Clifford J. Woolf

97.8k total citations · 37 hit papers
379 papers, 69.4k citations indexed

About

Clifford J. Woolf is a scholar working on Physiology, Cellular and Molecular Neuroscience and Molecular Biology. According to data from OpenAlex, Clifford J. Woolf has authored 379 papers receiving a total of 69.4k indexed citations (citations by other indexed papers that have themselves been cited), including 242 papers in Physiology, 186 papers in Cellular and Molecular Neuroscience and 120 papers in Molecular Biology. Recurrent topics in Clifford J. Woolf's work include Pain Mechanisms and Treatments (221 papers), Nerve injury and regeneration (75 papers) and Neuropeptides and Animal Physiology (65 papers). Clifford J. Woolf is often cited by papers focused on Pain Mechanisms and Treatments (221 papers), Nerve injury and regeneration (75 papers) and Neuropeptides and Animal Physiology (65 papers). Clifford J. Woolf collaborates with scholars based in United States, United Kingdom and Germany. Clifford J. Woolf's co-authors include Joachim Scholz, Ru‐Rong Ji, Alban Latrémolière, Michael W. Salter, Isabelle Décosterd, Michael Costigan, Richard Mannion, Henrik Kehlet, Troels S. Jensen and Steve Thompson and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Clifford J. Woolf

375 papers receiving 67.7k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Central sensitization: Implications for the diagnosis and treatment of pain

2010 3.2k citations Clifford J. Woolf Pain profile →
Neuronal Plasticity: Increasing the Gain in Pain

2000 2.9k citations Clifford J. Woolf et al. profile →
Persistent postsurgical pain: risk factors and prevention

2006 2.8k citations Henrik Kehlet, Troels S. Jensen et al. The Lancet profile →
Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

2009 2.7k citations Alban Latrémolière, Clifford J. Woolf Journal of Pain profile →
Spared nerve injury: an animal model of persistent peripheral neuropathic pain

2000 1.8k citations Clifford J. Woolf et al. Pain profile →
Neuropathic pain: aetiology, symptoms, mechanisms, and management

1999 1.6k citations Clifford J. Woolf, Richard Mannion The Lancet profile →
Evidence for a central component of post-injury pain hypersensitivity

1983 1.6k citations Clifford J. Woolf Nature profile →
The induction and maintenance of central sensitization is dependent on N -methyl-d-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states

1991 1.6k citations Clifford J. Woolf et al. Pain profile →
Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage

2009 1.5k citations Michael Costigan, Clifford J. Woolf et al. profile →
The neuropathic pain triad: neurons, immune cells and glia

2007 1.4k citations Clifford J. Woolf et al. Nature Neuroscience profile →
Preemptive Analgesia—Treating Postoperative Pain by Preventing the Establishment of Central Sensitization

1993 1.3k citations Clifford J. Woolf et al. profile →
Central sensitization and LTP: do pain and memory share similar mechanisms?

2003 1.1k citations Ru‐Rong Ji, Clifford J. Woolf et al. profile →
Interleukin-1β-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity

2001 1.0k citations Clifford J. Woolf et al. Nature profile →
TRPA1 Contributes to Cold, Mechanical, and Chemical Nociception but Is Not Essential for Hair-Cell Transduction

2006 1.0k citations Clifford J. Woolf et al. Neuron profile →
p38 MAPK Activation by NGF in Primary Sensory Neurons after Inflammation Increases TRPV1 Levels and Maintains Heat Hyperalgesia

2002 1.0k citations Ru‐Rong Ji, Clifford J. Woolf et al. Neuron profile →
A three-dimensional human neural cell culture model of Alzheimer’s disease

2014 879 citations Seungkyu Lee, Brian J. Wainger et al. Nature profile →
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

2006 811 citations Jason Campagna, Clifford J. Woolf et al. profile →
Pain: Moving from Symptom Control toward Mechanism-Specific Pharmacologic Management

2004 771 citations Clifford J. Woolf profile →
p38 Mitogen-Activated Protein Kinase Is Activated after a Spinal Nerve Ligation in Spinal Cord Microglia and Dorsal Root Ganglion Neurons and Contributes to the Generation of Neuropathic Pain

2003 725 citations Clifford J. Woolf, Ru‐Rong Ji et al. Journal of Neuroscience profile →
Nociceptors—Noxious Stimulus Detectors

2007 719 citations Clifford J. Woolf, Qiufu Ma Neuron profile →
Bacteria activate sensory neurons that modulate pain and inflammation

2013 675 citations Isaac M. Chiu, Nader Ghasemlou et al. Nature profile →
Partial Peripheral Nerve Injury Promotes a Selective Loss of GABAergic Inhibition in the Superficial Dorsal Horn of the Spinal Cord

2002 667 citations Clifford J. Woolf et al. Journal of Neuroscience profile →
ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model

2005 655 citations Clifford J. Woolf, Ru‐Rong Ji et al. Pain profile →
Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity

1999 650 citations Ru‐Rong Ji, Clifford J. Woolf et al. Nature Neuroscience profile →
Can we conquer pain?

