William A. O’Brien

8.0k citations

65 papers · 6.5k indexed · 3 hit papers · h-index 34

Impact in

Virology top 0.05%
- HIV Research and Treatment
Infectious Diseases top 0.2%
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions

Papers in

Virology 43
- HIV Research and Treatment 43
Infectious Diseases 36
- HIV/AIDS drug development and treatment 29
- HIV/AIDS Research and Interventions 22

Co-authors: Georges Herbein Jerome A. Zack Yoshio Koyanagi Irvin S. Y. Chen George M. Shaw Julie M. Decker Lee Ratner Eric Hunter
Journals: Journal of Virology (12 papers)JAIDS Journal of Acquired Immune Deficiency Syndromes (4 papers)Clinical Infectious Diseases (3 papers)Vaccine (2 papers)Nature (2 papers)
Partner nations: United States Spain United Kingdom

In The Last Decade

William A. O’Brien

62 papers receiving 6.3k citations

Hit Papers

align trajectories log scale

Sensitivity of Human Immunodeficiency Virus Type 1 to the Fusion Inhibitor T-20 Is Modulated by Coreceptor Specificity Defined by the V3 Loop of gp120 2000 · 643 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2000 Journal of Virology
1996 New England Journal of Medicine
1990 Nature

Peers

Countries citing papers authored by William A. O’Brien

Since Specialization

Citations

This map shows the geographic impact of William A. O’Brien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William A. O’Brien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William A. O’Brien more than expected).

Fields of papers citing papers by William A. O’Brien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William A. O’Brien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William A. O’Brien. The network helps show where William A. O’Brien may publish in the future.

