal functionality (2021)
    Kaihua Zhang, David Julius et al. Cell
  48. Irritant-evoked activation and calcium modulation of the TRPA1 receptor (2020)
    Jianhua Zhao, John V. Lin King et al. Nature
  49. Gut enterochromaffin cells drive visceral pain and anxiety (2023)
    James R. Bayrer, Joel Castro et al. Nature

Immediate Impact

42 by Nobel laureates 63 from Science/Nature 106 standout
Sub-graph 1 of 15

Citing Papers

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Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
39 intermediate papers

Works of David Julius being referenced

Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNature
A Yeast Genetic Screen Reveals a Critical Role for the Pore Helix Domain in TRP Channel Gating
2008
and 25 more

Author Peers

Author Last Decade Papers Cites
David Julius 26675 17574 18092 17735 136 54.8k
David E. Clapham 12371 32626 16806 5409 320 56.4k
Makoto Tominaga 16677 7677 7635 10025 396 30.0k
Bernd Nilius 19522 16063 9031 6181 406 35.8k
Allan I. Basbaum 10575 11528 20815 26254 293 45.2k
Michael J. Caterina 15122 5918 7192 9457 94 23.7k
Ardem Patapoutian 13017 12270 8719 13577 111 32.1k
Michael J. Berridge 7060 41817 19000 7633 196 64.9k
Jon D. Levine 8011 8986 11430 19057 579 35.6k
Clifford J. Woolf 5786 15120 22845 38459 375 67.7k
Thomas Voets 13078 9226 6026 3798 244 22.4k

All Works

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