Zhenning He

1.4k citations

23 papers · 1.0k indexed · 1 hit paper · h-index 14

Impact in

Business and International Management top 2%
- Innovation and Socioeconomic Development
Genetics top 5%
- Virus-based gene therapy research

Papers in ⓘ

Genetics 8
- Virus-based gene therapy research 10
- Hemoglobinopathies and Related Disorders 8
Hematology 4
- Iron Metabolism and Disorders 4

Co-authors: James M. Wilson (12 shared papers)Lili Wang (12 shared papers)Peter Bell (11 shared papers)Hongwei Yu (6 shared papers)John White (7 shared papers)Deirdre McMenamin (4 shared papers)Yang Yang (3 shared papers)Hiroki Morizono (3 shared papers)
Journals: Blood (4 papers)Nature Biotechnology (3 papers)Molecular Therapy (2 papers)Molecular Therapy — Methods & Clinical Development (2 papers)British Journal of Haematology (1 paper)
Partner nations: United States China Taiwan

In The Last Decade

Zhenning He

23 papers receiving 1.0k citations

Hit Papers

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A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice 2016 · 433 citations

Peers

Countries citing papers authored by Zhenning He

Since Specialization

Citations

This map shows the geographic impact of Zhenning He's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Zhenning He with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Zhenning He more than expected).

Fields of papers citing papers by Zhenning He

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Zhenning He. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Zhenning He. The network helps show where Zhenning He may publish in the future.