Co-authorship network

The 25 scholars most cited alongside William A. O’Brien, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with William A. O’Brien Line = papers co-authored together William A. O’Brien links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Nuclear trafficking of the HIV-1 pre-integration complex depends on the ADAM10 intracellular domain Virology ·Mark Endsley, Anoma Somasunderam, Guangyu Li, Numan Oezguen, Varatharasa Thiviyanathan, James L. Murray, Donald H. Rubin, Thomas Hodge, William A. O’Brien, حسین زند, Monique R. Ferguson	2014	14
2	Identification of Cellular Proteins Required for Replication of Human Immunodeficiency Virus Type 1 AIDS Research and Human Retroviruses ·Natallia Dziuba, Monique R. Ferguson, William A. O’Brien, Anthony Sanchez, Andrew Prussia, Gerlin Eduardo Hernández-Angulo, Brian Friedrich, Guangyu Li, Michael W. Shaw, Jinsong Sheng, Thomas Hodge, Donald H. Rubin, James L. Murray	2012	28
3	Experience of a pediatric HIV clinic in Guatemala City Revista Panamericana de Salud Pública ·Blanca Samayoa, Matthew Anderson, Vander Felipe Ortiz dos Santos, NURALIYAH HAMSENG, Margo S. Harrison, William A. O’Brien, Eduardo Arathoon	2009	4
4	Impact of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitor Drug Resistance Mutation Interactions on Phenotypic Susceptibility AIDS Research and Human Retroviruses ·D Nabakabya, Ninon Camus, V. Ghetti, Daniel R. Rojo, Trianka Priya Utama, Neil Parkin, William A. O’Brien, Monique R. Ferguson	2008	7
5	A critical role for CD63 in HIV replication and infection of macrophages and cell lines Virology ·Hui Chen, Natallia Dziuba, Brian Friedrich, Ninon Camus, James L. Murray, Daniel R. Rojo, Thomas Hodge, William A. O’Brien, Monique R. Ferguson	2008	33
6	Special issues in the management of patients with ESRD and HIV infection American Journal of Kidney Diseases ·Tejinder S. Ahuja, William A. O’Brien	2003	17
7	Randomized trial of the quantitative and functional antibody responses to a 7-valent pneumococcal conjugate vaccine and/or 23-valent polysaccharide vaccine among HIV-infected adults Vaccine ·Daniel R. Feikin, Cheryl M. Elie, Matthew Bidwell Goetz, Jeffrey L. Lennox, George M. Carlone, Sandra Romero‐Steiner, Patricia Holder, William A. O’Brien, Cynthia G. Whitney, Jay C. Butler, Robert F. Breiman	2001	117
8	Resistance to Apoptosis in HIV-Infected CD4+ T Lymphocytes Is Mediated by Macrophages: Role for Nef and Immune Activation in Viral Persistence The Journal of Immunology ·Ulrich Mahlknecht, Cheng Deng, Michael Lu, Thomas C. Greenough, John L. Sullivan, William A. O’Brien, Georges Herbein	2000	49
9	Comparison of Immunologic Restoration and Virologic Response in Plasma, Tonsillar Tissue, and Cerebrospinal Fluid in HIV-1???Infected Patients Treated With Double Versus Triple Antiretroviral Therapy in Very Early Stages: The Spanish Earth-2 Study JAIDS Journal of Acquired Immune Deficiency Syndromes ·Shaobin He, H. Mazidi, Joan Romeu, Hernando Knobel, Julio Arrizabalaga, Elena Ferrer, David Dalmau, Isabel Ruíz-Camps, Francesc Vidal, Manfred Frank, Ferrán Segura, Juan Luís Gómez-Sirvent, Anna Cruceta, Bonaventura Clotet, Pingyi Zhu, Teresa Gallart, William A. O’Brien, Ro-Cheon Park, P. V. Dukhota	2000	14
10	Resistance against Reverse Transcriptase Inhibitors Clinical Infectious Diseases ·William A. O’Brien	2000	22
11	The Significance of Vitamin A and Carotenoid Status in Persons Infected by the Human Immunodeficiency Virus Clinical Infectious Diseases ·Shu-Mei Yang, William A. O’Brien, Matthew Bidwell Goetz	1998	16
12	Apoptosis of CD8+ T cells is mediated by macrophages through interaction of HIV gp120 with chemokine receptor CXCR4 Nature ·Georges Herbein, Ulrich Mahlknecht, Franak Batliwalla, Peter K. Gregersen, Todd C. Pappas, John Butler, William A. O’Brien, Eric Verdin	1998	351
13	Effects of influenza vaccination in HIV-infected adults: a double-blind, placebo-controlled trial Vaccine ·Sybil Tasker, William A. O’Brien, John J. Treanor, Peter Weiss, Patrick E. Olson, Andrew H. Kaplan, Mark R. Wallace	1998	76
14	The effect of exercise training on aerobic fitness, immune indices, and quality of life in HIV+ patients Medicine & Science in Sports & Exercise ·俊樹中野, Brenda Junker, William A. O’Brien, Christopher Beck, Vincent Dumlao	1998	104
15	Impact on the immune system of undetectable plasma HIV-1 RNA for more than 2 years AIDS ·Albert Goday, Caroline Sole, Manel Juan, Ana Maria Bourguinon, Teresa Puig, Montserrat Balagué, Joan Romeu, Ricardo Pujol‐Borrell, William A. O’Brien, Bonaventura Clotet	1998	37
16	HIV viral load markers in clinical practice Nature Medicine ·Michael S. Saag, Mark Holodniy, Daniel R. Kuritzkes, William A. O’Brien, Robert W. Coombs, Mayurdeep Pathak, Donna M. Jacobsen, George M. Shaw, Douglas D. Richman, Paul A. Volberding	1996	393
17	Increased susceptibility of differentiated mononuclear phagocytes to productive infection with human immunodeficiency virus-1 (HIV-1). Journal of Clinical Investigation ·Elizabeth A. Rich, Sabine Prat, Jerome A. Zack, LS Fernández Jiménez, William A. O’Brien	1992	194
18	A Controlled Trial of Early versus Late Treatment with Zidovudine in Symptomatic Human Immunodeficiency Virus Infection New England Journal of Medicine ·John D. Hamilton, Pamela Hartigan, Michael S. Simberkoff, Philip L. Day, Gigi R. Diamond, Gordon M. Dickinson, George L. Drusano, Merrill J. Egorin, W. Lance George, Fred M. Gordin, Clifton A. Hawkes, Peter Jensen, Nancy G. Klimas, Ann M. Labriola, Christopher J. Lahart, William A. O’Brien, Charles N. Oster, Kent J. Weinhold, Naomi R. Wray, Susan Zolla‐Pazner	1992	242
19	HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain Nature ·William A. O’Brien, Yoshio Koyanagi, Ali Namazie, Jiaqi Zhao, Amadou Diagne, 市原拓也, Jerome A. Zack, Irvin S. Y. Chen Hit paper breakdown →	1990	503
20	[40] Isolation of somatic cell glycoprotein mutants Methods in enzymology on CD-ROM/Methods in enzymology ·Raymond M. Baker, Carlos B. Hirschberg, William A. O’Brien, Tamara E. Awerbuch, Masanori YonahaNote	1982	8

About William A. O’Brien

William A. O’Brien is a scholar working on Virology, Infectious Diseases, Immunology, Emergency Medicine and Biochemistry, having authored 65 papers that have together received 6.5k indexed citations. Recurring topics across this work include HIV Research and Treatment (43 papers), HIV/AIDS drug development and treatment (29 papers), HIV/AIDS Research and Interventions (22 papers), Immune Cell Function and Interaction (15 papers), HIV-related health complications and treatments (7 papers), T-cell and B-cell Immunology (6 papers), Pneumocystis jirovecii pneumonia detection and treatment (4 papers) and Influenza Virus Research Studies (2 papers). The work is most often cited by research in Virology (4.5k citations), Infectious Diseases (3.1k citations), Immunology (2.1k citations), Emergency Medicine (514 citations) and Epidemiology (1.4k citations). William A. O’Brien has collaborated with scholars based in United States, Spain and United Kingdom. Frequent co-authors include Georges Herbein, Jerome A. Zack, Yoshio Koyanagi, Irvin S. Y. Chen, George M. Shaw, Julie M. Decker, Lee Ratner, Eric Hunter, Cynthia A. Derdeyn and Si‐Hua Mao. Their work appears in journals such as Journal of Virology, JAIDS Journal of Acquired Immune Deficiency Syndromes, Clinical Infectious Diseases, Vaccine and Nature.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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