2002 637 citations Clifford J. Woolf et al. Nature Neuroscience profile →
Neuronal Plasticity and Signal Transduction in Nociceptive Neurons: Implications for the Initiation and Maintenance of Pathological Pain

2001 593 citations Ru‐Rong Ji, Clifford J. Woolf profile →
Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity

1994 562 citations Clifford J. Woolf et al. profile →
Nociceptors Are Interleukin-1β Sensors

2008 559 citations Alexander M. Binshtok, Ru‐Rong Ji et al. Journal of Neuroscience profile →
Cytokines, nerve growth factor and inflammatory hyperalgesia: the contribution of tumour necrosis factor α

1997 552 citations Clifford J. Woolf et al. profile →
Regeneration of Dorsal Column Fibers into and beyond the Lesion Site following Adult Spinal Cord Injury

1999 520 citations Clifford J. Woolf et al. Neuron profile →
Transient receptor potential channels: targeting pain at the source

2008 520 citations Simon Tate, Clifford J. Woolf et al. profile →
Contribution of interleukin‐1β to the inflammation‐induced increase in nerve growth factor levels and inflammatory hyperalgesia

1995 508 citations Clifford J. Woolf et al. profile →
Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons

2011 508 citations Justin K. Ichida, Brian J. Wainger et al. profile →
Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology

2012 492 citations Isaac M. Chiu, Clifford J. Woolf et al. Nature Neuroscience profile →
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair

2019 345 citations Kuchuan Chen, Brian J. Wainger et al. Nature Neuroscience profile →
Transcriptional Reprogramming of Distinct Peripheral Sensory Neuron Subtypes after Axonal Injury

2020 298 citations Clifford J. Woolf et al. Neuron profile →
TRPA1 Contributes to Cold Hypersensitivity

2010 235 citations Lee Barrett, Michael Costigan et al. Journal of Neuroscience profile →

Peers

Countries citing papers authored by Clifford J. Woolf

Since Specialization

Citations

This map shows the geographic impact of Clifford J. Woolf's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Clifford J. Woolf with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Clifford J. Woolf more than expected).

Fields of papers citing papers by Clifford J. Woolf

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Clifford J. Woolf. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Clifford J. Woolf. The network helps show where Clifford J. Woolf may publish in the future.

