Yi Chen

4.7k citations

126 papers · 3.2k indexed · 1 hit paper · h-index 31

Impact in

Toxicology top 1%
- Bioactive Compounds and Antitumor Agents
Oncology top 5%

Papers in ⓘ

Toxicology 9
- Bioactive Compounds and Antitumor Agents 9
Oncology 40
- HER2/EGFR in Cancer Research 6

Co-authors: Jian Ding (54 shared papers)Jian Ding (2 shared papers)Meiyu Geng (27 shared papers)Yu Lei (2 shared papers)Wei Lü (15 shared papers)Yanyan Shen (13 shared papers)Ze‐Hong Miao (10 shared papers)Linjiang Tong (18 shared papers)
Journals: Acta Pharmacologica Sinica (14 papers)European Journal of Medicinal Chemistry (10 papers)Bioorganic & Medicinal Chemistry Letters (7 papers)Journal of Medicinal Chemistry (7 papers)Bioorganic & Medicinal Chemistry (6 papers)
Partner nations: China United States United Kingdom

In The Last Decade

Yi Chen

119 papers receiving 3.2k citations

Hit Papers

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Osteoarthritis burden and inequality from 1990 to 2021: a systematic analysis for the global burden of disease Study 2021 2025 · 18 citations

Peers

Countries citing papers authored by Yi Chen

Since Specialization

Citations

This map shows the geographic impact of Yi Chen's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Yi Chen with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Yi Chen more than expected).

Fields of papers citing papers by Yi Chen

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Yi Chen. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Yi Chen. The network helps show where Yi Chen may publish in the future.

