William R. Skach

7.3k total citations · 1 hit paper
87 papers, 5.3k citations indexed

About

William R. Skach is a scholar working on Molecular Biology, Pulmonary and Respiratory Medicine and Cell Biology. According to data from OpenAlex, William R. Skach has authored 87 papers receiving a total of 5.3k indexed citations (citations by other indexed papers that have themselves been cited), including 60 papers in Molecular Biology, 26 papers in Pulmonary and Respiratory Medicine and 20 papers in Cell Biology. Recurrent topics in William R. Skach's work include Cystic Fibrosis Research Advances (23 papers), RNA and protein synthesis mechanisms (22 papers) and Ion Transport and Channel Regulation (19 papers). William R. Skach is often cited by papers focused on Cystic Fibrosis Research Advances (23 papers), RNA and protein synthesis mechanisms (22 papers) and Ion Transport and Channel Regulation (19 papers). William R. Skach collaborates with scholars based in United States, United Kingdom and Germany. William R. Skach's co-authors include A.S. Verkman, Tonghui Ma, Hajime Hasegawa, Jeffrey L. Brodsky, Vishwanath R. Lingappa, Arthur E. Johnson, Zhongying Yang, Michael A. Matthay, Alfred N. Van Hoek and A. S. Verkman and has published in prestigious journals such as Science, Cell and Journal of Biological Chemistry.

In The Last Decade

William R. Skach

87 papers receiving 5.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations

2016 422 citations William R. Skach, David N. Sheppard et al. Molecular Biology of the Cell profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
William R. Skach United States	42	3.9k	1.4k	1.0k	710	359	87	5.3k
Aron B. Jaffe United States	18	2.9k 0.8×	609 0.4×	1.6k 1.6×	546 0.8×	244 0.7×	27	5.0k
Cara J. Gottardi United States	43	4.4k 1.1×	726 0.5×	1.4k 1.4×	509 0.7×	236 0.7×	85	6.5k
James F. Collawn United States	47	4.0k 1.0×	1.7k 1.2×	1.7k 1.6×	594 0.8×	674 1.9×	144	7.6k
Darrell J. Yamashiro United States	42	3.4k 0.9×	563 0.4×	784 0.8×	353 0.5×	284 0.8×	128	5.6k
Qais Al‐Awqati United States	53	6.0k 1.6×	1.5k 1.1×	860 0.9×	500 0.7×	191 0.5×	140	8.3k
Troy Stevens United States	51	3.2k 0.8×	1.8k 1.3×	718 0.7×	389 0.5×	368 1.0×	158	6.6k
Margarida D. Amaral Portugal	43	2.3k 0.6×	3.8k 2.6×	533 0.5×	583 0.8×	263 0.7×	192	5.8k
Søren Jensby Nielsen Denmark	35	5.6k 1.4×	1.6k 1.1×	268 0.3×	490 0.7×	350 1.0×	62	6.9k
Seiji Matsumoto Japan	32	1.9k 0.5×	845 0.6×	559 0.6×	241 0.3×	292 0.8×	235	4.5k
Makoto Kinoshita Japan	44	3.8k 1.0×	351 0.2×	1.8k 1.8×	417 0.6×	400 1.1×	131	6.1k

Countries citing papers authored by William R. Skach

Since Specialization

Citations

This map shows the geographic impact of William R. Skach's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William R. Skach with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William R. Skach more than expected).

Fields of papers citing papers by William R. Skach

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William R. Skach. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William R. Skach. The network helps show where William R. Skach may publish in the future.

Co-authorship network of co-authors of William R. Skach

This figure shows the co-authorship network connecting the top 25 collaborators of William R. Skach. A scholar is included among the top collaborators of William R. Skach based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with William R. Skach. William R. Skach is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Krainer, Georg, Hideki Shishido, Jae Seok Yoon, et al.. (2020). Towards next generation therapies for cystic fibrosis: Folding, function and pharmacology of CFTR. Journal of Cystic Fibrosis. 19. S25–S32. 21 indexed citations

Shishido, Hideki, Jae Seok Yoon, Zhongying Yang, & William R. Skach. (2020). CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates. Nature Communications. 11(1). 4258–4258. 25 indexed citations

Lueck, John D., Jae Seok Yoon, Alfredo Perales‐Puchalt, et al.. (2019). Engineered transfer RNAs for suppression of premature termination codons. Nature Communications. 10(1). 822–822. 105 indexed citations

