T.M. Penning

27.9k total citations · 6 hit papers
353 papers, 21.0k citations indexed

About

T.M. Penning is a scholar working on Cell Biology, Endocrinology, Diabetes and Metabolism and Molecular Biology. According to data from OpenAlex, T.M. Penning has authored 353 papers receiving a total of 21.0k indexed citations (citations by other indexed papers that have themselves been cited), including 203 papers in Cell Biology, 155 papers in Endocrinology, Diabetes and Metabolism and 110 papers in Molecular Biology. Recurrent topics in T.M. Penning's work include Aldose Reductase and Taurine (202 papers), Hormonal and reproductive studies (78 papers) and Hormonal Regulation and Hypertension (74 papers). T.M. Penning is often cited by papers focused on Aldose Reductase and Taurine (202 papers), Hormonal and reproductive studies (78 papers) and Hormonal Regulation and Hypertension (74 papers). T.M. Penning collaborates with scholars based in United States, United Kingdom and Slovenia. T.M. Penning's co-authors include Joseph M. Jez, Yi Jin, Ronald G. Harvey, Michael E. Burczynski, Ian A. Blair, Nisha Palackal, Judy L. Bolton, Terrence J. Monks, Michael A. Trush and Glenn Dryhurst and has published in prestigious journals such as Science, Chemical Reviews and Proceedings of the National Academy of Sciences.

In The Last Decade

T.M. Penning

350 papers receiving 20.6k citations

Hit Papers

Role of Quinones in Toxicology 1997 2026 2006 2016 2000 2006 2015 1997 2000 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Role of Quinones in Toxicology
    2000 1.3k citations T.M. Penning et al. profile →
  2. Increased Expression of Genes Converting Adrenal Androgens to Testosterone in Androgen-Independent Prostate Cancer
    2006 843 citations T.M. Penning, Steven P. Balk et al. profile →
  3. Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
    2015 672 citations T.M. Penning et al. profile →
  4. Comparative anatomy of the aldo–keto reductase superfamily
    1997 526 citations Joseph M. Jez, Mitchell Lewis et al. profile →
  5. Human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1‒AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones
    2000 505 citations T.M. Penning, Joseph M. Jez et al. profile →
  6. The aldo-keto reductases (AKRs): Overview
    2014 370 citations T.M. Penning Chemico-Biological Interactions profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
T.M. Penning United States 76 8.4k 7.5k 5.4k 2.4k 2.4k 353 21.0k
Bruce Α. Freeman United States 100 15.9k 1.9× 2.3k 0.3× 2.0k 0.4× 3.8k 1.6× 1.5k 0.6× 297 46.5k
Kathy K. Griendling United States 95 17.0k 2.0× 1.8k 0.2× 5.8k 1.1× 2.6k 1.0× 2.1k 0.9× 231 46.1k
Roland Stocker Australia 87 13.8k 1.6× 2.1k 0.3× 1.8k 0.3× 1.4k 0.6× 937 0.4× 314 32.0k
Victor Darley‐Usmar United States 101 15.2k 1.8× 2.4k 0.3× 1.2k 0.2× 1.9k 0.8× 2.1k 0.9× 373 33.2k
Rodney L. Levine United States 76 13.2k 1.6× 3.0k 0.4× 855 0.2× 1.4k 0.6× 1.0k 0.4× 204 27.1k
Tilman Grune Germany 88 12.4k 1.5× 4.3k 0.6× 1.5k 0.3× 795 0.3× 878 0.4× 474 26.0k
John D. Hayes United Kingdom 84 27.9k 3.3× 2.2k 0.3× 913 0.2× 1.4k 0.6× 3.2k 1.3× 262 37.1k
Stefan L. Marklund Sweden 78 9.6k 1.1× 1.3k 0.2× 1.5k 0.3× 1.2k 0.5× 799 0.3× 305 27.8k
Paul J. Thornalley United Kingdom 89 9.4k 1.1× 2.0k 0.3× 6.4k 1.2× 576 0.2× 1.1k 0.4× 330 27.7k
Thomas W. Kensler United States 104 28.8k 3.4× 1.9k 0.2× 875 0.2× 2.4k 1.0× 4.7k 2.0× 407 42.4k

Countries citing papers authored by T.M. Penning

Since Specialization
Citations

This map shows the geographic impact of T.M. Penning's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by T.M. Penning with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites T.M. Penning more than expected).

Fields of papers citing papers by T.M. Penning

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by T.M. Penning. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by T.M. Penning. The network helps show where T.M. Penning may publish in the future.

