Standout Papers

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutat... 1985 2026 1998 2012 6.2k
  1. Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene (1998)
    Alexander Poltorak, Xiaolong He et al. Science
  2. Shock and Tissue Injury Induced by Recombinant Human Cachectin (1986)
    Kevin J. Tracey, Bruce Beutler et al. Science
  3. Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin (1985)
    Bruce Beutler, Anthony Cerami et al. Science
  4. The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response (1989)
    Bruce Beutler, Anthony Cerami Annual Review of Immunology
  5. Cachectin and tumour necrosis factor as two sides of the same biological coin (1986)
    Bruce Beutler, Anthony Cerami Nature
  6. Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators. (1986)
    Daniel Caput, Bruce Beutler et al. Proceedings of the National Academy of Sciences
  7. Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1. (1986)
    C A Dinarello, Joseph G. Cannon et al. The Journal of Experimental Medicine
  8. Cachectin: More Than a Tumor Necrosis Factor (1987)
    Bruce Beutler, Anthony Cerami et al. New England Journal of Medicine
  9. Inferences, questions and possibilities in Toll-like receptor signalling (2004)
    Bruce Beutler Nature
  10. Control of Cachectin (Tumor Necrosis Factor) Synthesis: Mechanisms of Endotoxin Resistance (1986)
    Bruce Beutler, Christina Luedke et al. Science
  11. Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts. (1985)
    Jean‐Michel Dayer, Bruce Beutler et al. The Journal of Experimental Medicine
  12. Innate immune sensing and its roots: the story of endotoxin (2003)
    Bruce Beutler, Ernst Rietschel Nature reviews. Immunology
  13. Intracellular Toll-like Receptors (2010)
    Amanda L. Blasius, Bruce Beutler Immunity
  14. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling (2003)
    Kasper Hoebe, Xin Du et al. Nature
  15. The Tumor Necrosis Factor Ligand and Receptor Families (1996)
    Flavia Bazzoni, Bruce Beutler New England Journal of Medicine
  16. TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY (2004)
    Argyrios N. Theofilopoulos, Roberto Baccalà et al. Annual Review of Immunology
  17. Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus (2006)
    Leonid Gitlin, Winfried Barchet et al. Proceedings of the National Academy of Sciences
  18. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections (2005)
    Jochen Mattner, Kristin L. DeBord et al. Nature
  19. Innate immunity: an overview (2003)
    Bruce Beutler Molecular Immunology
  20. Identity of tumour necrosis factor and the macrophage-secreted factor cachectin (1985)
    Bruce Beutler, David A. Greenwald et al. Nature
  21. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection (2004)
    Koichi Tabeta, Philippe Georgel et al. Proceedings of the National Academy of Sciences
  22. TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR (1988)
    Bruce Beutler, Anthony Cerami Annual Review of Biochemistry
  23. Purification of cachectin, a lipoprotein lipase-suppressing hormone secreted by endotoxin-induced RAW 264.7 cells. (1985)
    Bruce Beutler, James A. Mahoney et al. The Journal of Experimental Medicine
  24. CD36 is a sensor of diacylglycerides (2005)
    Kasper Hoebe, Philippe Georgel et al. Nature
  25. Cachectin/tumor necrosis factor: production, distribution, and metabolic fate in vivo. (1985)
    Bruce Beutler, Anthony Cerami et al. The Journal of Immunology
  26. TLRs and innate immunity (2008)
    Bruce Beutler Blood
  27. The interface between innate and adaptive immunity (2004)
    Kasper Hoebe, Edith M. Janssen et al. Nature Immunology
  28. Tlr4: central component of the sole mammalian LPS sensor (2000)
    Bruce Beutler Current Opinion in Immunology
  29. GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large (2006)
    Bruce Beutler, Zhengfan Jiang et al. Annual Review of Immunology
  30. Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation. (1988)
    Kevin J. Tracey, Wei He et al. The Journal of Experimental Medicine
  31. The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9 (2006)
    Koichi Tabeta, Kasper Hoebe et al. Nature Immunology
  32. CD14 is required for MyD88-independent LPS signaling (2005)
    Zhengfan Jiang, Philippe Georgel et al. Nature Immunology
  33. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria (2006)
    Yuki Kinjo, Emmanuel Tupin et al. Nature Immunology
  34. The evolution and genetics of innate immunity (2001)
