Stefano Fiorucci

25.5k total citations · 7 hit papers
355 papers, 20.0k citations indexed

About

Stefano Fiorucci is a scholar working on Oncology, Surgery and Molecular Biology. According to data from OpenAlex, Stefano Fiorucci has authored 355 papers receiving a total of 20.0k indexed citations (citations by other indexed papers that have themselves been cited), including 131 papers in Oncology, 118 papers in Surgery and 71 papers in Molecular Biology. Recurrent topics in Stefano Fiorucci's work include Drug Transport and Resistance Mechanisms (117 papers), Liver Disease Diagnosis and Treatment (51 papers) and Inflammatory mediators and NSAID effects (48 papers). Stefano Fiorucci is often cited by papers focused on Drug Transport and Resistance Mechanisms (117 papers), Liver Disease Diagnosis and Treatment (51 papers) and Inflammatory mediators and NSAID effects (48 papers). Stefano Fiorucci collaborates with scholars based in Italy, United States and Canada. Stefano Fiorucci's co-authors include Eleonora Distrutti, Andrea Mencarelli, Barbara Renga, Antonio Morelli, Sabrina Cipriani, Giuseppe Cirino, John L. Wallace, Angela Zampella, Luca Santucci and Michele Biagioli and has published in prestigious journals such as Proceedings of the National Academy of Sciences, Journal of Biological Chemistry and Circulation.

In The Last Decade

Stefano Fiorucci

351 papers receiving 19.6k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Hydrogen sulfide is an endogenous modulator of leukocyte‐mediated inflammation

2006 751 citations Eleonora Distrutti, Stefano Fiorucci et al. profile →
6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity

2002 617 citations Roberto Pellicciari, Stefano Fiorucci et al. Journal of Medicinal Chemistry profile →
The Third Gas: H2S Regulates Perfusion Pressure in Both the Isolated and Perfused Normal Rat Liver and in Cirrhosis *

2005 512 citations Stefano Fiorucci, Elisabetta Antonelli et al. Hepatology profile →
The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity

2009 510 citations Andrea Mencarelli, Barbara Renga et al. profile →
Bile Acid-Activated Receptors, Intestinal Microbiota, and the Treatment of Metabolic Disorders

2015 389 citations Stefano Fiorucci, Eleonora Distrutti profile →
Bile Acids Activated Receptors Regulate Innate Immunity

2018 389 citations Stefano Fiorucci, Michele Biagioli et al. profile →
Bile acids and their receptors in metabolic disorders

2021 173 citations Stefano Fiorucci, Eleonora Distrutti et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Stefano Fiorucci Italy	73	6.0k	5.7k	5.0k	4.1k	3.4k	355	20.0k
Wolfgang Stremmel Germany	87	4.4k 0.7×	9.4k 1.7×	4.5k 0.9×	5.1k 1.2×	1.2k 0.4×	660	27.5k
Samuel W. French United States	79	2.4k 0.4×	7.6k 1.3×	3.3k 0.7×	8.4k 2.0×	1.8k 0.5×	574	22.4k
Kristina Schoonjans Switzerland	89	8.6k 1.4×	16.6k 2.9×	7.6k 1.5×	6.9k 1.7×	1.6k 0.5×	203	32.8k
Folkert Kuipers Netherlands	80	9.6k 1.6×	8.7k 1.5×	9.5k 1.9×	5.6k 1.4×	1.3k 0.4×	461	23.8k
Neil Kaplowitz United States	95	4.4k 0.7×	8.4k 1.5×	2.7k 0.5×	9.7k 2.4×	3.7k 1.1×	314	30.6k
Hartmut Jaeschke United States	107	5.6k 0.9×	8.2k 1.4×	6.5k 1.3×	9.1k 2.2×	1.8k 0.5×	399	34.7k
Peter A. Edwards United States	80	6.4k 1.1×	11.8k 2.1×	10.4k 2.1×	3.2k 0.8×	2.0k 0.6×	166	23.8k
Dietrich Keppler Germany	85	14.0k 2.3×	5.6k 1.0×	4.3k 0.9×	2.3k 0.6×	2.6k 0.8×	261	22.5k
Eleonora Distrutti Italy	51	2.7k 0.4×	3.1k 0.5×	2.3k 0.5×	2.0k 0.5×	2.4k 0.7×	162	10.4k
Jean‐Charles Fruchart France	94	3.9k 0.7×	15.8k 2.8×	10.3k 2.1×	5.0k 1.2×	2.6k 0.8×	382	31.8k

Countries citing papers authored by Stefano Fiorucci

Since Specialization

Citations

This map shows the geographic impact of Stefano Fiorucci's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Stefano Fiorucci with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Stefano Fiorucci more than expected).

Fields of papers citing papers by Stefano Fiorucci

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Stefano Fiorucci. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Stefano Fiorucci. The network helps show where Stefano Fiorucci may publish in the future.

Co-authorship network of co-authors of Stefano Fiorucci

This figure shows the co-authorship network connecting the top 25 collaborators of Stefano Fiorucci. A scholar is included among the top collaborators of Stefano Fiorucci based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Stefano Fiorucci. Stefano Fiorucci is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Moraca, Federica, Elva Morretta, Cristina Di Giorgio, et al.. (2025). Harnessing the Estradienone Scaffold to Develop Dual GPBAR1 and LIFR Modulators for Liver Fibrosis. Journal of Medicinal Chemistry. 68(19). 20037–20059.