Co-authorship network of co-authors of Clifford J. Woolf

This figure shows the co-authorship network connecting the top 25 collaborators of Clifford J. Woolf. A scholar is included among the top collaborators of Clifford J. Woolf based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Clifford J. Woolf. Clifford J. Woolf is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Age-dependent small fiber neuropathy: Mechanistic insights from animal models 2024 ·Experimental Neurology ·Daniel G. Taub, Clifford J. Woolf	1
2	Identification of novel neuroprotectants against vincristine-induced neurotoxicity in iPSC-derived neurons 2024 ·Cellular and Molecular Life Sciences ·Veselina Petrova, (unknown), (unknown), (unknown), Bhagat Singh, (unknown), Kuchuan Chen, (unknown), (unknown), Lee Barrett, Jennifer A. Smith, Clifford J. Woolf	0
3	β-Endorphin mediates radiation therapy fatigue 2022 ·Science Advances ·(unknown), Gillian L. Fell, Lajos V. Kemény, Claire Y. Fung, Kathryn D. Held, Peter J. Biggs, Phillip D. Rivera, Staci D. Bilbo, Vivien Igras, Henning Willers, Jong Kung, Liliana Gheorghiu, Katalin Hidéghety, Jianren Mao, Clifford J. Woolf, David E. Fisher	7
4	Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer 2022 ·Science Translational Medicine ·Shane J. F. Cronin, Shuan Rao, Miguel Á. Tejada, Bruna Lenfers Turnes, (unknown), Takao Omura, Christian Brenneis, (unknown), Lee Barrett, Alban Latrémolière, Nick Andrews, Keith M. Channon, Alexandra Latini, Anthony C. Arvanites, Lance S. Davidow, Michael Costigan, Lee L. Rubin, Josef Penninger, Clifford J. Woolf	21
5	Cryoneurolysis with Injectable Ice Slurry Modulates Mechanical Skin Pain 2022 ·Journal of Investigative Dermatology ·Sara Moradi Tuchayi, Ying Wang, Alla Khodorova, Isaac J. Pence, Conor L. Evans, R. Rox Anderson, Ethan A. Lerner, Clifford J. Woolf, Lilit Garibyan	4
6	Dissecting the precise nature of itch-evoked scratching 2021 ·Neuron ·(unknown), (unknown), (unknown), Cliff Vuong, (unknown), Diana M. Bautista, Clifford J. Woolf	23
7	Reduced MC4R signaling alters nociceptive thresholds associated with red hair 2021 ·Science Advances ·Kathleen C. Robinson, Lajos V. Kemény, Gillian L. Fell, (unknown), (unknown), Weihua Ding, Ajay Yekkirala, Jennifer J. Hsiao, Mack Y. Su, Nicholas Theodosakis, Gábor Kozák, Yuichi Takeuchi, Shiqian Shen, Antal Berényi, Jianren Mao, Clifford J. Woolf, David E. Fisher	11
8	Epineural optogenetic activation of nociceptors initiates and amplifies inflammation 2020 ·Nature Biotechnology ·(unknown), Corey R. Seehus, Philipp Schönle, (unknown), Daniel G. Taub, (unknown), Aakanksha Jain, Ivan Furfaro, Outman Akouissi, (unknown), (unknown), Katia Galan, Benjamin Doyle, (unknown), Sébastien Talbot, Liam E. Browne, Qiuting Huang, Clifford J. Woolf, Stéphanie P. Lacour	61
9	Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts 2014 ·Nature Neuroscience ·Brian J. Wainger, Elizabeth D. Buttermore, Júlia Teixeira Oliveira, (unknown), Seungkyu Lee, Wardiya Afshar Saber, Amy J. Wang, Justin K. Ichida, Isaac M. Chiu, Lee Barrett, Eric A. Huebner, (unknown), Naomi Tsujimoto, Christian Brenneis, Kush Kapur, Lee L. Rubin, Kevin Eggan, Clifford J. Woolf	164
10	Permeation and block of TRPV1 channels by the cationic lidocaine derivative QX-314 2013 ·Journal of Neurophysiology ·Michelino Puopolo, Alexander M. Binshtok, (unknown), Seog Bae Oh, Clifford J. Woolf, Bruce P. Bean	73
11	5,6-EET Is Released upon Neuronal Activity and Induces Mechanical Pain Hypersensitivity via TRPA1 on Central Afferent Terminals 2012 ·Journal of Neuroscience ·Marco Sisignano, Chul‐Kyu Park, Carlo Angioni, Dong Dong Zhang, Christian von Hehn, Enrique J. Cobos, Nader Ghasemlou, Zhen‐Zhong Xu, (unknown), Ruirui Lu, Andrew Grant, Michael J. M. Fischer, Achim Schmidtko, Peter W. Reeh, Ru‐Rong Ji, Clifford J. Woolf, Gerd Geißlinger, Klaus Scholich, Christian Brenneis	100
12	Central sensitization: Implications for the diagnosis and treatment of pain breakdown → 2010 ·Pain ·Clifford J. Woolf	3193
13	Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity breakdown → 2009 ·Journal of Pain ·Alban Latrémolière, Clifford J. Woolf	2689
14	Runx1 Determines Nociceptive Sensory Neuron Phenotype and Is Required for Thermal and Neuropathic Pain 2006 ·Neuron ·(unknown), Daniel C. Broom, Yang Liu, Joriene C. de Nooij, Zhe Li, (unknown), Omar Abdel Samad, Thomas M. Jessell, Clifford J. Woolf, Qiufu Ma	267
15	Persistent postsurgical pain: risk factors and prevention breakdown → 2006 ·The Lancet ·Henrik Kehlet, Troels S. Jensen, Clifford J. Woolf	2832
16	Mechanisms of pain and their therapeutic implications 2001 ·Journal of the American Veterinary Medical Association ·William W. Muir, Clifford J. Woolf	86
17	Pain 1999 ·Current Biology ·Allan I. Basbaum, Clifford J. Woolf	70
18	Heat Shock Protein 27: Developmental Regulation and Expression after Peripheral Nerve Injury 1998 ·Journal of Neuroscience ·Michael Costigan, Richard Mannion, Giles S Kendall, Susan E. Lewis, Jason Campagna, Richard E. Coggeshall, (unknown), Simon Tate, Clifford J. Woolf	149
19	The role of nitric oxide and cutaneous nerves in the erythema of psoriasis and atopic eczema 1994 ·Journal of Investigative Dermatology ·(unknown), N. J. Levell, Anthony Bewley, (unknown), J.C. Foreman, Clifford J. Woolf, P.M. Dowd	4
20	Evidence for a central component of post-injury pain hypersensitivity breakdown → 1983 ·Nature ·Clifford J. Woolf	1641

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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