Co-authors

The 25 scholars most cited alongside Zhenning He, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Zhenning He Line = papers co-authored together Zhenning He links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 23 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	A dual AAV system enables the Cas9-mediated correction of a metabolic liver disease in newborn mice Nature Biotechnology ·Yang Yang, Lili Wang, Peter Bell, Deirdre McMenamin, Zhenning He, John White, Hongwei Yu, Chenyu Xu, Hiroki Morizono, Kiran Musunuru, Mark L. Batshaw, James M. Wilson Hit paper breakdown →	2016	433
2	Meganuclease targeting of PCSK9 in macaque liver leads to stable reduction in serum cholesterol Nature Biotechnology ·Lili Wang, Jeff Smith, Camilo Breton, Peter Clark, Jia Zhang, Ying Lei, Yan Che, Janel Lape, Peter Bell, Roberto Calcedo, Elizabeth L. Buza, A. Saveliev, Victor V. Bartsevich, Zhenning He, John W. White, Mingyao Li, Derek Jantz, James M. Wilson	2018	89
3	Comparative Study of Liver Gene Transfer With AAV Vectors Based on Natural and Engineered AAV Capsids Molecular Therapy ·Lili Wang, Peter Bell, Suryanarayan Somanathan, Qiang Wang, Zhenning He, Hongwei Yu, Deirdre McMenamin, Tamara Goode, Roberto Calcedo, James M. Wilson	2015	76
4	Integrated vector genomes may contribute to long-term expression in primate liver after AAV administration Nature Biotechnology ·Jenny A. Greig, Kelly M. Martins, Camilo Breton, Jason Lamontagne, Yanqing Zhu, Zhenning He, John W. White, Jingxu Zhu, Jessica A. Chichester, Qi Zheng, Zhe Zhang, Peter Bell, Lili Wang, James M. Wilson	2023	73
5	CRISPR/Cas9-mediated in vivo gene targeting corrects hemostasis in newborn and adult factor IX–knockout mice Blood ·Lili Wang, Yang Yang, Camilo Breton, John White, Jia Zhang, Yan Che, A. Saveliev, Deirdre McMenamin, Zhenning He, Caitlin Latshaw, Mingyao Li, James M. Wilson	2019	62
6	A mutation-independent CRISPR-Cas9–mediated gene targeting approach to treat a murine model of ornithine transcarbamylase deficiency Science Advances ·Lili Wang, Yang Yang, Camilo Breton, Peter Bell, Mingyao Li, Jia Zhang, Yan Che, A. Saveliev, Zhenning He, John White, Caitlin Latshaw, Chenyu Xu, Deirdre McMenamin, Hongwei Yu, Hiroki Morizono, Mark L. Batshaw, James M. Wilson	2020	53
7	Long-term stable reduction of low-density lipoprotein in nonhuman primates following in vivo genome editing of PCSK9 Molecular Therapy ·Lili Wang, Camilo Breton, Claude C. Warzecha, Peter Bell, Hanying Yan, Zhenning He, John White, Yanqing Zhu, Mingyao Li, Elizabeth L. Buza, Derek Jantz, James M. Wilson	2021	48
8	AAV gene therapy corrects OTC deficiency and prevents liver fibrosis in aged OTC-knock out heterozygous mice Molecular Genetics and Metabolism ·Lili Wang, Peter Bell, Hiroki Morizono, Zhenning He, Elena Pumbo, Hongwei Yu, John White, Mark L. Batshaw, James M. Wilson	2017	38
9	Expression, purification, and characterization of human hemoglobins Gower-1 (ζ2ε2), Gower-2 (α2ε2), and Portland-2 (ζ2β2) assembled in complex transgenic–knockout mice Blood ·Zhenning He, Janice Russell	2001	32
10	Effects of Self-Complementarity, Codon Optimization, Transgene, and Dose on Liver Transduction with AAV8 Human Gene Therapy Methods ·Peter Bell, Lili Wang, Shu‐Jen Chen, Hongwei Yu, Yanqing Zhu, Mohamad Nayal, Zhenning He, John White, Deborah Lebel-Hagan, James M. Wilson	2016	21
11	Prednisolone reduces the interferon response to AAV in cynomolgus macaques and may increase liver gene expression Molecular Therapy — Methods & Clinical Development ·Lili Wang, Claude C. Warzecha, Alexander Kistner, Jessica A. Chichester, Peter Bell, Elizabeth L. Buza, Zhenning He, M. Betina Pampena, Julien Couthouis, Sunjay Sethi, Kathleen McKeever, Michael R. Betts, Emil Kakkis, James M. Wilson, Samuel Wadsworth, Barbara Sullivan	2022	19
12	Developing a second-generation clinical candidate AAV vector for gene therapy of familial hypercholesterolemia Molecular Therapy — Methods & Clinical Development ·Lili Wang, Ilayaraja Muthuramu, Suryanarayan Somanathan, Hong Zhang, Peter Bell, Zhenning He, Hongwei Yu, Yanqing Zhu, Anna P. Tretiakova, James M. Wilson	2021	19
13	Antisickling effects of an endogenous human α-like globin Nature Medicine ·Zhenning He, Janice Russell	2004	14
14	A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease Proceedings of the National Academy of Sciences ·Zhenning He, Janice Russell	2002	13
15	Effect of ζ-globin substitution on the O2-transport properties of Hb S in vitro and in vivo Biochemical and Biophysical Research Communications ·Zhenning He, Janice Russell	2004	10
16	Functional effects of replacing human α‐ and β‐globins with their embryonic globin homologues in defined haemoglobin heterotetramers British Journal of Haematology ·Zhenning He, Lurong Lian, Toshio Asakura, Janice Russell	2000	9
17	Structure of fully liganded Hb ζ₂β₂^strapped in a tense conformation Acta Crystallographica Section D Biological Crystallography ·Martin K. Safo, Tzu‐Ping Ko, Osheiza Abdulmalik, Zhenning He, Andrew H.-J. Wang, Eric R. Schreiter, Janice Russell	2013	5
18	Dynamic posttranscriptional regulation of ϵ-globin gene expression in vivo Blood ·Zhenning He, Janice Russell	2006	5
19	A High-Throughput Microplate Method for Assessing Aggregation of Deoxygenated Hemoglobin S Heterotetramers in Vitro Analytical Biochemistry ·Zhenning He, Janice Russell	2002	4
20	Structural determinants of human ζ-globin mRNA stability Journal of Hematology & Oncology ·Zhenning He, Decheng Song, Sebastiaan van Zalen, Janice Russell	2014	2

About Zhenning He

Zhenning He is a scholar working on Genetics, Hematology, Genetics, Clinical Biochemistry and Pediatrics, Perinatology and Child Health, having authored 23 papers that have together received 1.0k indexed citations. Recurring topics across this work include Virus-based gene therapy research (10 papers), Hemoglobinopathies and Related Disorders (8 papers), CRISPR and Genetic Engineering (7 papers), Iron Metabolism and Disorders (4 papers), Neonatal Health and Biochemistry (3 papers), RNA modifications and cancer (3 papers), RNA Interference and Gene Delivery (3 papers) and Hemoglobin structure and function (3 papers). The work is most often cited by research in Business and International Management (76 citations), Genetics (470 citations), Aging (25 citations), Molecular Biology (826 citations) and Clinical Biochemistry (70 citations). Zhenning He has collaborated with scholars based in United States, China and Taiwan. Frequent co-authors include James M. Wilson, Lili Wang, Peter Bell, Hongwei Yu, John White, Deirdre McMenamin, Yang Yang, Hiroki Morizono, Mark L. Batshaw and Janice Russell. Their work appears in journals such as Blood, Nature Biotechnology, Molecular Therapy, Molecular Therapy — Methods & Clinical Development and British Journal of Haematology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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