Standout Papers

Gene Ontology: tool for the unification of biology... 1980 2026 1995 2010 28.9k
  1. Gene Ontology: tool for the unification of biology (2000)
    Michael Ashburner, Catherine A. Ball et al. Nature Genetics
  2. Cluster analysis and display of genome-wide expression patterns (1998)
    Michael B. Eisen, Paul T. Spellman et al. Proceedings of the National Academy of Sciences
  3. Molecular portraits of human breast tumours (2000)
    Charles M. Perou, Thérese Sørlie et al. Nature
  4. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications (2001)
    Thérese Sørlie, Charles M. Perou et al. Proceedings of the National Academy of Sciences
  5. Construction of a genetic linkage map in man using restriction fragment length polymorphisms. (1980)
    David Botstein, R. White et al. PubMed
  6. Mapping mendelian factors underlying quantitative traits using RFLP linkage maps. (1989)
    Eric S. Lander, David Botstein Genetics
  7. Repeated observation of breast tumor subtypes in independent gene expression data sets (2003)
    Thérese Sørlie, Robert Tibshirani et al. Proceedings of the National Academy of Sciences
  8. Genomic Expression Programs in the Response of Yeast Cells to Environmental Changes (2000)
    Audrey P. Gasch, Paul T. Spellman et al. Molecular Biology of the Cell
  9. Comprehensive Identification of Cell Cycle–regulated Genes of the YeastSaccharomyces cerevisiaeby Microarray Hybridization (1998)
    Paul T. Spellman, Gavin Sherlock et al. Molecular Biology of the Cell
  10. Missing value estimation methods for DNA microarrays (2001)
    Olga G. Troyanskaya, Michael Cantor et al. Bioinformatics
  11. Exploring the new world of the genome with DNA microarrays (1999)
    Patrick O. Brown, David Botstein Nature Genetics
  12. Systematic variation in gene expression patterns in human cancer cell lines (2000)
    Douglas T. Ross, Uwe Scherf et al. Nature Genetics
  13. The Transcriptional Program in the Response of Human Fibroblasts to Serum (1999)
    Vishwanath R. Iyer, Michael B. Eisen et al. Science
  14. GO::TermFinder—open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes (2004)
    Shuai Weng, Jeremy Gollub et al. Bioinformatics
  15. Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase (1982)
    Marian Carlson, David Botstein Cell
  16. The Transcriptional Program of Sporulation in Budding Yeast (1998)
    Joseph L. DeRisi, Michael B. Eisen et al. Science
  17. Singular value decomposition for genome-wide expression data processing and modeling (2000)
    Orly Alter, Patrick O. Brown et al. Proceedings of the National Academy of Sciences
  18. Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors (2002)
    Michael L. Whitfield, Gavin Sherlock et al. Molecular Biology of the Cell
  19. A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector (1987)
    Mark D. Rose, Peter Novick et al. Gene
  20. Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data (2003)
    Eran Segal, Michal Shapira et al. Nature Genetics
  21. Genome-wide analysis of DNA copy-number changes using cDNA microarrays (1999)
    Jonathan R. Pollack, Charles M. Perou et al. Nature Genetics
  22. Distinctive gene expression patterns in human mammary epithelial cells and breast cancers (1999)
    Charles M. Perou, Stefanie S. Jeffrey et al. Proceedings of the National Academy of Sciences
  23. A gene expression database for the molecular pharmacology of cancer (2000)
    Uwe Scherf, Douglas T. Ross et al. Nature Genetics
  24. Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease (2003)
    David Botstein, Neil Risch Nature Genetics
  25. Diversity of gene expression in adenocarcinoma of the lung (2001)
    Mitchell Garber, Olga G. Troyanskaya et al. Proceedings of the National Academy of Sciences
  26. Gene expression profiling identifies clinically relevant subtypes of prostate cancer (2004)
    Jacques Lapointe, Chunde Li et al. Proceedings of the National Academy of Sciences
  27. Sterile host yeasts (SHY): A eukaryotic system of biological containment for recombinant DNA experiments (1979)
    David Botstein, S. Carl Falco et al. Gene
  28. Microarray analysis reveals a major direct role of DNA copy number alteration in the transcriptional program of human breast tumors (2002)
    Jonathan R. Pollack, Thérese Sørlie et al. Proceedings of the National Academy of Sciences
  29. Diversity, topographic differentiation, and positional memory in human fibroblasts (2002)
    Howard Y. Chang, Jen‐Tsan Chi et al. Proceedings of the National Academy of Sciences
  30. Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF (2001)
    Vishwanath R. Iyer, Christine E. Horak et al. Nature
  31. Relation of Gene Expression Phenotype to Immunoglobulin Mutation Genotype in B Cell Chronic Lymphocytic Leukemia (2001)
    Andreas Rosenwald, Ash A. Alizadeh et al. The Journal of Experimental Medicine
  32. Advanced Bacterial Genetics: A Manual for Genetic Engineering (1980)
    David Botstein, John R. Roth et al. Medical Entomology and Zoology
  33. Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and Wounds (2004)
    Howard Y. Chang, Julie B. Sneddon et al. PLoS Biology
  34. Prediction of Survival in Diffuse Large-B-Cell Lymphoma Based on the Expression of Six Genes (2004)
    Izidore S. Lossos, Debra K. Czerwinski et al. New England Journal of Medicine
  35. Gene Expression Patterns in Human Liver Cancers (2002)
    Xin Chen, ST Cheung et al. Molecular Biology of the Cell
  36. DNA topoisomerase II is required at the time of mitosis in yeast (1985)
    Christian Holm, Takashi Goto et al. Cell
  37. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer (1998)
    Robert Pitti, Scot A. Marsters et al. Nature
  38. Homozygosity Mapping: A Way to Map Human Recessive Traits with the DNA of Inbred Children (1987)
    Eric S. Lander, David Botstein Science
  39. The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery (1988)
    Nava Segev, Jon Mulholland et al. Cell
  40. Endothelial cell diversity revealed by global expression profiling (2003)
    Jen‐Tsan Chi, Howard Y. Chang et al. Proceedings of the National Academy of Sciences
  41. Promoter-specific binding of Rap1 revealed by genome-wide maps of protein–DNA association (2001)
    Jason D. Lieb, David Botstein et al. Nature Genetics
  42. Genome-wide analysis of DNA copy number variation in breast cancer using DNA microarrays (1999)
    Jonathan R. Pollack, Charles M. Perou et al. Nature Genetics
  43. Saccharomyces genome database (2002)
    Laurie Issel‐Tarver, Karen Christie et al. Methods in enzymology on CD-ROM/Methods in enzymology
  44. Genetic engineering in Vivo using translocatable drug-resistance elements (1977)
    Nancy Kleckner, John R. Roth et al. Journal of Molecular Biology
  45. Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations (2013)
    Gregory I. Lang, Daniel P. Rice et al. Nature