Co-authorship network of co-authors of T.M. Penning

This figure shows the co-authorship network connecting the top 25 collaborators of T.M. Penning. A scholar is included among the top collaborators of T.M. Penning based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with T.M. Penning. T.M. Penning is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Jonnalagadda, Sravan K., Ling Duan, Elizabeth A. Kosmacek, et al.. (2024). Coumarin‐Based Aldo‐Keto Reductase Family 1C (AKR1C) 2 and 3 Inhibitors. ChemMedChem. 19(21). e202400081–e202400081. 1 indexed citations
2.
Penning, T.M., et al.. (2023). Germline Mutations in Steroid Metabolizing Enzymes: A Focus on Steroid Transforming Aldo-Keto Reductases. International Journal of Molecular Sciences. 24(3). 1873–1873. 8 indexed citations
3.
Ma, Lin, Dongxiao Sun, Guangli Xiu, et al.. (2022). Quantification of Plasma 8-Isoprostane by High-Performance Liquid Chromatography with Tandem Mass Spectrometry in a Case-Control Study of Lung Cancer. International Journal of Environmental Research and Public Health. 19(19). 12488–12488. 6 indexed citations
4.
Gangitano, Elena, Niall Dempster, Sherly George, et al.. (2021). Differential activity and expression of human 5β-reductase (AKR1D1) splice variants. Journal of Molecular Endocrinology. 66(3). 181–194. 6 indexed citations
5.
Verma, Kshitij, Nehal Gupta, Tianzhu Zang, et al.. (2018). AKR1C3 Inhibitor KV-37 Exhibits Antineoplastic Effects and Potentiates Enzalutamide in Combination Therapy in Prostate Adenocarcinoma Cells. Molecular Cancer Therapeutics. 17(9). 1833–1845. 38 indexed citations
6.
Mostaghel, Elahe A., Ailin Zhang, Susana Hernández, et al.. (2018). Contribution of Adrenal Glands to Intratumor Androgens and Growth of Castration-Resistant Prostate Cancer. Clinical Cancer Research. 25(1). 426–439. 49 indexed citations
7.
Penning, T.M.. (2018). Dehydroepiandrosterone (DHEA)-SO 4 Depot and Castration-Resistant Prostate Cancer. Vitamins and hormones. 108. 309–331. 13 indexed citations
8.
Sullivan, J. P., Gilbert T. Rowe, Harshica Fernando, et al.. (2018). Building and Maintaining a Citizen Science Network With Fishermen and Fishing Communities Post Deepwater Horizon Oil Disaster Using a CBPR Approach. NEW SOLUTIONS A Journal of Environmental and Occupational Health Policy. 28(3). 416–447. 22 indexed citations
9.
Zang, Tianzhu, Kshitij Verma, Mo Chen, et al.. (2014). Screening baccharin analogs as selective inhibitors against type 5 17β-hydroxysteroid dehydrogenase (AKR1C3). Chemico-Biological Interactions. 234. 339–348. 29 indexed citations
10.
Zhang, Li, Yi Jin, Mo Chen, et al.. (2011). Detoxication of Structurally Diverse Polycyclic Aromatic Hydrocarbon (PAH) o-Quinones by Human Recombinant Catechol-O-methyltransferase (COMT) via O-Methylation of PAH Catechols. Journal of Biological Chemistry. 286(29). 25644–25654. 28 indexed citations
11.
Park, Jong‐Heum, Dipti Mangal, Alexander J. Frey, et al.. (2009). Aryl Hydrocarbon Receptor Facilitates DNA Strand Breaks and 8-Oxo-2′-deoxyguanosine Formation by the Aldo-Keto Reductase Product Benzo[a]pyrene-7,8-dione. Journal of Biological Chemistry. 284(43). 29725–29734. 67 indexed citations
12.
Patte‐Mensah, Christine, T.M. Penning, & Ayikoe Guy Mensah‐Nyagan. (2004). Anatomical and cellular localization of neuroactive 5α/3α‐reduced steroid‐synthesizing enzymes in the spinal cord. The Journal of Comparative Neurology. 477(3). 286–299. 73 indexed citations
13.
Harvey, Ronald G., Qing Dai, Chongzhao Ran, Sridhar Gopishetty, & T.M. Penning. (2004). EFFICIENT NEW SYNTHESES OF POLYCYCLIC AROMATIC HYDROCARBON ORTHO-QUINONES AND THEIR 2′-DEOXYRIBONUCLEOSIDE ADDUCTS. Polycyclic aromatic compounds. 24(4-5). 257–269. 2 indexed citations
14.
Penning, T.M., et al.. (2004). POLYCYCLIC AROMATIC HYDROCARBON O -QUINONES MUTATE p 53 IN HUMAN LUNG ADENOCARCINOMA (A549) CELLS. Polycyclic aromatic compounds. 24(4-5). 583–596. 2 indexed citations
15.
Penning, T.M., Yi Jin, Vladi V. Heredia, & Mitchell Lewis. (2003). Structure–function relationships in 3α-hydroxysteroid dehydrogenases: a comparison of the rat and human isoforms. The Journal of Steroid Biochemistry and Molecular Biology. 85(2-5). 247–255. 57 indexed citations
16.
Hyndman, David, David R. Bauman, Vladi V. Heredia, & T.M. Penning. (2003). The aldo-keto reductase superfamily homepage. Chemico-Biological Interactions. 143-144. 621–631. 263 indexed citations
17.
Jin, Yi, William C. Cooper, & T.M. Penning. (2003). Examination of the differences in structure–function of human and rat 3α-hydroxysteroid dehydrogenase. Chemico-Biological Interactions. 143-144. 383–392. 2 indexed citations
18.
Penning, T.M. & Joseph M. Jez. (2001). Enzyme Redesign. Chemical Reviews. 101(10). 3027–3046. 99 indexed citations
19.
Hardy, Dianne O., et al.. (2000). Identification of the Oxidative 3α-Hydroxysteroid Dehydrogenase Activity of Rat Leydig Cells as Type II Retinol Dehydrogenase*. Endocrinology. 141(5). 1608–1617. 33 indexed citations
20.
Smithgall, Thomas E., Ronald G. Harvey, & T.M. Penning. (1987). Spectroscopic Identification of ortho-Quinones as the Products of Polycyclic Aromatic trans-Dihydrodiol Oxidation Catalyzed by Dihydrodiol Dehydrogenase. Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States). 26 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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