    Deborah A. Kimbrell, Bruce Beutler Nature Reviews Genetics
  35. Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. (1988)
    Stephen D. Wolpe, G. Davatelis et al. The Journal of Experimental Medicine
  36. How we detect microbes and respond to them: the Toll-like receptors and their transducers (2003)
    Bruce Beutler, Kasper Hoebe et al. Journal of Leukocyte Biology
  37. Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling (2006)
    Amanda L. Gavin, Kasper Hoebe et al. Science
  38. A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease (2003)
    Thomas R. Hawn, Annelies Verbon et al. The Journal of Experimental Medicine
  39. A Macrophage Factor Inhibits Adipocyte Gene Expression: An in Vitro Model of Cachexia (1985)
    Frank M. Torti, B Dieckmann et al. Science
  40. Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. (1990)
    Jeong Han, Tashalee R. Brown et al. The Journal of Experimental Medicine
  41. The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency (2008)
    Xin Du, Terri Gelbart et al. Science
  42. Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway. (1990)
    Jeong Han, Patricia A. Thompson et al. The Journal of Experimental Medicine
  43. Toll-like receptors (2011)
    Eva Marie Y. Moresco, Bruce Beutler et al. Current Biology
  44. Innate and Adaptive Immunity Cooperate Flexibly to Maintain Host-Microbiota Mutualism (2009)
    Emma Slack, Siegfried Hapfelmeier et al. Science
  45. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity (2007)
    Roberto Baccalà, Kasper Hoebe et al. Nature Medicine
  46. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways (2003)
    Kasper Hoebe, Edith M. Janssen et al. Nature Immunology
  47. Unraveling Function in the TNF Ligand and Receptor Families (1994)
    Bruce Beutler, Christophe Van Huffel Science
  48. Three novel mammalian toll-like receptors: gene structure, expression, and evolution. (2000)
    Xin Du, Alexander Poltorak et al. PubMed
  49. Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation (2000)
    Alexander Poltorak, Paola Ricciardi‐Castagnoli et al. Proceedings of the National Academy of Sciences
  50. The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling (2007)
    Melanie M. Brinkmann, Eric Spooner et al. The Journal of Cell Biology
  51. Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog. (1987)
    Kevin J. Tracey, S. F. Lowry et al. PubMed
  52. Genetic and Physical Mapping of theLpsLocus: Identification of the Toll-4 Receptor as a Candidate Gene in the Critical Region (1998)
    Alexander Poltorak, Irina Smirnova et al. Blood Cells Molecules and Diseases
  53. Tumor Necrosis Factor: The molecules and Their Emerging Role in Medicine (1992)
    Bruce Beutler, Junyan Han et al. Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles)
  54. The role of cachectin/TNF in endotoxic shock and cachexia (1988)
    Bruce Beutler et al. Immunology Today
  55. Cachectin/tumor necrosis factor-alpha formation in human decidua. Potential role of cytokines in infection-induced preterm labor. (1989)
    M.Linette Casey, Susan M. Cox et al. Journal of Clinical Investigation
  56. Correlation of interleukin-1β and cachectin concentrations in cerebrospinal fluid and outcome from bacterial meningitis (1989)
    Mahmoud M. Mustafa, Marc Lebel et al. The Journal of Pediatrics

Immediate Impact

33 by Nobel laureates 115 from Science/Nature 302 standout
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Citing Papers

Interactions Between the Microbiota and the Immune System
2012 StandoutScience
Hallmarks of Cancer: The Next Generation
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9 intermediate papers

Works of Bruce Beutler being referenced

The interface between innate and adaptive immunity
2004 Standout
Shock and Tissue Injury Induced by Recombinant Human Cachectin
1986 StandoutScience
and 5 more

Author Peers

Author Last Decade Papers Cites
Bruce Beutler 37780 17041 10744 401 63.8k
Siamon Gordon 40753 21755 10477 453 76.9k
Luke O'neill 31895 23194 8150 380 59.7k
Osamu Takeuchi 55315 23714 15082 349 80.2k
Douglas T. Golenbock 30420 14972 10569 287 50.3k
Taro Kawai 46136 19829 12341 175 65.8k
Ruslan Medzhitov 60569 27356 13228 221 95.1k
Kiyoshi Takeda 56555 27378 14493 454 91.3k
Katherine A. Fitzgerald 39041 37056 12136 331 67.9k
Yoichiro Iwakura 32339 17870 8560 689 60.5k
Gabriel Núñez 33855 47173 10577 407 83.1k

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