Co-authors

The 25 scholars most cited alongside Yi Chen, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Yi Chen Line = papers co-authored together Yi Chen links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 126 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Iron Metabolism in Cancer International Journal of Molecular Sciences ·Yafang Wang, Yu Lei, Jian Ding, Yi Chen	2018	225
2	TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling Nature Communications ·Rongxuan Zhu, Olivier Gires, Li Zhu, Jun Liu, Junjian Li, Hao Yang, Gaoda Ju, Jing Huang, Weiyu Ge, Yi Chen, Zhimin Lu, Hongxia Wang	2019	141
3	Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer Cancer Cell ·Hanlin Zeng, Jia Qu, Nan Jin, Jun Xu, Chenchu Lin, Yi Chen, Xinying Yang, Xiang He, Shuai Tang, Xiaojing Lan, Xiaotong Yang, Ziqi Chen, Min Huang, Jian Ding, Meiyu Geng	2016	134
4	Alpha-2 agonists for long-term sedation during mechanical ventilation in critically ill patients Cochrane Database of Systematic Reviews ·Ken Chen, Zhijun Lü, Xin Yi, Yong Cai, Yi Chen, Shu Ming Pan	2015	103
5	Synthesis and c-Met Kinase Inhibition of 3,5-Disubstituted and 3,5,7-Trisubstituted Quinolines: Identification of 3-(4-Acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a Novel Anticancer Agent Journal of Medicinal Chemistry ·Yuanxiang Wang, Jing Ai, Ying Wang, Yi Chen, Lu Wang, Gang Liu, Meiyu Geng, Ao Zhang	2011	101
6	Synthesis and activity of Combretastatin A-4 analogues: 1,2,3-thiadiazoles as potent antitumor agents Bioorganic & Medicinal Chemistry Letters ·Maojiang Wu, Qiming Sun, Chunhao Yang, Dongdong Chen, Jian Ding, Yi Chen, Li‐Ping Lin, Yuyuan Xie	2006	93
7	Tumor‐Microenvironment‐Adaptive Nanoparticles Codeliver Paclitaxel and siRNA to Inhibit Growth and Lung Metastasis of Breast Cancer Advanced Functional Materials ·Shan Tang, Qingshuo Meng, Huiping Sun, Jinghan Su, Qi Yin, Zhiwen Zhang, Haijun Yu, Lingli Chen, Yi Chen, Wangwen Gu, Yaping Li	2016	87
8	G9a regulates breast cancer growth by modulating iron homeostasis through the repression of ferroxidase hephaestin Nature Communications ·Ya‐Fang Wang, Jie Zhang, Yi Su, Yanyan Shen, Dongxian Jiang, Yingyong Hou, Meiyu Geng, Jian Ding, Yi Chen	2017	83
9	Role of CD8+ T lymphocyte cells: Interplay with stromal cells in tumor microenvironment Acta Pharmaceutica Sinica B ·Qin Xie, Jian Ding, Yi Chen	2021	82
10	SH‐7, a new synthesized shikonin derivative, exerting its potent antitumor activities as a topoisomerase inhibitor International Journal of Cancer ·Fan Yang, Yi Chen, Wenhu Duan, Chao Zhang, Hong Zhu, Jian Ding	2006	73
11	Design, Synthesis, and Biological Evaluation of a Series of Benzo[de][1,7]naphthyridin-7(8H)-ones Bearing a Functionalized Longer Chain Appendage as Novel PARP1 Inhibitors Journal of Medicinal Chemistry ·Na Ye, Chuan-Huizi Chen, Tiantian Chen, Zilan Song, Jin-Xue He, Xia-Juan Huan, Shan-shan Song, Qiufeng Liu, Yi Chen, Jian Ding, Yechun Xu, Ze-Hong Miao, Ao Zhang	2013	73
12	Codelivery of Sorafenib and Curcumin by Directed Self-Assembled Nanoparticles Enhances Therapeutic Effect on Hepatocellular Carcinoma Molecular Pharmaceutics ·Haiqiang Cao, Yixin Wang, Xinyu He, Zhiwen Zhang, Qi Yin, Yi Chen, Haijun Yu, Yongzhuo Huang, Lingli Chen, Ming‐Hua Xu, Wangwen Gu, Yaping Li	2015	72
13	Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors European Journal of Medicinal Chemistry ·Xuan Zhang, Yannan Kong, Jie Zhang, Mingbo Su, Yubo Zhou, Yi Zang, Jia Li, Yi Chen, Yanfen Fang, Xiongwen Zhang, Wei Lü	2015	70
14	The discovery of colchicine-SAHA hybrids as a new class of antitumor agents Bioorganic & Medicinal Chemistry ·Xuan Zhang, Jie Zhang, Linjiang Tong, Yu Luo, Mingbo Su, Yi Zang, Jia Li, Wei Lü, Yi Chen	2013	62
15	Combined Src and Aromatase Inhibition Impairs Human Breast Cancer Growth In vivo and Bypass Pathways Are Activated in AZD0530-Resistant Tumors Clinical Cancer Research ·Yi Chen, Natalia Guggisberg, Mercè Jordà, Ana M. González-Angulo, Bryan T. Hennessy, Gordon B. Mills, Chen-Keat Tan, Joyce M. Slingerland	2009	58
16	Design, synthesis and biological evaluation of substituted 11H-benzo[a]carbazole-5-carboxamides as novel antitumor agents European Journal of Medicinal Chemistry ·Yuqin Wang, Xiaohua Li, Qian He, Yi Chen, Yuyuan Xie, Jian Ding, Ze‐Hong Miao, Chunhao Yang	2011	55
17	Discovery of JND3229 as a New EGFR^C797S Mutant Inhibitor with In Vivo Monodrug Efficacy ACS Medicinal Chemistry Letters ·Xiaoyun Lu, Tao Zhang, Sujie Zhu, Qiuju Xun, Ling-Jiang Tong, Xianglong Hu, Yan Li, Shingpan Chan, Yi Su, Yiming Sun, Yi Chen, Jian Ding, Cai‐Hong Yun, Hua Xie, Ke Ding	2018	53
18	10-Boronic acid substituted camptothecin as prodrug of SN-38 European Journal of Medicinal Chemistry ·Lei Wang, Shao Xie, Longjun Ma, Yi Chen, Wei Lü	2016	52
19	Down-regulation of G9a triggers DNA damage response and inhibits colorectal cancer cells proliferation Oncotarget ·Jie Zhang, Pengxing He, Yong Xi, Meiyu Geng, Yi Chen, Jian Ding	2015	52
20	Histone deacetylase inhibitors promote breast cancer metastasis by elevating NEDD9 expression Signal Transduction and Targeted Therapy ·Zong-long Hu, Fan Wei, Yi Su, Wang Yf, Yanyan Shen, Yanfen Fang, Jian Ding, Yi Chen	2023	48

About Yi Chen

Yi Chen is a scholar working on Toxicology, Oncology, Molecular Biology, Hepatology and Cancer Research, having authored 126 papers that have together received 3.2k indexed citations. Recurring topics across this work include Histone Deacetylase Inhibitors Research (18 papers), Cancer therapeutics and mechanisms (17 papers), Epigenetics and DNA Methylation (12 papers), Protein Degradation and Inhibitors (12 papers), Liver physiology and pathology (9 papers), Bioactive Compounds and Antitumor Agents (9 papers), PI3K/AKT/mTOR signaling in cancer (7 papers) and HER2/EGFR in Cancer Research (6 papers). The work is most often cited by research in Toxicology (145 citations), Oncology (846 citations), Molecular Biology (1.9k citations), Cancer Research (349 citations) and Organic Chemistry (646 citations). Yi Chen has collaborated with scholars based in China, United States and United Kingdom. Frequent co-authors include Jian Ding, Jian Ding, Meiyu Geng, Yu Lei, Wei Lü, Yanyan Shen, Ze‐Hong Miao, Linjiang Tong, Chunhao Yang and Jing Ai. Their work appears in journals such as Acta Pharmacologica Sinica, European Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry and Bioorganic & Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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