Kim, Soo Jung, Jae Seok Yoon, Hideki Shishido, et al.. (2015). Translational tuning optimizes nascent protein folding in cells. Science. 348(6233). 444–448. 157 indexed citations

Conti, Brian J., Prasanna K. Devaraneni, Zhongying Yang, Larry L. David, & William R. Skach. (2015). Cotranslational Stabilization of Sec62/63 within the ER Sec61 Translocon Is Controlled by Distinct Substrate-Driven Translocation Events. Molecular Cell. 58(2). 269–283. 79 indexed citations

Kim, Soo Jung & William R. Skach. (2012). Mechanisms of CFTR Folding at the Endoplasmic Reticulum. Frontiers in Pharmacology. 3. 201–201. 88 indexed citations

Gubbens, Jacob, Soo Jung Kim, Zhongying Yang, Arthur E. Johnson, & William R. Skach. (2010). In vitro incorporation of nonnatural amino acids into protein using tRNA^Cys-derived opal, ochre, and amber suppressor tRNAs. RNA. 16(8). 1660–1672. 24 indexed citations

Pratt, Emily B., Pei‐Chun Chen, Fang Wang, et al.. (2010). Role of Hsp90 in Biogenesis of the β-Cell ATP-sensitive Potassium Channel Complex. Molecular Biology of the Cell. 21(12). 1945–1954. 37 indexed citations

Yang, Zhongying, et al.. (2008). Sequence-specific Retention and Regulated Integration of a Nascent Membrane Protein by the Endoplasmic Reticulum Sec61 Translocon. Molecular Biology of the Cell. 20(2). 685–698. 45 indexed citations

10.

Daniel, Colin J., Brian J. Conti, Arthur E. Johnson, & William R. Skach. (2008). Control of Translocation through the Sec61 Translocon by Nascent Polypeptide Structure within the Ribosome. Journal of Biological Chemistry. 283(30). 20864–20873. 31 indexed citations

11.

Carlson, Eric J., et al.. (2006). p97 functions as an auxiliary factor to facilitate TM domain extraction during CFTR ER‐associated degradation. The EMBO Journal. 25(19). 4557–4566. 50 indexed citations

12.

Chia, Dennis J., Teresa M. Buck, Vivian Hwa, et al.. (2005). Aberrant Folding of a Mutant Stat5b Causes Growth Hormone Insensitivity and Proteasomal Dysfunction. Journal of Biological Chemistry. 281(10). 6552–6558. 24 indexed citations

13.

Oberdorf, Jon, et al.. (2005). An Energy-dependent Maturation Step Is Required for Release of the Cystic Fibrosis Transmembrane Conductance Regulator from Early Endoplasmic Reticulum Biosynthetic Machinery. Journal of Biological Chemistry. 280(46). 38193–38202. 17 indexed citations

14.

Buck, Teresa M., et al.. (2002). Cooperativity and Flexibility of Cystic Fibrosis Transmembrane Conductance Regulator Transmembrane Segments Participate in Membrane Localization of a Charged Residue. Journal of Biological Chemistry. 277(42). 39507–39514. 32 indexed citations

15.

Kolosha, Vladimir O., Carlos de Céspedes, R Gitzelmann, et al.. (2000). Novel mutations in 13 probands with galactokinase deficiency. Human Mutation. 15(5). 447–453. 31 indexed citations

16.

Lu, Yun, et al.. (1998). Coupled Translocation Events Generate Topological Heterogeneity at the Endoplasmic Reticulum Membrane. Molecular Biology of the Cell. 9(9). 2681–2697. 33 indexed citations

17.

Skach, William R.. (1998). [19] Topology of P-glycoproteins. Methods in enzymology on CD-ROM/Methods in enzymology. 292. 265–278. 11 indexed citations

18.

Lu, Yun, et al.. (1998). Co- and Posttranslational Translocation Mechanisms Direct Cystic Fibrosis Transmembrane Conductance Regulator N Terminus Transmembrane Assembly. Journal of Biological Chemistry. 273(1). 568–576. 96 indexed citations

19.

Fisher, Aron B., Sheldon I. Feinstein, Tae‐Suk Kim, Chandra Dodia, & William R. Skach. (1997). Identification of a cDNA for Ca++-Independent Phospholipase A2 of Lung Lamellar Bodies/Lysosomes. CHEST Journal. 111(6). 88S–89S. 2 indexed citations

20.

Tu, Li-Wei, et al.. (1996). Voltage-gated K+ Channels Contain Multiple Intersubunit Association Sites. Journal of Biological Chemistry. 271(31). 18904–18911. 74 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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