Fiorucci, Stefano, et al.. (2024). Current Landscape and Evolving Therapies for Primary Biliary Cholangitis. Cells. 13(18). 1580–1580. 9 indexed citations

Festa, Carmen, Simona De Marino, Angela Zampella, & Stefano Fiorucci. (2023). Theonella: A Treasure Trove of Structurally Unique and Biologically Active Sterols. Marine Drugs. 21(5). 291–291. 3 indexed citations

Roselli, Rosalinda, Claudia Finamore, Michele Biagioli, et al.. (2023). Discovery of a Novel Class of Dual GPBAR1 Agonists–RORγt Inverse Agonists for the Treatment of IL-17-Mediated Disorders. ACS Omega. 8(6). 5983–5994. 5 indexed citations

Finamore, Claudia, Carmen Festa, Francesco Saverio Di Leva, et al.. (2023). Expanding the Library of 1,2,4-Oxadiazole Derivatives: Discovery of New Farnesoid X Receptor (FXR) Antagonists/Pregnane X Receptor (PXR) Agonists. Molecules. 28(6). 2840–2840. 5 indexed citations

Biagioli, Michele, Silvia Marchianò, Rosalinda Roselli, et al.. (2022). GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation. Cells. 11(7). 1187–1187. 16 indexed citations

Santinelli, Letizia, Giacomo Rossi, Giorgia Gioacchini, et al.. (2022). The crosstalk between gut barrier impairment, mitochondrial dysfunction, and microbiota alterations in people living with HIV. Journal of Medical Virology. 95(1). e28402–e28402. 6 indexed citations

Marino, Simona De, Claudia Finamore, Michele Biagioli, et al.. (2020). GPBAR1 Activation by C6-Substituted Hyodeoxycholane Analogues Protect against Colitis. ACS Medicinal Chemistry Letters. 11(5). 818–824. 9 indexed citations

Festa, Carmen, Claudia Finamore, Silvia Marchianò, et al.. (2019). Investigation around the Oxadiazole Core in the Discovery of a New Chemotype of Potent and Selective FXR Antagonists. ACS Medicinal Chemistry Letters. 10(4). 504–510. 29 indexed citations

10.

Carino, Adriana, Silvia Marchianò, Michele Biagioli, et al.. (2019). Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation. Nutrients. 11(5). 1132–1132. 26 indexed citations

11.

Sepe, Valentina, Silvia Marchianò, Claudia Finamore, et al.. (2018). Novel Isoxazole Derivatives with Potent FXR Agonistic Activity Prevent Acetaminophen-Induced Liver Injury. ACS Medicinal Chemistry Letters. 10(4). 407–412. 31 indexed citations

12.

Marino, Simona De, Adriana Carino, Claudia Finamore, et al.. (2017). Epoxide functionalization on cholane side chains in the identification of G-protein coupled bile acid receptor (GPBAR1) selective agonists. RSC Advances. 7(52). 32877–32885. 4 indexed citations

13.

Carino, Adriana, Sabrina Cipriani, Silvia Marchianò, et al.. (2017). Gpbar1 agonism promotes a Pgc-1α-dependent browning of white adipose tissue and energy expenditure and reverses diet-induced steatohepatitis in mice. Scientific Reports. 7(1). 13689–13689. 44 indexed citations

14.

Renga, Barbara, Andrea Mencarelli, Marco Migliorati, et al.. (2011). SHP-dependent and -independent induction of peroxisome proliferator-activated receptor-γ by the bile acid sensor farnesoid X receptor counter-regulates the pro-inflammatory phenotype of liver myofibroblasts. Inflammation Research. 60(6). 577–587. 47 indexed citations

15.

Renga, Barbara, Andrea Mencarelli, Marco Migliorati, Eleonora Distrutti, & Stefano Fiorucci. (2009). Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation. World Journal of Gastroenterology. 15(17). 2097–2097. 54 indexed citations

16.

Fiorucci, Stefano, Carlo Clerici, Elisabetta Antonelli, et al.. (2005). Protective Effects of 6-Ethyl Chenodeoxycholic Acid, a Farnesoid X Receptor Ligand, in Estrogen-Induced Cholestasis. Journal of Pharmacology and Experimental Therapeutics. 313(2). 604–612. 164 indexed citations

17.

Fiorucci, Stefano, Elisabetta Antonelli, Eleonora Distrutti, et al.. (2004). PAR1 antagonism protects against experimental liver fibrosis. Role of proteinase receptors in stellate cell activation. Hepatology. 39(2). 365–375. 136 indexed citations

18.

Aisa, Maria Cristina, et al.. (1999). Nitric oxide inhibits cathepsin B, UPA and plasmin activity via S-nitrosylation in vitro and in vivo.. Bone. 25. 167–167. 1 indexed citations

19.

Santucci, Luca, Stefano Fiorucci, Michael Chiorean, et al.. (1996). Interleukin 10 reduces lethality and hepatic injury induced by lipopolysaccharide in galactosamine-sensitized mice. Gastroenterology. 111(3). 736–744. 108 indexed citations

20.

Colozza, Mariantonietta, Maurizio Tonato, Anna Maria Mosconi, et al.. (1988). 5-fluorouracil and isoprinosine in the treatment of advanced colorectal cancer. A limited phase I, II evaluation. Cancer. 62(6). 1049–1052. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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