Sergio C. Chai

2.1k total citations
49 papers, 1.4k citations indexed

About

Sergio C. Chai is a scholar working on Pharmacology, Molecular Biology and Oncology. According to data from OpenAlex, Sergio C. Chai has authored 49 papers receiving a total of 1.4k indexed citations (citations by other indexed papers that have themselves been cited), including 22 papers in Pharmacology, 18 papers in Molecular Biology and 18 papers in Oncology. Recurrent topics in Sergio C. Chai's work include Pharmacogenetics and Drug Metabolism (22 papers), Hormonal Regulation and Hypertension (12 papers) and Peptidase Inhibition and Analysis (11 papers). Sergio C. Chai is often cited by papers focused on Pharmacogenetics and Drug Metabolism (22 papers), Hormonal Regulation and Hypertension (12 papers) and Peptidase Inhibition and Analysis (11 papers). Sergio C. Chai collaborates with scholars based in United States, United Kingdom and China. Sergio C. Chai's co-authors include Taosheng Chen, Yueming Wang, Qi-Zhuang Ye, Su Sien Ong, Wenwei Lin, Michael J. Maroney, Jing Wu, Milu T. Cherian, William C. Wright and Cameron D. Buchman and has published in prestigious journals such as Journal of the American Chemical Society, Nucleic Acids Research and Journal of Biological Chemistry.

In The Last Decade

Sergio C. Chai

49 papers receiving 1.4k citations

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Sergio C. Chai United States 23 625 495 475 247 231 49 1.4k
Paolo Lombardi Italy 26 1.2k 1.9× 388 0.8× 396 0.8× 66 0.3× 252 1.1× 76 2.2k
Natallia Strushkevich Belarus 15 462 0.7× 156 0.3× 461 1.0× 317 1.3× 159 0.7× 42 1.2k
Wen‐Xu Hong China 20 759 1.2× 222 0.4× 171 0.4× 79 0.3× 102 0.4× 77 1.5k
J M Trzaskos United States 19 916 1.5× 180 0.4× 300 0.6× 84 0.3× 274 1.2× 26 1.8k
Ursula Müller‐Vieira Germany 24 454 0.7× 112 0.2× 397 0.8× 422 1.7× 292 1.3× 29 1.5k
Yuko Matsushima‐Hibiya Japan 19 693 1.1× 338 0.7× 250 0.5× 103 0.4× 114 0.5× 29 1.3k
J. Neville Wright United Kingdom 21 691 1.1× 219 0.4× 685 1.4× 334 1.4× 469 2.0× 43 1.6k
Hiroyuki Miyachi Japan 28 1.1k 1.8× 340 0.7× 75 0.2× 95 0.4× 109 0.5× 93 2.1k
Won‐Jea Cho South Korea 24 1.1k 1.8× 237 0.5× 146 0.3× 188 0.8× 76 0.3× 76 2.3k

Countries citing papers authored by Sergio C. Chai

Since Specialization
Citations

This map shows the geographic impact of Sergio C. Chai's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Sergio C. Chai with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Sergio C. Chai more than expected).

Fields of papers citing papers by Sergio C. Chai

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Sergio C. Chai. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Sergio C. Chai. The network helps show where Sergio C. Chai may publish in the future.