Immediate Impact

84 by Nobel laureates 60 from Science/Nature 144 standout
Sub-graph 1 of 13

Citing Papers

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
2021 Standout
Excavating Neandertal and Denisovan DNA from the genomes of Melanesian individuals
2016 StandoutScienceNobel
8 intermediate papers

Works of David Botstein being referenced

Discovering genotypes underlying human phenotypes: past successes for mendelian disease, future approaches for complex disease
2003 Standout
Gene Ontology: tool for the unification of biology
2000 Standout
and 2 more

Author Peers

Author Last Decade Papers Cites
David Botstein 106977 27481 13640 22439 413 156.4k
Eric S. Lander 140597 51048 7738 34056 394 214.1k
Gordon K. Smyth 68030 12841 4772 20147 333 118.5k
Patrick O. Brown 82551 14464 5093 24176 266 117.1k
Matthias Mann 148683 11805 23689 14084 837 211.4k
Peer Bork 93864 14899 8210 9279 510 140.1k
Wolfgang Huber 64845 12160 4890 14172 228 105.3k
Steven L. Salzberg 106489 24093 6562 18460 233 174.6k
Douglas Hanahan 78402 13213 9385 35907 224 134.4k
Heng Li 65684 34691 4004 11652 277 117.2k
Richard Durbin 70817 41363 4547 11779 164 126.6k

All Works

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2026