Co-authorship network of co-authors of Sergio C. Chai

This figure shows the co-authorship network connecting the top 25 collaborators of Sergio C. Chai. A scholar is included among the top collaborators of Sergio C. Chai based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Sergio C. Chai. Sergio C. Chai is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Wang, Jingheng, Stanley Nithianantham, Sergio C. Chai, et al.. (2025). Decoding the selective chemical modulation of CYP3A4. Nature Communications. 16(1). 3423–3423. 1 indexed citations
2.
Huber, Andrew D., Sergio C. Chai, Stanley Nithianantham, et al.. (2024). Chemical manipulation of an activation/inhibition switch in the nuclear receptor PXR. Nature Communications. 15(1). 4054–4054. 13 indexed citations
3.
Das, Sourav, Clifford T. Gee, Sergio C. Chai, et al.. (2023). Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors. ACS Medicinal Chemistry Letters. 14(10). 1441–1447. 2 indexed citations
4.
Huber, Andrew D., Jing Wu, Darcie J. Miller, et al.. (2023). A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR. Nucleic Acids Research. 52(4). 1661–1676. 6 indexed citations
5.
Wang, Jingheng, Cameron D. Buchman, J. Seetharaman, et al.. (2021). Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5. Journal of the American Chemical Society. 143(44). 18467–18480. 13 indexed citations
6.
Wright, William C., Jingheng Wang, Hazel M. Girvan, et al.. (2020). Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5. Journal of Medicinal Chemistry. 63(3). 1415–1433. 34 indexed citations
7.
Cherian, Milu T., et al.. (2016). Identification and Characterization of CINPA1 Metabolites Facilitates Structure-Activity Studies of the Constitutive Androstane Receptor. Drug Metabolism and Disposition. 44(11). 1759–1770. 10 indexed citations
8.
Cherian, Milu T., Sergio C. Chai, & Taosheng Chen. (2015). Small-molecule modulators of the constitutive androstane receptor. Expert Opinion on Drug Metabolism & Toxicology. 11(7). 1099–1114. 26 indexed citations
9.
Wang, Yueming, et al.. (2014). Pregnane X receptor and drug-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology. 10(11). 1521–1532. 45 indexed citations
10.
Chai, Sergio C., Asli N. Goktug, & Taosheng Chen. (2013). Liquid handling devices in drug discovery: When, what, why?. 18(6). 11–14. 2 indexed citations
11.
Wang, Yueming, Wenwei Lin, Sergio C. Chai, et al.. (2013). Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1. Toxicology and Applied Pharmacology. 272(1). 96–107. 61 indexed citations
12.
Goktug, Asli N., Sergio C. Chai, & Taosheng Chen. (2013). A Timetable Organizer for the Planning and Implementation of Screenings in Manual or Semi-Automation Mode. SLAS DISCOVERY. 18(8). 938–942. 2 indexed citations
13.
Wang, Yueming, Su Sien Ong, Sergio C. Chai, & Taosheng Chen. (2012). Role of CAR and PXR in xenobiotic sensing and metabolism. Expert Opinion on Drug Metabolism & Toxicology. 8(7). 803–817. 186 indexed citations
14.
Chai, Sergio C., Arunmozhiarasi Armugam, Peter N. Strong, & Kandiah Jeyaseelan. (2012). Charaterization of bumarsin, a 3-hydroxy-3-methylglutaryl-coenzyme reductase inhibitor from Mesobuthus martensii Karsch venom. Toxicon. 60(3). 272–279. 8 indexed citations
15.
Chai, Sergio C., et al.. (2011). Growth inhibition of Escherichia coli and methicillin-resistant Staphylococcus aureus by targeting cellular methionine aminopeptidase. European Journal of Medicinal Chemistry. 46(8). 3537–3540. 23 indexed citations
16.
Chai, Sergio C., et al.. (2011). An Automated Approach to Efficiently Reformat a Large Collection of Compounds. PubMed. 5. 42–47. 6 indexed citations
17.
Chai, Sergio C. & Qi-Zhuang Ye. (2009). Metal-mediated inhibition is a viable approach for inhibiting cellular methionine aminopeptidase. Bioorganic & Medicinal Chemistry Letters. 19(24). 6862–6864. 11 indexed citations
18.
Ju, Tingting, et al.. (2006). One Protein, Two Enzymes Revisited: A Structural Entropy Switch Interconverts the Two Isoforms of Acireductone Dioxygenase. Journal of Molecular Biology. 363(4). 823–834. 49 indexed citations
19.
Chai, Sergio C., John Bruyere, & Michael J. Maroney. (2006). Probes of the Catalytic Site of Cysteine Dioxygenase. Journal of Biological Chemistry. 281(23). 15774–15779. 36 indexed citations
20.
Chai, Sergio C., et al.. (2004). Heterologous Expression, Purification, and Characterization of Recombinant Rat Cysteine Dioxygenase. Journal of Biological Chemistry. 280(11). 9865–9869. 58 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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